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Endoplasmic Reticulum acetyl-CoA C- acetyltransferase Hydroxymethylglutaryl- CoA synthase mevalonate kinase Phosphomevalonate kinase Diphosphomevalonate decarboxylase Isopentenyl- diphosphate Delta-isomerase Farnesyl pyrophosphate synthase Farnesyl pyrophosphate synthase Squalene synthase squalene monooxygenase Lanosterol synthase Lanosterol 14-alpha demethylase Delta(14)- sterol reductase Methylsterol monooxygenase Methylsterol monooxygenase Methylsterol monooxygenase C-3 sterol dehydrogenase 3-keto sterol reductase Methylsterol monooxygenase Methylsterol monooxygenase Methylsterol monooxygenase C-3 sterol dehydrogenase 3-keto sterol reductase Sterol 24-C- methyltransferase C-8 sterol isomerase C-5 sterol desaturase C-22 sterol desaturase C-24 sterol reductase C-8 sterol isomerase C-5 sterol desaturase 3-hydroxy-3- methylglutaryl- coenzyme A reductase 2 Desmosterol Cholesterol Acetyl-CoA CoA Acetoacetyl-CoA Acetyl-CoA H2O 3-Hydroxy-3- methylglutaryl- CoA CoA NADPH Mevalonic acid NADP CoA ATP Mevalonic acid-5P ADP ATP ADP (R)-5- Diphosphomevalonic acid ATP ADP Pi Isopentenyl pyrophosphate CO2 Dimethylallylpyrophosphate Isopentenyl pyrophosphate Geranyl-PP PPi Isopentenyl pyrophosphate Farnesyl pyrophosphate PPi NADPH Squalene NADP PPi O2 NADPH (S)-2,3- Epoxysqualene H2O NADP Lanosterol O2 NADPH 4,4- Dimethylcholesta- 8,14,24- trienol Formic acid NADP H2O NADPH 4,4-Dimethyl- 5a-cholesta- 8,24-dien-3- b-ol NADP H+ O2 NADPH 4α- hydroxymethyl- 4β-methyl-5α- cholesta- 8,24-dien-3β- ol NADP H2O H+ O2 NADPH 4α-formyl-4β- methyl-5α- cholesta- 8,24-dien-3β- ol H2O NADP O2 NADPH 4β-methyl-4α- carboxy- cholesta- 8,24-dien-3β- ol H2O NADP NADP 3-Keto-4- methylzymosterol CO2 NADPH NADPH H+ NADP 4a- Methylzymosterol H+ O2 NADPH H2O NADP 4α- hydroxymethyl- 5α-cholesta- 8,24-dien-3β- ol H+ O2 NADPH 4α-formyl-5α- cholesta- 8,24-dien-3β- ol H2O NADP O2 NADPH 4α-carboxy- 5α-cholesta- 8,24-dien-3β- ol H2O NADP NADP 5α-cholesta- 8,24-dien-3- one CO2 NADPH NADPH H+ Zymosterol NADP S- Adenosylmethionine fecosterol S- Adenosylhomocysteine H+ Episterol H+ O2 ferrocytochrome c 5,7,24(28)- Ergostatrienol H2O ferricytochrome c H+ NADPH O2 ergosta- 5,7,22,24(28)- tetraen-3-β- ol NADP H2O H+ NADPH Ergosterol NADP 5a-cholesta- 7,24-dien-3B- ol 7- Dehydrodesmosterol CoA long-chain fatty acyl-CoA Cholesteryl ester 3-hydroxy-3- methylglutaryl- coenzyme A reductase 1
Endoplasmic Reticulum ERG10 ERG13 ERG12 ERG8 MVD1 IDI1 ERG20 ERG20 ERG9 ERG1 ERG7 ERG11 ERG24 ERG25 ERG25 ERG25 ERG26 ERG27 ERG25 ERG25 ERG25 ERG26 ERG27 ERG6 ERG2 ERG3 ERG5 ERG4 ERG2 ERG3 HMG2 Desmosterol Cholesterol Acetyl-CoA Coenzyme A Acetoacetyl-CoA Acetyl-CoA Water 3-Hydroxy-3- methylglutaryl- CoA Coenzyme A NADPH Mevalonic acid NADP Coenzyme A Adenosine triphosphate Mevalonic acid-5P Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate (R)-5- Diphosphomevalonic acid Adenosine triphosphate Adenosine diphosphate Phosphate Isopentenyl pyrophosphate Carbon dioxide Dimethylallylpyrophosphate Isopentenyl pyrophosphate Geranyl-PP Pyrophosphate