2499PathwayPhosphatidylcholine BiosynthesisPhosphatidyl ethanolamine reacts with S-adenosylmethionine through a phosphatdylethanolamine N-methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The PE-NMe reacts with S'-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts with s-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PCMetabolicPW002720CenterPathwayVisualizationContext300613011827#000099PathwayVisualization24772499Phosphatidylcholine BiosynthesisPhosphatidyl ethanolamine reacts with S-adenosylmethionine through a phosphatdylethanolamine N-methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The PE-NMe reacts with S'-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts with s-adenosylmethionine through a phosphotidyl-N-methylethanolamine N-methyltransferase resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PCMetabolic18556020656373Aktas M, Wessel M, Hacker S, Klusener S, Gleichenhagen J, Narberhaus F: Phosphatidylcholine biosynthesis and its significance in bacteria interacting with eukaryotic cells. Eur J Cell Biol. 2010 Dec;89(12):888-94. doi: 10.1016/j.ejcb.2010.06.013. Epub 2010 Jul 24.2499Pathway556111115895Bolognese CP, McGraw P: The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase. Plant Physiol. 2000 Dec;124(4):1800-13.2499Pathway556216246068Boumann HA, de Kroon AI: The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast. Biochem Soc Trans. 2005 Nov;33(Pt 5):1146-9. doi: 10.1042/BST20051146.2499Pathway1CellCL:00000006MyocyteCL:00001875HepatocyteCL:000018218Saccharomyces cerevisiae4932EukaryoteYeast1Homo sapiens9606EukaryoteHuman4Arabidopsis thaliana3702EukaryoteThale cress12Mus musculus10090EukaryoteMouse5Bos taurus9913EukaryoteCattle17Rattus norvegicus10116EukaryoteRat6Caenorhabditis elegans6239EukaryoteRoundworm10Drosophila melanogaster7227EukaryoteFruit fly3Escherichia coli562Prokaryote2Bacteria2ProkaryoteBacteria24Solanum lycopersicum4081EukaryoteTomato21Xenopus laevis8355EukaryoteAfrican clawed frog25Escherichia coli (strain K12)83333Prokaryote23Pseudomonas aeruginosa287Prokaryote60Nitzschia sp.0001EukaryoteNitzschia42MitochondrionGO:000573913Endoplasmic ReticulumGO:00057837Endoplasmic Reticulum MembraneGO:000578939Mitochondrial membraneGO:003196612Mitochondrial Inner MembraneGO:000574310Cell MembraneGO:00058865CytoplasmGO:000573717NucleoplasmGO:00056541CytosolGO:000582915NucleusGO:00056343Mitochondrial MatrixGO:000575935ChloroplastGO:000950714Mitochondrial Outer MembraneGO:000574111Extracellular SpaceGO:000561524Mitochondrial Intermembrane SpaceGO:000575831Periplasmic SpaceGO:00056204PeroxisomeGO:000577736MembraneGO:001602053Endoplasmic Reticulum BodyGO:001016834Plant-Type VacuoleGO:000032532Inner MembraneGO:00702584Adrenal MedullaBTO:00000497181LiverBTO:00007597299MuscleBTO:00008871411828StomachBTO:0001307155268Blood VesselBTO:000110274111632181PW_BS0001631951318PW_BS00002449711PW_BS0000493093911PW_BS000024171211PW_BS0000172491341PW_BS0000242851041PW_BS0000243317121PW_BS00002813412121PW_BS00013436139121PW_BS000028383751PW_BS0001003841251PW_BS0001003863951PW_BS0001003987171PW_BS00011312112171PW_BS00012140139171PW_BS0001138511PW_BS000008301711PW_BS000030204111PW_BS0000203211PW_BS00000327151PW_BS0000272111PW_BS000002101711PW_BS000010509516PW_BS0000501355171PW_BS00013521013181PW_BS0000242137181PW_BS0000241601181PW_BS000160151141PW_BS0001511985181PW_BS000024222341PW_BS0000242253541PW_BS000024181311PW_BS00001829341PW_BS0000241644PW_BS000164224241PW_BS0000241115121PW_BS00011133817121PW_BS00002834141121PW_BS0000281321121PW_BS0001323511512PW_BS00002834695126PW_BS0000281122121PW_BS000112221411PW_BS0000223821451PW_BS0001003891461PW_BS0001123973961PW_BS00011339914171PW_BS000113122551PW_BS0001