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cis-homoaconitate CHEBI:16015 ChEBI 30572 ChemSpider (1R,2S)-homoisocitrate 17215925 ChemSpider C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider C7H10O7 Homocitric acid 206.04265 2K-ADIPATE BioCyc Allysine NADH C6H11NO4 Aminoadipic acid 161.0688 Lysine Metabolism P40495 UniProt 439153 PubChem-compound SMILES O CHEBI:16927 ChEBI Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 50 ChemSpider 1.0 C6H8O5 Oxoadipic acid 160.03717 C00449 KEGG Compound 3562-74-1 CAS CHEBI:16027 ChEBI NAD HMDB0000538 HMDB ATP BioCyc 5962 PubChem-compound C00322 KEGG Compound 1.0 1.0 6816 PubChem-compound 51 PubChem-compound 559142 ChemSpider CHEBI:15846 ChEBI SACCHAROPINE BioCyc 5747 ChemSpider 53-59-8 CAS 1.0 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI LYS BioCyc Oxoadipic acid 274 ChemSpider Adenosine monophosphate C5H6O5 Oxoglutaric acid 146.02153 Aminoadipic acid Homoisocitrate dehydrogenase, mitochondrial CHEBI:16908 ChEBI 70 ChemSpider 5858 ChemSpider C7H5O6 cis-homoaconitate 185.01025 C7H7O7 (1R,2S)-homoisocitrate 203.02083 Acetyl-CoA Homocitric acid NADPH 1010 ChemSpider Saccharomyces cerevisiae SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS NADP 71 PubChem-compound PPI BioCyc C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 1.0 1.0 NADPH BioCyc CHEBI:17027 ChEBI 207 PubChem-compound Hydrogen Ion HMDB0000208 HMDB Adenosine triphosphate 58-68-4 CAS 456 ChemSpider HMDB0001423 HMDB L-Glutamic acid 56-87-1 CAS SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB 1.0 CHEBI:30915 ChEBI 124-38-9 CAS 21158450 PubChem-compound CPD-468 BioCyc C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound CHEBI:18361 ChEBI C00005 KEGG Compound 388564 ChemSpider C00004 KEGG Compound C00003 KEGG Compound C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 202 ChemSpider HMDB0000225 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLT BioCyc 1.0 53-57-6 CAS C21H28N7O14P2 NAD 664.11694 469 PubChem-compound P49367 UniProt C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound HMDB0000902 HMDB C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 NAD(P) BioCyc HMDB0001206 HMDB 5957 PubChem-compound 1.0 Homoaconitase, mitochondrial H Hydrogen Ion 1.007825 L-2-aminoadipate reductase CHEBI:15753 ChEBI Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] C6H11NO3 Allysine 145.0739 Saccharopine dehydrogenase [NAD(+), L-lysine-forming] Homocitrate synthase, mitochondrial Homocitrate synthase, cytosolic isozyme C01475 KEGG Compound ALLYSINE BioCyc SMILES NCCCC[C@H](N)C(O)=O 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound CHEBI:52222 ChEBI Saccharopine 1.0 C11H20N2O6 Saccharopine 276.13214 1.0 5459812 PubChem-compound 3184-35-8 CAS 1.0 C00956 KEGG Compound HMDB0003518 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI Water AMP BioCyc C01251 KEGG Compound 1.0 P07702 UniProt HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS SMILES [H][C@](O)(C([O-])=O)[C@]([H])(CCC([O-])=O)C([O-])=O 141086 ChemSpider CO-A BioCyc SMILES [H]\C(C([O-])=O)=C(/CCC([O-])=O)C([O-])=O SMILES NC(CCCC=O)C(O)=O 5675 ChemSpider 72-89-9 CAS C00047 KEGG Compound Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 1.0 HMDB0000148 HMDB SMILES N[C@@H](CCCCN[C@@H](CCC(O)=O)C(O)=O)C(O)=O 997-68-2 CAS 542-32-5 CAS CHEBI:18019 ChEBI CHEBI:15422 ChEBI 6557 ChemSpider SMILES OC(=O)CC[C@@](O)(CC(O)=O)C(O)=O 1962-83-0 CAS SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 160556 PubChem-compound 1.0 7732-18-5 CAS 388299 ChemSpider 1.0 HMDB0001487 HMDB 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB0000279 HMDB 1.0 56-86-0 CAS 439459 PubChem-compound SMILES OC(=O)CCCC(=O)C(O)=O