Protein/5148 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rho guanine nucleotide exchange factor 7
stoichiometric coefficient: 1.0

Cyclic AMP-dependent transcription factor ATF-2
type: Protein
cellular location: Cytosol
entity reference: Cyclic AMP-dependent transcription factor ATF-2

Rap guanine nucleotide exchange factor 3
type: ProteinReference
xref: Reference/UniProt O95398
organism: Homo sapiens

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP
name: SubPathwayInput

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/1424 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase 8
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 8
name: Mitogen-activated protein kinase 8 → Mitogen-activated protein kinase 8 + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.11.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1783 Nucleus/Stoichiometry/1.0
right: Phosphate
right: Transcription factor AP-1
spontaneous: false
EC number: 2.7.11.24
left: Transcription factor AP-1
name: Transcription factor AP-1 → Phosphate + Transcription factor AP-1
conversion direction: LEFT_TO_RIGHT

Mitogen-activated protein kinase 11
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 11

2.7.11.24
type: BiochemicalReaction
participant stoichiometry: Protein/3332 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Cyclic AMP-dependent transcription factor ATF-2
spontaneous: false
EC number: 2.7.11.24
left: Cyclic AMP-dependent transcription factor ATF-2
name: Cyclic AMP-dependent transcription factor ATF-2 → Cyclic AMP-dependent transcription factor ATF-2 + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction2109
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006188 Cytosol/Stoichiometry/1.0
right: PIP3(16:0/16:0)
spontaneous: false
left: PIP3(16:0/16:0)
name: PIP3(16:0/16:0) → PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/974 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dual specificity mitogen-activated protein kinase kinase 6
spontaneous: false
EC number: 2.7.11.1
left: Dual specificity mitogen-activated protein kinase kinase 6
name: Dual specificity mitogen-activated protein kinase kinase 6 → Dual specificity mitogen-activated protein kinase kinase 6 + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/1248 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase 11
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 11
name: Mitogen-activated protein kinase 11 → Mitogen-activated protein kinase 11 + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction2104
type: BiochemicalReaction
participant stoichiometry: Protein/1604 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/3717 Cytosol/Stoichiometry/1.0
right: Serine/threonine-protein kinase PAK 1
right: Cell division control protein 42 homolog
spontaneous: false
left: Serine/threonine-protein kinase PAK 1
left: Cell division control protein 42 homolog
name: Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1 → Cell division control protein 42 homolog with GTP + Serine/threonine-protein kinase PAK 1
conversion direction: LEFT_TO_RIGHT

Protein/1808 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Protein/1601 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Reference/UniProt P19419
type: UnificationXref
id: P19419
db: UniProt

Protein/3717 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine/threonine-protein kinase PAK 1
stoichiometric coefficient: 1.0

Protein/4632 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 2
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Rap guanine nucleotide exchange factor 3
type: Protein
cellular location: Cytosol
entity reference: Rap guanine nucleotide exchange factor 3

Reference/UniProt P15056
type: UnificationXref
id: P15056
db: UniProt

Protein/1783 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcription factor AP-1
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/UniProt Q00653
type: UnificationXref
id: Q00653
db: UniProt

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

2.7.11.11
type: BiochemicalReaction
participant stoichiometry: Protein/1802 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Cyclic AMP-responsive element-binding protein 1
spontaneous: false
EC number: 2.7.11.11
left: Cyclic AMP-responsive element-binding protein 1
name: Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Phosphate
conversion direction: LEFT_TO_RIGHT

Protein/1707 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ras-related protein Rap-1A
stoichiometric coefficient: 1.0

Reference/ChemSpider 24767909
type: UnificationXref
id: 24767909
db: ChemSpider

Protein/5773 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor alpha
stoichiometric coefficient: 1.0

Compound/PW C000034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytosol
entity reference: Nuclear factor NF-kappa-B p105 subunit

Reference/UniProt O15530
type: UnificationXref
id: O15530
db: UniProt

Protein/3618 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Rho guanine nucleotide exchange factor 7
type: ProteinReference
xref: Reference/UniProt Q14155
organism: Homo sapiens

Guanine nucleotide-binding protein alpha-beta-gamma
type: Complex
component stoichiometry: Protein/1601 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3627 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3618 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Gβ
component: Guanine nucleotide-binding protein G(T) subunit gamma-T1

