Reference/ChEBI CHEBI 17347
type: UnificationXref
id: CHEBI:17347
db: ChEBI

Reference/ChemSpider 82579
type: UnificationXref
id: 82579
db: ChemSpider

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc 19-HYDROXYTESTOSTERONE
type: UnificationXref
id: 19-HYDROXYTESTOSTERONE
db: BioCyc

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ReactionCatalysis946
type: Catalysis
controller: Testosterone 17-beta-dehydrogenase 3
controlled: 1.1.1.64
control type: ACTIVATION

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ReactionCatalysis944
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction51
control type: ACTIVATION

ReactionCatalysis945
type: Catalysis
controller: Sulfotransferase family cytosolic 2B member 1
controlled: 2.8.2.2
control type: ACTIVATION

ReactionCatalysis943
type: Catalysis
controller: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
controlled: Reaction55
control type: ACTIVATION

Reference/PubChem-compound 6013
type: UnificationXref
id: 6013
db: PubChem-compound

Reference/BioCyc 3-BETA-HYDROXYANDROST-5-EN-17-ONE
type: UnificationXref
id: 3-BETA-HYDROXYANDROST-5-EN-17-ONE
db: BioCyc

Oxidized flavoprotein
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Oxidized flavoprotein

Reference/PathWhiz PW000059
type: UnificationXref
id: PW000059
db: PathWhiz

3-oxo-5-alpha-steroid 4-dehydrogenase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3-oxo-5-alpha-steroid 4-dehydrogenase 1

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Testosterone glucuronide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 108192
xref: Reference/BioCyc 19-HYDROXYTESTOSTERONE
xref: Reference/ChemSpider 97270
xref: Reference/HMDB HMDB0003193
xref: Reference/ChEBI CHEBI 28835
xref: Reference/CAS 1180-25-2
xref: Reference/KEGG Compound C11134
chemical formula: C25H36O8
molecular weight: 464.24103
structure: ChemicalStructure/PW C001802

Reference/ChEBI CHEBI 17474
type: UnificationXref
id: CHEBI:17474
db: ChEBI

Compound/PW C000814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroepiandrosterone sulfate
stoichiometric coefficient: 1.0

Reference/CAS 14808-79-8
type: UnificationXref
id: 14808-79-8
db: CAS

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006768
type: UnificationXref
id: HMDB0006768
db: HMDB

Reference/HMDB HMDB0006769
type: UnificationXref
id: HMDB0006769
db: HMDB

Cytochrome P450 19A1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 19A1

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/HMDB HMDB0006770
type: UnificationXref
id: HMDB0006770
db: HMDB

Phosphoadenosine phosphosulfate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoadenosine phosphosulfate

Dehydroepiandrosterone sulfate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 12594
xref: Reference/CAS 651-48-9
xref: Reference/ChemSpider 12074
xref: Reference/ChEBI CHEBI 16814
xref: Reference/HMDB HMDB0001032
xref: Reference/KEGG Compound C04555
chemical formula: C19H28O5S
molecular weight: 368.16574
structure: ChemicalStructure/PW C000814

SubPathwayInteraction167
type: Interaction
name: SubPathway167Reaction
name: SubPathwayReaction
participant: 17-Hydroxyprogesterone
participant: 17a-Hydroxypregnenolone

Reference/KEGG Compound C00468
type: UnificationXref
id: C00468
db: KEGG Compound

Reference/PubChem-compound 12594
type: UnificationXref
id: 12594
db: PubChem-compound

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Protein/Generic38 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized flavoprotein
stoichiometric coefficient: 1.0

Protein/Generic37 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced flavoprotein
stoichiometric coefficient: 1.0

Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Androstenedione
stoichiometric coefficient: 1.0

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/KEGG Compound C02538
type: UnificationXref
id: C02538
db: KEGG Compound

Testosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Testosterone

Reference/ChEBI CHEBI 17263
type: UnificationXref
id: CHEBI:17263
db: ChEBI

19-Hydroxytestosterone
type: SmallMoleculeReference
xref: Reference/CAS 2126-37-6
xref: Reference/HMDB HMDB0006769
xref: Reference/KEGG Compound C05294
xref: Reference/ChemSpider 17461292
xref: Reference/PubChem-compound 16395893
chemical formula: C19H28O3
molecular weight: 304.20386
structure: ChemicalStructure/PW C002920

5b-Dihydrotestosterone
type: SmallMoleculeReference
xref: Reference/CAS 571-22-2
xref: Reference/KEGG Compound C05293
xref: Reference/ChemSpider 10827
xref: Reference/PubChem-compound 11302
xref: Reference/HMDB HMDB0006770
xref: Reference/ChEBI CHEBI 428206
chemical formula: C19H30O2
molecular weight: 290.22458
structure: ChemicalStructure/PW C002921

Reference/PubChem-compound 3001028
type: UnificationXref
id: 3001028
db: PubChem-compound

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

Sulfotransferase family cytosolic 2B member 1
type: ProteinReference
xref: Reference/UniProt O00204
organism: Homo sapiens

Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 1180-25-2
type: UnificationXref
id: 1180-25-2
db: CAS

Reference/BioCyc 17-BETA-HYDROXY-5ALPHA-ANDROSTAN-3-O
type: UnificationXref
id: 17-BETA-HYDROXY-5ALPHA-ANDROSTAN-3-O
db: BioCyc

Reference/UniProt P08842
type: UnificationXref
id: P08842
db: UniProt

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Dehydroepiandrosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dehydroepiandrosterone

