Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/KEGG Compound C00438
type: UnificationXref
id: C00438
db: KEGG Compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Citrulline
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Citrulline
name: SubPathwayOutput

Reference/UniProt P30566
type: UnificationXref
id: P30566
db: UniProt

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/UniProt Q8N142
type: UnificationXref
id: Q8N142
db: UniProt

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6267
type: UnificationXref
id: 6267
db: PubChem-compound

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

L-Aspartic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Aspartic acid
name: SubPathwayInput

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

D-aspartate oxidase
type: ProteinReference
xref: Reference/UniProt Q99489
organism: Homo sapiens

Unknown
type: ProteinReference

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Transport10398
type: Transport
participant stoichiometry: Compound/PW C002766 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002766 Peroxisome/Stoichiometry/1.0
right: D-Aspartic acid
spontaneous: false
left: D-Aspartic acid
name: D-Aspartic acid (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Peroxisome
conversion direction: LEFT_TO_RIGHT

N-Acetylaspartate synthetase
type: ProteinReference
xref: Reference/UniProt Q8N9F0
organism: Homo sapiens

Transport10397
type: Transport
participant stoichiometry: Compound/PW C000040 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Mitochondrial Matrix/Stoichiometry/1.0
right: β-Alanine
spontaneous: false
left: β-Alanine
name: β-Alanine (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/CAS 13184-27-5
type: UnificationXref
id: 13184-27-5
db: CAS

Hydrogen peroxide
type: SmallMolecule
cellular location: Lysosome
entity reference: Hydrogen peroxide

Reference/ChEBI CHEBI 17202
type: UnificationXref
id: CHEBI:17202
db: ChEBI

Reference/PathWhiz PW000043
type: UnificationXref
id: PW000043
db: PathWhiz

Reference/PubChem-compound 8582
type: UnificationXref
id: 8582
db: PubChem-compound

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

RNA/4 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Asparaginyl-tRNA(Asn)
stoichiometric coefficient: 1.0

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/BioCyc ASN
type: UnificationXref
id: ASN
db: BioCyc

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/PathWhiz PW000162
type: UnificationXref
id: PW000162
db: PathWhiz

Reference/PathWhiz PW000160
type: UnificationXref
id: PW000160
db: PathWhiz

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

Reference/UniProt Q8N9F0
type: UnificationXref
id: Q8N9F0
db: UniProt

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/PathWhiz PW000032
type: UnificationXref
id: PW000032
db: PathWhiz

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

Compound/PW C002766 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Aspartic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/PubChem-compound 16950
type: UnificationXref
id: 16950
db: PubChem-compound

Reference/PathWhiz PW000151
type: UnificationXref
id: PW000151
db: PathWhiz

Adenylosuccinate synthetase isozyme 1
type: Protein
cellular location: Cytoplasm
entity reference: Adenylosuccinate synthetase isozyme 1

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/KEGG Compound C00222
type: UnificationXref
id: C00222
db: KEGG Compound

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

D-Aspartic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Aspartic acid

Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Asparagine synthetase [glutamine-hydrolyzing]
type: Protein
cellular location: Cytoplasm
entity reference: Asparagine synthetase [glutamine-hydrolyzing]

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Aspartate--tRNA ligase, cytoplasmic
type: Complex
component stoichiometry: Protein/575 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Aspartate--tRNA ligase, cytoplasmic

Reference/HMDB HMDB0001096
type: UnificationXref
id: HMDB0001096
db: HMDB

L-Aspartyl-tRNA(Asp)
type: Rna
cellular location: Cytoplasm
entity reference: L-Aspartyl-tRNA(Asp)

Compound/PW C000088 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Water
type: SmallMolecule
cellular location: Peroxisome
entity reference: Water

Carbamoyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 278
xref: Reference/BioCyc CARBAMOYL-P
xref: Reference/ChemSpider 272
xref: Reference/HMDB HMDB0001096
xref: Reference/CAS 590-55-6
xref: Reference/KEGG Compound C00169
xref: Reference/ChEBI CHEBI 17672
chemical formula: CH4NO5P
molecular weight: 140.98271
structure: ChemicalStructure/PW C000862

RNA/3 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Asn)
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid

Compound/PW C000035 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/UniProt Q99259
type: UnificationXref
id: Q99259
db: UniProt

Protein/526 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartoacylase
stoichiometric coefficient: 2.0

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

CAD protein
type: Complex
component stoichiometry: Protein/2335 Cytoplasm/Stoichiometry/6.0
cellular location: Cytoplasm
component: CAD protein

Compound/PW C000148 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Fumaric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Fumaric acid

Adenylosuccinate lyase
type: Protein
cellular location: Cytoplasm
entity reference: Adenylosuccinate lyase

Reference/PubChem-compound 93072
type: UnificationXref
id: 93072
db: PubChem-compound

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03406
type: UnificationXref
id: C03406
db: KEGG Compound