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

2.7.11.13
type: BiochemicalReaction
participant stoichiometry: Protein/1203 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Ribosomal protein S6 kinase alpha-1
spontaneous: false
EC number: 2.7.11.13
left: Ribosomal protein S6 kinase alpha-1
name: Ribosomal protein S6 kinase alpha-1 → Phosphate + Ribosomal protein S6 kinase alpha-1
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/5772 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Bcl2-associated agonist of cell death
spontaneous: false
EC number: 2.7.11.1
left: Bcl2-associated agonist of cell death
name: Bcl2-associated agonist of cell death → Bcl2-associated agonist of cell death + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction2110
type: BiochemicalReaction
participant stoichiometry: Protein/1281 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1604 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/3718 Cytosol/Stoichiometry/1.0
right: Protein kinase C zeta type
right: Partitioning defective 6 homolog alpha
right: Cell division control protein 42 homolog
spontaneous: false
left: Protein kinase C zeta type
left: Partitioning defective 6 homolog alpha
left: Cell division control protein 42 homolog
name: Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type → Cell division control protein 42 homolog with GTP + Partitioning defective 6 homolog alpha + Protein kinase C zeta type
conversion direction: LEFT_TO_RIGHT

Protein/5772 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Bcl2-associated agonist of cell death
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reaction2119
type: BiochemicalReaction
participant stoichiometry: Protein/5773 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/5774 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Cytosol/Stoichiometry/1.0
right: Nuclear factor NF-kappa-B p105 subunit
right: Nuclear factor NF-kappa-B p100 subunit
right: NF-kappa-B inhibitor alpha
spontaneous: true
left: Nuclear factor NF-kappa-B p105 subunit
left: Nuclear factor NF-kappa-B p100 subunit
left: NF-kappa-B inhibitor alpha
name: NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit → NF-kappa-B inhibitor alpha + Nuclear factor NF-kappa-B p100 subunit + Nuclear factor NF-kappa-B p105 subunit
conversion direction: LEFT_TO_RIGHT

2.7.11.10
type: BiochemicalReaction
participant stoichiometry: Protein/5773 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: NF-kappa-B inhibitor alpha
spontaneous: false
EC number: 2.7.11.10
left: NF-kappa-B inhibitor alpha
name: NF-kappa-B inhibitor alpha → NF-kappa-B inhibitor alpha + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/1292 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: RAC-alpha serine/threonine-protein kinase
right: PIP3(16:0/16:0)
spontaneous: false
EC number: 2.7.11.1
left: RAC-alpha serine/threonine-protein kinase
left: PIP3(16:0/16:0)
name: PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + Phosphate + RAC-alpha serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/1222 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1749 Cell Membrane/Stoichiometry/1.0
right: Inhibitor of nuclear factor kappa-B kinase subunit beta
right: Phosphate
right: Inhibitor of nuclear factor kappa-B kinase subunit alpha
spontaneous: false
EC number: 2.7.11.1
left: Inhibitor of nuclear factor kappa-B kinase subunit beta
left: Inhibitor of nuclear factor kappa-B kinase subunit alpha
name: Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta → Inhibitor of nuclear factor kappa-B kinase subunit alpha + Inhibitor of nuclear factor kappa-B kinase subunit beta + Phosphate
conversion direction: LEFT_TO_RIGHT

Adenosine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Adenosine

Reaction2113
type: BiochemicalReaction
participant stoichiometry: Protein/1328/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188/Stoichiometry/1.0
right: PIP3(16:0/16:0)
right: 3-phosphoinositide-dependent protein kinase 1
spontaneous: false
left: PIP3(16:0/16:0)
left: 3-phosphoinositide-dependent protein kinase 1
name: 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0) → 3-phosphoinositide-dependent protein kinase 1 + PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reaction2114
type: BiochemicalReaction
participant stoichiometry: Protein/1292 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
right: RAC-alpha serine/threonine-protein kinase
right: PIP3(16:0/16:0)
spontaneous: true
left: RAC-alpha serine/threonine-protein kinase
left: PIP3(16:0/16:0)
name: PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase → PIP3(16:0/16:0) + RAC-alpha serine/threonine-protein kinase
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O95398
type: UnificationXref
id: O95398
db: UniProt

Guanine nucleotide-binding protein gamma-beta
type: Complex
component stoichiometry: Protein/3627 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3618 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Gβ
component: Guanine nucleotide-binding protein G(T) subunit gamma-T1

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Serine/threonine-protein kinase PAK 1
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein kinase PAK 1

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Cyclic AMP-responsive element-binding protein 1
type: Protein
cellular location: Cytosol
entity reference: Cyclic AMP-responsive element-binding protein 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Protein/1341 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase kinase kinase 4
stoichiometric coefficient: 1.0

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: Reference/UniProt P16220
organism: Homo sapiens

