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Pathway Description
Metipranolol Action Pathway
Homo sapiens
Drug Action Pathway
Metipranolol (also known as Betanol or Disorat) is an beta blocker (non-selective) that can used as an antihypertensive, antiarrhythmic and antiglaucoma agent. Metipranolol binds to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle. Metipranolol demonstrates low intrinsic sympathomimetic activity, and weak local anesthetic (membrane-stabilizing) and myocardial depressant activity. Metipranolol can also reduce the producion of aqueous humor.
References
Metipranolol Pathway References
Chrapek O, Jirkova B, Kandrnal V, Rehak J, Sin M: Treatment of central serous chorioretinopathy with beta-blocker metipranolol. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Mar;159(1):120-3. doi: 10.5507/bp.2013.015. Epub 2013 Mar 21.
Pubmed: 23549516
Osborne NN, Wood JP: The beta-adrenergic receptor antagonist metipranolol blunts zinc-induced photoreceptor and RPE apoptosis. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3178-86. doi: 10.1167/iovs.05-1370.
Pubmed: 16799065
Striated Muscle Contraction References
Cooke R: The sliding filament model: 1972-2004. J Gen Physiol. 2004 Jun;123(6):643-56. doi: 10.1085/jgp.200409089.
Pubmed: 15173218
Szent-Gyorgyi A: The mechanism of muscle contraction. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3343-4.
Pubmed: 4610574
Kuo IY, Ehrlich BE: Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023.
Pubmed: 25646377
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