Reference/SMPDB SMP0000408
type: UnificationXref
id: SMP0000408
db: SMPDB

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/4299/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel protein type 10 subunit alpha
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit gamma

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Protein/5735/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pro-opiomelanocortin
stoichiometric coefficient: 1.0

Compound/PW C000178/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

SubPathwayControl492
type: Interaction
name: SubPathway492Control
name: ActivatingSubPathwayControl
participant: Norepinephrine activation of Alpha-1A adrenergic receptor
participant: Alpha-1A adrenergic receptor
participant: Norepinephrine

SubPathwayControl493
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway493Control
participant: Dopamine activation of dopamine receptor
participant: Dopamine
participant: D(1A) dopamine receptor

Reference/UniProt P31645
type: UnificationXref
id: P31645
db: UniProt

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Pro-opiomelanocortin
type: Protein
entity reference: Pro-opiomelanocortin

Neuronal acetylcholine receptor subunit beta-2
type: Protein
entity reference: Neuronal acetylcholine receptor subunit beta-2

Neuronal acetylcholine receptor subunit alpha-4
type: Protein
entity reference: Neuronal acetylcholine receptor subunit alpha-4

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5
organism: BiologicalState73

Neuroendocrine convertase 2
type: Protein
entity reference: Neuroendocrine convertase 2

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C008862
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P21728
type: UnificationXref
id: P21728
db: UniProt

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Compound/PW C008862/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methadone
stoichiometric coefficient: 1.0

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Sodium channel
type: Complex
component stoichiometry: Protein/4299/Stoichiometry/1.0
component stoichiometry: Protein/4288/Stoichiometry/1.0
component: Sodium channel protein type 10 subunit alpha
component: Sodium channel subunit beta-1

Protein/1515/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit zeta-1
stoichiometric coefficient: 1.0

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Nicotinic Acetylcholine Receptor
type: Complex
component stoichiometry: Protein/5733/Stoichiometry/2.0
component stoichiometry: Protein/5734/Stoichiometry/2.0
component: Neuronal acetylcholine receptor subunit beta-2
component: Neuronal acetylcholine receptor subunit alpha-4

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Sodium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q07699

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Sodium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Sodium

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/PubChem-compound 4095
type: UnificationXref
id: 4095
db: PubChem-compound

Protein/1520 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit epsilon-1
stoichiometric coefficient: 1.0

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Protein/1515 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit zeta-1
stoichiometric coefficient: 1.0

Sodium channel protein type 10 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9Y5Y9

Glutamate receptor ionotropic
type: Complex
component stoichiometry: Protein/1515/Stoichiometry/1.0
component stoichiometry: Protein/3065/Stoichiometry/1.0
component stoichiometry: Protein/1520/Stoichiometry/1.0
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit zeta-1

Protein/5734/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit alpha-4
stoichiometric coefficient: 2.0

Transport154
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Neuron, Cytoplasm to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport153
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/BioCyc FORMALDEHYDE
type: UnificationXref
id: FORMALDEHYDE
db: BioCyc

Transport155
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport271
type: Transport
participant stoichiometry: Compound/PW C008862 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008862 Extracellular Space/Stoichiometry/1.0
right: Methadone
spontaneous: false
left: Methadone
name: Methadone (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Protein/5733/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit beta-2
stoichiometric coefficient: 2.0

Protein/5703/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beta-endorphin
stoichiometric coefficient: 1.0

Compound/PW C008862 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methadone
stoichiometric coefficient: 1.0

Compound/PW C000457 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Reference/UniProt P17787
type: UnificationXref
id: P17787
db: UniProt

Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

BiologicalState73
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Transport158
type: Transport
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport157
type: Transport
participant stoichiometry: Protein/5703 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/5703/Stoichiometry/1.0
right: Beta-endorphin
spontaneous: false
left: Beta-endorphin
name: Beta-endorphin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport159
type: Transport
participant stoichiometry: Compound/PW C000178 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178/Stoichiometry/1.0
right: Serotonin
spontaneous: false
left: Serotonin
name: Serotonin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Transport161
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
right: Sodium
spontaneous: false
left: Sodium
left: Norepinephrine
name: Norepinephrine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Transport160
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000178/Stoichiometry/1.0
right: Serotonin
right: Sodium
spontaneous: false
left: Sodium
left: Serotonin
name: Serotonin (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Transport163
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
right: Sodium
spontaneous: false
left: Sodium
left: Dopamine
name: Dopamine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Transport162
type: Transport
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Potassium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Potassium

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Sodium/potassium ATPase
type: Complex
cellular location: Cell Membrane
component: Sodium/potassium-transporting ATPase subunit alpha-3
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Sodium-dependent serotonin transporter
type: ProteinReference
xref: Reference/UniProt P31645

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Reference/HMDB HMDB0060672
type: UnificationXref
id: HMDB0060672
db: HMDB

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

BiologicalState29
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Sodium
type: SmallMolecule
entity reference: Sodium

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Reference/HMDB HMDB0000259
type: UnificationXref
id: HMDB0000259
db: HMDB

ChemicalStructure/PW C000178
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=C(O)C=C2

Reference/ChemSpider 8285690
type: UnificationXref
id: 8285690
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/UniProt Q9Y5Y9
type: UnificationXref
id: Q9Y5Y9
db: UniProt

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

5-hydroxytryptamine receptor 1A
type: Protein
cellular location: Cell Membrane
entity reference: 5-hydroxytryptamine receptor 1A
name: SubPathwayActivation

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Methadone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Methadone

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Compound/PW C008862 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methadone
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis1616
type: Catalysis
controller: Cytochrome P450 3A4
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis1615
type: Catalysis
controller: Cytochrome P450 2D6
controlled: 1.14.13.-
control type: ACTIVATION

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

ChemicalStructure/PW C040521
type: ChemicalStructure
structure format: SMILES
structure data: CCC1=[N+](C)C(C)CC1(C1=CC=CC=C1)C1=CC=CC=C1

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Reference/UniProt P01189
type: UnificationXref
id: P01189
db: UniProt

ChemicalStructure/PW C040522
type: ChemicalStructure
structure format: SMILES
structure data: CCC1=NC(C)CC1(C1=CC=CC=C1)C1=CC=CC=C1

ReactionCatalysis1618
type: Catalysis
controller: Cytochrome P450 2C19
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis1617
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis1619
type: Catalysis
controller: Cytochrome P450 2C8
controlled: 1.14.13.-
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

ReactionCatalysis1620
type: Catalysis
controller: Cytochrome P450 3A7
controlled: 1.14.13.-
control type: ACTIVATION

Reference/CAS 76-99-3
type: UnificationXref
id: 76-99-3
db: CAS

Beta-Endorphin activation of Mu-Type Receptor
type: Pathway
name: ActivatingSubPathway

Serotonin activate of 5-hydroxytryptamine receptor 1A
type: Pathway
name: ActivatingSubPathway

ReactionCatalysis1624
type: Catalysis
controller: Cytochrome P450 3A7
controlled: 1.14.14.1
control type: ACTIVATION

Norepinephrine activation of Alpha-1A adrenergic receptor
type: Pathway
name: ActivatingSubPathway

Alpha-1A adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Alpha-1A adrenergic receptor
name: SubPathwayActivation

Dopamine activation of dopamine receptor
type: Pathway
name: ActivatingSubPathway

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Beta-endorphin
type: Protein
cellular location: Extracellular Space
entity reference: Beta-endorphin
name: SubPathwayActivator

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Reference/ChemSpider 3953
type: UnificationXref
id: 3953
db: ChemSpider

Reference/KEGG Compound C00067
type: UnificationXref
id: C00067
db: KEGG Compound

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Compound/PW C040521 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
stoichiometric coefficient: 1.0

Reference/UniProt P20813
type: UnificationXref
id: P20813
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C16660
type: UnificationXref
id: C16660
db: KEGG Compound