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Gβ
type: Protein
cellular location: Cytosol
entity reference: Gβ

Reference/UniProt P52564
type: UnificationXref
id: P52564
db: UniProt

Protein/5774 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p100 subunit
stoichiometric coefficient: 1.0

Adenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P63211
type: UnificationXref
id: P63211
db: UniProt

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P16220
type: UnificationXref
id: P16220
db: UniProt

PIP3(16:0/16:0)
type: SmallMolecule
entity reference: PIP3(16:0/16:0)

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Cell Membrane
entity reference: RAC-alpha serine/threonine-protein kinase

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt P19838
organism: Homo sapiens

Protein/3718 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Partitioning defective 6 homolog alpha
stoichiometric coefficient: 1.0

PIP3(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010147
xref: Reference/ChemSpider 24768024
chemical formula: C41H82O22P4
molecular weight: 1050.4248
structure: ChemicalStructure/PW C006188

Compound/PW C006188 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Protein kinase C zeta type
type: Protein
cellular location: Cytosol
entity reference: Protein kinase C zeta type

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Dual specificity mitogen-activated protein kinase kinase 2
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 2

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

Protein/1067 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase kinase kinase 1
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reaction2042
type: BiochemicalReaction
participant stoichiometry: Protein/1527 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1601 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
right: Guanine nucleotide-binding protein gamma-beta
right: Guanosine diphosphate
right: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
right: Adenosine receptor A2a
spontaneous: false
left: Adenosine receptor A2a
left: Guanosine triphosphate
name: Adenosine receptor A2a + Guanosine triphosphate → Adenosine receptor A2a + Guanine nucleotide-binding protein alpha + Guanine nucleotide-binding protein gamma-beta + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Protein/1160 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
stoichiometric coefficient: 1.0

GTPase HRas
type: ProteinReference
xref: Reference/UniProt P01112
organism: Homo sapiens

Rho guanine nucleotide exchange factor 7
type: Protein
cellular location: Cytosol
entity reference: Rho guanine nucleotide exchange factor 7

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P31749
type: UnificationXref
id: P31749
db: UniProt

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Compound/PW C006188/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Ras-related protein Rap-1A
type: ProteinReference
xref: Reference/UniProt P62834
organism: Homo sapiens

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Reference/UniProt Q92934
type: UnificationXref
id: Q92934
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

ReactionCatalysis1959
type: Catalysis
controller: GTPase HRas
controlled: Reaction2082
control type: ACTIVATION

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

ReactionCatalysis1962
type: Catalysis
controller: Rho guanine nucleotide exchange factor 7
controlled: Reaction2084
control type: ACTIVATION

Protein/1424 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 8
stoichiometric coefficient: 1.0

ReactionCatalysis1961
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.11
control type: ACTIVATION

ReactionCatalysis1964
type: Catalysis
controller: Cell division control protein 42 homolog
controlled: 2.7.11.25
control type: ACTIVATION

ReactionCatalysis1963
type: Catalysis
controller: Mitogen-activated protein kinase kinase kinase 4
controlled: 2.7.11.25
control type: ACTIVATION

ReactionCatalysis1845
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.11
control type: ACTIVATION

Ribosomal protein S6 kinase alpha-1
type: Protein
cellular location: Cytosol
entity reference: Ribosomal protein S6 kinase alpha-1

ReactionCatalysis1965
type: Catalysis
controller: Mitogen-activated protein kinase kinase kinase 1
controlled: 2.7.11.25
control type: ACTIVATION

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1117 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase 1
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 1
name: Mitogen-activated protein kinase 1 → Mitogen-activated protein kinase 1 + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ReactionCatalysis1960
type: Catalysis
controller: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: Reaction2082
control type: ACTIVATION

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

SubPathwayInteraction665
type: Interaction
name: SubPathwayReaction
name: SubPathway665Reaction
participant: Bcl2-associated agonist of cell death

Cell division control protein 42 homolog
type: ProteinReference
xref: Reference/UniProt P60953
organism: Homo sapiens

Reference/UniProt P05412
type: UnificationXref
id: P05412
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: Homo sapiens

Phosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Phosphate

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/UniProt P15336
type: UnificationXref
id: P15336
db: UniProt

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Cytosol
entity reference: NF-kappa-B inhibitor alpha

Reference/ChemSpider 24768024
type: UnificationXref
id: 24768024
db: ChemSpider

Protein/1117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

Reaction2056
type: BiochemicalReaction
participant stoichiometry: Protein/2012 Cytosol/Stoichiometry/1.0
right: Serine/threonine-protein kinase B-raf
spontaneous: false
left: Serine/threonine-protein kinase B-raf
name: Serine/threonine-protein kinase B-raf → Serine/threonine-protein kinase B-raf
conversion direction: LEFT_TO_RIGHT