Reference/CAS 50-28-2
type: UnificationXref
id: 50-28-2
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc Beta-D-Glucuronides
type: UnificationXref
id: Beta-D-Glucuronides
db: BioCyc

Compound/PW C002919 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19-Oxoandrost-4-ene-3,17-dione
stoichiometric coefficient: 1.0

Reference/UniProt P18405
type: UnificationXref
id: P18405
db: UniProt

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

ChemicalStructure/PW C000814
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChEBI CHEBI 16189
type: UnificationXref
id: CHEBI:16189
db: ChEBI

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Compound/PW C000098 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estradiol
stoichiometric coefficient: 1.0

Steryl-sulfatase
type: ProteinReference
xref: Reference/UniProt P08842
organism: Homo sapiens

UDP-glucuronosyltransferase 2B17
type: ProteinReference
xref: Reference/UniProt O75795
organism: Homo sapiens

UDP-glucuronosyltransferase 2B11
type: ProteinReference
xref: Reference/UniProt O75310
organism: Homo sapiens

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxygen

Estrone sulfate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Estrone sulfate

Reference/KEGG Compound C11134
type: UnificationXref
id: C11134
db: KEGG Compound

Cytochrome P450 19A1
type: Protein
cellular location: Cytoplasm
entity reference: Cytochrome P450 19A1

Reference/KEGG Compound C01227
type: UnificationXref
id: C01227
db: KEGG Compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C002016 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19-Hydroxyandrost-4-ene-3,17-dione
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6128
type: UnificationXref
id: 6128
db: PubChem-compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/ChemSpider 5660
type: UnificationXref
id: 5660
db: ChemSpider

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/UniProt P37058
type: UnificationXref
id: P37058
db: UniProt

Reference/ChemSpider 10189
type: UnificationXref
id: 10189
db: ChemSpider

Dehydroepiandrosterone sulfate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dehydroepiandrosterone sulfate

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

19-Oxoandrost-4-ene-3,17-dione
type: SmallMoleculeReference
xref: Reference/ChemSpider 17465008
xref: Reference/KEGG Compound C05297
xref: Reference/HMDB HMDB0006768
xref: Reference/ChEBI CHEBI 1069535
xref: Reference/PubChem-compound 16399653
chemical formula: C19H24O3
molecular weight: 300.17255
structure: ChemicalStructure/PW C002919

Reference/ChemSpider 5898
type: UnificationXref
id: 5898
db: ChemSpider

Reference/HMDB HMDB0003193
type: UnificationXref
id: HMDB0003193
db: HMDB

Reference/ChEBI CHEBI 17252
type: UnificationXref
id: CHEBI:17252
db: ChEBI

Reference/PubChem-compound 6238
type: UnificationXref
id: 6238
db: PubChem-compound

Reference/UniProt O75310
type: UnificationXref
id: O75310
db: UniProt

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/UniProt O75795
type: UnificationXref
id: O75795
db: UniProt

17a-Hydroxypregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 17a-Hydroxypregnenolone

Compound/PW C000157 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

17-β-Estradiol-3-glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 17-β-Estradiol-3-glucuronide

5b-Dihydrotestosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5b-Dihydrotestosterone

Reference/CAS 482-67-7
type: UnificationXref
id: 482-67-7
db: CAS

Reference/HMDB HMDB0006224
type: UnificationXref
id: HMDB0006224
db: HMDB

19-Hydroxyandrost-4-ene-3,17-dione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 19-Hydroxyandrost-4-ene-3,17-dione

Reference/UniProt P14060
type: UnificationXref
id: P14060
db: UniProt

Reference/UniProt P14061
type: UnificationXref
id: P14061
db: UniProt

1.14.14.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002919 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38 Cytoplasm/Stoichiometry/1.0
right: Water
right: Formic acid
right: Oxidized flavoprotein
right: Estrone
spontaneous: false
EC number: 1.14.14.14
left: Oxygen
left: 19-Oxoandrost-4-ene-3,17-dione
left: Reduced flavoprotein
name: 19-Oxoandrost-4-ene-3,17-dione + Oxygen + Reduced flavoprotein → Estrone + Formic acid + Oxidized flavoprotein + Water
conversion direction: LEFT_TO_RIGHT

1.14.14.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002016 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C002919 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38 Cytoplasm/Stoichiometry/1.0
right: 19-Oxoandrost-4-ene-3,17-dione
right: Water
right: Oxidized flavoprotein
spontaneous: false
EC number: 1.14.14.14
left: Oxygen
left: 19-Hydroxyandrost-4-ene-3,17-dione
left: Reduced flavoprotein
name: 19-Hydroxyandrost-4-ene-3,17-dione + Oxygen + Reduced flavoprotein → 19-Oxoandrost-4-ene-3,17-dione + Oxidized flavoprotein + 2 Water
conversion direction: LEFT_TO_RIGHT

1.14.14.14
type: BiochemicalReaction
participant stoichiometry: Protein/Generic38 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002016 Endoplasmic Reticulum/Stoichiometry/1.0
right: Water
right: Oxidized flavoprotein
right: 19-Hydroxyandrost-4-ene-3,17-dione
spontaneous: false
EC number: 1.14.14.14
left: Reduced flavoprotein
left: Oxygen
left: Androstenedione
name: Androstenedione + Oxygen + Reduced flavoprotein → 19-Hydroxyandrost-4-ene-3,17-dione + Oxidized flavoprotein + Water
conversion direction: LEFT_TO_RIGHT

