Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt O95470
type: UnificationXref
id: O95470
db: UniProt

Reference/KEGG Compound C00319
type: UnificationXref
id: C00319
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C00550
type: UnificationXref
id: C00550
db: KEGG Compound

Reference/ChemSpider 4696849
type: UnificationXref
id: 4696849
db: ChemSpider

Reference/BioCyc DEHYDROSPHINGANINE
type: UnificationXref
id: DEHYDROSPHINGANINE
db: BioCyc

Arylsulfatase A
type: Protein
cellular location: Lysosome
entity reference: Arylsulfatase A

Reference/UniProt P15289
type: UnificationXref
id: P15289
db: UniProt

CerP(d18:1/18:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: CerP(d18:1/18:0)

Reference/BioCyc SPHINGO-MYELIN
type: UnificationXref
id: SPHINGO-MYELIN
db: BioCyc

Reference/HMDB HMDB0006752
type: UnificationXref
id: HMDB0006752
db: HMDB

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

Reference/PubChem-compound 11958364
type: UnificationXref
id: 11958364
db: PubChem-compound

SM(d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: SM(d18:1/18:0)

Sphingosine 1-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine 1-phosphate

Reference/ChemSpider 388480
type: UnificationXref
id: 388480
db: ChemSpider

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C006717 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C002210 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galabiosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/CAS 14808-79-8
type: UnificationXref
id: 14808-79-8
db: CAS

Galabiosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Lysosome
entity reference: Galabiosylceramide (d18:1/18:0)

ReactionCatalysis932
type: Catalysis
controller: Sialidase-3
controlled: 3.2.1.18
control type: ACTIVATION

ReactionCatalysis930
type: Catalysis
controller: Alpha-galactosidase A
controlled: 3.2.1.22
control type: ACTIVATION

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine diphosphate

Reference/ChemSpider 959
type: UnificationXref
id: 959
db: ChemSpider

Reference/PubChem-compound 16755624
type: UnificationXref
id: 16755624
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Phosphoadenosine phosphosulfate
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Phosphoadenosine phosphosulfate

Reference/UniProt P16278
type: UnificationXref
id: P16278
db: UniProt

Alpha-galactosidase A
type: Protein
cellular location: Lysosome
entity reference: Alpha-galactosidase A

Compound/PW C002313 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Reference/PubChem-compound 53477679
type: UnificationXref
id: 53477679
db: PubChem-compound

Compound/PW C000886 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoadenosine phosphosulfate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Compound/PW C001070 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 133-89-1
type: UnificationXref
id: 133-89-1
db: CAS

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

Reference/ChemSpider 559277
type: UnificationXref
id: 559277
db: ChemSpider

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00346
type: UnificationXref
id: C00346
db: KEGG Compound

Reference/KEGG Compound C00588
type: UnificationXref
id: C00588
db: KEGG Compound

Reference/UniProt P04062
type: UnificationXref
id: P04062
db: UniProt

Compound/PW C003990 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: PC(15:0/18:2(9Z,12Z))
stoichiometric coefficient: 1.0

SubPathwayInteraction166
type: Interaction
name: SubPathway166Reaction
name: SubPathwayReaction
participant: L-Serine

ReactionCatalysis872
type: Catalysis
controller: Sphingosine kinase 2
controlled: 2.7.1.91
control type: ACTIVATION

ReactionCatalysis873
type: Catalysis
controller: Sphingosine-1-phosphate phosphatase 2
controlled: 3.1.3.-
control type: ACTIVATION

Galactosylglycerol
type: SmallMoleculeReference
xref: Reference/ChemSpider 570889
xref: Reference/HMDB HMDB0006790
xref: Reference/ChEBI CHEBI 15754
xref: Reference/PubChem-compound 656504
xref: Reference/KEGG Compound C05401
chemical formula: C9H18O8
molecular weight: 254.10017
structure: ChemicalStructure/PW C002928

Reference/PubChem-compound 24778664
type: UnificationXref
id: 24778664
db: PubChem-compound

Reference/HMDB HMDB0006790
type: UnificationXref
id: HMDB0006790
db: HMDB

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 20057275
type: UnificationXref
id: 20057275
db: PubChem-compound

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Phosphatidylcholine:ceramide cholinephosphotransferase 1
type: Protein
cellular location: Golgi Apparatus
entity reference: Phosphatidylcholine:ceramide cholinephosphotransferase 1

Reference/BioCyc PHOSPHATIDYLCHOLINE
type: UnificationXref
id: PHOSPHATIDYLCHOLINE
db: BioCyc

Reference/CAS 1071-23-4
type: UnificationXref
id: 1071-23-4
db: CAS

Sphingosine-1-phosphate lyase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine-1-phosphate lyase 1

Compound/PW C000093 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Galactose
stoichiometric coefficient: 1.0

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000184 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001070 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum/Stoichiometry/1.0
right: Adenosine triphosphate
right: Sphinganine
spontaneous: false
EC number: 3.1.3.-
left: Sphinganine 1-phosphate
left: Adenosine diphosphate
name: Adenosine diphosphate + Sphinganine 1-phosphate → Adenosine triphosphate + Sphinganine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001202 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001070 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: Sphinganine
spontaneous: false
EC number: 3.1.3.4
left: Sphinganine 1-phosphate
left: Water
name: Sphinganine 1-phosphate + Water → Phosphate + Sphinganine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis869
type: Catalysis
controller: 3-ketodihydrosphingosine reductase
controlled: 1.1.1.102
control type: ACTIVATION

Uridine diphosphate glucose
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucose

ReactionCatalysis868
type: Catalysis
controller: Serine palmitoyltransferase 1
controlled: 2.3.1.50
control type: ACTIVATION

Reference/BioCyc PALMITALDEHYDE
type: UnificationXref
id: PALMITALDEHYDE
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C002334 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChEBI CHEBI 16189
type: UnificationXref
id: CHEBI:16189
db: ChEBI

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Lipid phosphate phosphohydrolase 1
type: ProteinReference
xref: Reference/UniProt O14494
organism: Homo sapiens

1.1.1.102
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001139 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: 3-Dehydrosphinganine
right: NADP
spontaneous: false
EC number: 1.1.1.102
left: Sphinganine
left: NADPH
name: NADPH + Sphinganine → 3-Dehydrosphinganine + NADP
conversion direction: LEFT_TO_RIGHT

2.3.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001139 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: 3-Dehydrosphinganine
right: Carbon dioxide
spontaneous: false
EC number: 2.3.1.50
left: Palmitoyl-CoA
left: L-Serine
name: L-Serine + Palmitoyl-CoA → 3-Dehydrosphinganine + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Compound/PW C000188 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine 1-phosphate
stoichiometric coefficient: 1.0

Dihydroceramide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 31488
xref: Reference/ChemSpider 21436314
xref: Reference/HMDB HMDB0006752
xref: Reference/PubChem-compound 16755624
xref: Reference/KEGG Compound C12126
chemical formula: C19H39NO3
molecular weight: 329.293
structure: ChemicalStructure/PW C002905

Reference/ChemSpider 388895
type: UnificationXref
id: 388895
db: ChemSpider

Dihydroceramide
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroceramide

ReactionCatalysis890
type: Catalysis
controller: Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
controlled: Reaction1186
control type: ACTIVATION