Hydrogen peroxide
type: SmallMolecule
cellular location: Peroxisome
entity reference: Hydrogen peroxide

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C00130
type: UnificationXref
id: C00130
db: KEGG Compound

L-Asparagine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Asparagine

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/ChEBI CHEBI 17364
type: UnificationXref
id: CHEBI:17364
db: ChEBI

4-aminobutyrate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P80404
organism: Homo sapiens

Reference/UniProt Q7L266
type: UnificationXref
id: Q7L266
db: UniProt

Ureidosuccinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ureidosuccinic acid

Reference/ChemSpider 58576
type: UnificationXref
id: 58576
db: ChemSpider

Carbamoyl phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbamoyl phosphate

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/UniProt Q99489
type: UnificationXref
id: Q99489
db: UniProt

Compound/PW C001065 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Aspartoacylase
type: Complex
component stoichiometry: Protein/526 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Aspartoacylase

Compound/PW C000148 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

Reference/ChEBI CHEBI 29172
type: UnificationXref
id: CHEBI:29172
db: ChEBI

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/KEGG Compound C00152
type: UnificationXref
id: C00152
db: KEGG Compound

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Glutamate decarboxylase 1
type: ProteinReference
xref: Reference/UniProt Q99259
organism: Homo sapiens

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Argininosuccinate lyase
type: ProteinReference
xref: Reference/UniProt P04424
organism: Homo sapiens

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Argininosuccinate synthase
type: Protein
cellular location: Cytoplasm
entity reference: Argininosuccinate synthase

Reference/ChEBI CHEBI 17196
type: UnificationXref
id: CHEBI:17196
db: ChEBI

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/KEGG Compound C03794
type: UnificationXref
id: C03794
db: KEGG Compound

Reference/KEGG Compound C00169
type: UnificationXref
id: C00169
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: Reference/UniProt P08243
organism: Homo sapiens

Adenylosuccinate lyase
type: ProteinReference
xref: Reference/UniProt P30566
organism: Homo sapiens

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Argininosuccinate lyase
type: Complex
component stoichiometry: Protein/661 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Argininosuccinate lyase

Protein/2335 Cytoplasm/Stoichiometry/6.0
type: Stoichiometry
physical entity: CAD protein
stoichiometric coefficient: 6.0

N-Acetyl-L-aspartic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01042
xref: Reference/ChemSpider 58576
xref: Reference/BioCyc CPD-420
xref: Reference/ChEBI CHEBI 21547
xref: Reference/CAS 997-55-7
xref: Reference/HMDB HMDB0000812
xref: Reference/PubChem-compound 65065
chemical formula: C6H9NO5
molecular weight: 175.04807
structure: ChemicalStructure/PW C000649

1.4.3.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/1.0
right: Oxalacetic acid
right: Hydrogen peroxide
right: Ammonia
spontaneous: false
EC number: 1.4.3.2
left: Water
left: Oxygen
left: L-Aspartic acid
name: L-Aspartic acid + Oxygen + Water ↔ Ammonia + Hydrogen peroxide + Oxalacetic acid
conversion direction: REVERSIBLE

Reaction14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000662 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
right: Phosphate
right: Ureidosuccinic acid
spontaneous: false
left: L-Aspartic acid
left: Carbamoyl phosphate
name: Carbamoyl phosphate + L-Aspartic acid ↔ Phosphate + Ureidosuccinic acid
conversion direction: REVERSIBLE

6.3.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000413 Cytoplasm/Stoichiometry/1.0
right: Adenylsuccinic acid
right: Phosphate
right: Guanosine diphosphate
spontaneous: false
EC number: 6.3.4.4
left: L-Aspartic acid
left: Inosinic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Inosinic acid + L-Aspartic acid ↔ Adenylsuccinic acid + Guanosine diphosphate + Phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

6.1.1.12
type: BiochemicalReaction
participant stoichiometry: RNA/6 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/5 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Aspartyl-tRNA(Asp)
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.12
left: L-Aspartic acid
left: Adenosine triphosphate
left: tRNA(Asp)
name: Adenosine triphosphate + L-Aspartic acid + tRNA(Asp) ↔ Adenosine monophosphate + L-Aspartyl-tRNA(Asp) + Pyrophosphate
conversion direction: REVERSIBLE

1.4.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000148 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002766 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Peroxisome/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: Oxalacetic acid
spontaneous: false
EC number: 1.4.3.1
left: Oxygen
left: Water
left: D-Aspartic acid
name: D-Aspartic acid + Oxygen + Water ↔ Ammonia + Hydrogen peroxide + Oxalacetic acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 21547
type: UnificationXref
id: CHEBI:21547
db: ChEBI

4.3.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000036 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000396 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Cytoplasm/Stoichiometry/1.0
right: Fumaric acid
right: L-Arginine
spontaneous: false
EC number: 4.3.2.1
left: Argininosuccinic acid
name: 2 Argininosuccinic acid → Fumaric acid + L-Arginine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001783 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