1.14.14.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002920 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 19-Hydroxytestosterone
right: Oxidized flavoprotein
spontaneous: false
EC number: 1.14.14.14
left: Testosterone
left: Oxygen
left: Reduced flavoprotein
name: Oxygen + Reduced flavoprotein + Testosterone → 19-Hydroxytestosterone + Oxidized flavoprotein + Water
conversion direction: LEFT_TO_RIGHT

Dihydrotestosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dihydrotestosterone

1.3.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001745 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Testosterone
right: NADPH
right: Hydrogen Ion
spontaneous: false
EC number: 1.3.1.22
left: Dihydrotestosterone
left: NADP
name: Dihydrotestosterone + NADP ↔ Hydrogen Ion + NADPH + Testosterone
conversion direction: REVERSIBLE

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000054
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 17465008
type: UnificationXref
id: 17465008
db: ChemSpider

3-oxo-5-alpha-steroid 4-dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P18405
organism: Homo sapiens

Reference/KEGG Compound C00280
type: UnificationXref
id: C00280
db: KEGG Compound

Reference/HMDB HMDB0000374
type: UnificationXref
id: HMDB0000374
db: HMDB

1.14.14.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000098 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002018 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38 Cytoplasm/Stoichiometry/1.0
right: Estradiol
right: Formic acid
right: Oxidized flavoprotein
spontaneous: false
EC number: 1.14.14.14
left: Oxygen
left: 19-Oxotestosterone
left: Reduced flavoprotein
name: 19-Oxotestosterone + Oxygen + Reduced flavoprotein → Estradiol + Formic acid + Oxidized flavoprotein
conversion direction: LEFT_TO_RIGHT

1.14.14.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002920 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C002018 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic37 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38 Cytoplasm/Stoichiometry/1.0
right: Water
right: Oxidized flavoprotein
right: 19-Oxotestosterone
spontaneous: false
EC number: 1.14.14.14
left: Oxygen
left: 19-Hydroxytestosterone
left: Reduced flavoprotein
name: 19-Hydroxytestosterone + Oxygen + Reduced flavoprotein → 19-Oxotestosterone + Oxidized flavoprotein + 2 Water
conversion direction: LEFT_TO_RIGHT

1.1.1.62
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000098 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Estrone
right: NADPH
spontaneous: false
EC number: 1.1.1.62
left: Estradiol
left: NADP
name: Estradiol + NADP ↔ Estrone + NADPH
conversion direction: REVERSIBLE

2.8.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000886 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000094 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001101 Cytoplasm/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: Estrone sulfate
spontaneous: false
EC number: 2.8.2.4
left: Estrone
left: Phosphoadenosine phosphosulfate
name: Estrone + Phosphoadenosine phosphosulfate → Adenosine 3',5'-diphosphate + Estrone sulfate
conversion direction: LEFT_TO_RIGHT

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002671 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000098 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 17-β-Estradiol-3-glucuronide
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: Estradiol
name: Estradiol + Uridine diphosphate glucuronic acid → 17-β-Estradiol-3-glucuronide + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Reference/HMDB HMDB0000145
type: UnificationXref
id: HMDB0000145
db: HMDB

Reference/PubChem-compound 108192
type: UnificationXref
id: 108192
db: PubChem-compound

Compound/PW C000054 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroepiandrosterone
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P14061
organism: Homo sapiens

17a-Hydroxypregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 17a-Hydroxypregnenolone
name: SubPathwayOutput

Reference/ChemSpider 12074
type: UnificationXref
id: 12074
db: ChemSpider

Testosterone 17-beta-dehydrogenase 3
type: ProteinReference
xref: Reference/UniProt P37058
organism: Homo sapiens

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/UniProt O00204
type: UnificationXref
id: O00204
db: UniProt

3.1.6.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000054 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001118 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Sulfate
right: Dehydroepiandrosterone
spontaneous: false
EC number: 3.1.6.2
left: Water
left: Dehydroepiandrosterone sulfate
name: Dehydroepiandrosterone sulfate + Water → Dehydroepiandrosterone + Sulfate
conversion direction: LEFT_TO_RIGHT

Phosphoadenosine phosphosulfate
type: SmallMoleculeReference
xref: Reference/BioCyc PAPS
xref: Reference/HMDB HMDB0001134
xref: Reference/CAS 482-67-7
xref: Reference/ChemSpider 9799
xref: Reference/KEGG Compound C00053
xref: Reference/PubChem-compound 10214
xref: Reference/ChEBI CHEBI 17980
chemical formula: C10H15N5O13P2S
molecular weight: 506.98624
structure: ChemicalStructure/PW C000886

Reference/KEGG Compound C05297
type: UnificationXref
id: C05297
db: KEGG Compound

Reference/ChemSpider 140102
type: UnificationXref
id: 140102
db: ChemSpider

Reference/BioCyc CPD-352
type: UnificationXref
id: CPD-352
db: BioCyc

Reference/KEGG Compound C05503
type: UnificationXref
id: C05503
db: KEGG Compound

Compound/PW C000157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001118
type: ChemicalStructure
structure format: SMILES
structure data: OS(O)(=O)=O

Reference/KEGG Compound C00054
type: UnificationXref
id: C00054
db: KEGG Compound

Reference/KEGG Compound C00053
type: UnificationXref
id: C00053
db: KEGG Compound

19-Hydroxyandrost-4-ene-3,17-dione
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 19-Hydroxyandrost-4-ene-3,17-dione

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00059
type: UnificationXref
id: C00059
db: KEGG Compound

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

19-Oxotestosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 19-Oxotestosterone

Compound/PW C002016 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19-Hydroxyandrost-4-ene-3,17-dione
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C000273
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000037
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000157
type: ChemicalStructure
structure format: SMILES