Compound/PW C001070 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Sphinganine 1-phosphate

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
type: Protein
cellular location: Golgi Apparatus
entity reference: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/ChEBI CHEBI 16393
type: UnificationXref
id: CHEBI:16393
db: ChEBI

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Compound/PW C000172 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine
stoichiometric coefficient: 1.0

3.5.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002905 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cytosol/Stoichiometry/1.0
right: Sphinganine
spontaneous: false
EC number: 3.5.1.-
left: Dihydroceramide
name: Dihydroceramide → Sphinganine
conversion direction: LEFT_TO_RIGHT

2.7.1.138
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006709 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: CerP(d18:1/18:0)
spontaneous: false
EC number: 2.7.1.138
left: Adenosine triphosphate
left: Ceramide (d18:1/18:0)
name: Adenosine triphosphate + Ceramide (d18:1/18:0) → Adenosine diphosphate + CerP(d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

Compound/PW C001070 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000188 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000172 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Sphingosine 1-phosphate
right: Water
spontaneous: false
EC number: 3.1.3.4
left: Phosphate
left: Sphingosine
name: Phosphate + Sphingosine → Sphingosine 1-phosphate + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C001139 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Dehydrosphinganine
stoichiometric coefficient: 1.0

3.5.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Sphingosine
spontaneous: false
EC number: 3.5.1.23
left: Water
left: Ceramide (d18:1/18:0)
name: Ceramide (d18:1/18:0) + Water → Sphingosine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

2.7.1.91
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Sphingosine 1-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.91
left: Sphingosine
left: Adenosine triphosphate
name: Adenosine triphosphate + Sphingosine → Adenosine diphosphate + Sphingosine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Sialidase-3
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Sialidase-3

Compound/PW C000184 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Sphingosine
right: Adenosine triphosphate
spontaneous: false
EC number: 3.1.3.-
left: Sphingosine 1-phosphate
left: Adenosine diphosphate
name: Adenosine diphosphate + Sphingosine 1-phosphate → Adenosine triphosphate + Sphingosine
conversion direction: LEFT_TO_RIGHT

4.1.2.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Palmitaldehyde
right: O-Phosphoethanolamine
spontaneous: false
EC number: 4.1.2.27
left: Sphingosine 1-phosphate
name: Sphingosine 1-phosphate → O-Phosphoethanolamine + Palmitaldehyde
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0010701
type: UnificationXref
id: HMDB0010701
db: HMDB

ReactionCatalysis886
type: Catalysis
controller: Sphingosine-1-phosphate lyase 1
controlled: 4.1.2.27
control type: ACTIVATION

Reference/HMDB HMDB0010709
type: UnificationXref
id: HMDB0010709
db: HMDB

Reference/KEGG Compound C00029
type: UnificationXref
id: C00029
db: KEGG Compound

Reference/CAS 59-23-4
type: UnificationXref
id: 59-23-4
db: CAS

Reference/KEGG Compound C02686
type: UnificationXref
id: C02686
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/PubChem-compound 5771775
type: UnificationXref
id: 5771775
db: PubChem-compound

Galabiosylceramide sulfate (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Galabiosylceramide sulfate (d18:1/18:0)

Reference/ChEBI CHEBI 73144
type: UnificationXref
id: CHEBI:73144
db: ChEBI

Reaction1186
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002905 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Ceramide (d18:1/18:0)
spontaneous: false
left: Dihydroceramide
name: Dihydroceramide ? Ceramide (d18:1/18:0)

Galactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Galactosylceramide (d18:1/18:0)

Reference/BioCyc PHOSPHORYL-CHOLINE
type: UnificationXref
id: PHOSPHORYL-CHOLINE
db: BioCyc

Ceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Lysosome
entity reference: Ceramide (d18:1/18:0)

Reference/CAS 482-67-7
type: UnificationXref
id: 482-67-7
db: CAS

Serine palmitoyltransferase 2
type: Protein
cellular location: Cytosol
entity reference: Serine palmitoyltransferase 2

Compound/PW C000172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/KEGG Compound C12126
type: UnificationXref
id: C12126
db: KEGG Compound

ReactionCatalysis874
type: Catalysis
controller: Lipid phosphate phosphohydrolase 1
controlled: 3.1.3.4
control type: ACTIVATION

Sphinganine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphinganine

ChemicalStructure/PW C006709
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

ChemicalStructure/PW C001139
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(=O)[C@@H](N)CO

Compound/PW C001034 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Galactocerebrosidase
type: ProteinReference
xref: Reference/UniProt P54803
organism: Homo sapiens

Reference/KEGG Compound C01120
type: UnificationXref
id: C01120
db: KEGG Compound

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/KEGG Compound C00157
type: UnificationXref
id: C00157
db: KEGG Compound

Compound/PW C104814 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylneuraminyl-galactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 31488
type: UnificationXref
id: CHEBI:31488
db: ChEBI

Reference/HMDB HMDB0001348
type: UnificationXref
id: HMDB0001348
db: HMDB

Reference/CAS 104404-17-3
type: UnificationXref
id: 104404-17-3
db: CAS

Compound/PW C007187 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

ChemicalStructure/PW C000172
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO

Reference/HMDB HMDB0004972
type: UnificationXref
id: HMDB0004972
db: HMDB

Compound/PW C000414 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine triphosphate

Lactosylceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01290
xref: Reference/ChEBI CHEBI 84759
xref: Reference/HMDB HMDB0011591
xref: Reference/ChemSpider 8435601
xref: Reference/PubChem-compound 10260120
chemical formula: C48H91NO13
molecular weight: 889.64905
structure: ChemicalStructure/PW C007187

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0000252
type: UnificationXref
id: HMDB0000252
db: HMDB

Reference/PubChem-compound 5283583
type: UnificationXref
id: 5283583
db: PubChem-compound

Compound/PW C007846 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-O-Sulfogalactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Galactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Galactosylceramide (d18:1/18:0)

Glucosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Lysosome
entity reference: Glucosylceramide (d18:1/18:0)

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Arylsulfatase A
type: ProteinReference
xref: Reference/UniProt P15289
organism: Homo sapiens

Sialidase-3
type: ProteinReference
xref: Reference/UniProt Q9UQ49
organism: Homo sapiens

ChemicalStructure/PW C006717
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Galactosylceramide sulfotransferase
type: ProteinReference
xref: Reference/UniProt Q99999
organism: Homo sapiens

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000184
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO

Sphinganine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Sphinganine

Ceramide glucosyltransferase
type: ProteinReference
xref: Reference/UniProt Q16739
organism: Homo sapiens

Reference/HMDB HMDB0000269
type: UnificationXref
id: HMDB0000269
db: HMDB

ChemicalStructure/PW C000188
type: ChemicalStructure
structure format: SMILES

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Reference/PubChem-compound 5283588
type: UnificationXref
id: 5283588
db: PubChem-compound

Reference/HMDB HMDB0000143
type: UnificationXref
id: HMDB0000143
db: HMDB

Compound/PW C000120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Compound/PW C000201 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Phosphoadenosine phosphosulfate
type: SmallMoleculeReference
xref: Reference/BioCyc PAPS
xref: Reference/HMDB HMDB0001134
xref: Reference/CAS 482-67-7
xref: Reference/ChemSpider 9799
xref: Reference/KEGG Compound C00053
xref: Reference/PubChem-compound 10214
xref: Reference/ChEBI CHEBI 17980
chemical formula: C10H15N5O13P2S
molecular weight: 506.98624
structure: ChemicalStructure/PW C000886

