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cystathionine beta-lyase cystathionine beta-lyase subunit 2 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 Selenocysteine 937 ChemSpider C05689 KEGG Compound CHEBI:16134 ChEBI C05688 KEGG Compound Succinic acid 64-19-7 CAS 57 ChemSpider SMILES O H3N Ammonia 17.026548 C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate Acetylhomoserine 1.0 1.0 CHEBI:16027 ChEBI HMDB0000538 HMDB PW002472 PathWhiz ATP BioCyc C04489 KEGG Compound C05699 KEGG Compound C05335 KEGG Compound C05698 KEGG Compound 1.0 559142 ChemSpider Pyruvic acid 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 1.0 1.0 1.0 53-59-8 CAS SMILES N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O SMILES NC(CC[Se]CC(N)C(O)=O)C(O)=O 5742 ChemSpider tRNA(Met) CHEBI:9100 ChEBI 1038 PubChem-compound CHEBI:16474 ChEBI 88693 ChemSpider C04144 KEGG Compound Ammonia P43623 UniProt CHEBI:27812 ChEBI Adenosine monophosphate HMDB0004119 HMDB Methylselenic acid HMDB0060488 HMDB HMDB0004113 HMDB methylselenol HMDB0060489 HMDB 5858 ChemSpider C00109 KEGG Compound thioredoxin reductase 2 NADPH 1010 ChemSpider Acetic acid Saccharomyces cerevisiae SELENOMETHIONINE BioCyc SMILES NC(CC[SeH])C(O)=O 600-18-0 CAS NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 10236-58-5 CAS C21H29N7O17P3 NADP 744.08325 SMILES C[Se]C[C@H](N)C(O)=O methionine--tRNA ligase MES1 1.0 1.0 cystathionine gamma-synthase NADPH BioCyc thioredoxin reductase 1 Hydrogen Ion methionine--tRNA ligase MSM1 C8H13NO6 O-succinyl-L-homoserine 219.07428 1.0 L-SELENOCYSTEINE BioCyc 217 ChemSpider Adenosine triphosphate SUC BioCyc 1.0 C6H11NO4 Acetylhomoserine 161.0688 HMDB0000217 HMDB HMDB0003966 HMDB HMDB0003288 HMDB P05694 UniProt C00006 KEGG Compound 16722111 PubChem-compound CHEBI:18009 ChEBI 16722112 PubChem-compound C00001 KEGG Compound C29H37N9O12 Tetrahydropteroyltri-L-glutamate 703.25616 C5H11NO2Se Selenomethionine 196.9955 CHEBI:18361 ChEBI C00005 KEGG Compound 2-OXOBUTANOATE BioCyc C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O cystathionine beta-lyase 7664-41-7 CAS cystathionine beta-lyase subunit 2 HMDB0029423 HMDB cystathionine gamma-lyase 53-57-6 CAS CHEBI:15741 ChEBI Tetrahydropteroyltri-L-glutamate 222 PubChem-compound 1.0 C00014 KEGG Compound 1110 PubChem-compound Selenomethionine C00013 KEGG Compound 440763 PubChem-compound O7P2 Pyrophosphate 173.91193 NAD(P) BioCyc 5957 PubChem-compound 25076 PubChem-compound N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase C4H6O4 Succinic acid 118.02661 CHEBI:64685 ChEBI P38816 UniProt H Hydrogen Ion 1.007825 C3H7NO2Se Selenocysteine 168.9642 389632 ChemSpider 1.0 CPD-1302 BioCyc 129633 ChemSpider C00022 KEGG Compound CHEBI:16160 ChEBI 56-65-5 CAS C00020 KEGG Compound SMP0002371 SMPDB CHEBI:26630 ChEBI HMDB0000243 HMDB ACET BioCyc HMDB0000005 HMDB SMILES CCC(=O)C(O)=O 1.0 HMDB0006343 HMDB 