Isopentenyl pyrophosphate Farnesyl pyrophosphate Pyrophosphate NADPH Squalene NADP Pyrophosphate Oxygen NADPH (S)-2,3- Epoxysqualene Water NADP Lanosterol Oxygen NADPH 4,4- Dimethylcholesta- 8,14,24- trienol Formic acid NADP Water NADPH 4,4-Dimethyl- 5a-cholesta- 8,24-dien-3- b-ol NADP Hydrogen Ion Oxygen NADPH 4α- hydroxymethyl- 4β-methyl-5α- cholesta- 8,24-dien-3β- ol NADP Water Hydrogen Ion Oxygen NADPH 4α-formyl-4β- methyl-5α- cholesta- 8,24-dien-3β- ol Water NADP Oxygen NADPH 4β-methyl-4α- carboxy- cholesta- 8,24-dien-3β- ol Water NADP NADP 3-Keto-4- methylzymosterol Carbon dioxide NADPH NADPH Hydrogen Ion NADP 4a- Methylzymosterol Hydrogen Ion Oxygen NADPH Water NADP 4α- hydroxymethyl- 5α-cholesta- 8,24-dien-3β- ol Hydrogen Ion Oxygen NADPH 4α-formyl-5α- cholesta- 8,24-dien-3β- ol Water NADP Oxygen NADPH 4α-carboxy- 5α-cholesta- 8,24-dien-3β- ol Water NADP NADP 5α-cholesta- 8,24-dien-3- one Carbon dioxide NADPH NADPH Hydrogen Ion Zymosterol NADP S- Adenosylmethionine fecosterol S- Adenosylhomocysteine Hydrogen Ion Episterol Hydrogen Ion Oxygen ferrocytochrome c 5,7,24(28)- Ergostatrienol Water ferricytochrome c Hydrogen Ion NADPH Oxygen ergosta- 5,7,22,24(28)- tetraen-3-β- ol NADP Water Hydrogen Ion NADPH Ergosterol NADP 5a-cholesta- 7,24-dien-3B- ol 7- Dehydrodesmosterol Coenzyme A long-chain fatty acyl-CoA Cholesteryl ester HMG1
Endoplasmic Reticulum ERG10 ERG13 ERG12 ERG8 MVD1 IDI1 ERG20 ERG20 ERG9 ERG1 ERG7 ERG11 ERG24 ERG25 ERG25 ERG25 ERG26 ERG27 ERG25 ERG25 ERG25 ERG26 ERG27 ERG6 ERG2 ERG3 ERG5 ERG4 ERG2 ERG3 HMG2 Desmost Lanol Ac-CoA CoA ActaCoA Ac-CoA H2O HMG-CoA CoA NADPH Mva NADP CoA ATP Mvn-5P ADP ATP ADP R-5DPMA ATP ADP Pi IsopPyr CO2 Ipe IsopPyr Gryl-PP PPi IsopPyr FarPP PPi NADPH Squalen NADP PPi O2 NADPH S23O H2O NADP Lastrol O2 NADPH FF-Mas Formate NADP H2O NADPH 44Dcdol NADP H+ O2 NADPH Cid NADP H2O H+ O2 NADPH fmcdol H2O NADP O2 NADPH 4M4Cdol H2O NADP NADP 3K4Mzol CO2 NADPH NADPH H+ NADP 4aMzmol H+ O2 NADPH H2O NADP HMCDBol H+ O2 NADPH 45FCDol H2O NADP O2 NADPH 4C5C8D3 H2O NADP NADP 5aChone CO2 NADPH NADPH H+ Zymstol NADP SAMe fecoste SAH H+ Epister H+ O2 FerocyC 5Ergol H2O FrcytcC H+ NADPH O2 E57T3βO NADP H2O H+ NADPH Ergoste NADP 5acdol 7-DHMOL CoA LCFAC CE HMG1
Endoplasmic Reticulum ERG10 ERG13 ERG12 ERG8 MVD1 IDI1 ERG20 ERG20 ERG9 ERG1 ERG7 ERG11 ERG24 ERG25 ERG25 ERG25 ERG26 ERG27 ERG25 ERG25 ERG25 ERG26 ERG27 ERG6 ERG2 ERG3 ERG5 ERG4 ERG2 ERG3 HMG2 Desmost Lanol Ac-CoA CoA ActaCoA Ac-CoA H2O HMG-CoA CoA NADPH Mva NADP CoA ATP Mvn-5P ADP ATP ADP R-5DPMA ATP ADP Pi IsopPyr CO2 Ipe IsopPyr Gryl-PP Ppi IsopPyr FarPP Ppi NADPH Squalen NADP Ppi O2 NADPH S23O H2O NADP Lastrol O2 NADPH FF-Mas Formate NADP H2O NADPH 44Dcdol NADP H+ O2 NADPH Cid NADP H2O H+ O2 NADPH fmcdol H2O NADP O2 NADPH 4M4Cdol H2O NADP NADP 3K4Mzol CO2 NADPH NADPH H+ NADP 4aMzmol H+ O2 NADPH H2O NADP HMCDBol H+ O2 NADPH 45FCDol H2O NADP O2 NADPH 4C5C8D3 H2O NADP NADP 5aChone CO2 NADPH NADPH H+ Zymstol NADP SAMe fecoste SAH H+ Epister H+ O2 FerocyC 5Ergol H2O FrcytcC H+ NADPH O2 E57T3βO NADP H2O H+ NADPH Ergoste NADP 5acdol 7-DHMOL CoA LCFAC CE HMG1