SMILES NC(CCCC(O)=O)C(O)=O C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 Homoisocitrate dehydrogenase, mitochondrial 1.0 SMP0002337 SMPDB CHEBI:16526 ChEBI 1.0 1.0 HMDB0000045 HMDB ReactionCatalysis6400 ACTIVATION 1.0 ReactionCatalysis6402 ACTIVATION ReactionCatalysis6401 ACTIVATION 962 PubChem-compound 2-KETOGLUTARATE BioCyc 2.3.3.14 false 2.3.3.14 Acetyl-CoA + Oxoglutaric acid + Water → Coenzyme A + Homocitric acid + Hydrogen Ion LEFT_TO_RIGHT 392413 ChemSpider Reaction6471 true Homocitric acid → Water + cis-homoaconitate LEFT_TO_RIGHT CO2 Carbon dioxide 43.98983 P48570 UniProt 5893 PubChem-compound 2.3.3.14 false 2.3.3.14 Acetyl-CoA + Oxoglutaric acid + Water → Coenzyme A + Homocitric acid + Hydrogen Ion LEFT_TO_RIGHT C00080 KEGG Compound holo-[LYS2 peptidyl-carrier-protein] Oxoglutaric acid L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] 1.0 HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0001263 HMDB CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] C6H14N2O2 L-Lysine 146.10553 P38999 UniProt P38998 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound CHEBI:37024 ChEBI 1.0 280 PubChem-compound HMDB0000182 HMDB HOMO-CIT BioCyc Q12122 UniProt 644102 PubChem-compound 4932 TAXONOMY 444493 PubChem-compound ReactionCatalysis6396 ACTIVATION PW002420 PathWhiz ReactionCatalysis6395 ACTIVATION 6083 PubChem-compound L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] holo-[LYS2 peptidyl-carrier-protein] L-Lysine 1.0 22833512 PubChem-compound HMDB0000510 HMDB ACETYL-COA BioCyc H2O Water 18.010565 Saccharopine dehydrogenase [NAD(+), L-lysine-forming] Homoaconitase, mitochondrial Homocitrate synthase, cytosolic isozyme ReactionCatalysis6399 ACTIVATION ReactionCatalysis6398 ACTIVATION Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] ReactionCatalysis6397 ACTIVATION L-2-aminoadipate reductase NADH BioCyc Homocitrate synthase, mitochondrial NAD BioCyc HMDB0059597 HMDB Carbon dioxide HMDB0001967 HMDB CHEBI:15351 ChEBI 4.2.1.36 false 4.2.1.36 cis-homoaconitate → (1R,2S)-homoisocitrate + Water LEFT_TO_RIGHT 85-61-0 CAS 1.1.1.87 false 1.1.1.87 (1R,2S)-homoisocitrate + NAD → Carbon dioxide + NADH + Oxoadipic acid LEFT_TO_RIGHT Reaction6474 false L-Glutamic acid + Oxoadipic acid → Aminoadipic acid + Oxoglutaric acid LEFT_TO_RIGHT 1.2.1.95 false 1.2.1.95 Adenosine triphosphate + Aminoadipic acid + holo-[LYS2 peptidyl-carrier-protein] → Adenosine monophosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + Pyrophosphate LEFT_TO_RIGHT Reaction6476 false Hydrogen Ion + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + NADPH → Allysine + NADP + holo-[LYS2 peptidyl-carrier-protein] LEFT_TO_RIGHT 1.5.1.10 false 1.5.1.10 Allysine + Hydrogen Ion + L-Glutamic acid + NADPH → NADP + Saccharopine + Water LEFT_TO_RIGHT 1.5.1.7 false 1.5.1.7 NAD + Saccharopine + Water → Hydrogen Ion + L-Lysine + NADH + Oxoglutaric acid LEFT_TO_RIGHT Mitochondria Homocitrate synthase, mitochondrial Homocitrate synthase, cytosolic isozyme Homoaconitase, mitochondrial Homoisocitrate dehydrogenase, mitochondrial L-2- aminoadipate reductase L-2- aminoadipate reductase Saccharopine dehydrogenase [NADP(+), L-glutamate- forming] Saccharopine dehydrogenase [NAD(+), L-lysine- forming] Oxoglutaric acid Acetyl-CoA H 2 O CoA Homocitric acid H + Oxoglutaric acid Acetyl-CoA H 2 O Homocitric acid CoA H + H 2 O cis- homoaconitate H 2 O cis- homoaconitate H 2 O (1R,2S)- homoisocitrate NAD CO 2 NADH Oxoadipic acid L-Glutamic acid Oxoglutaric acid Aminoadipic acid ATP PP i AMP H + NADPH NADP Allysine NADPH L-Glutamic acid H + H 2 O NADP Saccharopine NAD H 2 O NADH H + Oxoglutaric acid L-Lysine holo-[LYS2 peptidyl- carrier- protein] L-2- aminoadipyl- [LYS2 peptidyl- carrier- protein] holo-[LYS2 peptidyl- carrier- protein]
