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Pathway Description
Carvedilol Action Pathway
Homo sapiens
Drug Action Pathway
Carvedilol, trade name Coreg, is a nonselective beta-blocker that blocks both alpha and beta receptors of the heart and blood vessels. It is prescribed to treat hypertension, stable angina pectoris and congestive heart failure. Carvedilol also blocks calcium channels. Its activity decreases heart rate, myocardial contractility and oxygen demand and decreases vascular resistance. It also posses a unique feature for a beta-blocker, it has an anti-free-radical effect. This effect may prevent free radical damage to treat chronic heart failure.
References
Carvedilol Pathway References
Borchard, U. Pharmacological properties of beta-adrenoceptor blocking drugs. Journal of Clinical and Basic Cardiology. 1998;1(1):5-9.
Carvedilol. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved July 25, 2009.
DiPiro, J.T., Talbert, R.L., Yee, G.C., Matzke, G.R., Wells, B.G, & Posey, M.L. Pharmacotherapy: A pathologic approach. (6th ed) (2005) p.207-208. New York: McGraw-Hill Medical Publishing Division.
Li T, Ke W, Sun P, Chen X, Belgaumkar A, Huang Y, Xian W, Li J, Zheng Q: Carvedilol for portal hypertension in cirrhosis: systematic review with meta-analysis. BMJ Open. 2016 May 4;6(5):e010902. doi: 10.1136/bmjopen-2015-010902.
Pubmed: 27147389
Konyi A: [Carvedilol in the everyday interventional cardiology practice]. Orv Hetil. 2017 Sep;158(37):1453-1457. doi: 10.1556/650.2017.30812.
Pubmed: 28891709
Beattie K, Phadke G, Novakovic J: Carvedilol. Profiles Drug Subst Excip Relat Methodol. 2013;38:113-57. doi: 10.1016/B978-0-12-407691-4.00004-6.
Pubmed: 23668404
Striated Muscle Contraction References
Cooke R: The sliding filament model: 1972-2004. J Gen Physiol. 2004 Jun;123(6):643-56. doi: 10.1085/jgp.200409089.
Pubmed: 15173218
Szent-Gyorgyi A: The mechanism of muscle contraction. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3343-4.
Pubmed: 4610574
Kuo IY, Ehrlich BE: Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023.
Pubmed: 25646377
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