TransportCatalysis121
type: Catalysis
controller: Sodium channel
controlled: Transport153
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637
organism: BiologicalState73

TransportCatalysis120
type: Catalysis
controller: L type Calcium channel
controlled: Transport155
control type: ACTIVATION

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/4299/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel protein type 10 subunit alpha
stoichiometric coefficient: 1.0

Dibucaine Action Pathway
type: Pathway
pathway order: PathwaySubPathway/492
pathway order: PathwaySubPathway/493
pathway order: PathwaySubPathway/500
pathway order: PathwayTransport/1950
pathway order: PathwayEnzymeReaction/1953
pathway order: PathwayTransport/1961
pathway order: PathwayTransport/1960
pathway order: PathwayTransport/1954
pathway order: PathwayTransport/1945
pathway order: PathwayTransport/1956
pathway order: PathwayTransport/1955
pathway order: PathwayTransport/1947
pathway order: PathwayTransport/1958
pathway order: PathwaySubPathway/490
pathway order: PathwayTransport/1946
pathway order: PathwayTransport/1957
pathway order: PathwaySubPathway/491
pathway order: PathwayTransport/1949
pathway order: PathwayTransport/1948
pathway order: PathwayTransport/1959
pathway order: PathwayEnzymeReaction/211632
pathway component: Transport154
pathway component: TransportCatalysis121
pathway component: Transport153
pathway component: TransportCatalysis120
pathway component: Transport155
pathway component: SubPathwayControl500
pathway component: TransportCatalysis118
pathway component: ReactionCoupledTransportCatalysis14
pathway component: TransportCatalysis117
pathway component: TransportCatalysis116
pathway component: Transport158
pathway component: Transport157
pathway component: 3.4.21.94
pathway component: SubPathwayControl490
pathway component: Transport159
pathway component: SubPathwayControl491
pathway component: SubPathwayControl492
pathway component: SubPathwayControl493
pathway component: Transport161
pathway component: Transport160
pathway component: Transport163
pathway component: Transport162
pathway component: 3.6.3.9
pathway component: TransportCatalysis127
pathway component: TransportCatalysis126
pathway component: TransportCatalysis125
pathway component: ReactionCatalysis1410
pathway component: TransportCatalysis123
pathway component: TransportCatalysis122
xref: Reference/PathWhiz PW000402
xref: Reference/SMPDB SMP0000396
organism: Homo sapiens

Dopamine
type: SmallMolecule
entity reference: Dopamine

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Serotonin
type: SmallMolecule
entity reference: Serotonin

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

TransportCatalysis118
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport155
control type: ACTIVATION

Protein/5735/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pro-opiomelanocortin
stoichiometric coefficient: 1.0

TransportCatalysis117
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport154
control type: ACTIVATION

TransportCatalysis116
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport153
control type: ACTIVATION

ChemicalStructure/PW C009024
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P01203
type: UnificationXref
id: P01203
db: UniProt

Compound/PW C000178/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Sodium channel protein type 10 subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel protein type 10 subunit alpha

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

SubPathwayControl492
type: Interaction
name: SubPathway492Control
name: ActivatingSubPathwayControl
participant: Norepinephrine activation of Alpha-1A adrenergic receptor
participant: Alpha-1A adrenergic receptor
participant: Norepinephrine

SubPathwayControl493
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway493Control
participant: Dopamine activation of dopamine receptor
participant: Dopamine
participant: D(1A) dopamine receptor

Reference/UniProt P31645
type: UnificationXref
id: P31645
db: UniProt

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState73

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Pro-opiomelanocortin
type: Protein
entity reference: Pro-opiomelanocortin

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Neuronal acetylcholine receptor subunit beta-2
type: Protein
entity reference: Neuronal acetylcholine receptor subunit beta-2

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/KEGG Compound C07879
type: UnificationXref
id: C07879
db: KEGG Compound

Neuronal acetylcholine receptor subunit alpha-4
type: Protein
entity reference: Neuronal acetylcholine receptor subunit alpha-4

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5

Neuroendocrine convertase 2
type: Protein
entity reference: Neuroendocrine convertase 2

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt P21728
type: UnificationXref
id: P21728
db: UniProt

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

TransportCatalysis127
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport163
control type: ACTIVATION

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

TransportCatalysis126
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport160
control type: ACTIVATION

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

TransportCatalysis125
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport161
control type: ACTIVATION

TransportCatalysis123
type: Catalysis
controller: Glutamate receptor ionotropic
controlled: Transport155
control type: ACTIVATION

TransportCatalysis122
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport154
control type: ACTIVATION

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Sodium channel
type: Complex
component stoichiometry: Protein/4299/Stoichiometry/1.0
component stoichiometry: Protein/4288/Stoichiometry/1.0
component: Sodium channel protein type 10 subunit alpha
component: Sodium channel subunit beta-1