Glucosylceramidase
type: ProteinReference
xref: Reference/UniProt P04062
organism: Homo sapiens

Reference/ChEBI CHEBI 28061
type: UnificationXref
id: CHEBI:28061
db: ChEBI

Reference/ChemSpider 140102
type: UnificationXref
id: 140102
db: ChemSpider

Reference/ChEBI CHEBI 18132
type: UnificationXref
id: CHEBI:18132
db: ChEBI

ChemicalStructure/PW C001118
type: ChemicalStructure
structure format: SMILES
structure data: OS(O)(=O)=O

Reference/PubChem-compound 644260
type: UnificationXref
id: 644260
db: PubChem-compound

ChemicalStructure/PW C000149
type: ChemicalStructure
structure format: SMILES
structure data: NCCOP(O)(O)=O

Reference/KEGG Compound C00054
type: UnificationXref
id: C00054
db: KEGG Compound

3-O-Sulfogalactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Lysosome
entity reference: 3-O-Sulfogalactosylceramide (d18:1/18:0)

Reference/KEGG Compound C00053
type: UnificationXref
id: C00053
db: KEGG Compound

Reference/CAS 16105-69-4
type: UnificationXref
id: 16105-69-4
db: CAS

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Phosphorylcholine
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Phosphorylcholine

Reference/BioCyc CERAMIDE
type: UnificationXref
id: CERAMIDE
db: BioCyc

Reference/KEGG Compound C00059
type: UnificationXref
id: C00059
db: KEGG Compound

Reference/CAS 19794-97-9
type: UnificationXref
id: 19794-97-9
db: CAS

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphinganine 1-phosphate

Reference/HMDB HMDB0000277
type: UnificationXref
id: HMDB0000277
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C002334
type: ChemicalStructure
structure format: SMILES

Alpha-galactosidase A
type: ProteinReference
xref: Reference/UniProt P06280
organism: Homo sapiens

ChemicalStructure/PW C002210
type: ChemicalStructure
structure format: SMILES

Beta-1,4-galactosyltransferase 6
type: Protein
cellular location: Golgi Apparatus
entity reference: Beta-1,4-galactosyltransferase 6

Reference/HMDB HMDB0001480
type: UnificationXref
id: HMDB0001480
db: HMDB

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Water
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Water

Palmitoyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Palmitoyl-CoA

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Sphingosine kinase 2
type: Protein
cellular location: Cytosol
entity reference: Sphingosine kinase 2

Reference/UniProt P54803
type: UnificationXref
id: P54803
db: UniProt

Ceramide glucosyltransferase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ceramide glucosyltransferase

Compound/PW C002334 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10214
type: UnificationXref
id: 10214
db: PubChem-compound

Reference/CAS 107-73-3
type: UnificationXref
id: 107-73-3
db: CAS

Reference/HMDB HMDB0001134
type: UnificationXref
id: HMDB0001134
db: HMDB

ChemicalStructure/PW C000043
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00195
type: UnificationXref
id: C00195
db: KEGG Compound

Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2

Glucosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Glucosylceramide (d18:1/18:0)

Reference/ChemSpider 21436314
type: UnificationXref
id: 21436314
db: ChemSpider

Reference/HMDB HMDB0000286
type: UnificationXref
id: HMDB0000286
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc GLUCOSYL CERAMIDE
type: UnificationXref
id: GLUCOSYL_CERAMIDE
db: BioCyc

Compound/PW C002905 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroceramide
stoichiometric coefficient: 1.0

Compound/PW C001031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

3-ketodihydrosphingosine reductase
type: Protein
cellular location: Cytosol
entity reference: 3-ketodihydrosphingosine reductase

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Sphingosine-1-phosphate lyase 1
type: ProteinReference
xref: Reference/UniProt O95470
organism: BiologicalState10

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C05401
type: UnificationXref
id: C05401
db: KEGG Compound

ChemicalStructure/PW C007846
type: ChemicalStructure
structure format: SMILES

Sphinganine
type: SmallMolecule
cellular location: Cytosol
entity reference: Sphinganine

Reference/KEGG Compound C01290
type: UnificationXref
id: C01290
db: KEGG Compound

ReactionCatalysis908
type: Catalysis
controller: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
controlled: 3.1.4.12
control type: ACTIVATION

Compound/PW C001040 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: SM(d18:1/18:0)
stoichiometric coefficient: 1.0

ReactionCatalysis909
type: Catalysis
controller: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
controlled: 2.4.1.45
control type: ACTIVATION

Sphingosine 1-phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphingosine 1-phosphate

ReactionCatalysis907
type: Catalysis
controller: Phosphatidylcholine:ceramide cholinephosphotransferase 1
controlled: 2.7.8.27
control type: ACTIVATION

Galactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Galactosylceramide (d18:1/18:0)

ReactionCatalysis904
type: Catalysis
controller: Lipid phosphate phosphohydrolase 1
controlled: 3.1.3.4
control type: ACTIVATION

ReactionCatalysis905
type: Catalysis
controller: Sphingosine-1-phosphate phosphatase 2
controlled: 3.1.3.-
control type: ACTIVATION

Phosphorylcholine
type: SmallMoleculeReference
xref: Reference/CAS 107-73-3
xref: Reference/HMDB HMDB0001565
xref: Reference/BioCyc PHOSPHORYL-CHOLINE
xref: Reference/PubChem-compound 1014
xref: Reference/ChEBI CHEBI 18132
xref: Reference/KEGG Compound C00588
xref: Reference/ChemSpider 989
chemical formula: C5H15NO4P
molecular weight: 184.07387
structure: ChemicalStructure/PW C001202

ReactionCatalysis902
type: Catalysis
controller: Alkaline ceramidase 3
controlled: 3.5.1.-
control type: ACTIVATION

ReactionCatalysis903
type: Catalysis
controller: Ceramide kinase
controlled: 2.7.1.138
control type: ACTIVATION

Sphingosine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine

ReactionCatalysis900
type: Catalysis
controller: Lipid phosphate phosphohydrolase 1
controlled: 3.1.3.4
control type: ACTIVATION

ReactionCatalysis901
type: Catalysis
controller: Alkaline ceramidase 1
controlled: 3.5.1.23
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/HMDB HMDB0001383
type: UnificationXref
id: HMDB0001383
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

ChemicalStructure/PW C000093
type: ChemicalStructure
structure format: SMILES

Compound/PW C006709 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: CerP(d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Protein/829 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine palmitoyltransferase 1
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Compound/PW C006717 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Protein/831 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine palmitoyltransferase 2
stoichiometric coefficient: 1.0

Compound/PW C006717 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

PC(15:0/18:2(9Z,12Z))
type: SmallMoleculeReference
xref: Reference/ChemSpider 24766615
xref: Reference/PubChem-compound 24778664
xref: Reference/HMDB HMDB0007940
xref: Reference/KEGG Compound C00157
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
chemical formula: C41H78NO8P
molecular weight: 743.5465
structure: ChemicalStructure/PW C003990

