Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Phosphatidylinositol 4-kinase alpha
type: ProteinReference
xref: Reference/UniProt P42356
organism: Homo sapiens

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Inositol 1,4,5-trisphosphate

Synaptojanin-1
type: Protein
cellular location: Cell Membrane
entity reference: Synaptojanin-1

Reference/ChEBI CHEBI 75466
type: UnificationXref
id: CHEBI:75466
db: ChEBI

PIP(18:1(9Z)/16:0)
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/PubChem-compound 53480165
xref: Reference/ChemSpider 24767851
xref: Reference/HMDB HMDB0009970
chemical formula: C43H82O16P2
molecular weight: 916.5078
structure: ChemicalStructure/PW C006015

Polyphosphoinositide phosphatase
type: Protein
cellular location: Cell Membrane
entity reference: Polyphosphoinositide phosphatase

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt O15327
type: UnificationXref
id: O15327
db: UniProt

Reference/KEGG Compound C13861
type: UnificationXref
id: C13861
db: KEGG Compound

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/CAS 3123-73-7
type: UnificationXref
id: 3123-73-7
db: CAS

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Compound/PW C006015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP(18:1(9Z)/16:0)
stoichiometric coefficient: 1.0

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
type: ProteinReference
xref: Reference/UniProt O14735
organism: Homo sapiens

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Type II inositol 3,4-bisphosphate 4-phosphatase
type: Protein
cellular location: Cytosol
entity reference: Type II inositol 3,4-bisphosphate 4-phosphatase

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Reference/UniProt P48426
type: UnificationXref
id: P48426
db: UniProt

Protein/5720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein VAC14 homolog
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

PIP2(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP2(16:0/18:1(9Z))

PIP2(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2(16:0/18:1(9Z))

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: Reference/UniProt P60484
organism: Homo sapiens

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt Q9Y2I7
type: UnificationXref
id: Q9Y2I7
db: UniProt

Reference/UniProt Q9NQ66
type: UnificationXref
id: Q9NQ66
db: UniProt

ChemicalStructure/PW C003022
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc MYO-INOSITOL
type: UnificationXref
id: MYO-INOSITOL
db: BioCyc

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha

SubPathwayInteraction297
type: Interaction
name: SubPathway297Reaction
name: SubPathwayReaction
participant: myo-Inositol

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Complex
component stoichiometry: Protein/1074 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2388 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
component: Phosphatidylinositol 3-kinase regulatory subunit alpha

SubPathwayInteraction296
type: Interaction
name: SubPathway296Reaction
name: SubPathwayReaction
participant: Inositol 1,4,5-trisphosphate

Reference/PathWhiz PW000156
type: UnificationXref
id: PW000156
db: PathWhiz

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/ChemSpider 24767914
type: UnificationXref
id: 24767914
db: ChemSpider

myo-Inositol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000211
xref: Reference/ChEBI CHEBI 17268
xref: Reference/ChemSpider 10239179
xref: Reference/CAS 87-89-8
xref: Reference/BioCyc MYO-INOSITOL
xref: Reference/KEGG Compound C00137
xref: Reference/PubChem-compound 892
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000137

Reference/ChemSpider 4445454
type: UnificationXref
id: 4445454
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

72 kDa inositol polyphosphate 5-phosphatase
type: Protein
cellular location: Cell Membrane
entity reference: 72 kDa inositol polyphosphate 5-phosphatase

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

72 kDa inositol polyphosphate 5-phosphatase
type: ProteinReference
xref: Reference/UniProt Q9NRR6
organism: Homo sapiens

Synaptojanin-1
type: ProteinReference
xref: Reference/UniProt O43426
organism: Homo sapiens

PI(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24767668
xref: Reference/HMDB HMDB0009783
chemical formula: C43H81O13P
molecular weight: 836.5415
structure: ChemicalStructure/PW C005831

Reference/CAS 87-89-8
type: UnificationXref
id: 87-89-8
db: CAS

Reference/PubChem-compound 53480165
type: UnificationXref
id: 53480165
db: PubChem-compound

ChemicalStructure/PW C003153
type: ChemicalStructure
structure format: SMILES

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

Reference/UniProt P04626
type: UnificationXref
id: P04626
db: UniProt

Activating molecule in BECN1-regulated autophagy protein 1
type: ProteinReference
xref: Reference/UniProt Q9C0C7
organism: Homo sapiens