Protein/1515/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit zeta-1
stoichiometric coefficient: 1.0

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000178 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Nicotinic Acetylcholine Receptor
type: Complex
component stoichiometry: Protein/5733/Stoichiometry/2.0
component stoichiometry: Protein/5734/Stoichiometry/2.0
component: Neuronal acetylcholine receptor subunit beta-2
component: Neuronal acetylcholine receptor subunit alpha-4

Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Dopamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Dopamine
name: SubPathwayActivator

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

Sodium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q07699
organism: BiologicalState73

Sodium-dependent serotonin transporter
type: Protein
entity reference: Sodium-dependent serotonin transporter

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Sodium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sodium

Reference/ChemSpider 2917
type: UnificationXref
id: 2917
db: ChemSpider

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8
organism: BiologicalState73

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Beta-endorphin
type: ProteinReference
xref: Reference/UniProt P01203
organism: BiologicalState73

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 85-79-0
type: UnificationXref
id: 85-79-0
db: CAS

Sodium channel protein type 10 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9Y5Y9
organism: BiologicalState73

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic
type: Complex
component stoichiometry: Protein/1515/Stoichiometry/1.0
component stoichiometry: Protein/3065/Stoichiometry/1.0
component stoichiometry: Protein/1520/Stoichiometry/1.0
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit zeta-1

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Protein/5734/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit alpha-4
stoichiometric coefficient: 2.0

Norepinephrine
type: SmallMolecule
entity reference: Norepinephrine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Transport154
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Neuron, Cytoplasm to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport153
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Transport155
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Protein/5733/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit beta-2
stoichiometric coefficient: 2.0

Sodium channel
type: Complex
component stoichiometry: Protein/4288 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/4299 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Sodium channel subunit beta-1
component: Sodium channel protein type 10 subunit alpha
name: SubPathwayInhibition

Compound/PW C000458 Cell Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Protein/5703/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beta-endorphin
stoichiometric coefficient: 1.0

SubPathwayControl500
type: Interaction
name: SubPathway500Control
name: InhibitorySubPathwayControl
participant: Sodium channel
participant: Dibucaine
participant: Dibucaine inhibition of Sodium Channel

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710
organism: BiologicalState73

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Compound/PW C000457 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Reference/UniProt P17787
type: UnificationXref
id: P17787
db: UniProt

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

BiologicalState73
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Protein/3065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit 3A
stoichiometric coefficient: 1.0

Transport158
type: Transport
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport157
type: Transport
participant stoichiometry: Protein/5703 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/5703/Stoichiometry/1.0
right: Beta-endorphin
spontaneous: false
left: Beta-endorphin
name: Beta-endorphin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport159
type: Transport
participant stoichiometry: Compound/PW C000178 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Transport161
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
right: Sodium
spontaneous: false
left: Sodium
left: Norepinephrine
name: Norepinephrine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Transport160
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178/Stoichiometry/1.0
right: Serotonin
right: Sodium
spontaneous: false
left: Sodium
left: Serotonin
name: Serotonin (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709
organism: BiologicalState73

Transport163
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
right: Sodium
spontaneous: false
left: Sodium
left: Dopamine
name: Dopamine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Transport162
type: Transport
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Potassium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Potassium

ReactionCatalysis1410
type: Catalysis
controller: Neuroendocrine convertase 2
controlled: 3.4.21.94
control type: ACTIVATION

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/PathWhiz PW000402
type: UnificationXref
id: PW000402
db: PathWhiz

Protein/4288 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Neuroendocrine convertase 2
type: ProteinReference
xref: Reference/UniProt P16519
organism: BiologicalState73

Neuronal acetylcholine receptor subunit alpha-4
type: ProteinReference
xref: Reference/UniProt P43681

Pro-opiomelanocortin
type: ProteinReference
xref: Reference/UniProt P01189
organism: BiologicalState73

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

D(1A) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21728
organism: BiologicalState73

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P17787

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Sodium/potassium ATPase
type: Complex
cellular location: Cell Membrane
component: Sodium/potassium-transporting ATPase subunit alpha-3
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Norepinephrine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Norepinephrine
name: SubPathwayActivator

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Sodium-dependent serotonin transporter
type: ProteinReference
xref: Reference/UniProt P31645

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Dibucaine inhibition of Sodium Channel
type: Pathway
name: InhibitorySubPathway

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026
organism: BiologicalState73

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Serotonin
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Serotonin
name: SubPathwayActivator

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415
organism: BiologicalState73

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium
type: SmallMolecule
entity reference: Sodium

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Dibucaine
type: SmallMolecule
entity reference: Dibucaine
name: SubPathwayInhibitor

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/UniProt Q9Y5Y9
type: UnificationXref
id: Q9Y5Y9
db: UniProt

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0014668
type: UnificationXref
id: HMDB0014668
db: HMDB

