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Pathway Description
Phospholipase C Signaling Pathway
Homo sapiens
Protein Pathway
Phospholipase C pathways is one of the major intracellular signalling pathways regulating hormones. It functions to activate inositol lipid signalling pathways causing the hydrolysis of PIP2 by PLC to IP3 and diacylglycerol to activate protein kinase C. IP3 releases calcium from the endoplasmic reticulum. PIP3 is an important regulator of AKT signaling and downstream pathways.
References
Phospholipase C Signaling Pathway References
Gresset A, Sondek J, Harden TK: The phospholipase C isozymes and their regulation. Subcell Biochem. 2012;58:61-94. doi: 10.1007/978-94-007-3012-0_3.
Pubmed: 22403074
Smrcka AV: Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes. J Cardiovasc Pharmacol. 2015 Mar;65(3):203-10. doi: 10.1097/FJC.0000000000000195.
Pubmed: 25658460
https://cgap.nci.nih.gov/Pathways/BioCarta/h_plcPathway
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