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CHEBI:16015 ChEBI 1.0 30572 ChemSpider Branched-chain-amino-acid aminotransferase, mitochondrial 1.0 6306 PubChem-compound P25377 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 8723 PubChem-compound 8398 ChemSpider 5682 ChemSpider 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES CCC(C)CO NADH SMILES CCC(C)C=O 1.0 439153 PubChem-compound Mitochondrial Matrix Branched-chain-amino-acid aminotransferase, cytosolic 50 ChemSpider 73-32-5 CAS 1.0 C6H10O3 (S)-3-methyl-2-oxopentanoate 130.06299 NAD Pyruvate decarboxylase isozyme 1 pyruvate decarboxylase 2 alcohol dehydrogenase subunit I Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit 2 ILE BioCyc P47176 UniProt C02223 KEGG Compound 1.0 SMP0002390 SMPDB 51 PubChem-compound HMDB0000148 HMDB CHEBI:17191 ChEBI 137-32-6 CAS CHEBI:15846 ChEBI CHEBI:48945 ChEBI 1038 PubChem-compound 388299 ChemSpider HMDB0001487 HMDB GO:0005829 GENE ONTOLOGY 1.0 56-86-0 CAS 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 pyruvate decarboxylase C5H9NO4 L-Glutamic acid 147.05316 CHEBI:16908 ChEBI 33032 PubChem-compound CHEBI:16526 ChEBI 1.0 1.0 1010 ChemSpider 1.0 Saccharomyces cerevisiae 1.0 (S)-3-methyl-2-oxopentanoate pyruvate decarboxylase 2 alcohol dehydrogenase subunit I Pyruvate decarboxylase isozyme 1 2-KETOGLUTARATE BioCyc Hydrogen Ion HMDB0000208 HMDB Cytosol CO2 Carbon dioxide 43.98983 P26263 UniProt 5893 PubChem-compound 58-68-4 CAS C00080 KEGG Compound L-Glutamic acid Oxoglutaric acid SMILES OC(=O)CCC(=O)C(O)=O C6H13NO2 L-Isoleucine 131.09464 CHEBI:30915 ChEBI 124-38-9 CAS HMDB0000172 HMDB Reaction6980 false ()-2-Methylbutanal + Hydrogen Ion + NADH → (S)-2-Methyl-1-butanol + NAD LEFT_TO_RIGHT SMILES N[C@@H](CCC(O)=O)C(O)=O Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit 2 Transport561 false (S)-3-methyl-2-oxopentanoate (→) Transport: Saccharomyces cerevisiae, Cell, Mitochondrial Matrix to Saccharomyces cerevisiae, Cytosol LEFT_TO_RIGHT CHEBI:15378 ChEBI SMILES [H+] C00407 KEGG Compound CHEBI:16182 ChEBI 96-17-3 CAS C00004 KEGG Compound C00003 KEGG Compound 7012 ChemSpider Reaction6977 false L-Isoleucine + Oxoglutaric acid → (S)-3-methyl-2-oxopentanoate + L-Glutamic acid LEFT_TO_RIGHT Reaction6978 false Hydrogen Ion + L-Isoleucine → (S)-3-methyl-2-oxopentanoate + Carbon dioxide LEFT_TO_RIGHT Branched-chain-amino-acid aminotransferase, cytosolic Reaction6979 false (S)-3-methyl-2-oxopentanoate + Hydrogen Ion → ()-2-Methylbutanal + Carbon dioxide LEFT_TO_RIGHT Branched-chain-amino-acid aminotransferase, mitochondrial GO:0005759 GENE ONTOLOGY 280 PubChem-compound P16467 UniProt GLT BioCyc 1.0 4932 TAXONOMY (S)-3-methyl-2-oxopentanoate C21H28N7O14P2 NAD 664.11694 Isoleucine Degradation (S)-3-methyl-2-oxopentanoate C00011 KEGG Compound SMILES O=C=O HMDB0000902 HMDB ()-2-Methylbutanal ReactionCatalysis6957 ACTIVATION ReactionCatalysis6956 ACTIVATION ReactionCatalysis6955 ACTIVATION Q04894 UniProt L-Isoleucine C21H29N7O14P2 NADH 665.12476 SMILES CC[C@H](C)[C@H](N)C(O)=O HMDB0031526 HMDB (S)-2-Methyl-1-butanol HMDB0031527 HMDB SMILES CC[C@H](C)C(=O)C(O)=O ReactionCatalysis6954 ACTIVATION C5H10O ()-2-Methylbutanal 86.073166 NADH BioCyc C5H12O (S)-2-Methyl-1-butanol 88.08881 NAD BioCyc H Hydrogen Ion 1.007825 HMDB0059597 HMDB 7284 PubChem-compound P06169 UniProt Carbon dioxide HMDB0001967 HMDB 53-84-9 CAS 6067 ChemSpider C00026 KEGG Compound C00025 KEGG Compound PW002491 PathWhiz alcohol dehydrogenase 1.0 P38891 UniProt Branched- chain-amino- acid aminotransferase, mitochondrial Branched- chain-amino- acid aminotransferase, cytosolic Pyruvate decarboxylase isozyme 1 pyruvate decarboxylase 2 Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit I alcohol dehydrogenase subunit 2 (S)-3-methyl- 2- oxopentanoate (S)-3-methyl- 2- oxopentanoate L-Isoleucine Oxoglutaric acid L-Glutamic acid L-Isoleucine H + CO 2 H + ()-2- Methylbutanal CO 2 NADH H + (S)-2-Methyl- 1-butanol NAD