1.0 C00033 KEGG Compound C7H14N2O4Se Selenocystathionine 270.01187 P47164 UniProt CHEBI:30831 ChEBI HMDB0000254 HMDB AMP BioCyc Water SMILES OC(=O)CCC(O)=O CHEBI:77012 ChEBI thioredoxin reductase CHEBI:29173 ChEBI 528 PubChem-compound P31373 UniProt HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS SMILES N[C@@H](C[SeH])C(O)=O 1.0 C00042 KEGG Compound 5675 ChemSpider 1078 ChemSpider Reaction6777 false Selenocystathionine + Water → Ammonia + Pyruvic acid + Selenohomocysteine LEFT_TO_RIGHT C4H9NO2Se Se-Methylselenocysteine 182.97984 C4H9NO2Se Selenohomocysteine 182.97984 1.0 14375 ChemSpider thioredoxin reductase 1 Se-Methylselenocysteine Selenohomocysteine methionine--tRNA ligase MES1 ReactionCatalysis6741 ACTIVATION methionine--tRNA ligase MSM1 cystathionine gamma-synthase 6.1.1.10 false 6.1.1.10 Adenosine triphosphate + Selenomethionine + tRNA(Met) → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met) LEFT_TO_RIGHT ReactionCatalysis6744 ACTIVATION 4.4.1.1 false 4.4.1.1 Selenomethionine + Water → 2-Ketobutyric acid + Ammonia + methylselenol LEFT_TO_RIGHT ReactionCatalysis6743 ACTIVATION ReactionCatalysis6742 ACTIVATION Reaction6776 false 5-Methyltetrahydropteroyltri-L-glutamate + Selenohomocysteine ↔ Selenomethionine + Tetrahydropteroyltri-L-glutamate REVERSIBLE CHEBI:16633 ChEBI CHEBI:15422 ChEBI thioredoxin reductase 2 1.0 SMILES CC(O)=O 7732-18-5 CAS 1.0 61-19-8 CAS 17625690 ChemSpider SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 127-17-3 CAS AMMONIA BioCyc SMILES N cystathionine beta-lyase 124489574 PubChem-compound 26046-90-2 CAS SMILES C[SeH] 1464-42-2 CAS 1.0 SMILES C[Se](O)=O 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17614 ChEBI SELENOHOMOCYSTEINE BioCyc Selenocystathionine O-succinyl-L-homoserine 15103 PubChem-compound C30H39N9O12 5-Methyltetrahydropteroyltri-L-glutamate 717.2718 HMDB0000045 HMDB SMILES CC(=O)C(O)=O P22438 UniProt 5-Methyltetrahydropteroyltri-L-glutamate 1.0 ReactionCatalysis6763 ACTIVATION ReactionCatalysis6762 ACTIVATION 17625689 ChemSpider 2.5.1.48 false 2.5.1.48 O-succinyl-L-homoserine + Selenocystathionine ↔ Selenocysteine + Succinic acid REVERSIBLE Reaction6794 false Acetylhomoserine + Selenocysteine ↔ Acetic acid + Selenocystathionine REVERSIBLE HMDB0000042 HMDB P29509 UniProt 1.8.1.9 false 1.8.1.9 Methylselenic acid + Hydrogen Ion + NADPH → NADP + Water + methylselenol LEFT_TO_RIGHT Reaction6796 false Se-Methylselenocysteine + Water → Ammonia + Pyruvic acid + methylselenol LEFT_TO_RIGHT ReactionCatalysis6765 ACTIVATION ReactionCatalysis6764 ACTIVATION 962 PubChem-compound CHEBI:15366 ChEBI 29412-93-9 CAS 1.0 1.0 CHEBI:17420 ChEBI 2196-58-9 CAS 147004 PubChem-compound C00080 KEGG Compound P00958 UniProt 110-15-6 CAS 7540-67-2 CAS CH4Se methylselenol 95.94782 Selenocompound Metabolism CH4O2Se Methylselenic acid 127.93765 HMDB0000051 HMDB 171 ChemSpider HMDB0002111 HMDB CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2-Ketobutyric acid CHEBI:7671 ChEBI Selenomethionyl-tRNA(Met) 23436 ChemSpider 1.0 SMILES CN1[C@@H](CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)CNC2=C1C(=O)N=C(N)N2 C4H6O3 2-Ketobutyric acid 102.03169 CHEBI:27585 ChEBI P53101 UniProt 644102 PubChem-compound 4932 TAXONOMY 6083 PubChem-compound Selenomethionyl-tRNA(Met) methionyl-tRNA synthetase HMDB0012177 HMDB 513 ChemSpider 22833512 PubChem-compound H2O Water 18.010565 HMDB0012290 HMDB tRNA(Met) SMILES CC(=O)OCCC(N)C(O)=O 1060 PubChem-compound N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase HMDB0059597 HMDB cystathionine gamma-lyase SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 SMILES C[Se]CCC(N)C(O)=O 176 PubChem-compound 98223 PubChem-compound methionine-- tRNA ligase MSM1 methionine-- tRNA ligase MES1 cystathionine gamma-lyase N5- methyltetrahydropteroyltriglutamate- homocysteine methyltransferase cystathionine beta-lyase cystathionine beta-lyase subunit 2 cystathionine gamma-synthase cystathionine gamma-synthase thioredoxin reductase 1 thioredoxin reductase 2 cystathionine gamma-lyase ATP Selenomethionine AMP PP i H 2 O methylselenol NH 3 2-Ketobutyric acid Selenohomocysteine 5- Methyltetrahydropteroyltri- L-glutamate Tetrahydropteroyltri- L-glutamate Selenocystathionine H 2 O NH 3 Pyruvic acid O-succinyl-L- homoserine Selenocysteine Succinic acid Selenocysteine Acetylhomoserine Acetic acid NADPH H + Methylselenic acid NADP H 2 O Se- Methylselenocysteine H 2 O NH 3 Pyruvic acid Selenomethionyl- tRNA(Met) tRNA(Met)
cystathionine beta-lyase cystathionine beta-lyase subunit 2 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 Selenocysteine 937 ChemSpider C05689 KEGG Compound CHEBI:16134 ChEBI C05688 KEGG Compound Succinic acid 64-19-7 CAS 57 ChemSpider SMILES O H3N Ammonia 17.026548 C10H14N5O7P Adenosine monophosphate 347.06308 Pyrophosphate Acetylhomoserine 1.0 1.0 CHEBI:16027 ChEBI HMDB0000538 HMDB PW002472 PathWhiz ATP BioCyc C04489 KEGG Compound C05699 KEGG Compound C05335 KEGG Compound C05698 KEGG Compound 1.0 559142 ChemSpider Pyruvic acid 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 1.0 1.0 1.0 53-59-8 CAS SMILES N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O SMILES NC(CC[Se]CC(N)C(O)=O)C(O)=O 5742 ChemSpider tRNA(Met) CHEBI:9100 ChEBI 1038 PubChem-compound CHEBI:16474 ChEBI 88693 ChemSpider C04144 KEGG Compound Ammonia P43623 UniProt CHEBI:27812 ChEBI Adenosine monophosphate HMDB0004119 HMDB Methylselenic acid HMDB0060488 HMDB HMDB0004113 HMDB methylselenol HMDB0060489 HMDB 5858 ChemSpider C00109 KEGG Compound thioredoxin reductase 2 NADPH 1010 ChemSpider Acetic acid Saccharomyces cerevisiae SELENOMETHIONINE BioCyc SMILES NC(CC[SeH])C(O)=O 600-18-0 CAS NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 10236-58-5 CAS C21H29N7O17P3 NADP 744.08325 SMILES C[Se]C[C@H](N)C(O)=O