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586
organism: BiologicalState73

5-hydroxytryptamine receptor 1A
type: ProteinReference
xref: Reference/UniProt P08908
organism: BiologicalState73

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Compound/PW C040521/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic
type: Complex
component stoichiometry: Protein/1520 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1515 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3065 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit zeta-1
component: Glutamate [NMDA] receptor subunit epsilon-1
name: SubPathwayInhibition

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/UniProt P35372
type: UnificationXref
id: P35372
db: UniProt

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 712
type: UnificationXref
id: 712
db: PubChem-compound

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879
organism: BiologicalState73

Sodium channel subunit beta-1
type: Protein
entity reference: Sodium channel subunit beta-1

Cytochrome P450 3A4
type: Protein
entity reference: Cytochrome P450 3A4

Reference/HMDB HMDB0014477
type: UnificationXref
id: HMDB0014477
db: HMDB

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8

Reference/UniProt Q07699
type: UnificationXref
id: Q07699
db: UniProt

Reference/UniProt P16519
type: UnificationXref
id: P16519
db: UniProt

Reference/PubChem-compound 10110164
type: UnificationXref
id: 10110164
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Sodium channel protein type 10 subunit alpha
type: Protein
entity reference: Sodium channel protein type 10 subunit alpha

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

SubPathwayControl490
type: Interaction
name: SubPathway490Control
name: ActivatingSubPathwayControl
participant: Beta-Endorphin activation of Mu-Type Receptor
participant: Beta-endorphin
participant: Mu-type opioid receptor

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

SubPathwayControl491
type: Interaction
name: SubPathway491Control
name: ActivatingSubPathwayControl
participant: Serotonin activate of 5-hydroxytryptamine receptor 1A
participant: 5-hydroxytryptamine receptor 1A
participant: Serotonin

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993
organism: BiologicalState73

Reference/CAS 50-00-0
type: UnificationXref
id: 50-00-0
db: CAS

3.6.3.9
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000457 Cell Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000458 Cell Membrane/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Sodium
right: Potassium
spontaneous: false
EC number: 3.6.3.9
left: Sodium
left: Adenosine triphosphate
left: Water
left: Potassium
name: Adenosine triphosphate + 2 Potassium + 3 Sodium + Water → Adenosine diphosphate + Phosphate + 2 Potassium + 3 Sodium
conversion direction: LEFT_TO_RIGHT

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt P08908
type: UnificationXref
id: P08908
db: UniProt

Cytochrome P450 2C19
type: Protein
entity reference: Cytochrome P450 2C19

Methadone inhibition of Glutamate receptor ionotropic
type: Pathway
name: InhibitorySubPathway

TransportCatalysis121
type: Catalysis
controller: Sodium channel
controlled: Transport153
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637
organism: BiologicalState73

Methadone activation of Mu-type opioid receptor
type: Pathway
name: ActivatingSubPathway

TransportCatalysis120
type: Catalysis
controller: L type Calcium channel
controlled: Transport155
control type: ACTIVATION

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Cytochrome P450 2D6
type: ProteinReference
xref: Reference/UniProt P10635
organism: BiologicalState29

Dopamine
type: SmallMolecule
entity reference: Dopamine

Serotonin
type: SmallMolecule
entity reference: Serotonin

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

TransportCatalysis118
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport155
control type: ACTIVATION

TransportCatalysis117
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport154
control type: ACTIVATION

TransportCatalysis116
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport153
control type: ACTIVATION

Reference/UniProt P01203
type: UnificationXref
id: P01203
db: UniProt

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Cytochrome P450 3A7
type: ProteinReference
xref: Reference/UniProt P24462
organism: BiologicalState29

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState73

Cytochrome P450 3A4
type: ProteinReference
xref: Reference/UniProt P08684
organism: BiologicalState29

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Cytochrome P450 2B6
type: ProteinReference
xref: Reference/UniProt P20813
organism: BiologicalState29

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Compound/PW C040522 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

