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Pathway Description
Pirenzepine Action Pathway
Homo sapiens
Drug Action Pathway
Pirenzepine (also known as Gastrozepin) is a selective antagonist (antimuscarinic) that will inhibit the muscarinic acetylcholine receptor M3 inside the stomach. Binding of pirenzepine on the receptor will decrease the level of exertion of gastric acid secretion, and also it can reduce muscle spasms. Therefore, pirenzipine can be used for treating peptic ulcers, prevent motion sickness, vomiting and nausea.
References
Pirenzepine Pathway References
Bertaccini G, Coruzzi G: Control of gastric acid secretion by histamine H2 receptor antagonists and anticholinergics. Pharmacol Res. 1989 Jul-Aug;21(4):339-52.
Pubmed: 2570417
Shamburek RD, Schubert ML: Pharmacology of gastric acid inhibition. Baillieres Clin Gastroenterol. 1993 Mar;7(1):23-54.
Pubmed: 8097411
Gastric Acid Production References
Wolfe MM, Soll AH: The physiology of gastric acid secretion. N Engl J Med. 1988 Dec 29;319(26):1707-15. doi: 10.1056/NEJM198812293192605.
Pubmed: 3060722
Schubert ML: Gastric acid secretion. Curr Opin Gastroenterol. 2016 Nov;32(6):452-460. doi: 10.1097/MOG.0000000000000308.
Pubmed: 27607343
Schubert ML: Functional anatomy and physiology of gastric secretion. Curr Opin Gastroenterol. 2015 Nov;31(6):479-85. doi: 10.1097/MOG.0000000000000213.
Pubmed: 26376477
Heitzmann D, Warth R: No potassium, no acid: K+ channels and gastric acid secretion. Physiology (Bethesda). 2007 Oct;22:335-41. doi: 10.1152/physiol.00016.2007.
Pubmed: 17928547
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