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Pathway Description
Roxithromycin Action Pathway
Homo sapiens
Drug Action Pathway
A member of the semi-synthetic macrolide class of antibiotics, roxithromycin is employed in infections of the respiratory tract, urinary, and soft tissue infections. Its macrocyclic lactone ring and deoxy sugars, defining features of macrolide antibiotics, mediates its mechanism of action as it inhibits peptide translocation by binding to the 50S subunit of the bacterial ribosome. Protein synthesis is thus inhibited by ribosomal binding. It has been demonstrated to have a longer half-life compared to other macrolide antibiotics such as erythromycin and is effective against certain Gram-negative bacteria.
References
Roxithromycin Pathway References
Bertho G, Gharbi-Benarous J, Delaforge M, Girault JP: Transferred nuclear Overhauser effect study of macrolide-ribosome interactions: correlation between antibiotic activities and bound conformations. Bioorg Med Chem. 1998 Feb;6(2):209-21.
Pubmed: 9547944
Fournet MP, Barre J, Zini R, Deforges L, Duval J, Tillement JP: Binding parameters and microbiological activity of macrolides, lincosamides and streptogramins against Staphylococcus aureus. J Pharm Pharmacol. 1987 Apr;39(4):319-22.
Pubmed: 2884302
Gentry LO: Roxithromycin, a new macrolide antibiotic, in the treatment of infections in the lower respiratory tract: an overview. J Antimicrob Chemother. 1987 Nov;20 Suppl B:145-52. doi: 10.1093/jac/20.suppl_b.145.
Pubmed: 3323166
Song, K.S. Ribosomal protein synthesis inhibitors. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p. 827-833. Berlin, Germany: Springer.
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
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