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Pathway Description
Clomipramine Pathway
Homo sapiens
Metabolic Pathway
Clomipramine is a dibenzazepine-derivative tricyclic antidepressant. Clomipramine may be used to treat obsessive-compulsive disorder (OCD) and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette's disorder). Clomipramine works by inhibiting seretonin reuptake, therefore increasing the seretonin levels. Administrated Clomipramine is quickly enters the blood stream and 98% becomes bound to plasma protein. Because of this and Clomipramine's lipophilic properties, Clomipramine has a large volume of distribution.
References
Clomipramine Pathway References
[PharmgKB](http://www.pharmgkb.org/pathway/PA165960076)
McTavish D, Benfield P: Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs. 1990 Jan;39(1):136-53. doi: 10.2165/00003495-199039010-00010.
Pubmed: 2178909
Balant-Gorgia AE, Gex-Fabry M, Balant LP: Clinical pharmacokinetics of clomipramine. Clin Pharmacokinet. 1991 Jun;20(6):447-62. doi: 10.2165/00003088-199120060-00002.
Pubmed: 2044329
da Costa CZ, de Morais RM, Zanetta DM, Turkiewicz G, Lotufo Neto F, Morikawa M, Rodrigues CL, Labbadia EM, Asbahr FR: Comparison among clomipramine, fluoxetine, and placebo for the treatment of anxiety disorders in children and adolescents. J Child Adolesc Psychopharmacol. 2013 Dec;23(10):687-92. doi: 10.1089/cap.2012.0110.
Pubmed: 24350814
Fallon BA, Liebowitz MR, Campeas R, Schneier FR, Marshall R, Davies S, Goetz D, Klein DF: Intravenous clomipramine for obsessive-compulsive disorder refractory to oral clomipramine: a placebo-controlled study. Arch Gen Psychiatry. 1998 Oct;55(10):918-24. doi: 10.1001/archpsyc.55.10.918.
Pubmed: 9783563
Benkelfat C, Murphy DL, Zohar J, Hill JL, Grover G, Insel TR: Clomipramine in obsessive-compulsive disorder. Further evidence for a serotonergic mechanism of action. Arch Gen Psychiatry. 1989 Jan;46(1):23-8. doi: 10.1001/archpsyc.1989.01810010025004.
Pubmed: 2910220
Jimenez AG, Winward JD, Smith DM, Ragan CM: Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats. Physiol Rep. 2018 May;6(9):e13615. doi: 10.14814/phy2.13615.
Pubmed: 29745454
Aitchison K, Datla K, Rooprai H, Fernando J, Dexter D: Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration. J Psychopharmacol. 2010 Aug;24(8):1261-8. doi: 10.1177/0269881109105789. Epub 2009 Jun 24.
Pubmed: 19553387
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