Reaction2054
type: BiochemicalReaction
participant stoichiometry: Protein/4632 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dual specificity mitogen-activated protein kinase kinase 2
spontaneous: false
left: Dual specificity mitogen-activated protein kinase kinase 2
name: Dual specificity mitogen-activated protein kinase kinase 2 → Dual specificity mitogen-activated protein kinase kinase 2 + Phosphate
conversion direction: LEFT_TO_RIGHT

GTPase HRas
type: Protein
cellular location: Cell Membrane
entity reference: GTPase HRas

ReactionCatalysis1975
type: Catalysis
controller: Mitogen-activated protein kinase 8
controlled: 2.7.11.24
control type: ACTIVATION

ReactionCatalysis1974
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 7
controlled: 2.7.12.2
control type: ACTIVATION

ReactionCatalysis1977
type: Catalysis
controller: Serine/threonine-protein kinase PAK 1
controlled: 2.7.11.1
control type: ACTIVATION

Reaction2050
type: BiochemicalReaction
participant stoichiometry: Protein/2086 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1707 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Ras-related protein Rap-1A
spontaneous: false
left: Ras-related protein Rap-1A
left: Rap guanine nucleotide exchange factor 3
left: cAMP
left: Guanosine triphosphate
name: Guanosine triphosphate + Rap guanine nucleotide exchange factor 3 + Ras-related protein Rap-1A + cAMP → Guanosine diphosphate + Ras-related protein Rap-1A
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1979
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 6
controlled: 2.7.12.2
control type: ACTIVATION

ReactionCatalysis1978
type: Catalysis
controller: Cell division control protein 42 homolog
controlled: 2.7.11.1
control type: ACTIVATION

Serine/threonine-protein kinase B-raf
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein kinase B-raf

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Ras-related protein Rap-1A
type: Protein
cellular location: Cytosol
entity reference: Ras-related protein Rap-1A

Protein/1056 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rap guanine nucleotide exchange factor 2
stoichiometric coefficient: 1.0

2.7.11.25
type: BiochemicalReaction
participant stoichiometry: Protein/3977 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Dual specificity mitogen-activated protein kinase kinase 7
spontaneous: false
EC number: 2.7.11.25
left: Dual specificity mitogen-activated protein kinase kinase 7
name: Dual specificity mitogen-activated protein kinase kinase 7 → Dual specificity mitogen-activated protein kinase kinase 7 + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1984
type: Catalysis
controller: Ribosomal protein S6 kinase alpha-1
controlled: 2.7.11.1
control type: ACTIVATION

ReactionCatalysis1983
type: Catalysis
controller: Cell division control protein 42 homolog
controlled: 2.7.11.13
control type: ACTIVATION

2.7.11.25
type: BiochemicalReaction
participant stoichiometry: Protein/1067 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Mitogen-activated protein kinase kinase kinase 1
spontaneous: false
EC number: 2.7.11.25
left: Mitogen-activated protein kinase kinase kinase 1
name: Mitogen-activated protein kinase kinase kinase 1 → Mitogen-activated protein kinase kinase kinase 1 + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1986
type: Catalysis
controller: RAC-alpha serine/threonine-protein kinase
controlled: 2.7.11.1
control type: ACTIVATION

ReactionCatalysis1985
type: Catalysis
controller: 3-phosphoinositide-dependent protein kinase 1
controlled: 2.7.11.1
control type: ACTIVATION

Reaction2085
type: BiochemicalReaction
participant stoichiometry: Protein/1604 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1341 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase kinase kinase 4
right: Cell division control protein 42 homolog
spontaneous: true
left: Mitogen-activated protein kinase kinase kinase 4
left: Cell division control protein 42 homolog
name: Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4 → Cell division control protein 42 homolog with GTP + Mitogen-activated protein kinase kinase kinase 4
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1988
type: Catalysis
controller: Inhibitor of nuclear factor kappa-B kinase subunit beta
controlled: 2.7.11.10
control type: ACTIVATION

ReactionCatalysis1987
type: Catalysis
controller: Inhibitor of nuclear factor kappa-B kinase subunit alpha
controlled: 2.7.11.10
control type: ACTIVATION

