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Pathway Description
Apoptotic DNA Fragmentation and Tissue Homeostasis
Homo sapiens
Protein Pathway
Apoptotic endonucleases degrade chromosomal DNA during programmed cell death. ICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis. Once released from the mitochondrial intermembrane space, EndoG activity is caspase independent.
References
Apoptotic DNA Fragmentation and Tissue Homeostasis References
Zhang J, Xu M: Apoptotic DNA fragmentation and tissue homeostasis. Trends Cell Biol. 2002 Feb;12(2):84-9.
Pubmed: 11849972
https://cgap.nci.nih.gov/Pathways/BioCarta/h_DNAfragmentPathway
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