Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Anileridine Action Pathway
Homo sapiens
Drug Action Pathway
Anileridine (also known as Leritine) is analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAMP by inhibiting adenylate cyclase. The binding of anileridine will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
References
Anileridine Pathway References
Cho TM, Ge BL, Yamato C, Smith AP, Loh HH: Isolation of opiate binding components by affinity chromatography and reconstitution of binding activities. Proc Natl Acad Sci U S A. 1983 Sep;80(17):5176-80. doi: 10.1073/pnas.80.17.5176.
Pubmed: 6310562
Simonds WF: The molecular basis of opioid receptor function. Endocr Rev. 1988 May;9(2):200-12. doi: 10.1210/edrv-9-2-200.
Pubmed: 2841104
Neuron Function References
Lovinger DM: Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. Alcohol Res Health. 2008;31(3):196-214.
Pubmed: 23584863
Kress GJ, Mennerick S: Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience. 2009 Jan 12;158(1):211-22. doi: 10.1016/j.neuroscience.2008.03.021. Epub 2008 Mar 19.
Pubmed: 18472347
Platkiewicz J, Brette R: A threshold equation for action potential initiation. PLoS Comput Biol. 2010 Jul 8;6(7):e1000850. doi: 10.1371/journal.pcbi.1000850.
Pubmed: 20628619
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Settings