Estrogen sulfotransferase
type: Complex
component stoichiometry: Protein/339 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Estrogen sulfotransferase

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Oxidized flavoprotein
type: Protein
cellular location: Cytoplasm
entity reference: Oxidized flavoprotein

Reference/HMDB HMDB0000151
type: UnificationXref
id: HMDB0000151
db: HMDB

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Reaction24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Androstenedione
spontaneous: false
left: 17-Hydroxyprogesterone
name: 17-Hydroxyprogesterone → Androstenedione
conversion direction: LEFT_TO_RIGHT

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001802 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Testosterone glucuronide
spontaneous: false
EC number: 2.4.1.17
left: Testosterone
name: Testosterone → Testosterone glucuronide
conversion direction: LEFT_TO_RIGHT

Reference/CAS 68-96-2
type: UnificationXref
id: 68-96-2
db: CAS

1.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000157 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Testosterone
right: NADPH
spontaneous: false
EC number: 1.3.1.3
left: 5b-Dihydrotestosterone
left: NADP
name: 5b-Dihydrotestosterone + NADP ↔ Hydrogen Ion + NADPH + Testosterone
conversion direction: REVERSIBLE

Estrogen sulfotransferase
type: ProteinReference
xref: Reference/UniProt P49888
organism: Homo sapiens

Compound/PW C002018 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19-Oxotestosterone
stoichiometric coefficient: 1.0

Dihydrotestosterone
type: SmallMoleculeReference
xref: Reference/CAS 521-18-6
xref: Reference/KEGG Compound C03917
xref: Reference/HMDB HMDB0002961
xref: Reference/PubChem-compound 10635
xref: Reference/ChEBI CHEBI 16330
xref: Reference/BioCyc 17-BETA-HYDROXY-5ALPHA-ANDROSTAN-3-O
xref: Reference/ChemSpider 10189
chemical formula: C19H30O2
molecular weight: 290.22458
structure: ChemicalStructure/PW C001745

Reference/PubChem-compound 11302
type: UnificationXref
id: 11302
db: PubChem-compound

Reference/PubChem-compound 10214
type: UnificationXref
id: 10214
db: PubChem-compound

Reaction21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000054 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Dehydroepiandrosterone
spontaneous: false
left: 17a-Hydroxypregnenolone
name: 17a-Hydroxypregnenolone → Dehydroepiandrosterone
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0001134
type: UnificationXref
id: HMDB0001134
db: HMDB

ChemicalStructure/PW C000043
type: ChemicalStructure
structure format: SMILES

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Compound/PW C000094 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Protein/Generic38 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized flavoprotein
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reduced flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086
organism: Homo sapiens

Compound/PW C000098 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estradiol
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04555
type: UnificationXref
id: C04555
db: KEGG Compound

Oxidized flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086
organism: Homo sapiens

ChemicalStructure/PW C000098
type: ChemicalStructure
structure format: SMILES

Steroid 17-alpha-hydroxylase/17,20 lyase
type: ProteinReference
xref: Reference/UniProt P05093
organism: Homo sapiens

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/HMDB HMDB0000053
type: UnificationXref
id: HMDB0000053
db: HMDB

ChemicalStructure/PW C000094
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Compound/PW C002920 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19-Hydroxytestosterone
stoichiometric coefficient: 1.0

Compound/PW C000043 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine 3',5'-diphosphate
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 1
type: Protein
cellular location: Cytoplasm
entity reference: Estradiol 17-beta-dehydrogenase 1

Reference/KEGG Compound C01176
type: UnificationXref
id: C01176
db: KEGG Compound

Reference/CAS 53-43-0
type: UnificationXref
id: 53-43-0
db: CAS

Steryl-sulfatase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Steryl-sulfatase

Sulfotransferase family cytosolic 2B member 1
type: Protein
cellular location: Cytoplasm
entity reference: Sulfotransferase family cytosolic 2B member 1

Testosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Testosterone

Reference/HMDB HMDB0000061
type: UnificationXref
id: HMDB0000061
db: HMDB

Reference/HMDB HMDB0001032
type: UnificationXref
id: HMDB0001032
db: HMDB

Compound/PW C000886 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoadenosine phosphosulfate
stoichiometric coefficient: 1.0

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

3-oxo-5-beta-steroid 4-dehydrogenase
type: ProteinReference
xref: Reference/UniProt P51857
organism: Homo sapiens

Reference/PubChem-compound 16399653
type: UnificationXref
id: 16399653
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Androstenedione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Androstenedione

ChemicalStructure/PW C002016
type: ChemicalStructure
structure format: SMILES

UDP-glucuronosyltransferase 2B11
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 2B11

Protein/Generic37 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced flavoprotein
stoichiometric coefficient: 1.0

Reference/UniProt P49888
type: UnificationXref
id: P49888
db: UniProt

ReactionCatalysis929
type: Catalysis
controller: Estrogen sulfotransferase
controlled: 2.8.2.4
control type: ACTIVATION

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

Reference/ChemSpider 18667985
type: UnificationXref
id: 18667985
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Testosterone 17-beta-dehydrogenase 3
type: Protein
cellular location: Cytoplasm
entity reference: Testosterone 17-beta-dehydrogenase 3

Reference/HMDB HMDB0000077
type: UnificationXref
id: HMDB0000077
db: HMDB

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ChemicalStructure/PW C002018
type: ChemicalStructure
structure format: SMILES

Steroid 17-alpha-hydroxylase/17,20 lyase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Steroid 17-alpha-hydroxylase/17,20 lyase

