454-29-5
CAS
17215925
ChemSpider
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
439161
PubChem-compound
SMILES
N[C@@H](CS)C(O)=O
Methionine synthase
CYS
BioCyc
Cystathionine gamma-synthase
C30H35N9O12
N5-methyl--tetrahydropteroyl tri-L-glutamate
713.24274
Succinic acid
C05330
KEGG Compound
SMILES
N[C@@H](CCO)C(O)=O
CHEBI:58207
ChEBI
Methionine Biosynthesis
CHEBI:58020
ChEBI
1.0
HMDB0000099
HMDB
Homoserine O-succinyltransferase
SMILES
C[S+](C)CCC(N)C(O)=O
C00441
KEGG Compound
CHEBI:17230
ChEBI
6137
PubChem-compound
Homocysteine S-methyltransferase
6816
PubChem-compound
2.0
Methionine synthase
49791978
PubChem-compound
SMILES
NC(=C)C([O-])=O
53-59-8
CAS
SMILES
[H][C@](N)(CCOC(=O)CCC(O)=O)C(O)=O
CHEBI:15380
ChEBI
L-Methionine
SMILES
[H][C@@](CCC([O-])=N[C@@]([H])(CCC([O-])=N[C@@]([H])(CCC([O-])=O)C(O)=O)C(O)=O)(NC(=O)C1=CC=C(NC[C@@]2([H])CNC3=C(N2C)C([O-])=NC(=N)N3)C=C1)C(O)=O
C25H40N7O19P3S
Succinyl-CoA
867.1312
1038
PubChem-compound
CHEBI:17561
ChEBI
CHEBI:16474
ChEBI
SMILES
CSCC[C@H](N)C(O)=O
P00935
UniProt
GO:0005829
GENE ONTOLOGY
C04144
KEGG Compound
L-CYSTATHIONINE
BioCyc
P23256
UniProt
1.0
1.0
2.1.1.10
false
2.1.1.10
Homocysteine + S-Methylmethionine ↔ Hydrogen Ion + 2 L-Methionine
REVERSIBLE
Bifunctional aspartokinase/homoserine dehydrogenase 2
Bifunctional aspartokinase/homoserine dehydrogenase 1
2.7.2.4
false
2.7.2.4
Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP
LEFT_TO_RIGHT
1.0
Tetrahydropteroyltri-L-glutamate
NADPH
5862
PubChem-compound
1010
ChemSpider
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
NADP
13065-25-3
CAS
P25665
UniProt
C21H30N7O17P3
NADPH
745.0911
CHEBI:58140
ChEBI
C21H29N7O17P3
NADP
744.08325
SMP0000794
SMPDB
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O
1.0
P07623
UniProt
NADPH
BioCyc
Hydrogen Ion
C8H13NO6
O-succinyl-L-homoserine
219.07428
C3H4NO2
2-aminoprop-2-enoate
86.02475
672-15-1
CAS
Cytosol
2.0
C30H35N9O12
N5-methyl--tetrahydropteroyl tri-L-glutamate
713.24274
SUC
BioCyc
ReactionCatalysis2853
ACTIVATION
HMDB0000574
HMDB
HMDB0001423
HMDB
ReactionCatalysis2855
ACTIVATION
ReactionCatalysis2854
ACTIVATION
HMDB0000696
HMDB
ReactionCatalysis2857
ACTIVATION
ReactionCatalysis2856
ACTIVATION
HMDB0000217
HMDB
ReactionCatalysis2859
ACTIVATION
1.0
PW000771
PathWhiz
Cystathionine gamma-synthase
C00006
KEGG Compound
P00561
UniProt
CHEBI:18009
ChEBI
Hydrogen Ion
P00562
UniProt
16722112
PubChem-compound
C29H37N9O12
Tetrahydropteroyltri-L-glutamate
703.25616
1.0
C00005
KEGG Compound
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
445
ChemSpider
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
53-57-6
CAS
CHEBI:15741
ChEBI
1.0
Homocysteine S-methyltransferase
CHEBI:17482
ChEBI
1.0
1.0
C00010
KEGG Compound
1110
PubChem-compound
Homocysteine
1.0
NAD(P)
BioCyc
GO:0005620
GENE ONTOLOGY
SMILES
NC(CCS)C(O)=O
C4H6O4
Succinic acid
118.02661
562
TAXONOMY
12126
ChemSpider
H
Hydrogen Ion
1.007825
388307
ChemSpider
TransportCatalysis392
ACTIVATION
458
PubChem-compound
CPD-1302
BioCyc
CHEBI:16160
ChEBI
C00263
KEGG Compound
MET
BioCyc
2.0
5653
ChemSpider
56-88-2
CAS
1.0
L-Cystathionine
SMILES
N[C@@H](CC=O)C(O)=O
C7H14N2O4S
L-Cystathionine
222.06743
1.0
ReactionCatalysis2884
ACTIVATION
S-Methylmethionine
C5H11NO2S
