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Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-8 Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-8 Akt1 Serum response factor Rock1 Inositol 1,4,5- trisphosphate receptor type 1 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Unknown Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Unknown Inositol 1,4,5- trisphosphate Ca+ Ca+ ATP cAMP PPi H2O Lysophosphatidic acid Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 1,2-diacyl- sn-glycerol PKC phosphatidylinositol 4,5- bisphosphate Gαi/o Gα12/13 Gαq/11 Lysophosphatidic acid Magnesium Phospholipid Biosynthesis Magnesium Calcium GTP GTP GTP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors GDP Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane
Endoplasmic Reticulum Gng8 Gng8 Akt1 Srf Rock1 Itpr1 Gnb1 Unknown Gnb1 Unknown Inositol 1,4,5- trisphosphate Calcium Calcium Adenosine triphosphate cAMP Pyrophosphate Water Lysophosphatidic acid Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 1,2-diacyl- sn-glycerol PKC phosphatidylinositol 4,5- bisphosphate Gαi/o Gα12/13 Gαq/11 Lysophosphatidic acid Phospholipid Biosynthesis Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate Guanosine diphosphate
Gng8 Gng8 Akt1 Srf Rock1 Itpr1 Gnb1 Gnb1 Inotp Ca+ Ca+ ATP cAMP PPi H2O LA AC Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 12DSG PKC P45B Gαi/o Gα12/13 Gαq/11 LA Mg2+ PW000048 Mg2+ Ca2+ GTP GTP GTP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors GDP Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane
Endoplasmic Reticulum Gng8 Gng8 Akt1 Srf Rock1 Itpr1 Gnb1 Gnb1 Inotp Ca2+ Ca2+ ATP cAMP Ppi H2O LA AC Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 12DSG PKC P45B Gαi/o Gα12/13 Gαq/11 LA PW000048 GTP GTP GTP GTP GDP