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Pathway Description
Ribose Degradation
Escherichia coli
Metabolic Pathway
Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy for the cell. A high-affinity ABC transport system transports D-ribose into the cell as unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D-ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously. Ribokinase converts D-ribose to the pentose phosphate pathway intermediate, D-ribose 5-phosphate, which can enter the central metabolism pathways to meet the cells needs.
References
Ribose Degradation References
Mowbray SL, Cole LB: 1.7 A X-ray structure of the periplasmic ribose receptor from Escherichia coli. J Mol Biol. 1992 May 5;225(1):155-75.
Pubmed: 1583688
Pauly DF, Pepine CJ: D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther. 2000 Oct;5(4):249-58. doi: 10.1054/JCPT.2000.18011.
Pubmed: 11150394
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