Reference/UniProt P51857
type: UnificationXref
id: P51857
db: UniProt

Formic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Formic acid

UDP-glucuronosyltransferase 2B17
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 2B17

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reduced flavoprotein
type: Protein
cellular location: Cytoplasm
entity reference: Reduced flavoprotein

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChemSpider 97270
type: UnificationXref
id: 97270
db: ChemSpider

Compound/PW C001420 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Sulfate
type: SmallMoleculeReference
xref: Reference/BioCyc NH42SO4
xref: Reference/CAS 14808-79-8
xref: Reference/PubChem-compound 1117
xref: Reference/HMDB HMDB0001448
xref: Reference/ChemSpider 1085
xref: Reference/KEGG Compound C00059
xref: Reference/ChEBI CHEBI 16189
chemical formula: H2O4S
molecular weight: 97.96738
structure: ChemicalStructure/PW C001118

19-Hydroxytestosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 19-Hydroxytestosterone

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Testosterone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17347
xref: Reference/PubChem-compound 6013
xref: Reference/KEGG Compound C00535
xref: Reference/HMDB HMDB0000234
xref: Reference/CAS 58-22-0
xref: Reference/ChemSpider 5791
chemical formula: C19H28O2
molecular weight: 288.20892
structure: ChemicalStructure/PW C000157

17-Hydroxyprogesterone
type: SmallMoleculeReference
xref: Reference/CAS 68-96-2
xref: Reference/ChEBI CHEBI 17252
xref: Reference/KEGG Compound C01176
xref: Reference/PubChem-compound 6238
xref: Reference/ChemSpider 6002
xref: Reference/HMDB HMDB0000374
chemical formula: C21H30O3
molecular weight: 330.21948
structure: ChemicalStructure/PW C000273

ReactionCatalysis27
type: Catalysis
controller: 3-oxo-5-beta-steroid 4-dehydrogenase
controlled: 1.3.1.3
control type: ACTIVATION

Cytochrome P450 19A1
type: ProteinReference
xref: Reference/UniProt P11511
organism: Homo sapiens

2.8.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000886 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000054 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000814 Cytoplasm/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: Dehydroepiandrosterone sulfate
spontaneous: false
EC number: 2.8.2.2
left: Dehydroepiandrosterone
left: Phosphoadenosine phosphosulfate
name: Dehydroepiandrosterone + Phosphoadenosine phosphosulfate → Adenosine 3',5'-diphosphate + Dehydroepiandrosterone sulfate
conversion direction: LEFT_TO_RIGHT

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
type: ProteinReference
xref: Reference/UniProt P14060
organism: Homo sapiens

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

ReactionCatalysis29
type: Catalysis
controller: UDP-glucuronosyltransferase 2B17
controlled: 2.4.1.17
control type: ACTIVATION

Androstenedione
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16422
xref: Reference/ChemSpider 5898
xref: Reference/KEGG Compound C00280
xref: Reference/PubChem-compound 6128
xref: Reference/HMDB HMDB0000053
xref: Reference/BioCyc ANDROST4ENE
xref: Reference/CAS 63-05-8
chemical formula: C19H26O2
molecular weight: 286.19327
structure: ChemicalStructure/PW C000037

Reference/PubChem-compound 10635
type: UnificationXref
id: 10635
db: PubChem-compound

ReactionCatalysis20
type: Catalysis
controller: Steryl-sulfatase
controlled: 3.1.6.2
control type: ACTIVATION

ReactionCatalysis24
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction24
control type: ACTIVATION

Reference/ChemSpider 6002
type: UnificationXref
id: 6002
db: ChemSpider

Reduced flavoprotein
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced flavoprotein

ReactionCatalysis22
type: Catalysis
controller: Steroid 17-alpha-hydroxylase/17,20 lyase
controlled: Reaction21
control type: ACTIVATION

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Reference/HMDB HMDB0002961
type: UnificationXref
id: HMDB0002961
db: HMDB

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChEBI CHEBI 16814
type: UnificationXref
id: CHEBI:16814
db: ChEBI

Adenosine 3',5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17985
xref: Reference/CAS 1053-73-2
xref: Reference/PubChem-compound 159296
xref: Reference/ChemSpider 140102
xref: Reference/BioCyc 3-5-ADP
xref: Reference/KEGG Compound C00054
xref: Reference/HMDB HMDB0000061
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000043

Reference/PubChem-compound 5870
type: UnificationXref
id: 5870
db: PubChem-compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/ChemSpider 10827
type: UnificationXref
id: 10827
db: ChemSpider

Reference/CAS 651-48-9
type: UnificationXref
id: 651-48-9
db: CAS

Compound/PW C000814 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroepiandrosterone sulfate
stoichiometric coefficient: 1.0

ReactionCatalysis30
type: Catalysis
controller: 3-oxo-5-alpha-steroid 4-dehydrogenase 1
controlled: 1.3.1.22
control type: ACTIVATION

Reference/PubChem-compound 5757
type: UnificationXref
id: 5757
db: PubChem-compound

Reference/BioCyc ESTRONE-SULFATE
type: UnificationXref
id: ESTRONE-SULFATE
db: BioCyc

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ReactionCatalysis34
type: Catalysis
controller: Cytochrome P450 19A1
controlled: 1.14.14.14
control type: ACTIVATION

ReactionCatalysis35
type: Catalysis
controller: Cytochrome P450 19A1
controlled: 1.14.14.14
control type: ACTIVATION

Reference/PubChem-compound 16395893
type: UnificationXref
id: 16395893
db: PubChem-compound

ReactionCatalysis32
type: Catalysis
controller: Cytochrome P450 19A1
controlled: 1.14.14.14
control type: ACTIVATION