Polyphosphoinositide phosphatase
type: ProteinReference
xref: Reference/UniProt Q92562
organism: Homo sapiens

Type II inositol 3,4-bisphosphate 4-phosphatase
type: ProteinReference
xref: Reference/UniProt O15327
organism: Homo sapiens

Reference/ChEBI CHEBI 17268
type: UnificationXref
id: CHEBI:17268
db: ChEBI

EGFR protein
type: ProteinReference
xref: Reference/UniProt Q504U8
organism: Homo sapiens

Reference/ChemSpider 10239179
type: UnificationXref
id: 10239179
db: ChemSpider

Beclin-1
type: ProteinReference
xref: Reference/UniProt Q14457
organism: Homo sapiens

Compound/PW C006078 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

myo-Inositol
type: SmallMolecule
cellular location: Cytosol
entity reference: myo-Inositol
name: SubPathwayOutput

Phosphoinositide 3-kinase regulatory subunit 4
type: ProteinReference
xref: Reference/UniProt Q99570
organism: Homo sapiens

Reference/HMDB HMDB0000211
type: UnificationXref
id: HMDB0000211
db: HMDB

PIP[4'](16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP[4'](16:0/18:1(9Z))

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
type: ProteinReference
xref: Reference/UniProt P48426
organism: Homo sapiens

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/PubChem-compound 53480228
type: UnificationXref
id: 53480228
db: PubChem-compound

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Receptor tyrosine-protein kinase erbB-2
type: ProteinReference
xref: Reference/UniProt P04626
organism: Homo sapiens

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
type: ProteinReference
xref: Reference/UniProt Q99755
organism: Homo sapiens

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000137
type: ChemicalStructure
structure format: SMILES

Protein VAC14 homolog
type: ProteinReference
xref: Reference/UniProt Q08AM6
organism: Homo sapiens

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

ChemicalStructure/PW C005831
type: ChemicalStructure
structure format: SMILES

Polyphosphoinositide phosphatase
type: Complex
component stoichiometry: Protein/5719 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5720 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1196 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Polyphosphoinositide phosphatase
component: Protein VAC14 homolog
component: 1-phosphatidylinositol-3-phosphate 5-kinase

Reference/HMDB HMDB0010150
type: UnificationXref
id: HMDB0010150
db: HMDB

Reference/ChemSpider 24767668
type: UnificationXref
id: 24767668
db: ChemSpider

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/HMDB HMDB0010037
type: UnificationXref
id: HMDB0010037
db: HMDB

Reference/KEGG Compound C00137
type: UnificationXref
id: C00137
db: KEGG Compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

DG(16:0/18:1(9Z)/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: DG(16:0/18:1(9Z)/0:0)

Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha

Reference/UniProt Q504U8
type: UnificationXref
id: Q504U8
db: UniProt

ChemicalStructure/PW C040459
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040458
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 24765811
type: UnificationXref
id: 24765811
db: ChemSpider

ChemicalStructure/PW C040457
type: ChemicalStructure
structure format: SMILES

PIP[5'](16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP[5'](16:0/18:1(9Z))

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00269
type: UnificationXref
id: C00269
db: KEGG Compound

Compound/PW C000137 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: myo-Inositol
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: Complex
component stoichiometry: Protein/5718 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/4066 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5717 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2392 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Phosphatidylinositol 3-kinase catalytic subunit type 3
component: Phosphoinositide 3-kinase regulatory subunit 4
component: Activating molecule in BECN1-regulated autophagy protein 1
component: Beclin-1

Reference/UniProt Q9C0C7
type: UnificationXref
id: Q9C0C7
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

PIP2[4,5](16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2[4,5](16:0/18:1(9Z))

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Reference/HMDB HMDB0009970
type: UnificationXref
id: HMDB0009970
db: HMDB

Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/UniProt Q99570
type: UnificationXref
id: Q99570
db: UniProt

Cytidine monophosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Cytidine monophosphate

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

CDP-DG(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17962
xref: Reference/BioCyc CDPDIACYLGLYCEROL
xref: Reference/ChemSpider 24765811
xref: Reference/HMDB HMDB0006971
xref: Reference/PubChem-compound 53477915
xref: Reference/KEGG Compound C00269
chemical formula: C46H83N3O15P2
molecular weight: 979.52997
structure: ChemicalStructure/PW C003022