cis-homoaconitate CHEBI:16015 ChEBI 30572 ChemSpider (1R,2S)-homoisocitrate 17215925 ChemSpider C23H38N7O17P3S Acetyl-CoA 809.1258 937 ChemSpider C7H10O7 Homocitric acid 206.04265 2K-ADIPATE BioCyc Allysine NADH C6H11NO4 Aminoadipic acid 161.0688 Lysine Metabolism P40495 UniProt 439153 PubChem-compound SMILES O CHEBI:16927 ChEBI Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 50 ChemSpider 1.0 C6H8O5 Oxoadipic acid 160.03717 C00449 KEGG Compound 3562-74-1 CAS CHEBI:16027 ChEBI NAD HMDB0000538 HMDB ATP BioCyc 5962 PubChem-compound C00322 KEGG Compound 1.0 1.0 6816 PubChem-compound 51 PubChem-compound 559142 ChemSpider CHEBI:15846 ChEBI SACCHAROPINE BioCyc 5747 ChemSpider 53-59-8 CAS 1.0 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI LYS BioCyc Oxoadipic acid 274 ChemSpider Adenosine monophosphate C5H6O5 Oxoglutaric acid 146.02153 Aminoadipic acid Homoisocitrate dehydrogenase, mitochondrial CHEBI:16908 ChEBI 70 ChemSpider 5858 ChemSpider C7H5O6 cis-homoaconitate 185.01025 C7H7O7 (1R,2S)-homoisocitrate 203.02083 Acetyl-CoA Homocitric acid NADPH 1010 ChemSpider Saccharomyces cerevisiae SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS NADP 71 PubChem-compound PPI BioCyc C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 1.0 1.0 NADPH BioCyc CHEBI:17027 ChEBI 207 PubChem-compound Hydrogen Ion HMDB0000208 HMDB Adenosine triphosphate 58-68-4 CAS 456 ChemSpider HMDB0001423 HMDB L-Glutamic acid 56-87-1 CAS SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB 1.0 CHEBI:30915 ChEBI 124-38-9 CAS 21158450 PubChem-compound CPD-468 BioCyc C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound CHEBI:18361 ChEBI C00005 KEGG Compound 388564 ChemSpider C00004 KEGG Compound C00003 KEGG Compound C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 202 ChemSpider HMDB0000225 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLT BioCyc 1.0 53-57-6 CAS C21H28N7O14P2 NAD 664.11694 469 PubChem-compound P49367 UniProt C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound HMDB0000902 HMDB C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 NAD(P) BioCyc HMDB0001206 HMDB 5957 PubChem-compound 1.0 Homoaconitase, mitochondrial H Hydrogen Ion 1.007825 L-2-aminoadipate reductase CHEBI:15753 ChEBI Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] C6H11NO3 Allysine 145.0739 Saccharopine dehydrogenase [NAD(+), L-lysine-forming] Homocitrate synthase, mitochondrial Homocitrate synthase, cytosolic isozyme C01475 KEGG Compound ALLYSINE BioCyc SMILES NCCCC[C@H](N)C(O)=O 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound CHEBI:52222 ChEBI Saccharopine 1.0 C11H20N2O6 Saccharopine 276.13214 1.0 5459812 PubChem-compound 3184-35-8 CAS 1.0 C00956 KEGG Compound HMDB0003518 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 5682 ChemSpider 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI Water AMP BioCyc C01251 KEGG Compound 1.0 P07702 UniProt HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS SMILES [H][C@](O)(C([O-])=O)[C@]([H])(CCC([O-])=O)C([O-])=O 141086 ChemSpider CO-A BioCyc SMILES [H]\C(C([O-])=O)=C(/CCC([O-])=O)C([O-])=O SMILES NC(CCCC=O)C(O)=O 5675 ChemSpider 72-89-9 CAS C00047 KEGG Compound Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 1.0 HMDB0000148 HMDB SMILES N[C@@H](CCCCN[C@@H](CCC(O)=O)C(O)=O)C(O)=O 997-68-2 CAS 542-32-5 CAS CHEBI:18019 ChEBI CHEBI:15422 ChEBI 6557 ChemSpider SMILES OC(=O)CC[C@@](O)(CC(O)=O)C(O)=O 1962-83-0 CAS SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 160556 PubChem-compound 1.0 7732-18-5 CAS 388299 ChemSpider 1.0 HMDB0001487 HMDB 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 