4.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000088 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000413 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Fumaric acid
right: Adenosine monophosphate
spontaneous: false
EC number: 4.3.2.2
left: Adenylsuccinic acid
name: Adenylsuccinic acid ↔ Adenosine monophosphate + Fumaric acid
conversion direction: REVERSIBLE

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Oxalacetic acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: Oxalacetic acid

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

4-aminobutyrate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/242 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: 4-aminobutyrate aminotransferase, mitochondrial

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

6.3.4.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000036 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000723 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Argininosuccinic acid
right: Pyrophosphate
spontaneous: false
EC number: 6.3.4.5
left: L-Aspartic acid
left: Citrulline
left: Adenosine triphosphate
name: Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

6.1.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/4 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/3 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000110 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Asparaginyl-tRNA(Asn)
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.22
left: Adenosine triphosphate
left: L-Asparagine
left: tRNA(Asn)
name: Adenosine triphosphate + L-Asparagine + tRNA(Asn) ↔ Adenosine monophosphate + L-Asparaginyl-tRNA(Asn) + Pyrophosphate
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000036
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Reference/CAS 926-61-4
type: UnificationXref
id: 926-61-4
db: CAS

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/CAS 590-55-6
type: UnificationXref
id: 590-55-6
db: CAS

Reference/UniProt O43776
type: UnificationXref
id: O43776
db: UniProt

D-Aspartic acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: D-Aspartic acid

Reference/ChEBI CHEBI 29158
type: UnificationXref
id: CHEBI:29158
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Adenylsuccinic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440122
xref: Reference/HMDB HMDB0000536
xref: Reference/CAS 19046-78-7
xref: Reference/KEGG Compound C03794
xref: Reference/ChEBI CHEBI 15919
xref: Reference/ChemSpider 389122
chemical formula: C14H18N5O11P
molecular weight: 463.07404
structure: ChemicalStructure/PW C000413

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

6.3.5.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000110 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Glutamic acid
right: L-Asparagine
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.4
left: L-Aspartic acid
left: Water
left: Adenosine triphosphate
left: L-Glutamine
name: Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water ↔ Adenosine monophosphate + L-Asparagine + L-Glutamic acid + Pyrophosphate
conversion direction: REVERSIBLE

3.5.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000649 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
right: L-Aspartic acid
right: Acetic acid
spontaneous: false
EC number: 3.5.1.15
left: Water
left: N-Acetyl-L-aspartic acid
name: N-Acetyl-L-aspartic acid + Water ↔ Acetic acid + L-Aspartic acid
conversion direction: REVERSIBLE

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

4.1.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000040 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: β-Alanine
spontaneous: false
EC number: 4.1.1.15
left: L-Aspartic acid
name: L-Aspartic acid → Carbon dioxide + β-Alanine
conversion direction: LEFT_TO_RIGHT

Asparagine--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt O43776
organism: Homo sapiens

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/CAS 2387-71-5
type: UnificationXref
id: 2387-71-5
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0000168
type: UnificationXref
id: HMDB0000168
db: HMDB

Aspartate--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P14868
organism: Homo sapiens

Reference/KEGG Compound C01042
type: UnificationXref
id: C01042
db: KEGG Compound

Reaction5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006753 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Mitochondrial Matrix/Stoichiometry/1.0
right: Malonic semialdehyde
right: L-Glutamic acid
spontaneous: false
left: β-Alanine
left: Oxoglutaric acid
name: Oxoglutaric acid + β-Alanine → L-Glutamic acid + Malonic semialdehyde
conversion direction: LEFT_TO_RIGHT

Ureidosuccinic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00438
xref: Reference/CAS 13184-27-5
xref: Reference/BioCyc CARBAMYUL-L-ASPARTATE
xref: Reference/ChEBI CHEBI 15859
xref: Reference/ChemSpider 84022
xref: Reference/HMDB HMDB0000828
xref: Reference/PubChem-compound 93072
chemical formula: C5H8N2O5
molecular weight: 176.04332
structure: ChemicalStructure/PW C000662

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

ChemicalStructure/PW C000040
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(O)=O

Reference/ChEBI CHEBI 29265
type: UnificationXref
id: CHEBI:29265
db: ChEBI

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Protein/622 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Argininosuccinate synthase
stoichiometric coefficient: 4.0

Transport10402
type: Transport
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Lysosome/Stoichiometry/1.0
right: Oxalacetic acid
spontaneous: false
left: Oxalacetic acid
name: Oxalacetic acid (←) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Lysosome
conversion direction: LEFT_TO_RIGHT

D-Aspartic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00402
xref: Reference/BioCyc CPD-302
xref: Reference/ChemSpider 75697
xref: Reference/PubChem-compound 83887
xref: Reference/HMDB HMDB0006483
xref: Reference/CAS 1783-96-6
xref: Reference/ChEBI CHEBI 17364
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C002766