Reference/UniProt Q6UWV6
type: UnificationXref
id: Q6UWV6
db: UniProt

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Compound/PW C000193 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucose
stoichiometric coefficient: 1.0

L-Serine
type: SmallMolecule
entity reference: L-Serine
name: SubPathwayOutput

ChemicalStructure/PW C001070
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000061
type: UnificationXref
id: HMDB0000061
db: HMDB

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

Reference/CAS 244215-65-4
type: UnificationXref
id: 244215-65-4
db: CAS

Serine palmitoyltransferase 1
type: Protein
cellular location: Cytosol
entity reference: Serine palmitoyltransferase 1

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

ChemicalStructure/PW C001193
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC=O

Galactocerebrosidase
type: Protein
cellular location: Lysosome
entity reference: Galactocerebrosidase

Reference/PubChem-compound 984
type: UnificationXref
id: 984
db: PubChem-compound

Beta-1,4-galactosyltransferase 6
type: ProteinReference
xref: Reference/UniProt Q9UBX8
organism: Homo sapiens

Galactosylglycerol
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Galactosylglycerol

Lactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Lactosylceramide (d18:1/18:0)

N-Acetylneuraminyl-galactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: N-Acetylneuraminyl-galactosylceramide (d18:1/18:0)

Reference/UniProt Q9UBX8
type: UnificationXref
id: Q9UBX8
db: UniProt

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/KEGG Compound C01190
type: UnificationXref
id: C01190
db: KEGG Compound

Lipid phosphate phosphohydrolase 1
type: Protein
cellular location: Cell Membrane
entity reference: Lipid phosphate phosphohydrolase 1

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChemSpider 990
type: UnificationXref
id: 990
db: ChemSpider

Reference/UniProt Q99999
type: UnificationXref
id: Q99999
db: UniProt

ReactionCatalysis926
type: Catalysis
controller: Galactosylceramide sulfotransferase
controlled: 2.8.2.11
control type: ACTIVATION

ReactionCatalysis927
type: Catalysis
controller: Arylsulfatase A
controlled: 3.1.6.8
control type: ACTIVATION

Reference/HMDB HMDB0007940
type: UnificationXref
id: HMDB0007940
db: HMDB

ReactionCatalysis925
type: Catalysis
controller: Beta-1,4-galactosyltransferase 6
controlled: Reaction1221
control type: ACTIVATION

ReactionCatalysis922
type: Catalysis
controller: Ceramide glucosyltransferase
controlled: 2.4.1.80
control type: ACTIVATION

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

ReactionCatalysis923
type: Catalysis
controller: Beta-galactosidase
controlled: 3.2.1.23
control type: ACTIVATION

Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis920
type: Catalysis
controller: Glucosylceramidase
controlled: 3.2.1.45
control type: ACTIVATION

ChemicalStructure/PW C001040
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000193
type: ChemicalStructure
structure format: SMILES

Alkaline ceramidase 3
type: ProteinReference
xref: Reference/UniProt Q9NUN7
organism: Homo sapiens

Galabiosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Galabiosylceramide (d18:1/18:0)

Reference/UniProt Q86VZ5
type: UnificationXref
id: Q86VZ5
db: UniProt

Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
type: ProteinReference
xref: Reference/UniProt Q6QHC5
organism: BiologicalState10

Ceramide kinase
type: ProteinReference
xref: Reference/UniProt Q8TCT0
organism: Homo sapiens

Reference/PubChem-compound 5283560
type: UnificationXref
id: 5283560
db: PubChem-compound

Glucosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Glucosylceramide (d18:1/18:0)

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt Q06136
type: UnificationXref
id: Q06136
db: UniProt

Reference/ChemSpider 989
type: UnificationXref
id: 989
db: ChemSpider

Compound/PW C001420 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Uridine 5'-diphosphate

Compound/PW C000077 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5283565
type: UnificationXref
id: 5283565
db: PubChem-compound

ReactionCatalysis910
type: Catalysis
controller: Galactocerebrosidase
controlled: 3.2.1.46
control type: ACTIVATION

2.7.1.91
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000184 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001070 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Sphinganine 1-phosphate
spontaneous: false
EC number: 2.7.1.91
left: Sphinganine
left: Adenosine triphosphate
name: Adenosine triphosphate + Sphinganine → Adenosine diphosphate + Sphinganine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitaldehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

O-Phosphoethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000224
xref: Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
xref: Reference/ChemSpider 990
xref: Reference/PubChem-compound 1015
xref: Reference/KEGG Compound C00346
xref: Reference/ChEBI CHEBI 17553
xref: Reference/CAS 1071-23-4
chemical formula: C2H8NO4P
molecular weight: 141.01909
structure: ChemicalStructure/PW C000149

Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
type: UnificationXref
id: PHOSPHORYL-ETHANOLAMINE
db: BioCyc

Reference/ChemSpider 4446696
type: UnificationXref
id: 4446696
db: ChemSpider

Serine palmitoyltransferase 1
type: ProteinReference
xref: Reference/UniProt O15269
organism: Homo sapiens

Reference/PubChem-compound 1014
type: UnificationXref
id: 1014
db: PubChem-compound

Reference/PubChem-compound 1015
type: UnificationXref
id: 1015
db: PubChem-compound

Sulfate
type: SmallMoleculeReference
xref: Reference/BioCyc NH42SO4
xref: Reference/CAS 14808-79-8
xref: Reference/PubChem-compound 1117
xref: Reference/HMDB HMDB0001448
xref: Reference/ChemSpider 1085
xref: Reference/KEGG Compound C00059
xref: Reference/ChEBI CHEBI 16189
chemical formula: H2O4S
molecular weight: 97.96738
structure: ChemicalStructure/PW C001118

Galabiosylceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 20057275
xref: Reference/ChemSpider 16744851
xref: Reference/HMDB HMDB0004834
xref: Reference/CAS 77538-38-6
xref: Reference/KEGG Compound C06126
chemical formula: C48H91NO13
molecular weight: 889.64905
structure: ChemicalStructure/PW C002210

Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Glucosylceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/BioCyc GLUCOSYL CERAMIDE
xref: Reference/KEGG Compound C01190
xref: Reference/PubChem-compound 11958364
xref: Reference/CAS 85305-87-9
xref: Reference/ChEBI CHEBI 84719
xref: Reference/ChemSpider 10132611
xref: Reference/HMDB HMDB0004972
chemical formula: C42H81NO8
molecular weight: 727.5962
structure: ChemicalStructure/PW C002334

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/PubChem-compound 656504
type: UnificationXref
id: 656504
db: PubChem-compound

4.1.2.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001070 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Palmitaldehyde
right: O-Phosphoethanolamine
spontaneous: false
EC number: 4.1.2.27
left: Sphinganine 1-phosphate
name: Sphinganine 1-phosphate → O-Phosphoethanolamine + Palmitaldehyde
conversion direction: LEFT_TO_RIGHT

Ceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ceramide (d18:1/18:0)

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphinganine 1-phosphate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Serine palmitoyltransferase 2
type: ProteinReference
xref: Reference/UniProt O15270
organism: Homo sapiens

Reference/CAS 629-80-1
type: UnificationXref
id: 629-80-1
db: CAS

Sphingosine-1-phosphate phosphatase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine-1-phosphate phosphatase 2

