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CHEBI:16015 ChEBI 30572 ChemSpider 17215925 ChemSpider 937 ChemSpider 57 ChemSpider SMILES O 50 ChemSpider 1.0 73-32-5 CAS Threonine Biosynthesis SubPathway PW002476 PathWhiz H4N Ammonium 18.034374 1.0 51 PubChem-compound 46 ChemSpider Pyruvic acid Unknown 19796801 PubChem-compound 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 6288 PubChem-compound 562-43-6 CAS 53-59-8 CAS Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc 1038 PubChem-compound CHEBI:16474 ChEBI 274 ChemSpider Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 4.0 2-dehydropantoate 2-reductase C00109 KEGG Compound NADPH SMILES CC=C(N)C([O-])=O 1010 ChemSpider Saccharomyces cerevisiae C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 (R) 2,3-Dihydroxy-3-methylvalerate 2.0 600-18-0 CAS NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 1.0 NADPH BioCyc Ammonium Threo-3-hydroxyaspartate ammonia-lyase CHEBI:16857 ChEBI Hydrogen Ion Pyruvate decarboxylase isozyme 3 HMDB0000208 HMDB 218 ChemSpider P26263 UniProt (S)-2-Aceto-2-hydroxybutanoic acid SMILES CCC(C)C(=O)C(O)=O 72-19-5 CAS L-Glutamic acid CHEBI:27512 ChEBI 1.0 HMDB0000217 HMDB SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS CHEBI:30915 ChEBI Reaction5890 true 3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate REVERSIBLE 1.0 1.0 6.0 2-iminobutanoate C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound 1460-34-0 CAS C00005 KEGG Compound 2-OXOBUTANOATE BioCyc C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 6051 ChemSpider (2Z)-2-aminobut-2-enoate SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O GLT BioCyc 53-57-6 CAS Dihydroxy-acid dehydratase, mitochondrial C4H6NO2 2-iminobutanoate 100.040405 1.0 C01342 KEGG Compound C00011 KEGG Compound SMILES O=C=O CHEBI:28938 ChEBI SMILES C[C@@H](O)[C@H](N)C(O)=O 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT NAD(P) BioCyc SMILES CC[C@H](C)[C@H](N)C(O)=O 47 PubChem-compound H Hydrogen Ion 1.007825 1.0 C00022 KEGG Compound SubPathwayInteraction3732 SubPathwayReaction SubPathway3732Reaction C06006 KEGG Compound 6067 ChemSpider C06007 KEGG Compound C00026 KEGG Compound 440875 PubChem-compound C00025 KEGG Compound HMDB0000243 HMDB HMDB0000005 HMDB SMILES CCC(=O)C(O)=O HMDB0006900 HMDB 1.0 SMP0002375 SMPDB 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound 6306 PubChem-compound 2.0 CHEBI:30831 ChEBI ReactionCatalysis6738 ACTIVATION 328-50-7 CAS ReactionCatalysis6737 ACTIVATION Water ReactionCatalysis6736 ACTIVATION ReactionCatalysis6735 ACTIVATION 1.0 ReactionCatalysis6739 ACTIVATION HMDB0000491 HMDB ReactionCatalysis6734 ACTIVATION 395044 ChemSpider dihydroxy acid dehydratase, mitochondrial 5675 ChemSpider ILE BioCyc acetohydroxy acid isomeroreductase 14798-03-9 CAS HMDB0000148 HMDB CHEBI:58739 ChEBI CHEBI:17191 ChEBI 2.2.1.6 false 2.2.1.6 2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide LEFT_TO_RIGHT ReactionCatalysis6740 ACTIVATION Reaction6771 false (S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT P39522 UniProt Reaction6772 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT Threo-3-hydroxyaspartate ammonia-lyase Reaction6773 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid LEFT_TO_RIGHT Pyruvate decarboxylase isozyme 3 4.0 2-dehydropantoate 2-reductase 7732-18-5 CAS 1.0 C6H10O4 (S)-2-Aceto-2-hydroxybutanoic acid 146.0579 127-17-3 CAS 1.0 56-86-0 CAS 389708 ChemSpider C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] SMP0000837 SMPDB 6857401 PubChem-compound CHEBI:16526 ChEBI C00188 KEGG Compound HMDB0012140 HMDB 1.0 CHEBI:35146 ChEBI HMDB0000167 HMDB SMILES CC(=O)C(O)=O 1.0 CHEBI:35932 ChEBI SMILES CC[C@H](C)C(=O)C([O-])=O 962 PubChem-compound C4H9NO3 L-Threonine 119.05824 2-KETOGLUTARATE