TransportCatalysis127
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport163
control type: ACTIVATION

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

TransportCatalysis126
type: Catalysis
controller: Sodium-dependent serotonin transporter
controlled: Transport160
control type: ACTIVATION

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

TransportCatalysis125
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport161
control type: ACTIVATION

TransportCatalysis123
type: Catalysis
controller: Glutamate receptor ionotropic
controlled: Transport155
control type: ACTIVATION

Reference/UniProt P33261
type: UnificationXref
id: P33261
db: UniProt

TransportCatalysis122
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport154
control type: ACTIVATION

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008862/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040521/Stoichiometry/1.0
right: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
spontaneous: false
EC number: 1.14.13.-
left: Methadone
name: Methadone → 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
conversion direction: LEFT_TO_RIGHT

Compound/PW C000178 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

Reference/UniProt P24462
type: UnificationXref
id: P24462
db: UniProt

Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Dopamine
name: SubPathwayActivator

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

Methadone
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Methadone

Sodium-dependent serotonin transporter
type: Protein
entity reference: Sodium-dependent serotonin transporter

Cytochrome P450 2C8
type: ProteinReference
xref: Reference/UniProt P10632
organism: BiologicalState29

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Formaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16842
xref: Reference/BioCyc FORMALDEHYDE
xref: Reference/HMDB HMDB0001426
xref: Reference/PubChem-compound 712
xref: Reference/ChemSpider 692
xref: Reference/KEGG Compound C00067
xref: Reference/CAS 50-00-0
chemical formula: CH2O
molecular weight: 30.010565
structure: ChemicalStructure/PW C001102

Compound/PW C001102 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formaldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
type: SmallMolecule
entity reference: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8
organism: BiologicalState73

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/CAS 50-67-9
type: UnificationXref
id: 50-67-9
db: CAS

Beta-endorphin
type: ProteinReference
xref: Reference/UniProt P01203
organism: BiologicalState73

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Cytochrome P450 2C19
type: ProteinReference
xref: Reference/UniProt P33261
organism: BiologicalState29

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Norepinephrine
type: SmallMolecule
entity reference: Norepinephrine

Reference/HMDB HMDB0060931
type: UnificationXref
id: HMDB0060931
db: HMDB

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Cytochrome P450 3A7
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 3A7

Compound/PW C000458 Cell Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710
organism: BiologicalState73

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

ChemicalStructure/PW C001102
type: ChemicalStructure
structure format: SMILES
structure data: C=O

Reference/HMDB HMDB0001426
type: UnificationXref
id: HMDB0001426
db: HMDB

Reference/ChemSpider 692
type: UnificationXref
id: 692
db: ChemSpider

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/PathWhiz PW000414
type: UnificationXref
id: PW000414
db: PathWhiz

Protein/3065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit 3A
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADH

Glutamate [NMDA] receptor subunit 3A
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit 3A

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709
organism: BiologicalState73

Formaldehyde
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Formaldehyde

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040522 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001102 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040521 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Formaldehyde
right: NAD
right: 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
spontaneous: false
EC number: 1.14.14.1
left: NADH
left: Oxygen
left: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
name: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP) + NADH + Oxygen → 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline + Formaldehyde + NAD + Water
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1410
type: Catalysis
controller: Neuroendocrine convertase 2
controlled: 3.4.21.94
control type: ACTIVATION

Neuroendocrine convertase 2
type: ProteinReference
xref: Reference/UniProt P16519
organism: BiologicalState73

Neuronal acetylcholine receptor subunit alpha-4
type: ProteinReference
xref: Reference/UniProt P43681

Pro-opiomelanocortin
type: ProteinReference
xref: Reference/UniProt P01189
organism: BiologicalState73

D(1A) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21728
organism: BiologicalState73

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P17787

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Serotonin
type: SmallMoleculeReference
xref: Reference/CAS 50-67-9
xref: Reference/HMDB HMDB0000259
xref: Reference/ChemSpider 5013
xref: Reference/KEGG Compound C00780
xref: Reference/ChEBI CHEBI 28790
xref: Reference/PubChem-compound 5202
chemical formula: C10H12N2O
molecular weight: 176.09496
structure: ChemicalStructure/PW C000178