CHEBI:16015 ChEBI 1.0 30572 ChemSpider Branched-chain-amino-acid aminotransferase, mitochondrial 1.0 6306 PubChem-compound P25377 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 8723 PubChem-compound 8398 ChemSpider 5682 ChemSpider 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES CCC(C)CO NADH SMILES CCC(C)C=O 1.0 439153 PubChem-compound Mitochondrial Matrix Branched-chain-amino-acid aminotransferase, cytosolic 50 ChemSpider 73-32-5 CAS 1.0 C6H10O3 (S)-3-methyl-2-oxopentanoate 130.06299 NAD Pyruvate decarboxylase isozyme 1 pyruvate decarboxylase 2 alcohol dehydrogenase subunit I Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit 2 ILE BioCyc P47176 UniProt C02223 KEGG Compound 1.0 SMP0002390 SMPDB 51 PubChem-compound HMDB0000148 HMDB CHEBI:17191 ChEBI 137-32-6 CAS CHEBI:15846 ChEBI CHEBI:48945 ChEBI 1038 PubChem-compound 388299 ChemSpider HMDB0001487 HMDB GO:0005829 GENE ONTOLOGY 1.0 56-86-0 CAS 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 pyruvate decarboxylase C5H9NO4 L-Glutamic acid 147.05316 CHEBI:16908 ChEBI 33032 PubChem-compound CHEBI:16526 ChEBI 1.0 1.0 1010 ChemSpider 1.0 Saccharomyces cerevisiae 1.0 (S)-3-methyl-2-oxopentanoate pyruvate decarboxylase 2 alcohol dehydrogenase subunit I Pyruvate decarboxylase isozyme 1 2-KETOGLUTARATE BioCyc Hydrogen Ion HMDB0000208 HMDB Cytosol CO2 Carbon dioxide 43.98983 P26263 UniProt 5893 PubChem-compound 58-68-4 CAS C00080 KEGG Compound L-Glutamic acid Oxoglutaric acid SMILES OC(=O)CCC(=O)C(O)=O C6H13NO2 L-Isoleucine 131.09464 CHEBI:30915 ChEBI 124-38-9 CAS HMDB0000172 HMDB Reaction6980 false ()-2-Methylbutanal + Hydrogen Ion + NADH → (S)-2-Methyl-1-butanol + NAD LEFT_TO_RIGHT SMILES N[C@@H](CCC(O)=O)C(O)=O Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit 2 Transport561 false (S)-3-methyl-2-oxopentanoate (→) Transport: Saccharomyces cerevisiae, Cell, Mitochondrial Matrix to Saccharomyces cerevisiae, Cytosol LEFT_TO_RIGHT CHEBI:15378 ChEBI SMILES [H+] C00407 KEGG Compound CHEBI:16182 ChEBI 96-17-3 CAS C00004 KEGG Compound C00003 KEGG Compound 7012 ChemSpider Reaction6977 false L-Isoleucine + Oxoglutaric acid → (S)-3-methyl-2-oxopentanoate + L-Glutamic acid LEFT_TO_RIGHT Reaction6978 false Hydrogen Ion + L-Isoleucine → (S)-3-methyl-2-oxopentanoate + Carbon dioxide LEFT_TO_RIGHT Branched-chain-amino-acid aminotransferase, cytosolic Reaction6979 false (S)-3-methyl-2-oxopentanoate + Hydrogen Ion → ()-2-Methylbutanal + Carbon dioxide LEFT_TO_RIGHT Branched-chain-amino-acid aminotransferase, mitochondrial GO:0005759 GENE ONTOLOGY 280 PubChem-compound P16467 UniProt GLT BioCyc 1.0 4932 TAXONOMY (S)-3-methyl-2-oxopentanoate C21H28N7O14P2 NAD 664.11694 Isoleucine Degradation (S)-3-methyl-2-oxopentanoate C00011 KEGG Compound SMILES O=C=O HMDB0000902 HMDB ()-2-Methylbutanal ReactionCatalysis6957 ACTIVATION ReactionCatalysis6956 ACTIVATION ReactionCatalysis6955 ACTIVATION Q04894 UniProt L-Isoleucine C21H29N7O14P2 NADH 665.12476 SMILES CC[C@H](C)[C@H](N)C(O)=O HMDB0031526 HMDB (S)-2-Methyl-1-butanol HMDB0031527 HMDB SMILES CC[C@H](C)C(=O)C(O)=O ReactionCatalysis6954 ACTIVATION C5H10O ()-2-Methylbutanal 86.073166 NADH BioCyc C5H12O (S)-2-Methyl-1-butanol 88.08881 NAD BioCyc H Hydrogen Ion 1.007825 HMDB0059597 HMDB 7284 PubChem-compound P06169 UniProt Carbon dioxide HMDB0001967 HMDB 53-84-9 CAS 6067 ChemSpider C00026 KEGG Compound C00025 KEGG Compound PW002491 PathWhiz alcohol dehydrogenase 1.0 P38891 UniProt Mitochondria BAT1 BAT2 PDC1 PDC5 PDC6 ADH7 ADH6 (S)-3-methyl- 2- oxopentanoate (S)-3-methyl- 2- oxopentanoate L-Isoleucine Oxoglutaric acid L-Glutamic acid L-Isoleucine Hydrogen Ion Carbon dioxide Hydrogen Ion ()-2- Methylbutanal Carbon dioxide NADH Hydrogen Ion (S)-2-Methyl- 1-butanol NAD