D-Glucose
type: SmallMolecule
cellular location: Lysosome
entity reference: D-Glucose

Compound/PW C001118 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sulfate
stoichiometric coefficient: 1.0

Reference/UniProt Q9UQ49
type: UnificationXref
id: Q9UQ49
db: UniProt

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/PubChem-compound 10260120
type: UnificationXref
id: 10260120
db: PubChem-compound

Adenosine 3',5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17985
xref: Reference/CAS 1053-73-2
xref: Reference/PubChem-compound 159296
xref: Reference/ChemSpider 140102
xref: Reference/BioCyc 3-5-ADP
xref: Reference/KEGG Compound C00054
xref: Reference/HMDB HMDB0000061
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000043

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

Reference/ChemSpider 4446678
type: UnificationXref
id: 4446678
db: ChemSpider

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Lysosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005764

Beta-galactosidase
type: Protein
cellular location: Cytosol
entity reference: Beta-galactosidase

Reference/ChemSpider 4446673
type: UnificationXref
id: 4446673
db: ChemSpider

Reference/UniProt Q16880
type: UnificationXref
id: Q16880
db: UniProt

Alkaline ceramidase 1
type: ProteinReference
xref: Reference/UniProt Q8TDN7
organism: Homo sapiens

Reference/UniProt Q9NUN7
type: UnificationXref
id: Q9NUN7
db: UniProt

Phosphatidylcholine:ceramide cholinephosphotransferase 1
type: ProteinReference
xref: Reference/UniProt Q86VZ5
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/PubChem-compound 439853
type: UnificationXref
id: 439853
db: PubChem-compound

Reference/ChEBI CHEBI 84759
type: UnificationXref
id: CHEBI:84759
db: ChEBI

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Ceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/ChemSpider 4446678
xref: Reference/KEGG Compound C00195
xref: Reference/CAS 104404-17-3
xref: Reference/PubChem-compound 5283565
xref: Reference/HMDB HMDB0004950
xref: Reference/BioCyc CERAMIDE
xref: Reference/ChEBI CHEBI 72961
chemical formula: C36H71NO3
molecular weight: 565.5434
structure: ChemicalStructure/PW C002313

Compound/PW C000193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucose
stoichiometric coefficient: 1.0

ChemicalStructure/PW C007187
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q6QHC5
type: UnificationXref
id: Q6QHC5
db: UniProt

Reference/PubChem-compound 5353955
type: UnificationXref
id: 5353955
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

PC(15:0/18:2(9Z,12Z))
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: PC(15:0/18:2(9Z,12Z))

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Sphingosine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sphingosine

Compound/PW C002313 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/BioCyc 3-5-ADP
type: UnificationXref
id: 3-5-ADP
db: BioCyc

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Compound/PW C001420 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-649
type: UnificationXref
id: CPD-649
db: BioCyc

Reference/ChEBI CHEBI 37550
type: UnificationXref
id: CHEBI:37550
db: ChEBI

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/CAS 1053-73-2
type: UnificationXref
id: 1053-73-2
db: CAS

Ceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Ceramide (d18:1/18:0)

Reference/HMDB HMDB0012314
type: UnificationXref
id: HMDB0012314
db: HMDB

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

Sphinganine 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Sphinganine 1-phosphate

Alkaline ceramidase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Alkaline ceramidase 1

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/ChemSpider 570889
type: UnificationXref
id: 570889
db: ChemSpider

Uridine diphosphate glucose
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCOSE
xref: Reference/KEGG Compound C00029
xref: Reference/PubChem-compound 53477679
xref: Reference/CAS 133-89-1
xref: Reference/HMDB HMDB0000286
chemical formula: C15H24N2O17P2
molecular weight: 566.055
structure: ChemicalStructure/PW C000193

Reference/BioCyc UDP-GLUCOSE
type: UnificationXref
id: UDP-GLUCOSE
db: BioCyc

ChemicalStructure/PW C002313
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C007846 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-O-Sulfogalactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/GENE ONTOLOGY GO 0005764
type: UnificationXref
id: GO:0005764
db: GENE ONTOLOGY

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

SM(d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/CAS 85187-10-6
xref: Reference/ChemSpider 4446701
xref: Reference/HMDB HMDB0001348
xref: Reference/BioCyc SPHINGO-MYELIN
xref: Reference/ChEBI CHEBI 17636
xref: Reference/KEGG Compound C00550
xref: Reference/PubChem-compound 5283588
chemical formula: C41H83N2O6P
molecular weight: 730.5989
structure: ChemicalStructure/PW C001040

Lactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: Lactosylceramide (d18:1/18:0)

Reference/HMDB HMDB0011591
type: UnificationXref
id: HMDB0011591
db: HMDB

Compound/PW C000184 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

Adenosine 3',5'-diphosphate
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Adenosine 3',5'-diphosphate

3-ketodihydrosphingosine reductase
type: ProteinReference
xref: Reference/UniProt Q06136
organism: Homo sapiens

Sphingosine kinase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sphingosine kinase 2

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 9799
type: UnificationXref
id: 9799
db: ChemSpider

Reference/BioCyc SPHINGOSINE
type: UnificationXref
id: SPHINGOSINE
db: BioCyc

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Alkaline ceramidase 3
type: Protein
cellular location: Cytosol
entity reference: Alkaline ceramidase 3

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Adenosine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000224
type: UnificationXref
id: HMDB0000224
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 159296
type: UnificationXref
id: 159296
db: PubChem-compound

Compound/PW C002334 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway166
pathway component: SubPathwayInteraction166
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

Reference/HMDB HMDB0001551
type: UnificationXref
id: HMDB0001551
db: HMDB

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C002905 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroceramide
stoichiometric coefficient: 1.0

Sphingosine kinase 2
type: ProteinReference
xref: Reference/UniProt Q9NRA0
organism: Homo sapiens

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

3-Dehydrosphinganine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439853
xref: Reference/ChEBI CHEBI 17862
xref: Reference/ChemSpider 388895
xref: Reference/KEGG Compound C02934
xref: Reference/HMDB HMDB0001480
xref: Reference/CAS 16105-69-4
xref: Reference/BioCyc DEHYDROSPHINGANINE
chemical formula: C18H37NO2
molecular weight: 299.28244
structure: ChemicalStructure/PW C001139

D-Galactose
type: SmallMolecule
cellular location: Lysosome
entity reference: D-Galactose

CerP(d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 73144
xref: Reference/PubChem-compound 5283583
xref: Reference/ChemSpider 4446696
xref: Reference/HMDB HMDB0010701
chemical formula: C36H72NO6P
molecular weight: 645.5097
structure: ChemicalStructure/PW C006709

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Reference/KEGG Compound C06124
type: UnificationXref
id: C06124
db: KEGG Compound

Ceramide kinase
type: Protein
cellular location: Cell Membrane
entity reference: Ceramide kinase

Reference/HMDB HMDB0001565
type: UnificationXref
id: HMDB0001565
db: HMDB

ChemicalStructure/PW C001202
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP(O)(O)=O

Reference/PubChem-compound 1117
type: UnificationXref
id: 1117
db: PubChem-compound

Sulfate
type: SmallMolecule
cellular location: Lysosome
entity reference: Sulfate

