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Pathway Description
Pyruvate Decarboxylation to Acetyl-CoA
Escherichia coli
Metabolic Pathway
The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH.
References
Pyruvate Decarboxylation to Acetyl-CoA References
de Kok A, Hengeveld AF, Martin A, Westphal AH: The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria. Biochim Biophys Acta. 1998 Jun 29;1385(2):353-66.
Pubmed: 9655933
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