cis-homoaconitate
CHEBI:16015
ChEBI
30572
ChemSpider
(1R,2S)-homoisocitrate
17215925
ChemSpider
C23H38N7O17P3S
Acetyl-CoA
809.1258
937
ChemSpider
C7H10O7
Homocitric acid
206.04265
2K-ADIPATE
BioCyc
Allysine
NADH
C6H11NO4
Aminoadipic acid
161.0688
Lysine Metabolism
P40495
UniProt
439153
PubChem-compound
SMILES
O
CHEBI:16927
ChEBI
Pyrophosphate
C10H14N5O7P
Adenosine monophosphate
347.06308
50
ChemSpider
1.0
C6H8O5
Oxoadipic acid
160.03717
C00449
KEGG Compound
3562-74-1
CAS
CHEBI:16027
ChEBI
NAD
HMDB0000538
HMDB
ATP
BioCyc
5962
PubChem-compound
C00322
KEGG Compound
1.0
1.0
6816
PubChem-compound
51
PubChem-compound
559142
ChemSpider
CHEBI:15846
ChEBI
SACCHAROPINE
BioCyc
5747
ChemSpider
53-59-8
CAS
1.0
5742
ChemSpider
1038
PubChem-compound
CHEBI:16474
ChEBI
LYS
BioCyc
Oxoadipic acid
274
ChemSpider
Adenosine monophosphate
C5H6O5
Oxoglutaric acid
146.02153
Aminoadipic acid
Homoisocitrate dehydrogenase, mitochondrial
CHEBI:16908
ChEBI
70
ChemSpider
5858
ChemSpider
C7H5O6
cis-homoaconitate
185.01025
C7H7O7
(1R,2S)-homoisocitrate
203.02083
Acetyl-CoA
Homocitric acid
NADPH
1010
ChemSpider
Saccharomyces cerevisiae
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
NADP
71
PubChem-compound
PPI
BioCyc
C21H30N7O17P3
NADPH
745.0911
C21H29N7O17P3
NADP
744.08325
1.0
1.0
NADPH
BioCyc
CHEBI:17027
ChEBI
207
PubChem-compound
Hydrogen Ion
HMDB0000208
HMDB
Adenosine triphosphate
58-68-4
CAS
456
ChemSpider
HMDB0001423
HMDB
L-Glutamic acid
56-87-1
CAS
SMILES
OC(=O)CCC(=O)C(O)=O
HMDB0000217
HMDB
1.0
CHEBI:30915
ChEBI
124-38-9
CAS
21158450
PubChem-compound
CPD-468
BioCyc
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
CHEBI:18361
ChEBI
C00005
KEGG Compound
388564
ChemSpider
C00004
KEGG Compound
C00003
KEGG Compound
C00002
KEGG Compound
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
202
ChemSpider
HMDB0000225
HMDB
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
GLT
BioCyc
1.0
53-57-6
CAS
C21H28N7O14P2
NAD
664.11694
469
PubChem-compound
P49367
UniProt
C00011
KEGG Compound
SMILES
O=C=O
C00010
KEGG Compound
HMDB0000902
HMDB
C00013
KEGG Compound
O7P2
Pyrophosphate
173.91193
C21H29N7O14P2
NADH
665.12476
NAD(P)
BioCyc
HMDB0001206
HMDB
5957
PubChem-compound
1.0
Homoaconitase, mitochondrial
H
Hydrogen Ion
1.007825
L-2-aminoadipate reductase
CHEBI:15753
ChEBI
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
C6H11NO3
Allysine
145.0739
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
Homocitrate synthase, mitochondrial
Homocitrate synthase, cytosolic isozyme
C01475
KEGG Compound
ALLYSINE
BioCyc
SMILES
NCCCC[C@H](N)C(O)=O
56-65-5
CAS
53-84-9
CAS
C00020
KEGG Compound
C00026
KEGG Compound
C00025
KEGG Compound
C00024
KEGG Compound
CHEBI:52222
ChEBI
Saccharopine
1.0
C11H20N2O6
Saccharopine
276.13214
1.0
5459812
PubChem-compound
3184-35-8
CAS
1.0
C00956
KEGG Compound
HMDB0003518
HMDB
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
5682
ChemSpider
328-50-7
CAS
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
CHEBI:1146900
ChEBI
Water
AMP
BioCyc
C01251
KEGG Compound
1.0
P07702
UniProt
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
14000-31-8
CAS
SMILES
[H][C@](O)(C([O-])=O)[C@]([H])(CCC([O-])=O)C([O-])=O
141086
ChemSpider
CO-A
BioCyc
SMILES
[H]\C(C([O-])=O)=C(/CCC([O-])=O)C([O-])=O
SMILES
NC(CCCC=O)C(O)=O
5675
ChemSpider
72-89-9
CAS
C00047
KEGG Compound
Coenzyme A
C21H36N7O16P3S
Coenzyme A
767.11523
1.0
HMDB0000148
HMDB
SMILES
N[C@@H](CCCCN[C@@H](CCC(O)=O)C(O)=O)C(O)=O