Reference/ChEBI CHEBI 84719
type: UnificationXref
id: CHEBI:84719
db: ChEBI

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001448
type: UnificationXref
id: HMDB0001448
db: HMDB

Reference/HMDB HMDB0004834
type: UnificationXref
id: HMDB0004834
db: HMDB

Reference/HMDB HMDB0004950
type: UnificationXref
id: HMDB0004950
db: HMDB

Compound/PW C002313 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Sphingosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5353955
xref: Reference/KEGG Compound C00319
xref: Reference/BioCyc SPHINGOSINE
xref: Reference/ChEBI CHEBI 16393
xref: Reference/CAS 123-78-4
xref: Reference/ChemSpider 4510275
xref: Reference/HMDB HMDB0000252
chemical formula: C18H37NO2
molecular weight: 299.28244
structure: ChemicalStructure/PW C000172

Reference/UniProt Q8TCT0
type: UnificationXref
id: Q8TCT0
db: UniProt

Reference/ChEBI CHEBI 15754
type: UnificationXref
id: CHEBI:15754
db: ChEBI

Galactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Lysosome
entity reference: Galactosylceramide (d18:1/18:0)

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
type: ProteinReference
xref: Reference/UniProt Q6UWV6
organism: Homo sapiens

Galactosylceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53480653
xref: Reference/ChemSpider 24765745
xref: Reference/KEGG Compound C02686
xref: Reference/HMDB HMDB0010709
chemical formula: C42H81NO8
molecular weight: 727.5962
structure: ChemicalStructure/PW C006717

Reference/KEGG Compound C06125
type: UnificationXref
id: C06125
db: KEGG Compound

Reference/ChEBI CHEBI 72961
type: UnificationXref
id: CHEBI:72961
db: ChEBI

Reference/KEGG Compound C06126
type: UnificationXref
id: C06126
db: KEGG Compound

Palmitoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Compound/PW C000188 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphingosine 1-phosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C003990
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

Sphingosine 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000277
xref: Reference/ChEBI CHEBI 37550
xref: Reference/KEGG Compound C06124
xref: Reference/PubChem-compound 5283560
xref: Reference/ChemSpider 4446673
xref: Reference/CAS 26993-30-6
chemical formula: C18H38NO5P
molecular weight: 379.24875
structure: ChemicalStructure/PW C000188

Reference/ChemSpider 4510275
type: UnificationXref
id: 4510275
db: ChemSpider

Sphinganine
type: SmallMoleculeReference
xref: Reference/CAS 764-22-7
xref: Reference/ChEBI CHEBI 16566
xref: Reference/HMDB HMDB0000269
xref: Reference/KEGG Compound C00836
xref: Reference/PubChem-compound 91486
xref: Reference/ChemSpider 82609
chemical formula: C18H39NO2
molecular weight: 301.29807
structure: ChemicalStructure/PW C000184

Reference/ChEBI CHEBI 17985
type: UnificationXref
id: CHEBI:17985
db: ChEBI

ChemicalStructure/PW C104814
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17862
type: UnificationXref
id: CHEBI:17862
db: ChEBI

ChemicalStructure/PW C104815
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00836
type: UnificationXref
id: C00836
db: KEGG Compound

Reference/ChemSpider 10132611
type: UnificationXref
id: 10132611
db: ChemSpider

Beta-galactosidase
type: ProteinReference
xref: Reference/UniProt P16278
organism: Homo sapiens

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/ChemSpider 1085
type: UnificationXref
id: 1085
db: ChemSpider

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

2-hydroxyacylsphingosine 1-beta-galactosyltransferase
type: ProteinReference
xref: Reference/UniProt Q16880
organism: Homo sapiens

ChemicalStructure/PW C002905
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC=O

Reference/ChEBI CHEBI 16893
type: UnificationXref
id: CHEBI:16893
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Adenosine diphosphate

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/ChEBI CHEBI 17980
type: UnificationXref
id: CHEBI:17980
db: ChEBI

Reference/CAS 764-22-7
type: UnificationXref
id: 764-22-7
db: CAS

Reference/PubChem-compound 91486
type: UnificationXref
id: 91486
db: PubChem-compound

Compound/PW C104815 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galabiosylceramide sulfate (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

Reference/UniProt O15270
type: UnificationXref
id: O15270
db: UniProt

Reference/ChEBI CHEBI 17636
type: UnificationXref
id: CHEBI:17636
db: ChEBI

Reference/ChemSpider 82609
type: UnificationXref
id: 82609
db: ChemSpider

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Golgi Apparatus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005794

ReactionCatalysis898
type: Catalysis
controller: Sphingosine kinase 2
controlled: 2.7.1.91
control type: ACTIVATION

Reference/CAS 123-78-4
type: UnificationXref
id: 123-78-4
db: CAS

Reference/GENE ONTOLOGY GO 0005794
type: UnificationXref
id: GO:0005794
db: GENE ONTOLOGY

ReactionCatalysis899
type: Catalysis
controller: Sphingosine-1-phosphate phosphatase 2
controlled: 3.1.3.-
control type: ACTIVATION

ReactionCatalysis897
type: Catalysis
controller: Sphingosine-1-phosphate lyase 1
controlled: 4.1.2.27
control type: ACTIVATION

Reference/ChEBI CHEBI 17600
type: UnificationXref
id: CHEBI:17600
db: ChEBI

Reference/BioCyc NH42SO4
type: UnificationXref
id: NH42SO4
db: BioCyc

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/BioCyc GALACTOSE
type: UnificationXref
id: GALACTOSE
db: BioCyc

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/PathWhiz PW000202
type: UnificationXref
id: PW000202
db: PathWhiz

Serine palmitoyltransferase 1
type: Complex
component stoichiometry: Protein/829 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/831 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Serine palmitoyltransferase 2
component: Serine palmitoyltransferase 1

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Compound/PW C002334 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Compound/PW C007187 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

D-Galactose
type: SmallMoleculeReference
xref: Reference/BioCyc GALACTOSE
xref: Reference/PubChem-compound 439357
xref: Reference/CAS 59-23-4
xref: Reference/ChEBI CHEBI 28061
xref: Reference/ChemSpider 388480
xref: Reference/KEGG Compound C00984
xref: Reference/HMDB HMDB0000143
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000093

Reference/UniProt O15269
type: UnificationXref
id: O15269
db: UniProt

3-O-Sulfogalactosylceramide (d18:1/18:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012314
xref: Reference/BioCyc GALACTOSYLCERAMIDE-SULFATE
xref: Reference/ChemSpider 4696849
xref: Reference/CAS 244215-65-4
xref: Reference/KEGG Compound C06125
xref: Reference/PubChem-compound 5771775
chemical formula: C42H81NO11S
molecular weight: 807.55304
structure: ChemicalStructure/PW C007846

3-O-Sulfogalactosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: 3-O-Sulfogalactosylceramide (d18:1/18:0)

Reference/BioCyc GALACTOSYLCERAMIDE-SULFATE
type: UnificationXref
id: GALACTOSYLCERAMIDE-SULFATE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/UniProt Q8IWX5
type: UnificationXref
id: Q8IWX5
db: UniProt

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

O-Phosphoethanolamine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: O-Phosphoethanolamine