Protein/1074 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
type: ProteinReference
xref: Reference/UniProt Q92835
organism: Homo sapiens

1-phosphatidylinositol 3-phosphate 5-kinase
type: Complex
component stoichiometry: Protein/5719 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5720 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1196 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Polyphosphoinositide phosphatase
component: Protein VAC14 homolog
component: 1-phosphatidylinositol-3-phosphate 5-kinase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

2.7.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
right: PIP(18:1(9Z)/16:0)
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.153
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PI(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.36
left: PIP(18:1(9Z)/16:0)
left: Water
name: PIP(18:1(9Z)/16:0) + Water → PI(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

PIP[5'](16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061187
chemical formula: C43H82O16P2
molecular weight: 916.5078
structure: ChemicalStructure/PW C040457

2.7.8.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003022 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000137 Cell Membrane/Stoichiometry/1.0
right: Cytidine monophosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.8.11
left: myo-Inositol
left: CDP-DG(16:0/18:1(9Z))
name: CDP-DG(16:0/18:1(9Z)) + myo-Inositol → Cytidine monophosphate + PI(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

PIP2[4,5](16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061188
chemical formula: C42H82O19P3
molecular weight: 983.4663
structure: ChemicalStructure/PW C040458

PIP[4'](16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061186
chemical formula: C43H82O16P2
molecular weight: 916.5078
structure: ChemicalStructure/PW C040459

Receptor tyrosine-protein kinase erbB-2
type: Protein
cellular location: Cell Membrane
entity reference: Receptor tyrosine-protein kinase erbB-2

Reference/ChemSpider 24767851
type: UnificationXref
id: 24767851
db: ChemSpider

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/ChemSpider 24768027
type: UnificationXref
id: 24768027
db: ChemSpider

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: Reference/UniProt O00443
organism: Homo sapiens

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

DG(16:0/18:1(9Z)/0:0)
type: SmallMoleculeReference
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/ChemSpider 4445454
xref: Reference/KEGG Compound C13861
xref: Reference/PubChem-compound 5282283
xref: Reference/ChEBI CHEBI 75466
xref: Reference/CAS 3123-73-7
xref: Reference/HMDB HMDB0007102
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C003153

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
type: Protein
cellular location: Cell Membrane
entity reference: CDP-diacylglycerol--inositol 3-phosphatidyltransferase

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: Complex
component stoichiometry: Protein/5716 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1367 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2256 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: EGFR protein
component: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
component: Receptor tyrosine-protein kinase erbB-2

ReactionCatalysis1175
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.36
control type: ACTIVATION

Protein/1367 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Receptor tyrosine-protein kinase erbB-2
stoichiometric coefficient: 1.0

ReactionCatalysis1177
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
controlled: 2.7.1.154
control type: ACTIVATION

ReactionCatalysis1176
type: Catalysis
controller: Phosphatidylinositol 4-kinase alpha
controlled: 2.7.1.67
control type: ACTIVATION

ReactionCatalysis1179
type: Catalysis
controller: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
controlled: Reaction1463
control type: ACTIVATION

Reference/UniProt Q8NEB9
type: UnificationXref
id: Q8NEB9
db: UniProt

ReactionCatalysis1178
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: 2.7.1.153
control type: ACTIVATION

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

PIP(18:1(9Z)/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP(18:1(9Z)/16:0)

Reference/HMDB HMDB0061187
type: UnificationXref
id: HMDB0061187
db: HMDB

Reference/ChEBI CHEBI 17962
type: UnificationXref
id: CHEBI:17962
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/UniProt Q92835
type: UnificationXref
id: Q92835
db: UniProt

Reference/HMDB HMDB0061188
type: UnificationXref
id: HMDB0061188
db: HMDB

ReactionCatalysis1180
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: 2.7.1.153
control type: ACTIVATION

PIP3(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010150
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24768027
chemical formula: C43H84O22P4
molecular weight: 1076.4404
structure: ChemicalStructure/PW C006191