methionine--tRNA ligase MES1 1.0 1.0 cystathionine gamma-synthase NADPH BioCyc thioredoxin reductase 1 Hydrogen Ion methionine--tRNA ligase MSM1 C8H13NO6 O-succinyl-L-homoserine 219.07428 1.0 L-SELENOCYSTEINE BioCyc 217 ChemSpider Adenosine triphosphate SUC BioCyc 1.0 C6H11NO4 Acetylhomoserine 161.0688 HMDB0000217 HMDB HMDB0003966 HMDB HMDB0003288 HMDB P05694 UniProt C00006 KEGG Compound 16722111 PubChem-compound CHEBI:18009 ChEBI 16722112 PubChem-compound C00001 KEGG Compound C29H37N9O12 Tetrahydropteroyltri-L-glutamate 703.25616 C5H11NO2Se Selenomethionine 196.9955 CHEBI:18361 ChEBI C00005 KEGG Compound 2-OXOBUTANOATE BioCyc C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O cystathionine beta-lyase 7664-41-7 CAS cystathionine beta-lyase subunit 2 HMDB0029423 HMDB cystathionine gamma-lyase 53-57-6 CAS CHEBI:15741 ChEBI Tetrahydropteroyltri-L-glutamate 222 PubChem-compound 1.0 C00014 KEGG Compound 1110 PubChem-compound Selenomethionine C00013 KEGG Compound 440763 PubChem-compound O7P2 Pyrophosphate 173.91193 NAD(P) BioCyc 5957 PubChem-compound 25076 PubChem-compound N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase C4H6O4 Succinic acid 118.02661 CHEBI:64685 ChEBI P38816 UniProt H Hydrogen Ion 1.007825 C3H7NO2Se Selenocysteine 168.9642 389632 ChemSpider 1.0 CPD-1302 BioCyc 129633 ChemSpider C00022 KEGG Compound CHEBI:16160 ChEBI 56-65-5 CAS C00020 KEGG Compound SMP0002371 SMPDB CHEBI:26630 ChEBI HMDB0000243 HMDB ACET BioCyc HMDB0000005 HMDB SMILES CCC(=O)C(O)=O 1.0 HMDB0006343 HMDB 1.0 C00033 KEGG Compound C7H14N2O4Se Selenocystathionine 270.01187 P47164 UniProt CHEBI:30831 ChEBI HMDB0000254 HMDB AMP BioCyc Water SMILES OC(=O)CCC(O)=O CHEBI:77012 ChEBI thioredoxin reductase CHEBI:29173 ChEBI 528 PubChem-compound P31373 UniProt HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS SMILES N[C@@H](C[SeH])C(O)=O 1.0 C00042 KEGG Compound 5675 ChemSpider 1078 ChemSpider Reaction6777 false Selenocystathionine + Water → Ammonia + Pyruvic acid + Selenohomocysteine LEFT_TO_RIGHT C4H9NO2Se Se-Methylselenocysteine 182.97984 C4H9NO2Se Selenohomocysteine 182.97984 1.0 14375 ChemSpider thioredoxin reductase 1 Se-Methylselenocysteine Selenohomocysteine methionine--tRNA ligase MES1 ReactionCatalysis6741 ACTIVATION methionine--tRNA ligase MSM1 cystathionine gamma-synthase 6.1.1.10 false 6.1.1.10 Adenosine triphosphate + Selenomethionine + tRNA(Met) → Adenosine monophosphate + Pyrophosphate + Selenomethionyl-tRNA(Met) LEFT_TO_RIGHT ReactionCatalysis6744 ACTIVATION 4.4.1.1 false 4.4.1.1 Selenomethionine + Water → 2-Ketobutyric acid + Ammonia + methylselenol LEFT_TO_RIGHT ReactionCatalysis6743 ACTIVATION ReactionCatalysis6742 ACTIVATION Reaction6776 false 5-Methyltetrahydropteroyltri-L-glutamate + Selenohomocysteine ↔ Selenomethionine + Tetrahydropteroyltri-L-glutamate REVERSIBLE CHEBI:16633 ChEBI CHEBI:15422 ChEBI thioredoxin