Transport10403
type: Transport
participant stoichiometry: Compound/PW C000123 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
right: L-Aspartic acid
spontaneous: false
left: L-Aspartic acid
name: L-Aspartic acid (→) Transport: Homo sapiens, Cell, Lysosome to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Argininosuccinate synthase
type: ProteinReference
xref: Reference/UniProt P00966
organism: Homo sapiens

Transport10401
type: Transport
participant stoichiometry: Compound/PW C000148 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
right: Oxalacetic acid
spontaneous: false
left: Oxalacetic acid
name: Oxalacetic acid (→) Transport: Homo sapiens, Cell, Peroxisome to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000056
type: UnificationXref
id: HMDB0000056
db: HMDB

Ammonia
type: SmallMolecule
cellular location: Peroxisome
entity reference: Ammonia

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

ChemicalStructure/PW C006753
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC=O

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

L-Asparagine
type: SmallMoleculeReference
xref: Reference/ChemSpider 6031
xref: Reference/HMDB HMDB0000168
xref: Reference/CAS 70-47-3
xref: Reference/ChEBI CHEBI 17196
xref: Reference/BioCyc ASN
xref: Reference/KEGG Compound C00152
xref: Reference/PubChem-compound 6267
chemical formula: C4H8N2O3
molecular weight: 132.0535
structure: ChemicalStructure/PW C000110

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0000052
type: UnificationXref
id: HMDB0000052
db: HMDB

Reference/ChEBI CHEBI 15919
type: UnificationXref
id: CHEBI:15919
db: ChEBI

Reference/HMDB HMDB0000175
type: UnificationXref
id: HMDB0000175
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Inosinic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 8264
xref: Reference/ChEBI CHEBI 17202
xref: Reference/CAS 131-99-7
xref: Reference/PubChem-compound 8582
xref: Reference/BioCyc IMP
xref: Reference/KEGG Compound C00130
xref: Reference/HMDB HMDB0000175
chemical formula: C10H13N4O8P
molecular weight: 348.0471
structure: ChemicalStructure/PW C000114

Compound/PW C000035 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Protein/554 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Adenylosuccinate lyase
stoichiometric coefficient: 4.0

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/ChemSpider 845
type: UnificationXref
id: 845
db: ChemSpider

Protein/827 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenylosuccinate synthetase isozyme 1
stoichiometric coefficient: 2.0

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Malonic semialdehyde
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Malonic semialdehyde

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Inosinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inosinic acid

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 868
type: UnificationXref
id: 868
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Argininosuccinate lyase
type: Protein
cellular location: Cytoplasm
entity reference: Argininosuccinate lyase

Aspartoacylase
type: ProteinReference
xref: Reference/UniProt P45381
organism: Homo sapiens

Reference/KEGG Compound C00099
type: UnificationXref
id: C00099
db: KEGG Compound

Compound/PW C001783 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Compound/PW C000110 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Asparagine
stoichiometric coefficient: 1.0

Compound/PW C001420 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Argininosuccinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Argininosuccinic acid

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Oxygen
type: SmallMolecule
cellular location: Lysosome
entity reference: Oxygen

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Ammonia
type: SmallMolecule
cellular location: Lysosome
entity reference: Ammonia

RNA/6 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartyl-tRNA(Asp)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Adenylosuccinate lyase
type: Complex
component stoichiometry: Protein/554 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Adenylosuccinate lyase

SubPathwayInteraction118495
type: Interaction
name: SubPathway118495Reaction
name: SubPathwayReaction
participant: β-Alanine

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

N-Acetylaspartate synthetase
type: Protein
cellular location: Cytoplasm
entity reference: N-Acetylaspartate synthetase

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Compound/PW C001420 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

SubPathwayInteraction118497
type: Interaction
name: SubPathwayReaction
name: SubPathway118497Reaction
participant: β-Alanine

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/CAS 70-47-3
type: UnificationXref
id: 70-47-3
db: CAS

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Reference/UniProt P04424
type: UnificationXref
id: P04424
db: UniProt

Reference/ChEBI CHEBI 29186
type: UnificationXref
id: CHEBI:29186
db: ChEBI

Compound/PW C000413 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylsuccinic acid
stoichiometric coefficient: 1.0

ReactionCatalysis16
type: Catalysis
controller: L-amino-acid oxidase
controlled: 1.4.3.2
control type: ACTIVATION

TransportCatalysis1566
type: Catalysis
controller: Unknown
controlled: Transport10401
control type: ACTIVATION

ReactionCatalysis17
type: Catalysis
controller: Adenylosuccinate lyase
controlled: 4.3.2.2
control type: ACTIVATION

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

ReactionCatalysis14
type: Catalysis
controller: Adenylosuccinate synthetase isozyme 1
controlled: 6.3.4.4
control type: ACTIVATION

TransportCatalysis1568
type: Catalysis
controller: Unknown
controlled: Transport10403
control type: ACTIVATION