ReactionCatalysis33
type: Catalysis
controller: Cytochrome P450 19A1
controlled: 1.14.14.14
control type: ACTIVATION

17-Hydroxyprogesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 17-Hydroxyprogesterone
name: SubPathwayOutput

Compound/PW C002921 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5b-Dihydrotestosterone
stoichiometric coefficient: 1.0

17-β-Estradiol-3-glucuronide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05503
xref: Reference/HMDB HMDB0006224
xref: Reference/BioCyc Beta-D-Glucuronides
xref: Reference/PubChem-compound 13783824
xref: Reference/ChEBI CHEBI 36489
xref: Reference/ChemSpider 18667985
chemical formula: C24H32O8
molecular weight: 448.20972
structure: ChemicalStructure/PW C002671

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Estrone sulfate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001425
xref: Reference/KEGG Compound C02538
xref: Reference/ChemSpider 2272513
xref: Reference/BioCyc ESTRONE-SULFATE
xref: Reference/PubChem-compound 3001028
xref: Reference/CAS 481-97-0
xref: Reference/ChEBI CHEBI 17474
chemical formula: C18H22O5S
molecular weight: 350.1188
structure: ChemicalStructure/PW C001101

Reference/ChemSpider 17461292
type: UnificationXref
id: 17461292
db: ChemSpider

Reference/PubChem-compound 13783824
type: UnificationXref
id: 13783824
db: PubChem-compound

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

ReactionCatalysis49
type: Catalysis
controller: UDP-glucuronosyltransferase 2B11
controlled: 2.4.1.17
control type: ACTIVATION

Sulfate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sulfate

ReactionCatalysis47
type: Catalysis
controller: Cytochrome P450 19A1
controlled: 1.14.14.14
control type: ACTIVATION

ReactionCatalysis48
type: Catalysis
controller: Cytochrome P450 19A1
controlled: 1.14.14.14
control type: ACTIVATION

ReactionCatalysis46
type: Catalysis
controller: Estradiol 17-beta-dehydrogenase 1
controlled: 1.1.1.62
control type: ACTIVATION

Reference/ChemSpider 13628409
type: UnificationXref
id: 13628409
db: ChemSpider

Reference/ChemSpider 221136
type: UnificationXref
id: 221136
db: ChemSpider

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003955
type: UnificationXref
id: HMDB0003955
db: HMDB

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/BioCyc 3-5-ADP
type: UnificationXref
id: 3-5-ADP
db: BioCyc

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

17a-Hydroxypregnenolone
type: SmallMoleculeReference
xref: Reference/ChemSpider 82579
xref: Reference/PubChem-compound 91451
xref: Reference/CAS 387-79-1
xref: Reference/HMDB HMDB0000363
xref: Reference/KEGG Compound C05138
xref: Reference/ChEBI CHEBI 28750
chemical formula: C21H32O3
molecular weight: 332.23514
structure: ChemicalStructure/PW C000263

Compound/PW C000037 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Androstenedione
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/CAS 1053-73-2
type: UnificationXref
id: 1053-73-2
db: CAS

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/HMDB HMDB0003959
type: UnificationXref
id: HMDB0003959
db: HMDB

Reference/BioCyc ANDROST4ENE
type: UnificationXref
id: ANDROST4ENE
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001425
type: UnificationXref
id: HMDB0001425
db: HMDB

Reference/CAS 2126-37-6
type: UnificationXref
id: 2126-37-6
db: CAS

ChemicalStructure/PW C002671
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001101
type: ChemicalStructure
structure format: SMILES

19-Hydroxyandrost-4-ene-3,17-dione
type: SmallMoleculeReference
xref: Reference/CAS 510-64-5
xref: Reference/ChEBI CHEBI 27576
xref: Reference/PubChem-compound 252379
xref: Reference/ChemSpider 221136
xref: Reference/HMDB HMDB0003955
xref: Reference/KEGG Compound C05290
chemical formula: C19H26O3
molecular weight: 302.1882
structure: ChemicalStructure/PW C002016

Compound/PW C001101 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Estrone sulfate
stoichiometric coefficient: 1.0

Compound/PW C001118 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfate
stoichiometric coefficient: 1.0

17-beta Hydroxysteroid Dehydrogenase III Deficiency
type: Pathway
pathway order: PathwaySubPathway/167
pathway order: PathwayEnzymeReaction/1200
pathway order: PathwayEnzymeReaction/1211
pathway order: PathwayEnzymeReaction/1233
pathway order: PathwayEnzymeReaction/1210
pathway order: PathwayEnzymeReaction/1221
pathway order: PathwayEnzymeReaction/1232
pathway order: PathwayEnzymeReaction/1231
pathway order: PathwayEnzymeReaction/1230
pathway order: PathwayEnzymeReaction/1204
pathway order: PathwayEnzymeReaction/1226
pathway order: PathwayEnzymeReaction/1214
pathway order: PathwayEnzymeReaction/1225
pathway order: PathwayEnzymeReaction/1224
pathway order: PathwayEnzymeReaction/1223
pathway order: PathwayEnzymeReaction/1229
pathway order: PathwayEnzymeReaction/1217
pathway order: PathwayEnzymeReaction/1228
pathway order: PathwayEnzymeReaction/1205
pathway order: PathwayEnzymeReaction/1227
pathway component: 1.14.14.14
pathway component: 3.1.6.2
pathway component: Reaction51
pathway component: ReactionCatalysis30
pathway component: ReactionCatalysis34
pathway component: Reaction55
pathway component: ReactionCatalysis35
pathway component: ReactionCatalysis32
pathway component: ReactionCatalysis33
pathway component: 1.3.1.22
pathway component: Steroidogenesis
pathway component: ReactionCatalysis929
pathway component: ReactionCatalysis946
pathway component: ReactionCatalysis944
pathway component: ReactionCatalysis945
pathway component: ReactionCatalysis943
pathway component: ReactionCatalysis49
pathway component: ReactionCatalysis27
pathway component: 1.1.1.62
pathway component: ReactionCatalysis47
pathway component: Reaction24
pathway component: 2.8.2.4
pathway component: ReactionCatalysis48
pathway component: 2.8.2.2
pathway component: 1.1.1.64
pathway component: 2.4.1.17
pathway component: ReactionCatalysis29
pathway component: 1.3.1.3
pathway component: ReactionCatalysis20
pathway component: ReactionCatalysis46
pathway component: ReactionCatalysis24
pathway component: Reaction21
pathway component: ReactionCatalysis22
xref: Reference/PathWhiz PW000059
xref: Reference/SMPDB SMP0000356
organism: Homo sapiens