997-68-2
CAS
542-32-5
CAS
CHEBI:18019
ChEBI
CHEBI:15422
ChEBI
6557
ChemSpider
SMILES
OC(=O)CC[C@@](O)(CC(O)=O)C(O)=O
1962-83-0
CAS
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
160556
PubChem-compound
1.0
7732-18-5
CAS
388299
ChemSpider
1.0
HMDB0001487
HMDB
61-19-8
CAS
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
HMDB0000279
HMDB
1.0
56-86-0
CAS
439459
PubChem-compound
SMILES
OC(=O)CCCC(=O)C(O)=O
SMILES
NC(CCCC(O)=O)C(O)=O
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
C10H16N5O13P3
Adenosine triphosphate
506.99576
Homoisocitrate dehydrogenase, mitochondrial
1.0
SMP0002337
SMPDB
CHEBI:16526
ChEBI
1.0
1.0
HMDB0000045
HMDB
ReactionCatalysis6400
ACTIVATION
1.0
ReactionCatalysis6402
ACTIVATION
ReactionCatalysis6401
ACTIVATION
962
PubChem-compound
2-KETOGLUTARATE
BioCyc
2.3.3.14
false
2.3.3.14
Acetyl-CoA + Oxoglutaric acid + Water → Coenzyme A + Homocitric acid + Hydrogen Ion
LEFT_TO_RIGHT
392413
ChemSpider
Reaction6471
true
Homocitric acid → Water + cis-homoaconitate
LEFT_TO_RIGHT
CO2
Carbon dioxide
43.98983
P48570
UniProt
5893
PubChem-compound
2.3.3.14
false
2.3.3.14
Acetyl-CoA + Oxoglutaric acid + Water → Coenzyme A + Homocitric acid + Hydrogen Ion
LEFT_TO_RIGHT
C00080
KEGG Compound
holo-[LYS2 peptidyl-carrier-protein]
Oxoglutaric acid
L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein]
1.0
HMDB0002111
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
HMDB0001263
HMDB
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
C6H14N2O2
L-Lysine
146.10553
P38999
UniProt
P38998
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
5886
PubChem-compound
CHEBI:37024
ChEBI
1.0
280
PubChem-compound
HMDB0000182
HMDB
HOMO-CIT
BioCyc
Q12122
UniProt
644102
PubChem-compound
4932
TAXONOMY
444493
PubChem-compound
ReactionCatalysis6396
ACTIVATION
PW002420
PathWhiz
ReactionCatalysis6395
ACTIVATION
6083
PubChem-compound
L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein]
holo-[LYS2 peptidyl-carrier-protein]
L-Lysine
1.0
22833512
PubChem-compound
HMDB0000510
HMDB
ACETYL-COA
BioCyc
H2O
Water
18.010565
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
Homoaconitase, mitochondrial
Homocitrate synthase, cytosolic isozyme
ReactionCatalysis6399
ACTIVATION
ReactionCatalysis6398
ACTIVATION
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
ReactionCatalysis6397
ACTIVATION
L-2-aminoadipate reductase
NADH
BioCyc
Homocitrate synthase, mitochondrial
NAD
BioCyc
HMDB0059597
HMDB
Carbon dioxide
HMDB0001967
HMDB
CHEBI:15351
ChEBI
4.2.1.36
false
4.2.1.36
cis-homoaconitate → (1R,2S)-homoisocitrate + Water
LEFT_TO_RIGHT
85-61-0
CAS
1.1.1.87
false
1.1.1.87
(1R,2S)-homoisocitrate + NAD → Carbon dioxide + NADH + Oxoadipic acid
LEFT_TO_RIGHT
Reaction6474
false
L-Glutamic acid + Oxoadipic acid → Aminoadipic acid + Oxoglutaric acid
LEFT_TO_RIGHT
1.2.1.95
false
1.2.1.95
Adenosine triphosphate + Aminoadipic acid + holo-[LYS2 peptidyl-carrier-protein] → Adenosine monophosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + Pyrophosphate
LEFT_TO_RIGHT
Reaction6476
false
Hydrogen Ion + L-2-aminoadipyl-[LYS2 peptidyl-carrier-protein] + NADPH → Allysine + NADP + holo-[LYS2 peptidyl-carrier-protein]
LEFT_TO_RIGHT
1.5.1.10
false
1.5.1.10
Allysine + Hydrogen Ion + L-Glutamic acid + NADPH → NADP + Saccharopine + Water
LEFT_TO_RIGHT
1.5.1.7
false
1.5.1.7
NAD + Saccharopine + Water → Hydrogen Ion + L-Lysine + NADH + Oxoglutaric acid
LEFT_TO_RIGHT