Reference/HMDB HMDB0061186
type: UnificationXref
id: HMDB0061186
db: HMDB

Reference/UniProt O00443
type: UnificationXref
id: O00443
db: UniProt

ReactionCatalysis1182
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
controlled: 2.7.1.68
control type: ACTIVATION

ReactionCatalysis1181
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
controlled: 3.1.4.11
control type: ACTIVATION

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: Reference/UniProt P27986
organism: Homo sapiens

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/PubChem-compound 5282283
type: UnificationXref
id: 5282283
db: PubChem-compound

Reference/UniProt O00329
type: UnificationXref
id: O00329
db: UniProt

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/UniProt O14735
type: UnificationXref
id: O14735
db: UniProt

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: Reference/UniProt Q8NEB9
organism: Homo sapiens

Phosphoinositide 3-kinase regulatory subunit 4
type: Protein
cellular location: Cell Membrane
entity reference: Phosphoinositide 3-kinase regulatory subunit 4

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Compound/PW C000064 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C006015
type: ChemicalStructure
structure format: SMILES

myo-Inositol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: myo-Inositol

Reference/BioCyc CDPDIACYLGLYCEROL
type: UnificationXref
id: CDPDIACYLGLYCEROL
db: BioCyc

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1184
type: Catalysis
controller: 72 kDa inositol polyphosphate 5-phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

ReactionCatalysis1183
type: Catalysis
controller: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
controlled: 3.1.3.86
control type: ACTIVATION

Reference/PathWhiz PW000558
type: UnificationXref
id: PW000558
db: PathWhiz

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP3(16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.68
left: PIP2(16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP2(16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1186
type: Catalysis
controller: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
controlled: 3.1.3.86
control type: ACTIVATION

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1185
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.36
control type: ACTIVATION

3.1.3.86
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.86
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1188
type: Catalysis
controller: Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
controlled: 2.7.1.149
control type: ACTIVATION

PIP2(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53480228
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/ChemSpider 24767914
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010037
chemical formula: C43H83O19P3
molecular weight: 996.4741
structure: ChemicalStructure/PW C006078

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/HMDB HMDB0007102
type: UnificationXref
id: HMDB0007102
db: HMDB

ReactionCatalysis1189
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.36
control type: ACTIVATION

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Protein/5719 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Polyphosphoinositide phosphatase
stoichiometric coefficient: 1.0

ReactionCatalysis1190
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.-
control type: ACTIVATION

2.7.1.149
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.149
left: Adenosine triphosphate
left: PIP(18:1(9Z)/16:0)
name: Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Protein/4066 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 4
stoichiometric coefficient: 1.0

ReactionCatalysis1192
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
controlled: 2.7.1.68
control type: ACTIVATION

Reference/UniProt P60484
type: UnificationXref
id: P60484
db: UniProt

Reference/PubChem-compound 892
type: UnificationXref
id: 892
db: PubChem-compound

Protein VAC14 homolog
type: Protein
cellular location: Cell Membrane
entity reference: Protein VAC14 homolog

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

1-phosphatidylinositol-3-phosphate 5-kinase
type: Protein
cellular location: Cell Membrane
entity reference: 1-phosphatidylinositol-3-phosphate 5-kinase

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: Reference/UniProt Q9NQ66
organism: Homo sapiens

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Inositol Phosphate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway297
pathway order: SubPathwayInteractionSteps/SubPathway296
pathway component: SubPathwayInteraction297
pathway component: SubPathwayInteraction296
xref: Reference/PathWhiz PW000156
xref: Reference/SMPDB SMP0000462
name: SubPathway