reductase 2 1.0 SMILES CC(O)=O 7732-18-5 CAS 1.0 61-19-8 CAS 17625690 ChemSpider SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 127-17-3 CAS AMMONIA BioCyc SMILES N cystathionine beta-lyase 124489574 PubChem-compound 26046-90-2 CAS SMILES C[SeH] 1464-42-2 CAS 1.0 SMILES C[Se](O)=O 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17614 ChEBI SELENOHOMOCYSTEINE BioCyc Selenocystathionine O-succinyl-L-homoserine 15103 PubChem-compound C30H39N9O12 5-Methyltetrahydropteroyltri-L-glutamate 717.2718 HMDB0000045 HMDB SMILES CC(=O)C(O)=O P22438 UniProt 5-Methyltetrahydropteroyltri-L-glutamate 1.0 ReactionCatalysis6763 ACTIVATION ReactionCatalysis6762 ACTIVATION 17625689 ChemSpider 2.5.1.48 false 2.5.1.48 O-succinyl-L-homoserine + Selenocystathionine ↔ Selenocysteine + Succinic acid REVERSIBLE Reaction6794 false Acetylhomoserine + Selenocysteine ↔ Acetic acid + Selenocystathionine REVERSIBLE HMDB0000042 HMDB P29509 UniProt 1.8.1.9 false 1.8.1.9 Methylselenic acid + Hydrogen Ion + NADPH → NADP + Water + methylselenol LEFT_TO_RIGHT Reaction6796 false Se-Methylselenocysteine + Water → Ammonia + Pyruvic acid + methylselenol LEFT_TO_RIGHT ReactionCatalysis6765 ACTIVATION ReactionCatalysis6764 ACTIVATION 962 PubChem-compound CHEBI:15366 ChEBI 29412-93-9 CAS 1.0 1.0 CHEBI:17420 ChEBI 2196-58-9 CAS 147004 PubChem-compound C00080 KEGG Compound P00958 UniProt 110-15-6 CAS 7540-67-2 CAS CH4Se methylselenol 95.94782 Selenocompound Metabolism CH4O2Se Methylselenic acid 127.93765 HMDB0000051 HMDB 171 ChemSpider HMDB0002111 HMDB CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2-Ketobutyric acid CHEBI:7671 ChEBI Selenomethionyl-tRNA(Met) 23436 ChemSpider 1.0 SMILES CN1[C@@H](CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)CNC2=C1C(=O)N=C(N)N2 C4H6O3 2-Ketobutyric acid 102.03169 CHEBI:27585 ChEBI P53101 UniProt 644102 PubChem-compound 4932 TAXONOMY 6083 PubChem-compound Selenomethionyl-tRNA(Met) methionyl-tRNA synthetase HMDB0012177 HMDB 513 ChemSpider 22833512 PubChem-compound H2O Water 18.010565 HMDB0012290 HMDB tRNA(Met) SMILES CC(=O)OCCC(N)C(O)=O 1060 PubChem-compound N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase HMDB0059597 HMDB cystathionine gamma-lyase SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 SMILES C[Se]CCC(N)C(O)=O 176 PubChem-compound 98223 PubChem-compound MSM1 MES1 CYS3 MET6 IRC7 STR3 STR2 STR2 TRR1 TRR2 CYS3 Adenosine triphosphate Selenomethionine Adenosine monophosphate Pyrophosphate Water methylselenol Ammonia 2-Ketobutyric acid Selenohomocysteine 5- Methyltetrahydropteroyltri- L-glutamate Tetrahydropteroyltri- L-glutamate Selenocystathionine Water Ammonia Pyruvic acid O-succinyl-L- homoserine Selenocysteine Succinic acid Selenocysteine Acetylhomoserine Acetic acid NADPH Hydrogen Ion Methylselenic acid NADP Water Se- Methylselenocysteine Water Ammonia Pyruvic acid Selenomethionyl- tRNA(Met) tRNA(Met)