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Pathway Description
Levallorphan Action Pathway
Homo sapiens
Drug Action Pathway
Levallorphan (also known as Lorfan and Naloxifan) is a type of medication that can be used for treating drug overdoses and respirotry depression. Levallorphan can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron of central nerves system (CNS). Effects of opioids such as respiratory depression, hypotension and sedation can be prevented or reversed by levallorphan. Levallorphan can also be used for treating pentazocine which is a type of psychotomimetic and dysphoric effects of agonist-antagonists.
References
Levallorphan Pathway References
Simonds WF: The molecular basis of opioid receptor function. Endocr Rev. 1988 May;9(2):200-12. doi: 10.1210/edrv-9-2-200.
Pubmed: 2841104
Neuron Function References
Lovinger DM: Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. Alcohol Res Health. 2008;31(3):196-214.
Pubmed: 23584863
Kress GJ, Mennerick S: Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience. 2009 Jan 12;158(1):211-22. doi: 10.1016/j.neuroscience.2008.03.021. Epub 2008 Mar 19.
Pubmed: 18472347
Platkiewicz J, Brette R: A threshold equation for action potential initiation. PLoS Comput Biol. 2010 Jul 8;6(7):e1000850. doi: 10.1371/journal.pcbi.1000850.
Pubmed: 20628619
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