ReactionCatalysis15
type: Catalysis
controller: CAD protein
controlled: Reaction14
control type: ACTIVATION

TransportCatalysis1567
type: Catalysis
controller: Unknown
controlled: Transport10402
control type: ACTIVATION

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

TransportCatalysis1562
type: Catalysis
controller: Unknown
controlled: Transport10397
control type: ACTIVATION

Adenylosuccinate synthetase isozyme 1
type: ProteinReference
xref: Reference/UniProt Q8N142
organism: Homo sapiens

Reference/UniProt Q96RQ9
type: UnificationXref
id: Q96RQ9
db: UniProt

ReactionCatalysis18
type: Catalysis
controller: Argininosuccinate lyase
controlled: 4.3.2.1
control type: ACTIVATION

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

TransportCatalysis1563
type: Catalysis
controller: Unknown
controlled: Transport10398
control type: ACTIVATION

ReactionCatalysis19
type: Catalysis
controller: D-aspartate oxidase
controlled: 1.4.3.1
control type: ACTIVATION

Reference/UniProt P45381
type: UnificationXref
id: P45381
db: UniProt

Argininosuccinate synthase
type: Complex
component stoichiometry: Protein/622 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Argininosuccinate synthase

ReactionCatalysis12
type: Catalysis
controller: Argininosuccinate synthase
controlled: 6.3.4.5
control type: ACTIVATION

ReactionCatalysis13
type: Catalysis
controller: Aspartate--tRNA ligase, cytoplasmic
controlled: 6.1.1.12
control type: ACTIVATION

ReactionCatalysis10
type: Catalysis
controller: Asparagine synthetase [glutamine-hydrolyzing]
controlled: 6.3.5.4
control type: ACTIVATION

ReactionCatalysis11
type: Catalysis
controller: Asparagine--tRNA ligase, cytoplasmic
controlled: 6.1.1.22
control type: ACTIVATION

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Reference/HMDB HMDB0000536
type: UnificationXref
id: HMDB0000536
db: HMDB

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Argininosuccinic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03406
xref: Reference/ChemSpider 16059
xref: Reference/HMDB HMDB0000052
xref: Reference/PubChem-compound 16950
xref: Reference/CAS 2387-71-5
xref: Reference/ChEBI CHEBI 15682
chemical formula: C10H18N4O6
molecular weight: 290.12262
structure: ChemicalStructure/PW C000036

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Protein/661 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Argininosuccinate lyase
stoichiometric coefficient: 4.0

Compound/PW C000723 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

L-amino-acid oxidase
type: ProteinReference
xref: Reference/UniProt Q96RQ9
organism: Homo sapiens

Reference/BioCyc CPD-302
type: UnificationXref
id: CPD-302
db: BioCyc

Reference/BioCyc CPD-420
type: UnificationXref
id: CPD-420
db: BioCyc

Reference/PubChem-compound 239
type: UnificationXref
id: 239
db: PubChem-compound

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Compound/PW C000862 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Compound/PW C000040 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-Alanine
stoichiometric coefficient: 1.0

Reference/UniProt P27708
type: UnificationXref
id: P27708
db: UniProt

Histidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway848
pathway component: SubPathwayInteraction848
xref: Reference/PathWhiz PW000043
xref: Reference/SMPDB SMP0000044
name: SubPathway

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/CAS 131-99-7
type: UnificationXref
id: 131-99-7
db: CAS

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Nicotinate and Nicotinamide Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway854
pathway component: SubPathwayInteraction854
xref: Reference/SMPDB SMP0000048
xref: Reference/PathWhiz PW000151
name: SubPathway

β-Alanine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000056
xref: Reference/ChemSpider 234
xref: Reference/PubChem-compound 239
xref: Reference/ChEBI CHEBI 16958
xref: Reference/KEGG Compound C00099
xref: Reference/CAS 107-95-9
xref: Reference/BioCyc B-ALANINE
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000040

Pyrimidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118495
pathway component: SubPathwayInteraction118495
xref: Reference/SMPDB SMP0000046
xref: Reference/PathWhiz PW000160
name: SubPathway

SubPathwayInteraction851
type: Interaction
name: SubPathway851Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

SubPathwayInteraction852
type: Interaction
name: SubPathwayReaction
name: SubPathway852Reaction
participant: L-Aspartic acid

SubPathwayInteraction850
type: Interaction
name: SubPathway850Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

Lysosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005764

SubPathwayInteraction853
type: Interaction
name: SubPathwayReaction
name: SubPathway853Reaction
participant: L-Aspartic acid

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

SubPathwayInteraction854
type: Interaction
name: SubPathway854Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

Glutamate decarboxylase 1
type: Complex
component stoichiometry: Protein/667 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glutamate decarboxylase 1

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 272
type: UnificationXref
id: 272
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

β-Alanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: β-Alanine
name: SubPathwayOutput
name: SubPathwayInput