Norepinephrine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Norepinephrine
name: SubPathwayActivator

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/ChEBI CHEBI 16842
type: UnificationXref
id: CHEBI:16842
db: ChEBI

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

SubPathwayControl514
type: Interaction
name: SubPathway514Control
name: InhibitorySubPathwayControl
participant: Methadone inhibition of Glutamate receptor ionotropic
participant: Methadone
participant: Glutamate receptor ionotropic

SubPathwayControl515
type: Interaction
name: SubPathway515Control
name: ActivatingSubPathwayControl
participant: Methadone activation of Mu-type opioid receptor
participant: Methadone
participant: Mu-type opioid receptor

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Protein/3065 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit 3A
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026
organism: BiologicalState73

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Serotonin
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Serotonin
name: SubPathwayActivator

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415
organism: BiologicalState73

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

Reference/PubChem-compound 5202
type: UnificationXref
id: 5202
db: PubChem-compound

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

NAD
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NAD

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/PubChem-compound 9879368
type: UnificationXref
id: 9879368
db: PubChem-compound

Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Protein/4288/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel subunit beta-1
stoichiometric coefficient: 1.0

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
cellular location: Cell Membrane
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733
organism: BiologicalState73

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023
organism: BiologicalState73

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Protein/5703 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beta-endorphin
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

3.4.21.94
type: BiochemicalReaction
participant stoichiometry: Protein/5703/Stoichiometry/1.0
participant stoichiometry: Protein/5735/Stoichiometry/1.0
right: Beta-endorphin
spontaneous: false
EC number: 3.4.21.94
left: Pro-opiomelanocortin
name: Pro-opiomelanocortin → Beta-endorphin
conversion direction: LEFT_TO_RIGHT

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Compound/PW C000142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Mu-type opioid receptor
type: ProteinReference
xref: Reference/UniProt P35372
organism: BiologicalState73

Cytochrome P450 2D6
type: Protein
entity reference: Cytochrome P450 2D6

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Reference/ChEBI CHEBI 6807
type: UnificationXref
id: CHEBI:6807
db: ChEBI

Compound/PW C000052/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt P10635
type: UnificationXref
id: P10635
db: UniProt

Potassium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Potassium

Reference/UniProt P10632
type: UnificationXref
id: P10632
db: UniProt

Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 10110164
xref: Reference/HMDB HMDB0060931
xref: Reference/ChemSpider 8285690
chemical formula: C20H24N
molecular weight: 278.1909
structure: ChemicalStructure/PW C040521

2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16660
xref: Reference/ChemSpider 8055045
xref: Reference/HMDB HMDB0060672
xref: Reference/PubChem-compound 9879368
chemical formula: C19H21N
molecular weight: 263.1674
structure: ChemicalStructure/PW C040522

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Cytochrome P450 3A7
type: Protein
entity reference: Cytochrome P450 3A7

Reference/UniProt P43681
type: UnificationXref
id: P43681
db: UniProt

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Cytochrome P450 2B6
type: Protein
entity reference: Cytochrome P450 2B6

ReactionCoupledTransportCatalysis14
type: Catalysis
controller: Sodium/potassium ATPase
controlled: 3.6.3.9
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Reference/UniProt P08684
type: UnificationXref
id: P08684
db: UniProt

Sodium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Sodium

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChemSpider 8055045
type: UnificationXref
id: 8055045
db: ChemSpider

Cytochrome P450 2C8
type: Protein
entity reference: Cytochrome P450 2C8

Reference/KEGG Compound C07163
type: UnificationXref
id: C07163
db: KEGG Compound

Reference/ChEBI CHEBI 28790
type: UnificationXref
id: CHEBI:28790
db: ChEBI

2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP)

Protein/1520/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit epsilon-1
stoichiometric coefficient: 1.0