Joubert Syndrome
type: Pathway
pathway order: PathwaySubPathway/296
pathway order: PathwayEnzymeReaction/211591
pathway order: PathwaySubPathway/297
pathway order: PathwayEnzymeReaction/1530
pathway order: PathwayEnzymeReaction/1600
pathway order: PathwayEnzymeReaction/1542
pathway order: PathwayEnzymeReaction/1505
pathway order: PathwayEnzymeReaction/1527
pathway order: PathwayEnzymeReaction/1526
pathway order: PathwayEnzymeReaction/1602
pathway order: PathwayEnzymeReaction/1601
pathway order: PathwayEnzymeReaction/1623
pathway order: PathwayEnzymeReaction/1509
pathway order: PathwayEnzymeReaction/1608
pathway order: PathwayEnzymeReaction/1607
pathway order: PathwayEnzymeReaction/1606
pathway order: PathwayEnzymeReaction/1528
pathway order: PathwayEnzymeReaction/1605
pathway order: PathwayEnzymeReaction/1609
pathway order: PathwayEnzymeReaction/1541
pathway order: PathwayEnzymeReaction/1540
pathway order: PathwayEnzymeReaction/1611
pathway order: PathwayEnzymeReaction/1533
pathway order: PathwayEnzymeReaction/1610
pathway order: PathwayEnzymeReaction/1532
pathway order: PathwayEnzymeReaction/1516
pathway order: PathwayEnzymeReaction/1538
pathway order: PathwayEnzymeReaction/1615
pathway order: PathwayEnzymeReaction/1613
pathway order: PathwayEnzymeReaction/1612
pathway order: PathwayEnzymeReaction/1617
pathway order: PathwayEnzymeReaction/1616
pathway component: ReactionCatalysis1128
pathway component: ReactionCatalysis1127
pathway component: 3.1.3.36
pathway component: 2.7.1.153
pathway component: 2.7.8.11
pathway component: ReactionCatalysis1175
pathway component: ReactionCatalysis1177
pathway component: ReactionCatalysis1132
pathway component: ReactionCatalysis1176
pathway component: ReactionCatalysis1179
pathway component: ReactionCatalysis1178
pathway component: ReactionCatalysis1180
pathway component: ReactionCatalysis1182
pathway component: ReactionCatalysis1181
pathway component: ReactionCatalysis1148
pathway component: ReactionCatalysis1147
pathway component: 3.1.3.-
pathway component: 2.7.1.149
pathway component: 3.1.3.86
pathway component: ReactionCatalysis1184
pathway component: ReactionCatalysis1183
pathway component: ReactionCatalysis1142
pathway component: 2.7.1.68
pathway component: ReactionCatalysis1186
pathway component: ReactionCatalysis1141
pathway component: ReactionCatalysis1185
pathway component: ReactionCatalysis1188
pathway component: ReactionCatalysis1143
pathway component: ReactionCatalysis1145
pathway component: ReactionCatalysis1189
pathway component: ReactionCatalysis1190
pathway component: ReactionCatalysis1192
pathway component: Reaction1463
pathway component: Inositol Phosphate Metabolism
pathway component: 2.7.1.67
pathway component: 2.7.1.154
pathway component: 3.1.3.66

Reference/UniProt Q9NRR6
type: UnificationXref
id: Q9NRR6
db: UniProt

Reference/UniProt O43426
type: UnificationXref
id: O43426
db: UniProt

3.1.3.66
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: PIP(18:1(9Z)/16:0)
spontaneous: false
EC number: 3.1.3.66
left: PIP2(16:0/18:1(9Z))
left: Water
name: PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

PIP3(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP3(16:0/18:1(9Z))

Compound/PW C001155 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: PIP(18:1(9Z)/16:0)
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP2(16:0/18:1(9Z))
left: Water
name: PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

2.7.1.150
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.150
left: PIP(18:1(9Z)/16:0)
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.68
left: PIP(18:1(9Z)/16:0)
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

2.7.1.137
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
right: PIP(18:1(9Z)/16:0)
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.137
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

ChemicalStructure/PW C006191
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

PIP(18:1(9Z)/16:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP(18:1(9Z)/16:0)

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: Reference/UniProt O00329
organism: Homo sapiens

1-phosphatidylinositol-3-phosphate 5-kinase
type: ProteinReference
xref: Reference/UniProt Q9Y2I7
organism: Homo sapiens

Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP[4'](16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

ReactionCatalysis1128
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.36
control type: ACTIVATION

ReactionCatalysis1127
type: Catalysis
controller: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
controlled: 2.7.8.11
control type: ACTIVATION

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3

Reference/UniProt P42356
type: UnificationXref
id: P42356
db: UniProt

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.36
left: PIP[4'](16:0/18:1(9Z))
left: Water
name: PIP[4'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C006078
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Protein/2392 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase catalytic subunit type 3
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0009783
type: UnificationXref
id: HMDB0009783
db: HMDB

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2[4,5](16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/UniProt Q92562
type: UnificationXref
id: Q92562
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

PI(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PI(16:0/18:1(9Z))