Water
type: SmallMolecule
cellular location: Lysosome
entity reference: Water

Reference/UniProt Q9NRA0
type: UnificationXref
id: Q9NRA0
db: UniProt

Reference/CAS 85187-10-6
type: UnificationXref
id: 85187-10-6
db: CAS

Reference/ChemSpider 4446701
type: UnificationXref
id: 4446701
db: ChemSpider

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/KEGG Compound C00984
type: UnificationXref
id: C00984
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C002210 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galabiosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/ChemSpider 16744851
type: UnificationXref
id: 16744851
db: ChemSpider

Globoid Cell Leukodystrophy
type: Pathway
pathway order: PathwayEnzymeReaction/1191
pathway order: PathwayEnzymeReaction/1196
pathway order: PathwayEnzymeReaction/1151
pathway order: PathwayEnzymeReaction/1173
pathway order: PathwayEnzymeReaction/1194
pathway order: PathwayEnzymeReaction/1171
pathway order: PathwayEnzymeReaction/1193
pathway order: PathwayEnzymeReaction/1134
pathway order: PathwayEnzymeReaction/3151
pathway order: PathwayEnzymeReaction/1133
pathway order: PathwayEnzymeReaction/1132
pathway order: PathwayEnzymeReaction/1176
pathway order: PathwayEnzymeReaction/1198
pathway order: PathwayEnzymeReaction/1175
pathway order: PathwayEnzymeReaction/1197
pathway order: PathwayEnzymeReaction/1201
pathway order: PathwayEnzymeReaction/3149
pathway order: PathwayEnzymeReaction/2125749
pathway order: PathwaySubPathway/166
pathway order: PathwayEnzymeReaction/1163
pathway order: PathwayEnzymeReaction/1167
pathway order: PathwayEnzymeReaction/1189
pathway order: PathwayEnzymeReaction/1166
pathway order: PathwayEnzymeReaction/1165
pathway order: PathwayEnzymeReaction/1164
pathway order: PathwayEnzymeReaction/1136
pathway order: PathwayEnzymeReaction/2125751
pathway order: PathwayEnzymeReaction/1135
pathway order: PathwayEnzymeReaction/2125752
pathway order: PathwayEnzymeReaction/211576
pathway component: 2.7.1.91
pathway component: ReactionCatalysis872
pathway component: ReactionCatalysis873
pathway component: 3.2.1.23
pathway component: 2.8.2.11
pathway component: ReactionCatalysis908
pathway component: ReactionCatalysis909
pathway component: ReactionCatalysis907
pathway component: 3.1.3.-
pathway component: ReactionCatalysis904
pathway component: 3.1.3.4
pathway component: ReactionCatalysis905
pathway component: ReactionCatalysis869
pathway component: 4.1.2.27
pathway component: ReactionCatalysis902
pathway component: 2.4.1.80
pathway component: ReactionCatalysis903
pathway component: ReactionCatalysis900
pathway component: ReactionCatalysis868
pathway component: ReactionCatalysis901
pathway component: 3.2.1.45
pathway component: 3.2.1.46
pathway component: 3.1.4.12
pathway component: 2.4.1.45
pathway component: 1.1.1.102
pathway component: ReactionCatalysis898
pathway component: ReactionCatalysis899
pathway component: 2.7.8.27
pathway component: ReactionCatalysis932
pathway component: Glycine and Serine Metabolism
pathway component: 2.3.1.50
pathway component: ReactionCatalysis897
pathway component: ReactionCatalysis930
pathway component: ReactionCatalysis890
pathway component: 3.5.1.-
pathway component: 2.7.1.138
pathway component: 3.5.1.23
pathway component: ReactionCatalysis926
pathway component: ReactionCatalysis927
pathway component: ReactionCatalysis925
pathway component: ReactionCatalysis922
pathway component: ReactionCatalysis923
pathway component: ReactionCatalysis920

Sphinganine 1-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644260
xref: Reference/ChemSpider 559277
xref: Reference/KEGG Compound C01120
xref: Reference/HMDB HMDB0001383
xref: Reference/CAS 19794-97-9
xref: Reference/ChEBI CHEBI 16893
xref: Reference/BioCyc CPD-649
chemical formula: C18H40NO5P
molecular weight: 381.2644
structure: ChemicalStructure/PW C001070

Palmitaldehyde
type: SmallMoleculeReference
xref: Reference/PubChem-compound 984
xref: Reference/ChEBI CHEBI 17600
xref: Reference/KEGG Compound C00517
xref: Reference/ChemSpider 959
xref: Reference/HMDB HMDB0001551
xref: Reference/CAS 629-80-1
xref: Reference/BioCyc PALMITALDEHYDE
chemical formula: C16H32O
molecular weight: 240.24532
structure: ChemicalStructure/PW C001193

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Palmitaldehyde
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Palmitaldehyde

Reference/ChemSpider 8435601
type: UnificationXref
id: 8435601
db: ChemSpider

Reference/KEGG Compound C02934
type: UnificationXref
id: C02934
db: KEGG Compound

Reference/KEGG Compound C00517
type: UnificationXref
id: C00517
db: KEGG Compound

Reference/ChemSpider 24765745
type: UnificationXref
id: 24765745
db: ChemSpider

3.2.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002334 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007187 Cytosol/Stoichiometry/1.0
right: Glucosylceramide (d18:1/18:0)
spontaneous: false
EC number: 3.2.1.23
left: Lactosylceramide (d18:1/18:0)
name: Lactosylceramide (d18:1/18:0) → Glucosylceramide (d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

2.8.2.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002210 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000886 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104815 Golgi Apparatus/Stoichiometry/1.0
right: Adenosine 3',5'-diphosphate
right: Galabiosylceramide sulfate (d18:1/18:0)
spontaneous: false
EC number: 2.8.2.11
left: Galabiosylceramide (d18:1/18:0)
left: Phosphoadenosine phosphosulfate
name: Galabiosylceramide (d18:1/18:0) + Phosphoadenosine phosphosulfate → Adenosine 3',5'-diphosphate + Galabiosylceramide sulfate (d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000886
type: ChemicalStructure
structure format: SMILES

Reference/CAS 26993-30-6
type: UnificationXref
id: 26993-30-6
db: CAS

Reference/BioCyc PAPS
type: UnificationXref
id: PAPS
db: BioCyc

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Sphingosine-1-phosphate phosphatase 2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Sphingosine-1-phosphate phosphatase 2

Compound/PW C000149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoethanolamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439357
type: UnificationXref
id: 439357
db: PubChem-compound

2.4.1.80
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000193 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002334 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Glucosylceramide (d18:1/18:0)
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 2.4.1.80
left: Ceramide (d18:1/18:0)
left: Uridine diphosphate glucose
name: Ceramide (d18:1/18:0) + Uridine diphosphate glucose → Glucosylceramide (d18:1/18:0) + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

3.2.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002334 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/1.0
right: D-Glucose
right: Ceramide (d18:1/18:0)
spontaneous: false
EC number: 3.2.1.45
left: Water
left: Glucosylceramide (d18:1/18:0)
name: Glucosylceramide (d18:1/18:0) + Water → Ceramide (d18:1/18:0) + D-Glucose
conversion direction: LEFT_TO_RIGHT

L-Serine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Serine

Compound/PW C002313 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Glucosylceramidase
type: Protein
cellular location: Lysosome
entity reference: Glucosylceramidase