L-Methionine
149.05106
1.0
52-90-4
CAS
L-Homoserine
CHEBI:1146900
ChEBI
HMDB0000254
HMDB
SMILES
OC(=O)CCC(O)=O
Protein malY
Lysine Biosynthesis
SubPathway
CHEBI:15699
ChEBI
HMDB0012249
HMDB
CO-A
BioCyc
C00042
KEGG Compound
5675
ChemSpider
Uncharacterized protein YbjE
1078
ChemSpider
N5-methyl--tetrahydropteroyl tri-L-glutamate
L-Cysteine
1.0
Coenzyme A
1.0
604-98-8
CAS
C21H36N7O16P3S
Coenzyme A
767.11523
2.0
SMILES
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
4.0
aspartate kinase / homoserine dehydrogenase
SubPathwayInteraction109685
SubPathwayReaction
SubPathway109685Reaction
6557
ChemSpider
N5-methyl--tetrahydropteroyl tri-L-glutamate
Cystathionine beta-lyase metC
Escherichia coli
12647
PubChem-compound
17625690
ChemSpider
L-Aspartate-semialdehyde
SubPathwayOutput
2.3.1.46
false
2.3.1.46
L-Homoserine + Succinyl-CoA → Coenzyme A + O-succinyl-L-homoserine
LEFT_TO_RIGHT
63-68-3
CAS
5907
ChemSpider
SMP0000834
SMPDB
CHEBI:16643
ChEBI
1.0
O-succinyl-L-homoserine
2-aminoprop-2-enoate
L-Methionine
HMDB0000719
HMDB
C00073
KEGG Compound
1.0
4.0
1.0
388392
ChemSpider
L-Methionine
CHEBI:17420
ChEBI
Homoserine O-succinyltransferase
439235
PubChem-compound
C00080
KEGG Compound
110-15-6
CAS
Periplasmic Space
4.0
15106-57-7
CAS
Uncharacterized protein YbjE
PW000814
PathWhiz
HMDB0001022
HMDB
C4H9NO2S
Homocysteine
135.0354
ReactionCatalysis5840
ACTIVATION
CHEBI:15378
ChEBI
SMILES
[H+]
Succinyl-CoA
Protein malY
5886
PubChem-compound
1.0
HOMO-CYS
BioCyc
2.1.1.13
false
2.1.1.13
Homocysteine + N5-methyl--tetrahydropteroyl tri-L-glutamate → L-Methionine + Tetrahydropteroyltri-L-glutamate
LEFT_TO_RIGHT
C00091
KEGG Compound
P75826
UniProt
2.1.1.14
false
2.1.1.14
N5-methyl--tetrahydropteroyl tri-L-glutamate + Homocysteine → L-Methionine + Tetrahydropteroyltri-L-glutamate
LEFT_TO_RIGHT
2.5.1.48
false
2.5.1.48
L-Cysteine + O-succinyl-L-homoserine → Hydrogen Ion + L-Cystathionine + Succinic acid
LEFT_TO_RIGHT
4.4.1.8
false
4.4.1.8
L-Cystathionine → 2-aminoprop-2-enoate + Homocysteine + Hydrogen Ion
LEFT_TO_RIGHT
HMDB0000742
HMDB
L-Aspartate-semialdehyde
C4H7NO3
L-Aspartate-semialdehyde
117.042595
C3H7NO2S
L-Cysteine
121.01975
25243997
PubChem-compound
388372
ChemSpider
SMILES
CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC([O-])=O)C([O-])=O)C([O-])=O)C([O-])=O)CNC2=C1C(=O)NC(N)=N2
C00097
KEGG Compound
Bifunctional aspartokinase/homoserine dehydrogenase 1
757
ChemSpider
Bifunctional aspartokinase/homoserine dehydrogenase 2
P13009
UniProt
L-ASPARTATE-SEMIALDEHYDE
BioCyc
22833512
PubChem-compound
HOMO-SER
BioCyc
Homocysteine
CHEBI:18051
ChEBI
HMDB0012290
HMDB
3-METHYLBENZYLSUCCINYL-COA
BioCyc
C4H9NO3
L-Homoserine
119.05824
Transport457
false
L-Methionine (→), Hydrogen Ion (←) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space
LEFT_TO_RIGHT
1.0
C6H14NO2S
S-Methylmethionine
164.07452
Cystathionine beta-lyase metC
HMDB0059597
HMDB
P06721
UniProt
Hydrogen Ion
HMDB0038670
HMDB
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1
O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase
homoserine O-succinyltransferase
C02291
KEGG Compound
1.0
85-61-0
CAS
cystathionine-β-lyase / L-cysteine desulfhydrase
bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon
Q47690
UniProt