224131751PW_BS000115407251PW_BS000115124151PW_BS000124435155PW_BS00011544917171PW_BS0001151192171PW_BS0001191181171PW_BS0001184701517PW_BS0001152975101PW_BS0000244812101PW_BS0001152991101PW_BS0000244991510PW_BS000115205561PW_BS000024206261PW_BS000024388161PW_BS000112517156PW_BS0001154311PW_BS00000415111PW_BS000015311511PW_BS000031261115PW_BS000026541315PW_BS000054422411PW_BS0000427028511PW_BS000070103331PW_BS00010310813PW_BS000108107313PW_BS000107100521PW_BS000100105113PW_BS000105117131PW_BS0001171471241PW_BS0001471553241PW_BS0001551572241PW_BS0001571613181PW_BS00016115924PW_BS00015916611PW_BS0001661783211PW_BS00017815284PW_BS000152101531PW_BS000101188118PW_BS0000241873118PW_BS000024219314PW_BS00002422014PW_BS00002421217181PW_BS00002417018PW_BS000170226441PW_BS00002416212181PW_BS0001622811251PW_BS0000242863641PW_BS0000242875341PW_BS0000242273441PW_BS0000242231241PW_BS0000242941141PW_BS0000243081011PW_BS000024315123PW_BS0000243183123PW_BS0000243221231PW_BS0000243125231PW_BS0000243201123PW_BS0000241333121PW_BS0001331141112PW_BS00011432711125PW_BS00002834713125PW_BS00002834524121PW_BS00002813013121PW_BS0001303683601PW_BS000028310312PW_BS00002430412PW_BS000024943PW_BS000094390761PW_BS0001123361121PW_BS000028109323PW_BS000109406351PW_BS000115409115PW_BS0001154241155PW_BS0001154251355PW_BS0001154182451PW_BS0001151251351PW_BS0001251203171PW_BS0001201371117PW_BS00013745911175PW_BS00011546013175PW_BS00011545424171PW_BS00011513613171PW_BS0001364793101PW_BS0001154831110PW_BS0001154957101PW_BS00011548924101PW_BS00011548012101PW_BS00011530013101PW_BS000024501361PW_BS000115208116PW_BS0000245062461PW_BS0001153911261PW_BS0001123951361PW_BS0001134869PE(14:0/14:0)HMDB0008821PE(14:0/14:0) is a phosphatidylethanolamine. It is a glycerophospholipid in which a phosphorylethanolamine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoethanolamines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PE(14:0/14:0), in particular, consists of two tetradecanoyl chains at positions C-1 and C-2. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PEs are neutral zwitterions at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PE synthesis can occur via two pathways. The first requires that ethanolamine be activated by phosphorylation and then coupled to CDP. The ethanolamine is then transferred from CDP-ethanolamine to phosphatidic acid to yield PE. The second involves the decarboxylation of PS.998-07-2C003509852308L-1-PHOSPHATIDYL-ETHANOLAMINE8028021[H][C@@](COC(=O)CCCCCCCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCC33H66NO8PInChI=1S/C33H66NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-32(35)39-29-31(30-41-43(37,38)40-28-27-34)42-33(36)26-24-22-20-18-16-14-12-10-8-6-4-2/h31H,3-30,34H2,1-2H3,(H,37,38)/t31-/m1/s1NEZDNQCXEZDCBI-WJOKGBTCSA-N(2-aminoethoxy)[(2R)-2,3-bis(tetradecanoyloxy)propoxy]phosphinic acid635.864635.452605087-6.4922-aminoethoxy((2R)-2,3-bis(tetradecanoyloxy)propoxy)phosphinic acid00C003501,2-dimyristoyl-rac-glycero-3-phosphoethanolamine;Gpetn(14:0/14:0);Gpetn(28:0);Pe(14:0/14:0);Pe(28:0);Phophatidylethanolamine(14:0/14:0);Phophatidylethanolamine(28:0);Phosphatidylethanolamine (ditetradecanoyl, n-c14:0)PW_C004869PE149115163923419515394491539530922108172547824925479285893283318932913489330361105113383105114384105115386116041398116042121116043401921S-AdenosylmethionineHMDB0001185S-Adenosylmethionine (CAS: 29908-03-0), also known as SAM or AdoMet, is a physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in the treatment of chronic liver disease (From Merck, 11th ed). S-Adenosylmethionine is a natural substance present in the cells of the body. It plays a crucial biochemical role by donating a one-carbon methyl group in a process called transmethylation. S-Adenosylmethionine, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine, and other molecules.485-80-3C000192476216515414S-ADENOSYLMETHIONINE31983DB00118C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2NC15H23N6O5SInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1MEFKEPWMEQBLKI-AIRLBKTGSA-O[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium399.445399.145063566-2.565SAMe11FDB022473(3s)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine;2-s-adenosyl-l-methionine;5'-deoxyadenosine-5'-l-methionine disulfate ditosylate;Active methionine;Ademetionine;Adenosylmethionine;Adomet;Donamet;L-s-adenosylmethionine;S-(5'-adenosyl)-l-methionine;S-(5'-deoxyadenosin-5'-yl)-l-methionine;S-adenosyl methionine;S-adenosyl-l-methionine disulfate tosylate;S-adenosyl-l-methionine;S-adenosyl-methionine;S-adenosylmethionine;5'-deoxyadenosine-5'-l-methionine disulphate ditosylate;S-adenosyl-l-methionine disulphate tosylate;(3s)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt;[1-(adenin-9-yl)-1,5-dideoxy-beta-d-ribofuranos-5-yl][(3s)-3-amino-3-carboxypropyl](methyl)sulfonium;Acylcarnitine;Sam;SamePW_C000921SAMe51986333070420122031880272066246811050235056041357136163754021075442137632160826615192351951187419812031222123582251529324915345181536330976897293768991647698422477488111777313387777234178099132783033517833534679155112799613618086122948303829483338611328638911328839711554339911554640112039312212053741312093940712105212412228243512317144912350511912361611812483647012585929712587948112630429912644749912732120512734020612759538812801751745272PE-NMe(14:0/14:0)HMDB0112935PE-NMe(14:0/14:0) is a monomethylphosphatidylethanolamine. It is a glycerophospholipid, and is formed by sequential methylation of phosphatidylethanolamine as part of a mechanism for biosynthesis of phosphatidylcholine. Monomethylphosphatidylethanolamines are usually found at trace levels in animal or plant tissues. They can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. PE-NMe(14:0/14:0), in particular, consists of two tetradecanoyl chain at positions C-1 and C2. Fatty acids containing 16, 18 and 20 carbons are the most common. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.C01241 15958CPD-405[H]C(COC(=O)CCCCCCCCCCCCC)(COP(O)(=O)OCCNC)OC(=O)CCCCCCCCCCCCCC34H68NO8PInChI=1S/C34H68NO8P/c1-4-6-8-10-12-14-16-18-20-22-24-26-33(36)40-30-32(31-42-44(38,39)41-29-28-35-3)43-34(37)27-25-23-21-19-17-15-13-11-9-7-5-2/h32,35H,4-31H2,1-3H3,(H,38,39)JYWNCNMWXJZGME-UHFFFAOYSA-N[2,3-bis(tetradecanoyloxy)propoxy][2-(methylamino)ethoxy]phosphinic acid649.891649.468255152-6.7622,3-bis(tetradecanoyloxy)propoxy(2-(methylamino)ethoxy)phosphinic acid00MMPE;monomethylphosphatidylethanolamine;N-monomethylphosphatidylethanolamine;phosphatidyl-N-methylethanolaminePW_C045272MMPE9098213911616392361951539930925480249254812858933236110511738611604540140034Hydrogen IonHMDB0059597Hydrogen ion is recommended by IUPAC as a general term for all ions of hydrogen and its isotopes. Depending on the charge of the ion, two different classes can be distinguished: positively charged ions and negatively charged ions. Under aqueous conditions found in biochemistry, hydrogen ions exist as the hydrated form hydronium, H3O+, but these are often still referred to as hydrogen ions or even protons by biochemists. [WikiPedia])C000801038153781010[H+]HInChI=1S/p+1GPRLSGONYQIRFK-UHFFFAOYSA-Nhydron1.00791.0078250320hydron10H+;H(+);Hydrogen cation;Hydron;ProtonPW_C040034H+215467087531578831848311162146326146454223149278017425022425442454710457618469470524110353271115353112562610856391075699100572010557421175963147603715560701576093161613015962321666483178660115266921016843188691018771001637168205719120674532197454220747222275252137532210755821275721607590170819522582181518243226841316284202249139195915524911915164120152811218128512246286122662871252122713257223133252941533030842329315423543184240132242405312424543207691229377136133772101347737233177804114779551327799032777991347783793457992913080019368803873108038830480722119938231249482338311055038811285594113280390115537398115539118115856336116205109119973406120193407120549122120593409121170424121171425122569418122615384122687125122758120123183135123218137123742459123743460125141454125188121125273136125359479125550481125730483125736297125809299126517495126717489126766480126823300126902501127213208128308506128361391128430395749S-AdenosylhomocysteineHMDB0000939S-Adenosyl-L-homocysteine (SAH) is formed by the demethylation of S-adenosyl-L-methionine. S-Adenosylhomocysteine (AdoHcy or SAH) is also the immediate precursor of all of the homocysteine produced in the body. The reaction is catalyzed by S-adenosylhomocysteine hydrolase and is reversible with the equilibrium favoring formation of SAH. In vivo, the reaction is driven in the direction of homocysteine formation by the action of the enzyme adenosine deaminase which converts the second product of the S-adenosylhomocysteine hydrolase reaction, adenosine, to inosine. Except for methyl transfer from betaine and from methylcobalamin in the methionine synthase reaction, SAH is the product of all methylation reactions that involve S-adenosylmethionine (SAM) as the methyl donor. Methylation is significant in epigenetic regulation of protein expression via DNA and histone methylation. The inhibition of these SAM-mediated processes by SAH is a proven mechanism for metabolic alteration. Because the conversion of SAH to homocysteine is reversible, with the equilibrium favoring the formation of SAH, increases in plasma homocysteine are accompanied by an elevation of SAH in most cases. Disturbances in the transmethylation pathway indicated by abnormal SAH, SAM, or their ratio have been reported in many neurodegenerative diseases, such as dementia, depression, and Parkinson's disease (PMID: 18065573, 17892439). Therefore, when present in sufficiently high levels, S-adenosylhomocysteine can act as an immunotoxin and a metabotoxin. An immunotoxin disrupts, limits the function, or destroys immune cells. A metabotoxin is an endogenous metabolite that causes adverse health effects at chronically high levels. Chronically high levels of S-adenosylhomocysteine are associated with S-adenosylhomocysteine (SAH) hydrolase deficiency and adenosine deaminase deficiency. S-Adenosylhomocysteine forms when there are elevated levels of homocysteine and adenosine. S-Adenosyl-L-homocysteine is a potent inhibitor of S-adenosyl-L-methionine-dependent methylation reactions. It is toxic to immature lymphocytes and can lead to immunosuppression (PMID: 221926).979-92-0C000212524622216680ADENOSYL-HOMO-CYS388301N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=OC14H20N6O5SInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1ZJUKTBDSGOFHSH-WFMPWKQPSA-N(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid384.411384.12158847-1.975S-adenosyl-L-homocysteine00DBMET00514FDB022327(s)-5'-(s)-(3-amino-3-carboxypropyl)-5'-thioadenosine;2-s-adenosyl-l-homocysteine;5'-deoxy-s-adenosyl-l-homocysteine;5'-s-(3-amino-3-carboxypropyl)-5'-thio-l-adenosine;Adenosyl-l-homocysteine;Adenosyl-homo-cys;Adenosylhomo-cys;Adenosylhomocysteine;Adohcy;Formycinylhomocysteine;L-5'-s-(3-amino-3-carboxypropyl)-5'-thior-adenosine;L-s-adenosyl-homocysteine;L-s-adenosylhomocysteine;S-(5'-adenosyl)-l-homocysteine;S-(5'-deoxyadenosin-5'-yl)-l-homocysteine;S-(5'-deoxyadenosine-5')-l-homocysteine;S-adenosyl-l-homocysteine;S-adenosyl-homocysteine;Sah;(2s)-2-amino-4-({[(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid;S-[1-(adenin-9-yl)-1,5-dideoxy-beta-d-ribofuranos-5-yl]-l-homocysteine;S-adenosylhomocysteinePW_C000749SAH520857518635307052012213188227206724683105025505607136713716375422107546213763416082681519237195118751981235922515294249153643097748911177611130777333387777334178098132783053517833734679156112799623618086322948313829483438611328738911328939711554439911554740112039412212048612512053941312094040712105312412228443512303713512317344912350611912361711812483847012588048112630329912644949912734120612759638812801951745273PE-NMe2(14:0/14:0)HMDB0113837PE-NMe2(14:0/14:0) is a dimethylphosphatidylethanolamine. It is a glycerophospholipid, and is formed by sequential methylation of phosphatidylethanolamine as part of a mechanism for biosynthesis of phosphatidylcholine. Dimethylphosphatidylethanolamines are usually found at trace levels in animal or plant tissues. They can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions.PE-NMe2(14:0/14:0), in particular, consists of two tetradecanoyl chain at positions C-1 and C2. Fatty acids containing 16, 18 and 20 carbons are the most common. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.C0430852332CPD-160[H]C(COC(=O)CCCCCCCCCCCCC)(COP(O)(=O)OCCN(C)C)OC(=O)CCCCCCCCCCCCCC35H70NO8PInChI=1S/C35H70NO8P/c1-5-7-9-11-13-15-17-19-21-23-25-27-34(37)41-31-33(32-43-45(39,40)42-30-29-36(3)4)44-35(38)28-26-24-22-20-18-16-14-12-10-8-6-2/h33H,5-32H2,1-4H3,(H,39,40)ZYCQYQFZMFJHFN-UHFFFAOYSA-N[2,3-bis(tetradecanoyloxy)propoxy][2-(dimethylamino)ethoxy]phosphinic acid663.918663.483905216-6.6912,3-bis(tetradecanoyloxy)propoxy(2-(dimethylamino)ethoxy)phosphinic acid00dimethylphosphatidylethanolamine;DMPE;N-dimethylphosphatidylethanolamine ;phosphatidyl-N-dimethylethanolamine;phosphatidyl-N,N-dimethylethanolaminePW_C045273PE-NMe2910021391181639239195154003092548224925483285893333611051183861160464013916PC(14:0/14:0)HMDB0007866PC(14:0/14:0) is a phosphatidylchloline (PC). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylcholines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PC(14:0/14:0), in particular, consists of two tetradecanoyl chains at positions C-1 and C-2. In E. coli, PCs can be found in the integral component of the cell outer membrane. They are hydrolyzed by Phospholipases to a 2-acylglycerophosphocholine and a carboxylate.C00157545937745240 PHOSPHATIDYLCHOLINE4573168[H][C@@](COC(=O)CCCCCCCCCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCC36H72NO8PInChI=1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3/t34-/m1/s1CITHEXJVPOWHKC-UUWRZZSWSA-N(2-{[(2R)-2,3-bis(tetradecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium677.9325677.499554797-7.260dimyristoylphosphatidylcholine00FDB0250581,2-dimyristoyl-rac-glycero-3-phosphocholine;Gpcho(14:0/14:0);Gpcho(28:0);Lecithin;Pc(14:0/14:0);Pc(28:0);Phosphatidylcholine(14:0/14:0);Phosphatidylcholine(28:0);1,2-di-o-tetradecanoyl-sn-glycero-3-phosphocholine;1,2-dimyristoyl-l-3-phosphatidylcholine;1,2-dimyristoyl-sn-glycero-3-phosphocholine;1,2-dimyristoylphosphatidylcholine;1,2-ditetradecanoyl-sn-glycero-3-phosphocholine;Dimyristoyl phosphatidylcholine;Dimyristoylphosphatidylcholine;Dmpc;[(2r)-2,3-di(tetradecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphoric acidPW_C003916DMPC9113163924119515396491539730922105182548424925485285893343618933533110511938610512038311604740111604839811298Phosphatidylethanolamine N-methyltransferaseP05374Catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis.CHO2292.1.1.1790992139117163923819511299Phosphatidyl-N-methylethanolamine N-methyltransferaseP05375Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).OPI3292.1.1.17; 2.1.1.719101213911916392401955031Phosphatidylethanolamine N-methyltransferase18PW_P00503112322112985032Phosphatidyl-N-methylethanolamine N-methyltransferase18PW_P00503212323112997424falsePW_R007424Right3071048691Compoundfalse307119211Compoundfalse30712452721Compoundfalse30713400341Compoundfalse307147491Compoundfalse738450312.1.1.177425falsePW_R007425Right30715452721Compoundfalse307169211Compoundfalse30717452731Compoundfalse307187491Compoundfalse30719400341Compoundfalse738550322.1.1.17,2.1.1.717426falsePW_R007426Right30720452731Compoundfalse307219211Compoundfalse307227491Compoundfalse30723400341Compoundfalse3072439161Compoundfalse738650328946848691953false72936210regular100100894699211953false85945710regular10011089470452721953false132435610regular100110894714003419555false117529110regular7878894727491953false115945410regular100110894779211953false141448610regular10011089478452731953false132984610regular100110894797491953false143971610regular100110894804003419555false124971210regular7878894819211953false121994610regular100110894827491953false92494410regular100110894834003419555false94577410regular78788948439161953false77984710regular10010042021112981952false9743758subunitregular1507042023112991952false12996218subunitregular1507042024112991952false10498668subunitregular15070338435031247719541310420213384550322477195413124202333846503224771954131342024128040M829 412 C859 412 944 410 974 410 5false18128041M909 457 C911 417 932 410 974 410 5false18128042M1324 411 C1294 411 1154 410 1124 410 5false18trueM 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345false128043M1214 369 C1214 411 1154 410 1124 410 5false18trueM 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345false128044M1209 454 C1207 406 1164 409 1124 410 5false18trueM 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345false128049M1374 466 C1374 496 1374 591 1374 621 5false18128050M1414 541 C1378 542 1374 591 1374 621 5false18128051M1379 846 C1379 816 1374 721 1374 691 5false18trueM 529.9468550441649 296.261556296296 L 515 295 L 521.3808877211858 308.5751343230783false128052M1439 771 C1371 772 1374 721 1374 691 5false18trueM 529.9468550441649 296.261556296296 L 515 295 L 521.3808877211858 308.5751343230783false128053M1327 751 C1377 748 1374 721 1374 691 5false18trueM 529.9468550441649 296.261556296296 L 515 295 L 521.3808877211858 308.5751343230783false128054M1329 901 C1299 901 1229 901 1199 901 5false18128055M1269 946 C1267 900 1229 901 1199 901 5false18128056M974 944 C976 893 1019 901 1049 901 5false18trueM 529.9468550441649 681.261556296296 L 515 680 L 521.3808877211858 693.5751343230784false128057M984 852 C984 908 1019 901 1049 901 5false18trueM 529.9468550441649 681.261556296296 L 515 680 L 521.3808877211858 693.5751343230784false128058M879 897 C909 897 1019 901 1049 901 5false18trueM 529.9468550441649 681.261556296296 L 515 680 L 521.3808877211858 693.5751343230784false264282477742419510186489468128040Left10186589469128041Left10186689470128042Right10186789471128043Right10186889472128044Right25830738433843264302477742519510187389470128049Left10187489477128050Left10187589478128051Right10187689479128052Right10187789480128053Right25832738533845264312477742619510187889478128054Left10187989481128055Left10188089482128056Right10188189483128057Right10188289484128058Right258337386338461868001802081.01.002904844975129M125 225 C125 175 175 125 225 125 C642 125 1185 125 1602 125 C1652 125 1702 175 1702 225 C1702 483 1702 818 1702 1076 C1702 1126 1652 1176 1602 1176 C1185 1176 642 1176 225 1176 C175 1176 125 1126 125 1076 C125 818 125 483 125 225 1true61577.01051.010205643776912551625109839#FFEEDE4934843