2.7.11.11
type: BiochemicalReaction
participant stoichiometry: Protein/5148 Cell Membrane/Stoichiometry/1.0
right: Rho guanine nucleotide exchange factor 7
spontaneous: false
EC number: 2.7.11.11
left: Rho guanine nucleotide exchange factor 7
name: Rho guanine nucleotide exchange factor 7 → Rho guanine nucleotide exchange factor 7 with phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

Reaction2084
type: BiochemicalReaction
participant stoichiometry: Protein/1604 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Cell division control protein 42 homolog
spontaneous: false
left: Cell division control protein 42 homolog
left: Guanosine triphosphate
name: Cell division control protein 42 homolog with GDP + Guanosine triphosphate → Cell division control protein 42 homolog with GTP + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O14733
type: UnificationXref
id: O14733
db: UniProt

PIP2(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010032
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/PubChem-compound 53480223
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24767909
chemical formula: C41H81O19P3
molecular weight: 970.4585
structure: ChemicalStructure/PW C006073

ReactionCatalysis1980
type: Catalysis
controller: Mitogen-activated protein kinase 11
controlled: 2.7.11.24
control type: ACTIVATION

ReactionCatalysis1982
type: Catalysis
controller: Partitioning defective 6 homolog alpha
controlled: 2.7.11.13
control type: ACTIVATION

ReactionCatalysis1981
type: Catalysis
controller: Protein kinase C zeta type
controlled: 2.7.11.13
control type: ACTIVATION

Protein/5770 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: ETS domain-containing protein Elk-1
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/UniProt P19838
type: UnificationXref
id: P19838
db: UniProt

Reaction2081
type: BiochemicalReaction
participant stoichiometry: Protein/1160 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1703 Cell Membrane/Stoichiometry/1.0
right: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
right: GTPase HRas
spontaneous: false
left: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
left: GTPase HRas
name: GTPase HRas with GTP + Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform → GTPase HRas with GTP + Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
conversion direction: LEFT_TO_RIGHT

Reaction2082
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006188 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006073 Cell Membrane/Stoichiometry/1.0
right: PIP3(16:0/16:0)
spontaneous: false
left: PIP2(16:0/16:0)
name: PIP2(16:0/16:0) → PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reaction2080
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1703 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine diphosphate
right: GTPase HRas
spontaneous: false
left: GTPase HRas
left: Guanosine triphosphate
name: GTPase HRas with GDP + Guanosine triphosphate → GTPase HRas with GTP + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

2.7.11.24
type: BiochemicalReaction
participant stoichiometry: Protein/5770 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Nucleus/Stoichiometry/1.0
right: ETS domain-containing protein Elk-1
right: Phosphate
spontaneous: false
EC number: 2.7.11.24
left: ETS domain-containing protein Elk-1
name: ETS domain-containing protein Elk-1 → ETS domain-containing protein Elk-1 + Phosphate
conversion direction: LEFT_TO_RIGHT

Reaction2079
type: BiochemicalReaction
participant stoichiometry: Protein/1056 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Rap guanine nucleotide exchange factor 2
spontaneous: true
left: Rap guanine nucleotide exchange factor 2
left: cAMP
name: Rap guanine nucleotide exchange factor 2 + cAMP → Rap guanine nucleotide exchange factor 2 with cAMP
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: Reference/UniProt O15111
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 6
type: Complex
component stoichiometry: Protein/5771 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Dual specificity mitogen-activated protein kinase kinase 6

Protein/5771 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 2.0

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

ReactionCatalysis1920
type: Catalysis
controller: Guanine nucleotide-binding protein alpha-beta-gamma
controlled: Reaction2042
control type: ACTIVATION

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

ReactionCatalysis1923
type: Catalysis
controller: Rap guanine nucleotide exchange factor 3
controlled: Reaction2050
control type: ACTIVATION

Protein/1248 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 11
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

Adenosine receptor A2a
type: ProteinReference
xref: Reference/UniProt P29274

Transport200
type: Transport
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Extracellular Space/Stoichiometry/1.0
right: Adenosine
spontaneous: false
left: Adenosine
name: Adenosine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

ReactionCatalysis1926
type: Catalysis
controller: Ras-related protein Rap-1A
controlled: Reaction2054
control type: ACTIVATION

Rho guanine nucleotide exchange factor 7
type: Protein
cellular location: Cell Membrane
entity reference: Rho guanine nucleotide exchange factor 7

ReactionCatalysis1927
type: Catalysis
controller: Serine/threonine-protein kinase B-raf
controlled: Reaction2054
control type: ACTIVATION

Compound/PW C000034 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Protein/2012 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Serine/threonine-protein kinase B-raf
stoichiometric coefficient: 1.0

ReactionCatalysis1930
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 2
controlled: 2.7.12.2
control type: ACTIVATION