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

5-hydroxytryptamine receptor 1A
type: Protein
cellular location: Cell Membrane
entity reference: 5-hydroxytryptamine receptor 1A
name: SubPathwayActivation

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

Reference/PubChem-compound 3025
type: UnificationXref
id: 3025
db: PubChem-compound

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Protein/4288/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
cellular location: Cell Membrane
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733
organism: BiologicalState73

Reference/UniProt P01189
type: UnificationXref
id: P01189
db: UniProt

Reference/ChEBI CHEBI 247956
type: UnificationXref
id: CHEBI:247956
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023
organism: BiologicalState73

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Beta-Endorphin activation of Mu-Type Receptor
type: Pathway
name: ActivatingSubPathway

Protein/5703 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beta-endorphin
stoichiometric coefficient: 1.0

Serotonin activate of 5-hydroxytryptamine receptor 1A
type: Pathway
name: ActivatingSubPathway

Norepinephrine activation of Alpha-1A adrenergic receptor
type: Pathway
name: ActivatingSubPathway

Alpha-1A adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayActivation

Dopamine activation of dopamine receptor
type: Pathway
name: ActivatingSubPathway

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

3.4.21.94
type: BiochemicalReaction
participant stoichiometry: Protein/5703/Stoichiometry/1.0
participant stoichiometry: Protein/5735/Stoichiometry/1.0
right: Beta-endorphin
spontaneous: false
EC number: 3.4.21.94
left: Pro-opiomelanocortin
name: Pro-opiomelanocortin → Beta-endorphin
conversion direction: LEFT_TO_RIGHT

Beta-endorphin
type: Protein
cellular location: Extracellular Space
entity reference: Beta-endorphin
name: SubPathwayActivator

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Compound/PW C000142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Mu-type opioid receptor
type: ProteinReference
xref: Reference/UniProt P35372
organism: BiologicalState73

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Reference/SMPDB SMP0000396
type: UnificationXref
id: SMP0000396
db: SMPDB

Compound/PW C000052/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586

Potassium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Potassium

5-hydroxytryptamine receptor 1A
type: ProteinReference
xref: Reference/UniProt P08908
organism: BiologicalState73

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt P43681
type: UnificationXref
id: P43681
db: UniProt

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

ReactionCoupledTransportCatalysis14
type: Catalysis
controller: Sodium/potassium ATPase
controlled: 3.6.3.9
control type: ACTIVATION

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/UniProt P35372
type: UnificationXref
id: P35372
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Sodium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Sodium

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879

Sodium channel subunit beta-1
type: Protein
entity reference: Sodium channel subunit beta-1

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

Protein/1520/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit epsilon-1
stoichiometric coefficient: 1.0

D(1A) dopamine receptor
type: Protein
cellular location: Cell Membrane
entity reference: D(1A) dopamine receptor
name: SubPathwayActivation

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Beta-endorphin
type: Protein
entity reference: Beta-endorphin

Reference/UniProt Q07699
type: UnificationXref
id: Q07699
db: UniProt

Reference/UniProt P16519
type: UnificationXref
id: P16519
db: UniProt

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

Sodium channel protein type 10 subunit alpha
type: Protein
entity reference: Sodium channel protein type 10 subunit alpha

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Dibucaine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014668
xref: Reference/ChEBI CHEBI 247956
xref: Reference/ChemSpider 2917
xref: Reference/KEGG Compound C07879
xref: Reference/CAS 85-79-0
xref: Reference/PubChem-compound 3025
chemical formula: C20H29N3O2
molecular weight: 343.22598
structure: ChemicalStructure/PW C009024

SubPathwayControl490
type: Interaction
name: SubPathway490Control
name: ActivatingSubPathwayControl
participant: Beta-Endorphin activation of Mu-Type Receptor
participant: Beta-endorphin
participant: Mu-type opioid receptor

SubPathwayControl491
type: Interaction
name: SubPathway491Control
name: ActivatingSubPathwayControl
participant: Serotonin activate of 5-hydroxytryptamine receptor 1A
participant: 5-hydroxytryptamine receptor 1A
participant: Serotonin

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993
organism: BiologicalState73

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Sodium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel subunit beta-1

Protein/4299 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel protein type 10 subunit alpha
stoichiometric coefficient: 1.0

Mu-type opioid receptor
type: Protein
cellular location: Cell Membrane
entity reference: Mu-type opioid receptor
name: SubPathwayActivation

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

3.6.3.9
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000457 Cell Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000458 Cell Membrane/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Sodium
right: Potassium
spontaneous: false
EC number: 3.6.3.9
left: Sodium
left: Adenosine triphosphate
left: Water
left: Potassium
name: Adenosine triphosphate + 2 Potassium + 3 Sodium + Water → Adenosine diphosphate + Phosphate + 2 Potassium + 3 Sodium
conversion direction: LEFT_TO_RIGHT

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P08908
type: UnificationXref
id: P08908
db: UniProt