Reference/CAS 510-64-5
type: UnificationXref
id: 510-64-5
db: CAS

NADH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADH

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Androstenedione
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Androstenedione

Compound/PW C002920 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19-Hydroxytestosterone
stoichiometric coefficient: 1.0

Estrogen sulfotransferase
type: Protein
cellular location: Cytoplasm
entity reference: Estrogen sulfotransferase

19-Oxotestosterone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17347
xref: Reference/ChemSpider 13628409
xref: Reference/BioCyc 19-OXO-TESTOSTERONE
xref: Reference/PubChem-compound 12850019
xref: Reference/KEGG Compound C05295
xref: Reference/CAS 4075-13-2
xref: Reference/HMDB HMDB0003959
chemical formula: C19H26O3
molecular weight: 302.1882
structure: ChemicalStructure/PW C002018

Reference/ChemSpider 9799
type: UnificationXref
id: 9799
db: ChemSpider

Protein/Generic37 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced flavoprotein
stoichiometric coefficient: 1.0

Reference/CAS 58-22-0
type: UnificationXref
id: 58-22-0
db: CAS

Reference/KEGG Compound C05138
type: UnificationXref
id: C05138
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000263
type: ChemicalStructure
structure format: SMILES

Compound/PW C000037 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Androstenedione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 159296
type: UnificationXref
id: 159296
db: PubChem-compound

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Reference/ChEBI CHEBI 28835
type: UnificationXref
id: CHEBI:28835
db: ChEBI

Reference/PubChem-compound 91451
type: UnificationXref
id: 91451
db: PubChem-compound

Estrone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Estrone

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

17-Hydroxyprogesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 17-Hydroxyprogesterone

Reaction51
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000054 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NADH
right: Androstenedione
right: Hydrogen Ion
spontaneous: false
left: Dehydroepiandrosterone
left: NAD
name: Dehydroepiandrosterone + NAD → Androstenedione + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reaction55
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NADH
right: 17-Hydroxyprogesterone
right: Hydrogen Ion
spontaneous: false
left: NAD
left: 17a-Hydroxypregnenolone
name: 17a-Hydroxypregnenolone + NAD → 17-Hydroxyprogesterone + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000234
type: UnificationXref
id: HMDB0000234
db: HMDB

Steroidogenesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway167
pathway component: SubPathwayInteraction167
xref: Reference/PathWhiz PW000141
xref: Reference/SMPDB SMP0000130
name: SubPathway

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 1117
type: UnificationXref
id: 1117
db: PubChem-compound

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001448
type: UnificationXref
id: HMDB0001448
db: HMDB

Dehydroepiandrosterone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5881
xref: Reference/KEGG Compound C01227
xref: Reference/ChEBI CHEBI 28689
xref: Reference/BioCyc 3-BETA-HYDROXYANDROST-5-EN-17-ONE
xref: Reference/CAS 53-43-0
xref: Reference/ChemSpider 5670
xref: Reference/HMDB HMDB0000077
chemical formula: C19H28O2
molecular weight: 288.20892
structure: ChemicalStructure/PW C000054

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 571-22-2
type: UnificationXref
id: 571-22-2
db: CAS

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17-Hydroxyprogesterone
stoichiometric coefficient: 1.0

Dehydroepiandrosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dehydroepiandrosterone

Reference/HMDB HMDB0000363
type: UnificationXref
id: HMDB0000363
db: HMDB

Reference/ChEBI CHEBI 17985
type: UnificationXref
id: CHEBI:17985
db: ChEBI

Compound/PW C001745 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrotestosterone
stoichiometric coefficient: 1.0

19-Oxoandrost-4-ene-3,17-dione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 19-Oxoandrost-4-ene-3,17-dione

Estradiol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Estradiol

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/ChemSpider 1085
type: UnificationXref
id: 1085
db: ChemSpider

Reference/CAS 4075-13-2
type: UnificationXref
id: 4075-13-2
db: CAS

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00951
type: UnificationXref
id: C00951
db: KEGG Compound

Androstenedione
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Androstenedione

Reference/ChEBI CHEBI 17980
type: UnificationXref
id: CHEBI:17980
db: ChEBI

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 521-18-6
type: UnificationXref
id: 521-18-6
db: CAS

Reference/KEGG Compound C05293
type: UnificationXref
id: C05293
db: KEGG Compound

Reference/KEGG Compound C05295
type: UnificationXref
id: C05295
db: KEGG Compound

Reduced flavoprotein
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Reduced flavoprotein

