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Pathway Description
Pyruvate to Cytochrome bd Terminal Oxidase Electron Transfer
Escherichia coli
Metabolic Pathway
The reaction of pyruvate to cytochrome bd terminal oxidase electron transfer starts with 2 pyruvate and 2 water molecules reacting in a pyruvate oxidase resulting in the release of 4 electrons into the inner membrane, and releasing 2 carbon dioxide molecules , 2 acetate and 4 hydrogen ion into the cytosol.
2 ubiquinone,4 hydrogen ion and 4 electron ion react resulting in the release of 2 ubiquinol . The 2 ubiquinol in turn release 4 hydrogen ions into the periplasmic space through a cytochrome bd-I terminal oxidase and releasing 4 electrons through the enzyme. Oxygen and 4 hydrogen ion reacts with the 4 electrons resulting in 2 water molecules.
References
Pyruvate to Cytochrome bd Terminal Oxidase Electron Transfer References
Abdel-Hamid AM, Attwood MM, Guest JR: Pyruvate oxidase contributes to the aerobic growth efficiency of Escherichia coli. Microbiology. 2001 Jun;147(Pt 6):1483-98. doi: 10.1099/00221287-147-6-1483.
Pubmed: 11390679
Koland JG, Miller MJ, Gennis RB: Reconstitution of the membrane-bound, ubiquinone-dependent pyruvate oxidase respiratory chain of Escherichia coli with the cytochrome d terminal oxidase. Biochemistry. 1984 Jan 31;23(3):445-53.
Pubmed: 6367818
Unden G, Bongaerts J: Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors. Biochim Biophys Acta. 1997 Jul 4;1320(3):217-34.
Pubmed: 9230919
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