Urea Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway850
pathway order: SubPathwayInteractionSteps/SubPathway849
pathway component: SubPathwayInteraction850
pathway component: SubPathwayInteraction849
xref: Reference/SMPDB SMP0000059
xref: Reference/PathWhiz PW000162
name: SubPathway

Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

SubPathwayInteraction848
type: Interaction
name: SubPathway848Reaction
name: SubPathwayReaction
participant: L-Aspartic acid

SubPathwayInteraction849
type: Interaction
name: SubPathwayReaction
name: SubPathway849Reaction
participant: Citrulline

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Aspartate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/16
pathway order: PathwaySubPathway/850
pathway order: PathwayEnzymeReaction/15
pathway order: PathwaySubPathway/851
pathway order: PathwayEnzymeReaction/1192368
pathway order: PathwayEnzymeReaction/13
pathway order: PathwayEnzymeReaction/2459795
pathway order: PathwayEnzymeReaction/2512190
pathway order: PathwayEnzymeReaction/19
pathway order: PathwayEnzymeReaction/17
pathway order: PathwayTransport/2512191
pathway order: PathwaySubPathway/854
pathway order: PathwayEnzymeReaction/2512192
pathway order: PathwaySubPathway/852
pathway order: PathwayEnzymeReaction/9
pathway order: PathwaySubPathway/853
pathway order: PathwayEnzymeReaction/3522
pathway order: PathwaySubPathway/849
pathway order: PathwayTransport/2512202
pathway order: PathwayEnzymeReaction/20
pathway order: PathwaySubPathway/848
pathway order: PathwayTransport/2125887
pathway order: PathwayTransport/2125842
pathway order: PathwayEnzymeReaction/2512201
pathway order: PathwaySubPathway/118497
pathway order: PathwaySubPathway/118495
pathway order: PathwayEnzymeReaction/12
pathway order: PathwayEnzymeReaction/10
pathway order: PathwayTransport/2125845
pathway component: 1.4.3.2
pathway component: ReactionCatalysis16
pathway component: TransportCatalysis1566
pathway component: Reaction14
pathway component: ReactionCatalysis17
pathway component: 6.3.4.4
pathway component: ReactionCatalysis14
pathway component: TransportCatalysis1568
pathway component: 6.1.1.12
pathway component: ReactionCatalysis15
pathway component: TransportCatalysis1567
pathway component: TransportCatalysis1562
pathway component: 1.4.3.1
pathway component: 4.3.2.1
pathway component: ReactionCatalysis18
pathway component: 4.3.2.2
pathway component: TransportCatalysis1563
pathway component: ReactionCatalysis19
pathway component: Transport10402
pathway component: Transport10403
pathway component: 6.3.4.5
pathway component: ReactionCatalysis12
pathway component: 6.1.1.22
pathway component: ReactionCatalysis13
pathway component: ReactionCatalysis10
pathway component: ReactionCatalysis11
pathway component: Transport10401
pathway component: Reaction2307
pathway component: ReactionCatalysis8
pathway component: ReactionCatalysis6
pathway component: Urea Cycle
pathway component: ReactionCatalysis9
pathway component: 2.3.1.17
pathway component: ReactionCatalysis1171
pathway component: 6.3.5.4
pathway component: 3.5.1.15
pathway component: 4.1.1.15
pathway component: Transport10398
pathway component: Histidine Metabolism
pathway component: Transport10397
pathway component: Arginine and Proline Metabolism
pathway component: Reaction5
pathway component: beta-Alanine Metabolism
pathway component: ReactionCatalysis2200
pathway component: Pantothenate and CoA Biosynthesis
pathway component: Glycine and Serine Metabolism
pathway component: Nicotinate and Nicotinamide Metabolism
pathway component: Pyrimidine Metabolism
xref: Reference/PathWhiz PW000002
xref: Reference/SMPDB SMP0000067

Reference/ChemSpider 6031
type: UnificationXref
id: 6031
db: ChemSpider

Asparagine--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Asparagine--tRNA ligase, cytoplasmic

ReactionCatalysis2200
type: Catalysis
controller: Isoaspartyl peptidase/L-asparaginase
controlled: Reaction2307
control type: ACTIVATION

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

L-Asparagine
type: SmallMolecule
cellular location: Lysosome
entity reference: L-Asparagine

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Compound/PW C000110 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Asparagine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

ReactionCatalysis8
type: Catalysis
controller: Glutamate decarboxylase 1
controlled: 4.1.1.15
control type: ACTIVATION

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/SMPDB SMP0000048
type: UnificationXref
id: SMP0000048
db: SMPDB

Reference/GENE ONTOLOGY GO 0005764
type: UnificationXref
id: GO:0005764
db: GENE ONTOLOGY

ReactionCatalysis6
type: Catalysis
controller: 4-aminobutyrate aminotransferase, mitochondrial
controlled: Reaction5
control type: ACTIVATION