HMDB0000279 HMDB 1.0 56-86-0 CAS 439459 PubChem-compound SMILES OC(=O)CCCC(=O)C(O)=O SMILES NC(CCCC(O)=O)C(O)=O C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 Homoisocitrate dehydrogenase, mitochondrial 1.0 SMP0002337 SMPDB CHEBI:16526 ChEBI 1.0 1.0 HMDB0000045 HMDB ReactionCatalysis6400 ACTIVATION 1.0 ReactionCatalysis6402 ACTIVATION ReactionCatalysis6401 ACTIVATION 962 PubChem-compound 2-KETOGLUTARATE BioCyc 2.3.3.14 false 2.3.3.14 Acetyl-CoA + Oxoglutaric acid + Water → Coenzyme A + Homocitric acid + Hydrogen Ion LEFT_TO_RIGHT 392413 ChemSpider Reaction6471 true Homocitric acid → Water + cis-homoaconitate LEFT_TO_RIGHT CO2 Carbon dioxide 43.98983 P48570 UniProt 5893 PubChem-compound 2.3.3.14 false 2.3.3.14 Acetyl-CoA + Oxoglutaric acid + Water → Coenzyme A + Homocitric acid + Hydrogen Ion LEFT_TO_RIGHT C00080 KEGG Compound holo-[LYS2 peptidyl-carrier-protein] Oxoglutaric acid L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] 1.0 HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0001263 HMDB CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] C6H14N2O2 L-Lysine 146.10553 P38999 UniProt P38998 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound CHEBI:37024 ChEBI 1.0 280 PubChem-compound HMDB0000182 HMDB HOMO-CIT BioCyc Q12122 UniProt 644102 PubChem-compound 4932 TAXONOMY 444493 PubChem-compound ReactionCatalysis6396 ACTIVATION PW002420 PathWhiz ReactionCatalysis6395 ACTIVATION 6083 PubChem-compound L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] holo-[LYS2 peptidyl-carrier-protein] L-Lysine 1.0 22833512 PubChem-compound HMDB0000510 HMDB ACETYL-COA BioCyc H2O Water 18.010565 Saccharopine dehydrogenase [NAD(+), L-lysine-forming] Homoaconitase, mitochondrial Homocitrate synthase, cytosolic isozyme ReactionCatalysis6399 ACTIVATION ReactionCatalysis6398 ACTIVATION Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] ReactionCatalysis6397 ACTIVATION L-2-aminoadipate reductase NADH BioCyc Homocitrate synthase, mitochondrial NAD BioCyc HMDB0059597 HMDB Carbon dioxide HMDB0001967 HMDB CHEBI:15351 ChEBI 4.2.1.36 false 4.2.1.36 cis-homoaconitate → (1R,2S)-homoisocitrate + Water LEFT_TO_RIGHT 85-61-0 CAS 1.1.1.87 false 1.1.1.87 (1R,2S)-homoisocitrate + NAD → Carbon dioxide + NADH + Oxoadipic acid LEFT_TO_RIGHT Reaction6474 false L-Glutamic acid + Oxoadipic acid → Aminoadipic acid + Oxoglutaric acid LEFT_TO_RIGHT 1.2.1.95 false 1.2.1.95 Adenosine triphosphate + Aminoadipic acid + holo-[LYS2 peptidyl-carrier-protein] → Adenosine monophosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + Pyrophosphate LEFT_TO_RIGHT Reaction6476 false Hydrogen Ion + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + NADPH → Allysine + NADP + holo-[LYS2 peptidyl-carrier-protein] LEFT_TO_RIGHT 1.5.1.10 false 1.5.1.10 Allysine + Hydrogen Ion + L-Glutamic acid + NADPH → NADP + Saccharopine + Water LEFT_TO_RIGHT 1.5.1.7 false 1.5.1.7 NAD + Saccharopine + Water → Hydrogen Ion + L-Lysine + NADH + Oxoglutaric acid LEFT_TO_RIGHT Mitochondria LYS21 LYS20 LYS4 LYS12 LYS2 LYS2 LYS9 LYS1 Oxoglutaric acid Acetyl-CoA Water Coenzyme A Homocitric acid Hydrogen Ion Oxoglutaric acid Acetyl-CoA Water Homocitric acid Coenzyme A Hydrogen Ion Water cis- homoaconitate Water cis- homoaconitate Water (1R,2S)- homoisocitrate NAD Carbon dioxide NADH Oxoadipic acid L-Glutamic acid Oxoglutaric acid Aminoadipic acid Adenosine triphosphate Pyrophosphate Adenosine monophosphate Hydrogen Ion NADPH NADP Allysine NADPH L-Glutamic acid Hydrogen Ion Water NADP Saccharopine NAD Water NADH Hydrogen Ion Oxoglutaric acid L-Lysine holo-[LYS2 peptidyl- carrier- protein] L-2- aminoadipyl- [LYS2 peptidyl- carrier- protein] holo-[LYS2 peptidyl- carrier- protein]