D(1A) dopamine receptor
type: Protein
cellular location: Cell Membrane
entity reference: D(1A) dopamine receptor
name: SubPathwayActivation

Methadone Action Pathway
type: Pathway
pathway order: PathwaySubPathway/492
pathway order: PathwaySubPathway/493
pathway order: PathwayEnzymeReaction/3430
pathway order: PathwaySubPathway/515
pathway order: PathwaySubPathway/514
pathway order: PathwayEnzymeReaction/2240
pathway order: PathwayEnzymeReaction/2241
pathway order: PathwayEnzymeReaction/2239
pathway order: PathwayTransport/1950
pathway order: PathwayTransport/1954
pathway order: PathwayEnzymeReaction/2236
pathway order: PathwayEnzymeReaction/2237
pathway order: PathwayTransport/1956
pathway order: PathwayEnzymeReaction/2238
pathway order: PathwayTransport/1955
pathway order: PathwayTransport/1958
pathway order: PathwaySubPathway/490
pathway order: PathwayTransport/1957
pathway order: PathwaySubPathway/491
pathway order: PathwayTransport/1959
pathway order: PathwayEnzymeReaction/1953
pathway order: PathwayTransport/1961
pathway order: PathwayTransport/1960
pathway order: PathwayTransport/1945
pathway order: PathwayTransport/1947
pathway order: PathwayTransport/1946
pathway order: PathwayTransport/3728
pathway order: PathwayTransport/1949
pathway order: PathwayTransport/1948
pathway order: PathwayEnzymeReaction/211632
pathway component: Transport154
pathway component: TransportCatalysis121
pathway component: Transport153
pathway component: TransportCatalysis120
pathway component: Transport155
pathway component: 1.14.13.-
pathway component: Transport271
pathway component: ReactionCatalysis1618
pathway component: ReactionCatalysis1617
pathway component: ReactionCatalysis1619
pathway component: ReactionCatalysis1620
pathway component: ReactionCatalysis1624
pathway component: TransportCatalysis118
pathway component: ReactionCoupledTransportCatalysis14
pathway component: TransportCatalysis117
pathway component: TransportCatalysis116
pathway component: Transport158
pathway component: Transport157
pathway component: 3.4.21.94
pathway component: SubPathwayControl490
pathway component: Transport159
pathway component: SubPathwayControl491
pathway component: SubPathwayControl492
pathway component: SubPathwayControl493
pathway component: Transport161
pathway component: Transport160
pathway component: Transport163
pathway component: Transport162
pathway component: SubPathwayControl514
pathway component: SubPathwayControl515
pathway component: ReactionCatalysis1616
pathway component: 3.6.3.9
pathway component: ReactionCatalysis1615
pathway component: TransportCatalysis127
pathway component: TransportCatalysis126
pathway component: 1.14.14.1
pathway component: TransportCatalysis125
pathway component: ReactionCatalysis1410
pathway component: TransportCatalysis123
pathway component: TransportCatalysis122
xref: Reference/SMPDB SMP0000408
xref: Reference/PathWhiz PW000414
organism: Homo sapiens

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Beta-endorphin
type: Protein
entity reference: Beta-endorphin

2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/ChemSpider 5013
type: UnificationXref
id: 5013
db: ChemSpider

Reference/KEGG Compound C00780
type: UnificationXref
id: C00780
db: KEGG Compound

Mu-type opioid receptor
type: Protein
cellular location: Cell Membrane
entity reference: Mu-type opioid receptor
name: SubPathwayActivation

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Methadone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014477
xref: Reference/CAS 76-99-3
xref: Reference/PubChem-compound 4095
xref: Reference/KEGG Compound C07163
xref: Reference/ChemSpider 3953
xref: Reference/ChEBI CHEBI 6807
chemical formula: C21H27NO
molecular weight: 309.20926
structure: ChemicalStructure/PW C008862

Methadone
type: SmallMolecule
entity reference: Methadone
name: SubPathwayInhibitor
name: SubPathwayActivator