BioCyc SMILES CCC(=N)C([O-])=O 2-KETO-3-METHYL-VALERATE BioCyc Unknown CO2 Carbon dioxide 43.98983 C03465 KEGG Compound 2.0 C00080 KEGG Compound Oxoglutaric acid SMILES CC[C@](O)(C(C)=O)C(O)=O 3-Methyl-2-oxovaleric acid C6H13NO2 L-Isoleucine 131.09464 HMDB0000172 HMDB HMDB0002111 HMDB 1.0 CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000817 PathWhiz Isoleucine Biosynthesis CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc 2-Keto-3-methyl-valerate C00407 KEGG Compound 5886 PubChem-compound 2-Ketobutyric acid 1.0 1.0 acetohydroxybutanoate synthase / acetolactate synthase 280 PubChem-compound C4H6O3 2-Ketobutyric acid 102.03169 C6H9O3 2-Keto-3-methyl-valerate 129.05518 4932 TAXONOMY P36007 UniProt 16741146 PubChem-compound 22833512 PubChem-compound acetolactate synthase / acetohydroxybutanoate synthase 3 threonine deaminase L-Isoleucine H2O Water 18.010565 acetohydroxybutanoate synthase / acetolactate synthase 2 branched-chain amino-acid aminotransferase P38787 UniProt 1.0 1060 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide HMDB0001967 HMDB L-Threonine Dihydroxy-acid dehydratase, mitochondrial CHEBI:27681 ChEBI Unknown Threo-3- hydroxyaspartate ammonia-lyase Putative 2- hydroxyacyl- CoA lyase acetohydroxybutanoate synthase / acetolactate synthase acetohydroxybutanoate synthase / acetolactate synthase 2 acetohydroxybutanoate synthase / acetolactate synthase 2 Pyruvate decarboxylase isozyme 3 acetohydroxy acid isomeroreductase dihydroxy acid dehydratase, mitochondrial branched-chain amino-acid aminotransferase L-Threonine H + H 2 O (2Z)-2- aminobut-2- enoate 2- iminobutanoate H 2 O H + Ammonium 2-Ketobutyric acid H + Pyruvic acid CO 2 (S)-2-Aceto- 2- hydroxybutanoic acid NADPH H + NADP (R) 2,3- Dihydroxy-3- methylvalerate H 2 O 3-Methyl-2- oxovaleric acid L-Glutamic acid Oxoglutaric acid L-Isoleucine 2-Keto-3- methyl- valerate Threonine Biosynthesis
CHEBI:16015 ChEBI 30572 ChemSpider 17215925 ChemSpider 937 ChemSpider 57 ChemSpider SMILES O 50 ChemSpider 1.0 73-32-5 CAS Threonine Biosynthesis SubPathway PW002476 PathWhiz H4N Ammonium 18.034374 1.0 51 PubChem-compound 46 ChemSpider Pyruvic acid Unknown 19796801 PubChem-compound 58 PubChem-compound C3H4O3 Pyruvic acid 88.016045 6288 PubChem-compound 562-43-6 CAS 53-59-8 CAS Reaction2924 true 2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium LEFT_TO_RIGHT THR BioCyc 1038 PubChem-compound CHEBI:16474 ChEBI 274 ChemSpider Reaction2923 true (2Z)-2-aminobut-2-enoate → 2-iminobutanoate LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 C6H10O3 3-Methyl-2-oxovaleric acid 130.06299 4.0 2-dehydropantoate 2-reductase C00109 KEGG Compound NADPH SMILES CC=C(N)C([O-])=O 1010 ChemSpider Saccharomyces cerevisiae C6H12O4 (R) 2,3-Dihydroxy-3-methylvalerate 148.07356 (R) 2,3-Dihydroxy-3-methylvalerate 2.0 600-18-0 CAS NADP C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 1.0 NADPH BioCyc Ammonium Threo-3-hydroxyaspartate ammonia-lyase CHEBI:16857 ChEBI Hydrogen Ion Pyruvate decarboxylase isozyme 3 HMDB0000208 HMDB 218 ChemSpider P26263 UniProt (S)-2-Aceto-2-hydroxybutanoic acid SMILES CCC(C)C(=O)C(O)=O 72-19-5 CAS L-Glutamic acid CHEBI:27512 ChEBI 1.0 HMDB0000217 HMDB SMILES OC(=O)CCC(=O)C(O)=O 124-38-9 CAS CHEBI:30915 ChEBI Reaction5890 true 3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate REVERSIBLE 1.0 1.0 6.0 2-iminobutanoate C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound 1460-34-0 CAS C00005 KEGG Compound 2-OXOBUTANOATE BioCyc C4H6NO2 (2Z)-2-aminobut-2-enoate 100.040405 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 6051 ChemSpider (2Z)-2-aminobut-2-enoate SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES CC[C@@](C)(O)[C@@H](O)C(O)=O GLT BioCyc 53-57-6 CAS Dihydroxy-acid dehydratase, mitochondrial