Reference/KEGG Compound C05294
type: UnificationXref
id: C05294
db: KEGG Compound

Reference/KEGG Compound C05290
type: UnificationXref
id: C05290
db: KEGG Compound

Dehydroepiandrosterone sulfate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dehydroepiandrosterone sulfate

Reference/ChEBI CHEBI 16422
type: UnificationXref
id: CHEBI:16422
db: ChEBI

Estradiol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Estradiol

ChemicalStructure/PW C002919
type: ChemicalStructure
structure format: SMILES

3-oxo-5-beta-steroid 4-dehydrogenase
type: Protein
cellular location: Cytoplasm
entity reference: 3-oxo-5-beta-steroid 4-dehydrogenase

Reference/UniProt P05093
type: UnificationXref
id: P05093
db: UniProt

Reference/ChemSpider 5554
type: UnificationXref
id: 5554
db: ChemSpider

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Reference/ChemSpider 5670
type: UnificationXref
id: 5670
db: ChemSpider

Reference/ChemSpider 5791
type: UnificationXref
id: 5791
db: ChemSpider

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

NAD
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NAD

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/ChEBI CHEBI 28750
type: UnificationXref
id: CHEBI:28750
db: ChEBI

Reference/ChEBI CHEBI 428206
type: UnificationXref
id: CHEBI:428206
db: ChEBI

Reference/SMPDB SMP0000130
type: UnificationXref
id: SMP0000130
db: SMPDB

Reference/BioCyc NH42SO4
type: UnificationXref
id: NH42SO4
db: BioCyc

Reference/PubChem-compound 12850019
type: UnificationXref
id: 12850019
db: PubChem-compound

Compound/PW C000054 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dehydroepiandrosterone
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/BioCyc ESTRONE
type: UnificationXref
id: ESTRONE
db: BioCyc

Reference/ChEBI CHEBI 36489
type: UnificationXref
id: CHEBI:36489
db: ChEBI

Protein/339 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Estrogen sulfotransferase
stoichiometric coefficient: 2.0

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Protein/Generic38 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized flavoprotein
stoichiometric coefficient: 1.0

Estrone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000145
xref: Reference/PubChem-compound 5870
xref: Reference/KEGG Compound C00468
xref: Reference/CAS 53-16-7
xref: Reference/ChEBI CHEBI 17263
xref: Reference/BioCyc ESTRONE
xref: Reference/ChemSpider 5660
chemical formula: C18H22O2
molecular weight: 270.162
structure: ChemicalStructure/PW C000094

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

19-Hydroxytestosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 19-Hydroxytestosterone

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Estradiol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16469
xref: Reference/CAS 50-28-2
xref: Reference/BioCyc CPD-352
xref: Reference/PubChem-compound 5757
xref: Reference/ChemSpider 5554
xref: Reference/KEGG Compound C00951
xref: Reference/HMDB HMDB0000151
chemical formula: C18H24O2
molecular weight: 272.17764
structure: ChemicalStructure/PW C000098

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

ChemicalStructure/PW C001802
type: ChemicalStructure
structure format: SMILES

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 53-16-7
type: UnificationXref
id: 53-16-7
db: CAS

Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000886
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16330
type: UnificationXref
id: CHEBI:16330
db: ChEBI

Reference/PathWhiz PW000141
type: UnificationXref
id: PW000141
db: PathWhiz

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/BioCyc PAPS
type: UnificationXref
id: PAPS
db: BioCyc

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/ChEBI CHEBI 28689
type: UnificationXref
id: CHEBI:28689
db: ChEBI

Oxidized flavoprotein
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxidized flavoprotein

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cytochrome P450 19A1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 19A1

Reference/PubChem-compound 5881
type: UnificationXref
id: 5881
db: PubChem-compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/KEGG Compound C03917
type: UnificationXref
id: C03917
db: KEGG Compound

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16469
type: UnificationXref
id: CHEBI:16469
db: ChEBI

ChemicalStructure/PW C001745
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 2272513
type: UnificationXref
id: 2272513
db: ChemSpider

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Adenosine 3',5'-diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine 3',5'-diphosphate

Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a-Hydroxypregnenolone
stoichiometric coefficient: 1.0

Compound/PW C002671 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17-β-Estradiol-3-glucuronide
stoichiometric coefficient: 1.0

Reference/BioCyc 19-OXO-TESTOSTERONE
type: UnificationXref
id: 19-OXO-TESTOSTERONE
db: BioCyc

Reference/CAS 387-79-1
type: UnificationXref
id: 387-79-1
db: CAS

Reference/CAS 481-97-0
type: UnificationXref
id: 481-97-0
db: CAS

Reference/KEGG Compound C00535
type: UnificationXref
id: C00535
db: KEGG Compound

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002920
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002921
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 27576
type: UnificationXref
id: CHEBI:27576
db: ChEBI

Compound/PW C001802 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Testosterone glucuronide
stoichiometric coefficient: 1.0

Reference/CAS 63-05-8
type: UnificationXref
id: 63-05-8
db: CAS

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Reference/UniProt P11511
type: UnificationXref
id: P11511
db: UniProt

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

1.1.1.64
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000157 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000037 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
right: Androstenedione
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.64
left: Testosterone
left: NAD
name: NAD + Testosterone ↔ Androstenedione + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 1069535
type: UnificationXref
id: CHEBI:1069535
db: ChEBI

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Reference/PubChem-compound 252379
type: UnificationXref
id: 252379
db: PubChem-compound

Testosterone glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Testosterone glucuronide

Reference/SMPDB SMP0000356
type: UnificationXref
id: SMP0000356
db: SMPDB