Reference/SMPDB SMP0000046
type: UnificationXref
id: SMP0000046
db: SMPDB

Reference/SMPDB SMP0000044
type: UnificationXref
id: SMP0000044
db: SMPDB

ReactionCatalysis9
type: Catalysis
controller: Aspartoacylase
controlled: 3.5.1.15
control type: ACTIVATION

Adenylsuccinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenylsuccinic acid

CAD protein
type: ProteinReference
xref: Reference/UniProt P27708
organism: Homo sapiens

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/CAS 19046-78-7
type: UnificationXref
id: 19046-78-7
db: CAS

Reference/HMDB HMDB0011111
type: UnificationXref
id: HMDB0011111
db: HMDB

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/SMPDB SMP0000059
type: UnificationXref
id: SMP0000059
db: SMPDB

Reference/CAS 107-95-9
type: UnificationXref
id: 107-95-9
db: CAS

beta-Alanine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway852
pathway component: SubPathwayInteraction852
xref: Reference/PathWhiz PW000011
xref: Reference/SMPDB SMP0000007
name: SubPathway

Reference/ChemSpider 84022
type: UnificationXref
id: 84022
db: ChemSpider

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway853
pathway component: SubPathwayInteraction853
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

Oxalacetic acid
type: SmallMolecule
cellular location: Lysosome
entity reference: Oxalacetic acid

Isoaspartyl peptidase/L-asparaginase
type: ProteinReference
xref: Reference/UniProt Q7L266
organism: Homo sapiens

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ChemicalStructure/PW C002766
type: ChemicalStructure
structure format: SMILES
structure data: N[C@H](CC(O)=O)C(O)=O

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Protein/667 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutamate decarboxylase 1
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000110
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(N)=O)C(O)=O

Reference/ChemSpider 8264
type: UnificationXref
id: 8264
db: ChemSpider

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/ChemSpider 234
type: UnificationXref
id: 234
db: ChemSpider

ChemicalStructure/PW C000114
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Aspartoacylase
type: Protein
cellular location: Cytoplasm
entity reference: Aspartoacylase

Reference/SMPDB SMP0000067
type: UnificationXref
id: SMP0000067
db: SMPDB

Reference/ChEBI CHEBI 15859
type: UnificationXref
id: CHEBI:15859
db: ChEBI

Adenylosuccinate synthetase isozyme 1
type: Complex
component stoichiometry: Protein/827 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Adenylosuccinate synthetase isozyme 1

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/ChemSpider 75697
type: UnificationXref
id: 75697
db: ChemSpider

Reference/BioCyc CARBAMYUL-L-ASPARTATE
type: UnificationXref
id: CARBAMYUL-L-ASPARTATE
db: BioCyc

Reference/UniProt P14868
type: UnificationXref
id: P14868
db: UniProt

Arginine and Proline Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway851
pathway component: SubPathwayInteraction851
xref: Reference/PathWhiz PW000010
xref: Reference/SMPDB SMP0000020
name: SubPathway

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Reference/ChEBI CHEBI 16958
type: UnificationXref
id: CHEBI:16958
db: ChEBI

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Reference/ChemSpider 16059
type: UnificationXref
id: 16059
db: ChemSpider

Pantothenate and CoA Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118497
pathway component: SubPathwayInteraction118497
xref: Reference/PathWhiz PW000032
xref: Reference/SMPDB SMP0000027
name: SubPathway

Compound/PW C000036 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Argininosuccinic acid
stoichiometric coefficient: 2.0

Reference/SMPDB SMP0000007
type: UnificationXref
id: SMP0000007
db: SMPDB

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Protein/575 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate--tRNA ligase, cytoplasmic
stoichiometric coefficient: 2.0

Compound/PW C000123 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15682
type: UnificationXref
id: CHEBI:15682
db: ChEBI

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

RNA/5 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Asp)
stoichiometric coefficient: 1.0

Compound/PW C000396 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

Reference/BioCyc IMP
type: UnificationXref
id: IMP
db: BioCyc

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

CAD protein
type: Protein
cellular location: Cytoplasm
entity reference: CAD protein

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CARBAMOYL-P
type: UnificationXref
id: CARBAMOYL-P
db: BioCyc

ReactionCatalysis1171
type: Catalysis
controller: N-Acetylaspartate synthetase
controlled: 2.3.1.17
control type: ACTIVATION

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/HMDB HMDB0000812
type: UnificationXref
id: HMDB0000812
db: HMDB

Glutamate decarboxylase 1
type: Protein
cellular location: Cytoplasm
entity reference: Glutamate decarboxylase 1

Reference/PubChem-compound 65065
type: UnificationXref
id: 65065
db: PubChem-compound

Reference/UniProt P08243
type: UnificationXref
id: P08243
db: UniProt

Reference/BioCyc B-ALANINE
type: UnificationXref
id: B-ALANINE
db: BioCyc

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Oxygen
type: SmallMolecule
cellular location: Peroxisome
entity reference: Oxygen

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

ChemicalStructure/PW C000862
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)OP(O)(O)=O