2-hydroxyacylsphingosine 1-beta-galactosyltransferase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Sphingosine-1-phosphate phosphatase 2
type: ProteinReference
xref: Reference/UniProt Q8IWX5
organism: Homo sapiens

3-Dehydrosphinganine
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Dehydrosphinganine

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

CerP(d18:1/18:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: CerP(d18:1/18:0)

Reference/ChEBI CHEBI 17553
type: UnificationXref
id: CHEBI:17553
db: ChEBI

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Glucosylceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucosylceramide (d18:1/18:0)

3.2.1.46
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002313 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006717 Lysosome/Stoichiometry/1.0
right: Ceramide (d18:1/18:0)
spontaneous: false
EC number: 3.2.1.46
left: Galactosylceramide (d18:1/18:0)
name: Galactosylceramide (d18:1/18:0) → Ceramide (d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

3.1.4.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002313 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001040 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Golgi Apparatus/Stoichiometry/1.0
right: Ceramide (d18:1/18:0)
right: Phosphorylcholine
spontaneous: false
EC number: 3.1.4.12
left: SM(d18:1/18:0)
left: Water
name: SM(d18:1/18:0) + Water → Ceramide (d18:1/18:0) + Phosphorylcholine
conversion direction: LEFT_TO_RIGHT

2.4.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002313 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006717 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Galactosylceramide (d18:1/18:0)
spontaneous: false
EC number: 2.4.1.45
left: Ceramide (d18:1/18:0)
name: Ceramide (d18:1/18:0) → Galactosylceramide (d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

N-Acetylneuraminyl-galactosylceramide (d18:1/18:0)
type: SmallMoleculeReference
chemical formula: C53H98N2O16
molecular weight: 1018.69165
structure: ChemicalStructure/PW C104814

2.7.8.27
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002313 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002928 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001040 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003990 Golgi Apparatus/Stoichiometry/1.0
right: Galactosylglycerol
right: SM(d18:1/18:0)
spontaneous: false
EC number: 2.7.8.27
left: Ceramide (d18:1/18:0)
left: PC(15:0/18:2(9Z,12Z))
name: Ceramide (d18:1/18:0) + PC(15:0/18:2(9Z,12Z)) → Galactosylglycerol + SM(d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

Ceramide (d18:1/18:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Ceramide (d18:1/18:0)

Galabiosylceramide sulfate (d18:1/18:0)
type: SmallMoleculeReference
chemical formula: C48H91NO16S
molecular weight: 969.60583
structure: ChemicalStructure/PW C104815

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006709 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: Ceramide (d18:1/18:0)
spontaneous: false
EC number: 3.1.3.4
left: CerP(d18:1/18:0)
left: Water
name: CerP(d18:1/18:0) + Water → Ceramide (d18:1/18:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000184 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine
stoichiometric coefficient: 1.0

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006709 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002313 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: CerP(d18:1/18:0)
spontaneous: false
EC number: 3.1.3.-
left: Ceramide (d18:1/18:0)
name: Ceramide (d18:1/18:0) → CerP(d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

Galactosylceramide sulfotransferase
type: Protein
cellular location: Golgi Apparatus
entity reference: Galactosylceramide sulfotransferase

Reference/ChemSpider 24766615
type: UnificationXref
id: 24766615
db: ChemSpider

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/SMPDB SMP0000348
type: UnificationXref
id: SMP0000348
db: SMPDB

ChemicalStructure/PW C002928
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 53480653
type: UnificationXref
id: 53480653
db: PubChem-compound

Uridine diphosphate glucose
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Uridine diphosphate glucose

Reference/UniProt O14494
type: UnificationXref
id: O14494
db: UniProt

Reference/UniProt Q8TDN7
type: UnificationXref
id: Q8TDN7
db: UniProt

Compound/PW C006717 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactosylceramide (d18:1/18:0)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

Compound/PW C002928 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactosylglycerol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/ChEBI CHEBI 16566
type: UnificationXref
id: CHEBI:16566
db: ChEBI

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Compound/PW C006709 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: CerP(d18:1/18:0)
stoichiometric coefficient: 1.0

Compound/PW C000043 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine 3',5'-diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/UniProt P06280
type: UnificationXref
id: P06280
db: UniProt

ReactionCatalysis170269
type: Catalysis
controller: Galactosylceramide sulfotransferase
controlled: 2.8.2.11
control type: ACTIVATION

Compound/PW C001070 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sphinganine 1-phosphate
stoichiometric coefficient: 1.0

Reaction1221
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000193 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002334 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007187 Golgi Apparatus/Stoichiometry/1.0
right: Uridine diphosphate glucose
right: Glucosylceramide (d18:1/18:0)
spontaneous: false
left: Uridine 5'-diphosphate
left: Lactosylceramide (d18:1/18:0)
name: Lactosylceramide (d18:1/18:0) + Uridine 5'-diphosphate ← Glucosylceramide (d18:1/18:0) + Uridine diphosphate glucose
conversion direction: RIGHT_TO_LEFT

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Dihydroceramide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Dihydroceramide

Reference/CAS 85305-87-9
type: UnificationXref
id: 85305-87-9
db: CAS

Reference/UniProt Q16739
type: UnificationXref
id: Q16739
db: UniProt

3.2.1.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104814 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006717 Endoplasmic Reticulum/Stoichiometry/1.0
right: N-Acetylneuraminyl-galactosylceramide (d18:1/18:0)
spontaneous: false
EC number: 3.2.1.18
left: Galactosylceramide (d18:1/18:0)
name: Galactosylceramide (d18:1/18:0) → N-Acetylneuraminyl-galactosylceramide (d18:1/18:0)
conversion direction: LEFT_TO_RIGHT

3.2.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000093 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006717 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002210 Lysosome/Stoichiometry/1.0
right: Galabiosylceramide (d18:1/18:0)
spontaneous: false
EC number: 3.2.1.22
left: Galactosylceramide (d18:1/18:0)
left: D-Galactose
name: D-Galactose + Galactosylceramide (d18:1/18:0) ← Galabiosylceramide (d18:1/18:0)
conversion direction: RIGHT_TO_LEFT

Reference/CAS 77538-38-6
type: UnificationXref
id: 77538-38-6
db: CAS

2.8.2.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000886 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007846 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000043 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006717 Golgi Apparatus/Stoichiometry/1.0
right: 3-O-Sulfogalactosylceramide (d18:1/18:0)
right: Adenosine 3',5'-diphosphate
spontaneous: false
EC number: 2.8.2.11
left: Phosphoadenosine phosphosulfate
left: Galactosylceramide (d18:1/18:0)
name: Galactosylceramide (d18:1/18:0) + Phosphoadenosine phosphosulfate → 3-O-Sulfogalactosylceramide (d18:1/18:0) + Adenosine 3',5'-diphosphate
conversion direction: LEFT_TO_RIGHT

3.1.6.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007846 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001118 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006717 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/1.0
right: Galactosylceramide (d18:1/18:0)
right: Sulfate
spontaneous: false
EC number: 3.1.6.8
left: Water
left: 3-O-Sulfogalactosylceramide (d18:1/18:0)
name: 3-O-Sulfogalactosylceramide (d18:1/18:0) + Water → Galactosylceramide (d18:1/18:0) + Sulfate
conversion direction: LEFT_TO_RIGHT