C4H6NO2 2-iminobutanoate 100.040405 1.0 C01342 KEGG Compound C00011 KEGG Compound SMILES O=C=O CHEBI:28938 ChEBI SMILES C[C@@H](O)[C@H](N)C(O)=O 4.3.1.19 false 4.3.1.19 L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water LEFT_TO_RIGHT NAD(P) BioCyc SMILES CC[C@H](C)[C@H](N)C(O)=O 47 PubChem-compound H Hydrogen Ion 1.007825 1.0 C00022 KEGG Compound SubPathwayInteraction3732 SubPathwayReaction SubPathway3732Reaction C06006 KEGG Compound 6067 ChemSpider C06007 KEGG Compound C00026 KEGG Compound 440875 PubChem-compound C00025 KEGG Compound HMDB0000243 HMDB HMDB0000005 HMDB SMILES CCC(=O)C(O)=O HMDB0006900 HMDB 1.0 SMP0002375 SMPDB 1-KETO-2-METHYLVALERATE BioCyc 448154 PubChem-compound 6306 PubChem-compound 2.0 CHEBI:30831 ChEBI ReactionCatalysis6738 ACTIVATION 328-50-7 CAS ReactionCatalysis6737 ACTIVATION Water ReactionCatalysis6736 ACTIVATION ReactionCatalysis6735 ACTIVATION 1.0 ReactionCatalysis6739 ACTIVATION HMDB0000491 HMDB ReactionCatalysis6734 ACTIVATION 395044 ChemSpider dihydroxy acid dehydratase, mitochondrial 5675 ChemSpider ILE BioCyc acetohydroxy acid isomeroreductase 14798-03-9 CAS HMDB0000148 HMDB CHEBI:58739 ChEBI CHEBI:17191 ChEBI 2.2.1.6 false 2.2.1.6 2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide LEFT_TO_RIGHT ReactionCatalysis6740 ACTIVATION Reaction6771 false (S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP LEFT_TO_RIGHT P39522 UniProt Reaction6772 false (R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water LEFT_TO_RIGHT Threo-3-hydroxyaspartate ammonia-lyase Reaction6773 false 3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid LEFT_TO_RIGHT Pyruvate decarboxylase isozyme 3 4.0 2-dehydropantoate 2-reductase 7732-18-5 CAS 1.0 C6H10O4 (S)-2-Aceto-2-hydroxybutanoic acid 146.0579 127-17-3 CAS 1.0 56-86-0 CAS 389708 ChemSpider C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] SMP0000837 SMPDB 6857401 PubChem-compound CHEBI:16526 ChEBI C00188 KEGG Compound HMDB0012140 HMDB 1.0 CHEBI:35146 ChEBI HMDB0000167 HMDB SMILES CC(=O)C(O)=O 1.0 CHEBI:35932 ChEBI SMILES CC[C@H](C)C(=O)C([O-])=O 962 PubChem-compound C4H9NO3 L-Threonine 119.05824 2-KETOGLUTARATE BioCyc SMILES CCC(=N)C([O-])=O 2-KETO-3-METHYL-VALERATE BioCyc Unknown CO2 Carbon dioxide 43.98983 C03465 KEGG Compound 2.0 C00080 KEGG Compound Oxoglutaric acid SMILES CC[C@](O)(C(C)=O)C(O)=O 3-Methyl-2-oxovaleric acid C6H13NO2 L-Isoleucine 131.09464 HMDB0000172 HMDB HMDB0002111 HMDB 1.0 CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000817 PathWhiz Isoleucine Biosynthesis CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc 2-Keto-3-methyl-valerate C00407 KEGG Compound 5886 PubChem-compound 2-Ketobutyric acid 1.0 1.0 acetohydroxybutanoate synthase / acetolactate synthase 280 PubChem-compound C4H6O3 2-Ketobutyric acid 102.03169 C6H9O3 2-Keto-3-methyl-valerate 129.05518 4932 TAXONOMY P36007 UniProt 16741146 PubChem-compound 22833512 PubChem-compound acetolactate synthase / acetohydroxybutanoate synthase 3 threonine deaminase L-Isoleucine H2O Water 18.010565 acetohydroxybutanoate synthase / acetolactate synthase 2 branched-chain amino-acid aminotransferase P38787 UniProt 1.0 1060 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide HMDB0001967 HMDB L-Threonine Dihydroxy-acid dehydratase, mitochondrial CHEBI:27681 ChEBI Unknown SRY1 YEL020C Unknown Unknown Unknown PDC6 Unknown Unknown Unknown L-Threonine Hydrogen Ion Water (2Z)-2- aminobut-2- enoate 2- iminobutanoate Water Hydrogen Ion Ammonium 2-Ketobutyric acid Hydrogen Ion Pyruvic acid Carbon dioxide (S)-2-Aceto- 2- hydroxybutanoic acid NADPH Hydrogen Ion NADP (R) 2,3- Dihydroxy-3- methylvalerate Water 3-Methyl-2- oxovaleric acid L-Glutamic acid Oxoglutaric acid L-Isoleucine 2-Keto-3- methyl- valerate Threonine Biosynthesis