Compound/PW C000040 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-Alanine
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/HMDB HMDB0006483
type: UnificationXref
id: HMDB0006483
db: HMDB

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C000036 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Argininosuccinic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/SMPDB SMP0000027
type: UnificationXref
id: SMP0000027
db: SMPDB

Reference/CAS 997-55-7
type: UnificationXref
id: 997-55-7
db: CAS

Reference/UniProt P80404
type: UnificationXref
id: P80404
db: UniProt

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Oxalacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxalacetic acid

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000828
type: UnificationXref
id: HMDB0000828
db: HMDB

Reference/ChEBI CHEBI 17960
type: UnificationXref
id: CHEBI:17960
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine diphosphate

Malonic semialdehyde
type: SmallMoleculeReference
xref: Reference/CAS 926-61-4
xref: Reference/PubChem-compound 868
xref: Reference/ChEBI CHEBI 17960
xref: Reference/ChemSpider 845
xref: Reference/HMDB HMDB0011111
xref: Reference/KEGG Compound C00222
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C006753

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/SMPDB SMP0000020
type: UnificationXref
id: SMP0000020
db: SMPDB

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Aspartate--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Aspartate--tRNA ligase, cytoplasmic

Water
type: SmallMolecule
cellular location: Lysosome
entity reference: Water

L-Arginine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Arginine

Compound/PW C006753 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonic semialdehyde
stoichiometric coefficient: 1.0

Compound/PW C002766 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Aspartic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

tRNA(Asn)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Asn)

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

Reference/CAS 1783-96-6
type: UnificationXref
id: 1783-96-6
db: CAS

L-Aspartic acid
type: SmallMolecule
cellular location: Lysosome
entity reference: L-Aspartic acid

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

ChemicalStructure/PW C000649
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)N[C@@H](CC(O)=O)C(O)=O

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/ChemSpider 389122
type: UnificationXref
id: 389122
db: ChemSpider

4-aminobutyrate aminotransferase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: 4-aminobutyrate aminotransferase, mitochondrial

Reaction2307
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000110 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/1.0
right: Ammonia
right: L-Aspartic acid
spontaneous: false
left: L-Asparagine
left: Water
name: L-Asparagine + Water → Ammonia + L-Aspartic acid
conversion direction: LEFT_TO_RIGHT

tRNA(Asp)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Asp)

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

2.3.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000649 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
right: N-Acetyl-L-aspartic acid
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.17
left: L-Aspartic acid
left: Acetyl-CoA
name: Acetyl-CoA + L-Aspartic acid → Coenzyme A + N-Acetyl-L-aspartic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Reference/PubChem-compound 278
type: UnificationXref
id: 278
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/PathWhiz PW000011
type: UnificationXref
id: PW000011
db: PathWhiz

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Reference/KEGG Compound C00402
type: UnificationXref
id: C00402
db: KEGG Compound

Reference/PathWhiz PW000010
type: UnificationXref
id: PW000010
db: PathWhiz

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000413
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/ChEBI CHEBI 17672
type: UnificationXref
id: CHEBI:17672
db: ChEBI

Protein/242 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: 4-aminobutyrate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C000662
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)N[C@@H](CC(O)=O)C(O)=O

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

N-Acetyl-L-aspartic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-L-aspartic acid

Reference/UniProt P00966
type: UnificationXref
id: P00966
db: UniProt

Reference/PathWhiz PW000002
type: UnificationXref
id: PW000002
db: PathWhiz

L-Asparaginyl-tRNA(Asn)
type: RnaReference
xref: Reference/ChEBI CHEBI 29265
organism: Homo sapiens

tRNA(Asn)
type: RnaReference
xref: Reference/ChEBI CHEBI 29172
organism: Homo sapiens

L-Aspartyl-tRNA(Asp)
type: RnaReference
xref: Reference/ChEBI CHEBI 29158
organism: Homo sapiens

tRNA(Asp)
type: RnaReference
xref: Reference/ChEBI CHEBI 29186
organism: Homo sapiens

L-Asparaginyl-tRNA(Asn)
type: Rna
cellular location: Cytoplasm
entity reference: L-Asparaginyl-tRNA(Asn)

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

β-Alanine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: β-Alanine

Acetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetic acid

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/PubChem-compound 440122
type: UnificationXref
id: 440122
db: PubChem-compound

L-amino-acid oxidase
type: Protein
cellular location: Lysosome
entity reference: L-amino-acid oxidase

Compound/PW C000649 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-L-aspartic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 83887
type: UnificationXref
id: 83887
db: PubChem-compound

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

D-aspartate oxidase
type: Protein
cellular location: Peroxisome
entity reference: D-aspartate oxidase

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Compound/PW C001065 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C000662 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ureidosuccinic acid
stoichiometric coefficient: 1.0

Isoaspartyl peptidase/L-asparaginase
type: Protein
cellular location: Lysosome
entity reference: Isoaspartyl peptidase/L-asparaginase