Transport205
type: Transport
participant stoichiometry: Protein/5774 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/5774 Nucleus/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1808 Nucleus/Stoichiometry/1.0
right: Nuclear factor NF-kappa-B p105 subunit
right: Nuclear factor NF-kappa-B p100 subunit
spontaneous: false
left: Nuclear factor NF-kappa-B p105 subunit
left: Nuclear factor NF-kappa-B p100 subunit
name: Nuclear factor NF-kappa-B p105 subunit (→), Nuclear factor NF-kappa-B p100 subunit (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Nucleus
conversion direction: LEFT_TO_RIGHT

Compound/PW C006073 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: Reference/UniProt Q13153
organism: Homo sapiens

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

SubPathwayInteraction657
type: Interaction
name: SubPathwayReaction
name: SubPathway657Reaction
participant: cAMP

SubPathwayInteraction658
type: Interaction
name: SubPathway658Reaction
name: SubPathwayReaction
participant: cAMP

ReactionCatalysis1816
type: Catalysis
controller: cAMP-dependent protein kinase catalytic subunit beta
controlled: 2.7.11.11
control type: ACTIVATION

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Partitioning defective 6 homolog alpha
type: ProteinReference
xref: Reference/UniProt Q9NPB6
organism: Homo sapiens

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Protein/3977 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 7
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P45983
organism: Homo sapiens

Nuclear factor NF-kappa-B p100 subunit
type: Protein
cellular location: Cytosol
entity reference: Nuclear factor NF-kappa-B p100 subunit

Transcription factor AP-1
type: ProteinReference
xref: Reference/UniProt P05412
organism: Homo sapiens

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

ReactionCatalysis1957
type: Catalysis
controller: Rap guanine nucleotide exchange factor 2
controlled: Reaction2080
control type: ACTIVATION

ReactionCatalysis1956
type: Catalysis
controller: Mitogen-activated protein kinase 1
controlled: 2.7.11.24
control type: ACTIVATION

Reference/UniProt O14920
type: UnificationXref
id: O14920
db: UniProt

3-phosphoinositide-dependent protein kinase 1
type: Protein
cellular location: Cell Membrane
entity reference: 3-phosphoinositide-dependent protein kinase 1

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: Homo sapiens

Reference/UniProt P62834
type: UnificationXref
id: P62834
db: UniProt

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: Reference/UniProt O14733
organism: Homo sapiens

Protein/1203 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribosomal protein S6 kinase alpha-1
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: Homo sapiens

Reference/UniProt Q13153
type: UnificationXref
id: Q13153
db: UniProt

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytosol
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: Reference/UniProt P63211
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 8

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: Reference/UniProt O15530

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: Reference/UniProt Q15418
organism: Homo sapiens

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Protein/1703 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

PIP3(16:0/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP3(16:0/16:0)

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Regulation of glutamate and Dopamine release in the brain
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway657
pathway component: SubPathwayInteraction657
name: SubPathway

Coronary Artery Vasodilation in the heart
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway658
pathway component: SubPathwayInteraction658
name: SubPathway

Reference/UniProt Q05513
type: UnificationXref
id: Q05513
db: UniProt

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/1604 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division control protein 42 homolog
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/UniProt P01112
type: UnificationXref
id: P01112
db: UniProt

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: Reference/UniProt Q9Y6R4
organism: Homo sapiens

Bcl2-associated agonist of cell death
type: Protein
cellular location: Cytosol
entity reference: Bcl2-associated agonist of cell death
name: SubPathwayInput

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt O14920
organism: Homo sapiens

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Partitioning defective 6 homolog alpha
type: Protein
cellular location: Cytosol
entity reference: Partitioning defective 6 homolog alpha

Reference/UniProt Q9Y6R4
type: UnificationXref
id: Q9Y6R4
db: UniProt

Apoptosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway665
pathway component: SubPathwayInteraction665
name: SubPathway

Reference/UniProt P36507
type: UnificationXref
id: P36507
db: UniProt

TransportCatalysis162
type: Catalysis
controller: Adenosine receptor A2a
controlled: Transport200
control type: ACTIVATION

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Reference/UniProt Q9NPB6
type: UnificationXref
id: Q9NPB6
db: UniProt

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: Homo sapiens

Protein/1527 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine receptor A2a
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Protein/1292 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAC-alpha serine/threonine-protein kinase
stoichiometric coefficient: 1.0

Protein/1328/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-phosphoinositide-dependent protein kinase 1
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

2.7.11.11
type: BiochemicalReaction
participant stoichiometry: Protein/1315 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: cAMP-dependent protein kinase catalytic subunit beta
right: cAMP
spontaneous: false
EC number: 2.7.11.11
left: cAMP
name: cAMP → cAMP + cAMP-dependent protein kinase catalytic subunit beta
conversion direction: LEFT_TO_RIGHT

PIP3(16:0/16:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP3(16:0/16:0)

Protein/1315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Reference/PubChem-compound 53480223
type: UnificationXref
id: 53480223
db: PubChem-compound

Mitogen-activated protein kinase 11
type: ProteinReference
xref: Reference/UniProt Q15759
organism: Homo sapiens

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: Reference/UniProt P36507
organism: Homo sapiens

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/HMDB HMDB0010147
type: UnificationXref
id: HMDB0010147
db: HMDB

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/UniProt P25963
type: UnificationXref
id: P25963
db: UniProt

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/HMDB HMDB0010032
type: UnificationXref
id: HMDB0010032
db: HMDB

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Mitogen-activated protein kinase kinase kinase 4
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase kinase kinase 4

PIP2(16:0/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2(16:0/16:0)

Reference/UniProt P60953
type: UnificationXref
id: P60953
db: UniProt

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Transcription factor AP-1
type: Protein
cellular location: Nucleus
entity reference: Transcription factor AP-1

Adenosine receptor A2a
type: Protein
cellular location: Cytosol
entity reference: Adenosine receptor A2a

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/UniProt Q14155
type: UnificationXref
id: Q14155
db: UniProt

Nuclear factor NF-kappa-B p100 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p100 subunit

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(T) subunit gamma-T1

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: Reference/UniProt P15336
organism: Homo sapiens

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Adenosine receptor A2a
type: Protein
entity reference: Adenosine receptor A2a

Protein/5774 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p100 subunit
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: Reference/UniProt P42336
organism: Homo sapiens

Protein kinase C zeta type
type: ProteinReference
xref: Reference/UniProt Q05513
organism: Homo sapiens

Reaction596
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Protein/1749 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit alpha
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: Reference/UniProt P15056
organism: Homo sapiens

Reference/UniProt Q9Y4G8
type: UnificationXref
id: Q9Y4G8
db: UniProt

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
type: Pathway
pathway order: PathwayEnzymeReaction/2784
pathway order: PathwayEnzymeReaction/2780
pathway order: PathwayEnzymeReaction/2734
pathway order: PathwayEnzymeReaction/2658
pathway order: PathwayEnzymeReaction/2779
pathway order: PathwayTransport/2642
pathway order: PathwayEnzymeReaction/2736
pathway order: PathwayEnzymeReaction/2730
pathway order: PathwayEnzymeReaction/2774
pathway order: PathwayEnzymeReaction/2731
pathway order: PathwayEnzymeReaction/2775
pathway order: PathwayEnzymeReaction/2655
pathway order: PathwayEnzymeReaction/2656
pathway order: PathwayEnzymeReaction/2733
pathway order: PathwayEnzymeReaction/2777
pathway order: PathwayEnzymeReaction/2751
pathway order: PathwaySubPathway/665
pathway order: PathwayEnzymeReaction/2669
pathway order: PathwayEnzymeReaction/2746
pathway order: PathwayEnzymeReaction/211617
pathway order: PathwayEnzymeReaction/2742
pathway order: PathwayEnzymeReaction/211618
pathway order: PathwayEnzymeReaction/2666
pathway order: PathwayEnzymeReaction/211619
pathway order: PathwayEnzymeReaction/2667
pathway order: PathwayEnzymeReaction/211616
pathway order: PathwayEnzymeReaction/2760
pathway order: PathwayEnzymeReaction/2761
pathway order: PathwaySubPathway/658
pathway order: PathwayEnzymeReaction/2762
pathway order: PathwaySubPathway/657
pathway order: PathwayEnzymeReaction/2758
pathway order: PathwayTransport/2785
pathway order: PathwayEnzymeReaction/2759
pathway order: PathwayEnzymeReaction/2676
pathway order: PathwayEnzymeReaction/211620
pathway order: PathwayEnzymeReaction/211621
pathway order: PathwayEnzymeReaction/2772
pathway order: PathwayEnzymeReaction/2723
pathway order: PathwayEnzymeReaction/2767
pathway order: PathwayEnzymeReaction/2724
pathway order: PathwayEnzymeReaction/2768
pathway order: PathwayEnzymeReaction/2725
pathway order: PathwayEnzymeReaction/2763
pathway order: PathwayEnzymeReaction/2644
pathway order: PathwayEnzymeReaction/2765
pathway order: PathwayEnzymeReaction/2766
pathway order: PathwayEnzymeReaction/2727
pathway order: PathwayEnzymeReaction/2728
pathway order: PathwayEnzymeReaction/2729
pathway component: TransportCatalysis162
pathway component: ReactionCatalysis1959
pathway component: ReactionCatalysis1962
pathway component: 2.7.12.2
pathway component: ReactionCatalysis1961
pathway component: 2.7.11.24
pathway component: ReactionCatalysis1920
pathway component: ReactionCatalysis1964
pathway component: ReactionCatalysis1963
pathway component: ReactionCatalysis1845
pathway component: ReactionCatalysis1965
pathway component: ReactionCatalysis1923
pathway component: Reaction2109
pathway component: 2.7.11.1
pathway component: Reaction2104
pathway component: Reaction596
pathway component: 2.7.11.11
pathway component: ReactionCatalysis1960
pathway component: Transport200
pathway component: ReactionCatalysis1926
pathway component: ReactionCatalysis1927
pathway component: Reaction2056
pathway component: Reaction2054
pathway component: ReactionCatalysis1975
pathway component: ReactionCatalysis1930
pathway component: ReactionCatalysis1974

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P31749
organism: Homo sapiens

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Mitogen-activated protein kinase 8
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 8

ProteinComplex/120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein gamma-beta
stoichiometric coefficient: 1.0

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/PathWhiz PW000445
type: UnificationXref
id: PW000445
db: PathWhiz

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Rap guanine nucleotide exchange factor 2
type: ProteinReference
xref: Reference/UniProt Q9Y4G8
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase kinase kinase 1

Nuclear factor NF-kappa-B p100 subunit
type: ProteinReference
xref: Reference/UniProt Q00653
organism: Homo sapiens

Bcl2-associated agonist of cell death
type: ProteinReference
xref: Reference/UniProt Q92934
organism: Homo sapiens

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt P25963
organism: Homo sapiens

ETS domain-containing protein Elk-1
type: ProteinReference
xref: Reference/UniProt P19419
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: Reference/UniProt P52564
organism: Homo sapiens

Protein/2086 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Rap guanine nucleotide exchange factor 3
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Nucleus
entity reference: Nuclear factor NF-kappa-B p105 subunit

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q13233
organism: Homo sapiens

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Protein/1222 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inhibitor of nuclear factor kappa-B kinase subunit beta
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt Q13233
type: UnificationXref
id: Q13233
db: UniProt

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

Protein/3627 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(T) subunit gamma-T1
stoichiometric coefficient: 1.0

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

3-phosphoinositide-dependent protein kinase 1
type: Protein
entity reference: 3-phosphoinositide-dependent protein kinase 1

Reference/UniProt P45983
type: UnificationXref
id: P45983
db: UniProt

Protein/1281 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein kinase C zeta type
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 6

Reference/SMPDB SMP0000320
type: UnificationXref
id: SMP0000320
db: SMPDB

Reference/UniProt Q15418
type: UnificationXref
id: Q15418
db: UniProt

ChemicalStructure/PW C006073
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

ETS domain-containing protein Elk-1
type: Protein
cellular location: Nucleus
entity reference: ETS domain-containing protein Elk-1

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/UniProt O15111
type: UnificationXref
id: O15111
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Protein/1808 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nuclear factor NF-kappa-B p105 subunit
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Cell division control protein 42 homolog
type: Protein
cellular location: Cytosol
entity reference: Cell division control protein 42 homolog

Reference/UniProt P29274
type: UnificationXref
id: P29274
db: UniProt

Protein/3332 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic AMP-dependent transcription factor ATF-2
stoichiometric coefficient: 1.0

Reference/UniProt P42336
type: UnificationXref
id: P42336
db: UniProt

Mitogen-activated protein kinase 1
type: Protein
cellular location: Nucleus
entity reference: Mitogen-activated protein kinase 1

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cytosol
entity reference: Rap guanine nucleotide exchange factor 2

Protein/1802 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cyclic AMP-responsive element-binding protein 1
stoichiometric coefficient: 1.0

Reference/UniProt Q15759
type: UnificationXref
id: Q15759
db: UniProt

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Rap guanine nucleotide exchange factor 2
type: Protein
cellular location: Cell Membrane
entity reference: Rap guanine nucleotide exchange factor 2

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Compound/PW C001104 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ProteinComplex/974 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 6
stoichiometric coefficient: 1.0

ChemicalStructure/PW C006188
type: ChemicalStructure
structure format: SMILES