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Pathway Description
Buprenorphine Action Pathway
Homo sapiens
Drug Action Pathway
Buprenorphine, trade name subutex, suboxone, zubsolv and bunavail, is a partial agonist of mu-opioid receptors and a kappa-opioid receptor antagonist and is prescribed for opioid addiction to prevent cravings and symptoms of withdrawal. The binding of these receptors causes hyperpolarization and decreased neuronal excitability. Buprenorphine has a longer duration of action due to its slow dissociation from the receptor. This long rate of action causes a long clinical effect and decreases physical dependence. Buprenorphine can also prevent opioid use by inhibiting exogenous opioid effects. This elimination of the rush from the opioid can block the reinforcing behaviour of the drug and may treat opioid addiction. Buprenorphine is available on its own or in combination with naloxone.
References
Buprenorphine Pathway References
Noormohammadi A, Forinash A, Yancey A, Crannage E, Campbell K, Shyken J: Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. Ann Pharmacother. 2016 Aug;50(8):666-72. doi: 10.1177/1060028016648367. Epub 2016 May 19.
Pubmed: 27199497
Albayaty M, Linden M, Olsson H, Johnsson M, Strandgarden K, Tiberg F: Pharmacokinetic Evaluation of Once-Weekly and Once-Monthly Buprenorphine Subcutaneous Injection Depots (CAM2038) Versus Intravenous and Sublingual Buprenorphine in Healthy Volunteers Under Naltrexone Blockade: An Open-Label Phase 1 Study. Adv Ther. 2017 Feb;34(2):560-575. doi: 10.1007/s12325-016-0472-9. Epub 2017 Jan 9.
Pubmed: 28070862
Ling W: Buprenorphine implant for opioid addiction. Pain Manag. 2012 Jul;2(4):345-50. doi: 10.2217/pmt.12.26.
Pubmed: 24654720
Neuron Function References
Lovinger DM: Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol. Alcohol Res Health. 2008;31(3):196-214.
Pubmed: 23584863
Kress GJ, Mennerick S: Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience. 2009 Jan 12;158(1):211-22. doi: 10.1016/j.neuroscience.2008.03.021. Epub 2008 Mar 19.
Pubmed: 18472347
Platkiewicz J, Brette R: A threshold equation for action potential initiation. PLoS Comput Biol. 2010 Jul 8;6(7):e1000850. doi: 10.1371/journal.pcbi.1000850.
Pubmed: 20628619
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