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Protein/5718 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Activating molecule in BECN1-regulated autophagy protein 1
stoichiometric coefficient: 1.0

Protein/2388 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase regulatory subunit alpha
stoichiometric coefficient: 1.0

Reference/UniProt P27986
type: UnificationXref
id: P27986
db: UniProt

CDP-DG(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: CDP-DG(16:0/18:1(9Z))

ReactionCatalysis1132
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: 2.7.1.153
control type: ACTIVATION

Reference/UniProt Q14457
type: UnificationXref
id: Q14457
db: UniProt

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: Protein
cellular location: Cell Membrane
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

EGFR protein
type: Protein
cellular location: Cell Membrane
entity reference: EGFR protein

Compound/PW C003022 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-DG(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Protein/5717 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beclin-1
stoichiometric coefficient: 1.0

Protein/2256 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
stoichiometric coefficient: 1.0

ReactionCatalysis1148
type: Catalysis
controller: Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
controlled: 2.7.1.149
control type: ACTIVATION

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.36
left: PIP[5'](16:0/18:1(9Z))
left: Water
name: PIP[5'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1147
type: Catalysis
controller: Type II inositol 3,4-bisphosphate 4-phosphatase
controlled: 3.1.3.66
control type: ACTIVATION

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP[5'](16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.-
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

2.7.1.149
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP2[4,5](16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.149
left: PIP[5'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[5'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q99755
type: UnificationXref
id: Q99755
db: UniProt

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

3.1.3.86
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PIP[5'](16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.86
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[5'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0006971
type: UnificationXref
id: HMDB0006971
db: HMDB

ReactionCatalysis1142
type: Catalysis
controller: 1-phosphatidylinositol 3-phosphate 5-kinase
controlled: 2.7.1.150
control type: ACTIVATION

ReactionCatalysis1141
type: Catalysis
controller: Phosphatidylinositol 3-kinase catalytic subunit type 3
controlled: 2.7.1.137
control type: ACTIVATION

Reference/SMPDB SMP0000582
type: UnificationXref
id: SMP0000582
db: SMPDB

ReactionCatalysis1143
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
controlled: 2.7.1.68
control type: ACTIVATION

Reference/SMPDB SMP0000462
type: UnificationXref
id: SMP0000462
db: SMPDB

Reference/UniProt Q08AM6
type: UnificationXref
id: Q08AM6
db: UniProt

ReactionCatalysis1145
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.36
control type: ACTIVATION

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP[5'](16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.68
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP(18:1(9Z)/16:0)
stoichiometric coefficient: 1.0

Protein/5716 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: EGFR protein
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Beclin-1
type: Protein
cellular location: Cell Membrane
entity reference: Beclin-1

Protein/1196 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidylinositol-3-phosphate 5-kinase
stoichiometric coefficient: 1.0

Phosphatidylinositol 4-kinase alpha
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 4-kinase alpha

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

2.7.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.153
left: PIP[4'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reaction1463
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PIP2[4,5](16:0/18:1(9Z))
spontaneous: false
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2[4,5](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

2.7.1.67
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.67
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[4'](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

2.7.1.154
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.154
left: PIP[4'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Activating molecule in BECN1-regulated autophagy protein 1
type: Protein
cellular location: Cell Membrane
entity reference: Activating molecule in BECN1-regulated autophagy protein 1

Compound/PW C003153 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/18:1(9Z)/0:0)
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate
name: SubPathwayInput

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53477915
type: UnificationXref
id: 53477915
db: PubChem-compound

ReactionCatalysis1152
type: Catalysis
controller: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
controlled: 3.1.3.86
control type: ACTIVATION

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1155
type: Catalysis
controller: 72 kDa inositol polyphosphate 5-phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP2[4,5](16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.68
left: PIP[4'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1154
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
controlled: 2.7.1.68
control type: ACTIVATION

3.1.3.86
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.86
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP3(16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.153
left: PIP2[4,5](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP2[4,5](16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP[5'](16:0/18:1(9Z))
stoichiometric coefficient: 1.0

ReactionCatalysis1156
type: Catalysis
controller: Synaptojanin-1
controlled: 3.1.3.36
control type: ACTIVATION

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003153 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: DG(16:0/18:1(9Z)/0:0)
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → DG(16:0/18:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT