Reference/CAS 75-50-3
type: UnificationXref
id: 75-50-3
db: CAS

Reference/ChEBI CHEBI 15724
type: UnificationXref
id: CHEBI:15724
db: ChEBI

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000925
type: UnificationXref
id: HMDB0000925
db: HMDB

ChemicalStructure/PW C000725
type: ChemicalStructure
structure format: SMILES
structure data: CN(C)C

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Trimethylamine-N-oxide reductase 1
type: Protein
cellular location: Inner Membrane
entity reference: Trimethylamine-N-oxide reductase 1

Hydrogenase-1 small chain
type: ProteinReference
xref: Reference/UniProt P69739
organism: Escherichia coli

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C041683
type: ChemicalStructure
structure format: SMILES

ReactionCoupledTransportCatalysis209
type: Catalysis
controller: formate dehydrogenase-O
controlled: 1.2.1.2
control type: ACTIVATION

NADH-quinone oxidoreductase subunit J
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit J

ReactionCoupledTransportCatalysis208
type: Catalysis
controller: hydrogenase 1, oxygen tolerant hydrogenase
controlled: 1.12.99.6
control type: ACTIVATION

Reference/SMPDB SMP0001903
type: UnificationXref
id: SMP0001903
db: SMPDB

Reference/ChemSpider 1114
type: UnificationXref
id: 1114
db: ChemSpider

Reference/ChemSpider 1113
type: UnificationXref
id: 1113
db: ChemSpider

Menaquinol 8
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Menaquinol 8

NADH-quinone oxidoreductase subunit F
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit F

NADH-quinone oxidoreductase subunit E
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit E

NADH:quinone oxidoreductase I
type: Complex
cellular location: Inner Membrane
component: NADH-quinone oxidoreductase subunit A
component: NADH-quinone oxidoreductase subunit F
component: NADH-quinone oxidoreductase subunit L
component: NADH-quinone oxidoreductase subunit E
component: NADH-quinone oxidoreductase subunit N
component: NADH-quinone oxidoreductase subunit K
component: NADH-quinone oxidoreductase subunit I
component: NADH-quinone oxidoreductase subunit M
component: NADH-quinone oxidoreductase subunit G
component: NADH-quinone oxidoreductase subunit C/D
component: NADH-quinone oxidoreductase subunit B
component: NADH-quinone oxidoreductase subunit H
component: NADH-quinone oxidoreductase subunit J

Compound/PW C000738 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Trimethylamine N-oxide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000738
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)[O-]

Reference/KEGG Compound C00565
type: UnificationXref
id: C00565
db: KEGG Compound

Hydrogenase-1 small chain
type: Protein
cellular location: Inner Membrane
entity reference: Hydrogenase-1 small chain

Hydrogenase-1 large chain
type: ProteinReference
xref: Reference/UniProt P0ACD8
organism: Escherichia coli

Formic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Formic acid

Compound/PW C040034 Inner Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 3.0

NADH-quinone oxidoreductase subunit M
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit M

NADH-quinone oxidoreductase subunit C/D
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit C/D

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

trimethylamine N-oxide reductase TorCA
type: Complex
cellular location: Inner Membrane
component: Trimethylamine-N-oxide reductase 1
component: Cytochrome c-type protein torC

Reference/PubChem-compound 45479636
type: UnificationXref
id: 45479636
db: PubChem-compound

Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
type: Protein
cellular location: Inner Membrane
entity reference: Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit

Reference/UniProt P32176
type: UnificationXref
id: P32176
db: UniProt

Formate dehydrogenase-O major subunit
type: Protein
cellular location: Inner Membrane
entity reference: Formate dehydrogenase-O major subunit

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/ChEBI CHEBI 18139
type: UnificationXref
id: CHEBI:18139
db: ChEBI

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

NADH-quinone oxidoreductase subunit L
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit L

Escherichia coli
type: BioSource
xref: Reference/TAXONOMY 562

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Protein/7282 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
stoichiometric coefficient: 2.0

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/UniProt P0ACD8
type: UnificationXref
id: P0ACD8
db: UniProt

Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
type: ProteinReference
xref: Reference/UniProt P0AAM1
organism: Escherichia coli

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/UniProt P69739
type: UnificationXref
id: P69739
db: UniProt

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Carbon dioxide

1.12.99.6
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
right: Menaquinol 8
right: Hydrogen Ion
spontaneous: false
EC number: 1.12.99.6
left: Electron
left: menaquinone-8
left: Hydrogen Ion
name: Electron + Hydrogen Ion + 2 Hydrogen Ion + menaquinone-8 → Hydrogen Ion + Menaquinol 8
conversion direction: LEFT_TO_RIGHT

Formate dehydrogenase-O iron-sulfur subunit
type: Protein
cellular location: Inner Membrane
entity reference: Formate dehydrogenase-O iron-sulfur subunit

Reference/PathWhiz PW001889
type: UnificationXref
id: PW001889
db: PathWhiz

1.2.1.2
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Inner Membrane/Stoichiometry/1.0
right: Menaquinol 8
right: Carbon dioxide
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.1.2
left: Formic acid
left: Electron
left: menaquinone-8
left: Hydrogen Ion
name: Electron + Formic acid + Hydrogen Ion + menaquinone-8 → Carbon dioxide + Hydrogen Ion + Menaquinol 8
conversion direction: LEFT_TO_RIGHT

1.6.99.5
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/4.0
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Inner Membrane/Stoichiometry/1.0
right: Electron
right: NAD
right: Menaquinol 8
right: Hydrogen Ion
spontaneous: false
EC number: 1.6.99.5
left: menaquinone-8
left: NADH
left: Hydrogen Ion
name: 4 Hydrogen Ion + 2 Hydrogen Ion + NADH + menaquinone-8 ? Electron + Hydrogen Ion + 4 Hydrogen Ion + Menaquinol 8 + NAD

formate dehydrogenase-O
type: Complex
cellular location: Inner Membrane
component: Formate dehydrogenase, cytochrome b556(fdo) subunit
component: Formate dehydrogenase-O major subunit
component: Formate dehydrogenase-O iron-sulfur subunit

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

ReactionCoupledTransport173
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C041100 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000725 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/3.0
participant stoichiometry: Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000738 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
right: Water
right: menaquinone-8
right: Trimethylamine
right: Hydrogen Ion
spontaneous: false
left: Electron
left: Trimethylamine N-oxide
left: Menaquinol 8
left: Hydrogen Ion
name: 2 Electron + 3 Hydrogen Ion + Menaquinol 8 + Trimethylamine N-oxide → 2 Hydrogen Ion + Trimethylamine + Water + menaquinone-8
conversion direction: LEFT_TO_RIGHT

menaquinone-8
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5376507
xref: Reference/ChEBI CHEBI 44027
chemical formula: C51H72O2
molecular weight: 716.5532
structure: ChemicalStructure/PW C041683

Reference/UniProt P33602
type: UnificationXref
id: P33602
db: UniProt

NAD
type: SmallMolecule
cellular location: Inner Membrane
entity reference: NAD

Compound/PW C001144 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 1145
type: UnificationXref
id: 1145
db: PubChem-compound

Reference/PubChem-compound 1146
type: UnificationXref
id: 1146
db: PubChem-compound

Reference/UniProt P0AAJ5
type: UnificationXref
id: P0AAJ5
db: UniProt

NADH-quinone oxidoreductase subunit F
type: ProteinReference
xref: Reference/UniProt P31979
organism: Escherichia coli

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Reference/UniProt P33607
type: UnificationXref
id: P33607
db: UniProt

Compound/PW C041100 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Electron
stoichiometric coefficient: 2.0

Reference/UniProt P0AFC3
type: UnificationXref
id: P0AFC3
db: UniProt

Compound/PW C040034 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/UniProt P0AFC7
type: UnificationXref
id: P0AFC7
db: UniProt

ChemicalStructure/PW C041590
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

NADH-quinone oxidoreductase subunit A
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit A

Protein/6212 Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogenase-1 large chain
stoichiometric coefficient: 4.0

Reference/PubChem-compound 5376507
type: UnificationXref
id: 5376507
db: PubChem-compound

Hydrogenase-1 large chain
type: Protein
cellular location: Inner Membrane
entity reference: Hydrogenase-1 large chain

Reference/UniProt P33599
type: UnificationXref
id: P33599
db: UniProt

Reference/UniProt P31979
type: UnificationXref
id: P31979
db: UniProt

Formate dehydrogenase-O major subunit
type: ProteinReference
xref: Reference/UniProt P32176
organism: Escherichia coli

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

hydrogenase 1, oxygen tolerant hydrogenase
type: Complex
component stoichiometry: Protein/7282 Inner Membrane/Stoichiometry/2.0
component stoichiometry: Protein/6691 Inner Membrane/Stoichiometry/4.0
component stoichiometry: Protein/6212 Inner Membrane/Stoichiometry/4.0
cellular location: Inner Membrane
component: Hydrogenase-1 large chain
component: Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
component: Hydrogenase-1 small chain

Reference/UniProt P0AFE0
type: UnificationXref
id: P0AFE0
db: UniProt

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Formate dehydrogenase, cytochrome b556(fdo) subunit
type: ProteinReference
xref: Reference/UniProt P0AEL0
organism: Escherichia coli

Reference/UniProt P0AFD1
type: UnificationXref
id: P0AFD1
db: UniProt

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C041683 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: menaquinone-8
stoichiometric coefficient: 1.0

Reference/UniProt P0AFD4
type: UnificationXref
id: P0AFD4
db: UniProt

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/UniProt P0AFD6
type: UnificationXref
id: P0AFD6
db: UniProt

NADH-quinone oxidoreductase subunit G
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit G

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

NADH
type: SmallMolecule
cellular location: Inner Membrane
entity reference: NADH

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Electron
type: SmallMoleculeReference

Reference/UniProt P33226
type: UnificationXref
id: P33226
db: UniProt

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Compound/PW C001316 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/UniProt P0AEL0
type: UnificationXref
id: P0AEL0
db: UniProt

Reference/UniProt P33225
type: UnificationXref
id: P33225
db: UniProt

Compound/PW C041590 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Menaquinol 8
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt P0AFF0
type: UnificationXref
id: P0AFF0
db: UniProt

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADH-quinone oxidoreductase subunit B
type: ProteinReference
xref: Reference/UniProt P0AFC7
organism: Escherichia coli

NADH-quinone oxidoreductase subunit A
type: ProteinReference
xref: Reference/UniProt P0AFC3
organism: Escherichia coli

Compound/PW C041100 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Electron
stoichiometric coefficient: 1.0

Reference/UniProt P0AFE4
type: UnificationXref
id: P0AFE4
db: UniProt

Trimethylamine N-oxide
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Trimethylamine N-oxide

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/UniProt P0AFE8
type: UnificationXref
id: P0AFE8
db: UniProt

Trimethylamine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Trimethylamine

Menaquinol 8
type: SmallMoleculeReference
xref: Reference/PubChem-compound 45479636
xref: Reference/ChEBI CHEBI 61684
chemical formula: C51H74O2
molecular weight: 718.5689
structure: ChemicalStructure/PW C041590

Reference/ChEBI CHEBI 44027
type: UnificationXref
id: CHEBI:44027
db: ChEBI

NADH-quinone oxidoreductase subunit H
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit H

Trimethylamine
type: SmallMoleculeReference
xref: Reference/CAS 75-50-3
xref: Reference/ChEBI CHEBI 18139
xref: Reference/ChemSpider 1114
xref: Reference/BioCyc TRIMENTHLAMINE-N-O
xref: Reference/PubChem-compound 1146
xref: Reference/KEGG Compound C00565
xref: Reference/HMDB HMDB0000906
chemical formula: C3H9N
molecular weight: 59.073498
structure: ChemicalStructure/PW C000725

Reference/UniProt P0AAM1
type: UnificationXref
id: P0AAM1
db: UniProt

menaquinone-8
type: SmallMolecule
cellular location: Inner Membrane
entity reference: menaquinone-8

Protein/6691 Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogenase-1 small chain
stoichiometric coefficient: 4.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/CAS 1184-78-7
type: UnificationXref
id: 1184-78-7
db: CAS

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

NADH-quinone oxidoreductase subunit N
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit N

NADH-quinone oxidoreductase subunit K
type: ProteinReference
xref: Reference/UniProt P0AFE4
organism: Escherichia coli

NADH-quinone oxidoreductase subunit L
type: ProteinReference
xref: Reference/UniProt P33607
organism: Escherichia coli

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

NADH-quinone oxidoreductase subunit J
type: ProteinReference
xref: Reference/UniProt P0AFE0
organism: Escherichia coli

NADH-quinone oxidoreductase subunit K
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit K

NADH-quinone oxidoreductase subunit G
type: ProteinReference
xref: Reference/UniProt P33602
organism: Escherichia coli

NADH-quinone oxidoreductase subunit C/D
type: ProteinReference
xref: Reference/UniProt P33599
organism: Escherichia coli

NADH-quinone oxidoreductase subunit I
type: ProteinReference
xref: Reference/UniProt P0AFD6
organism: Escherichia coli

Reference/KEGG Compound C01104
type: UnificationXref
id: C01104
db: KEGG Compound

NADH-quinone oxidoreductase subunit H
type: ProteinReference
xref: Reference/UniProt P0AFD4
organism: Escherichia coli

NADH-quinone oxidoreductase subunit I
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit I

NADH-quinone oxidoreductase subunit E
type: ProteinReference
xref: Reference/UniProt P0AFD1
organism: Escherichia coli

Reference/HMDB HMDB0000906
type: UnificationXref
id: HMDB0000906
db: HMDB

Formate dehydrogenase, cytochrome b556(fdo) subunit
type: Protein
cellular location: Inner Membrane
entity reference: Formate dehydrogenase, cytochrome b556(fdo) subunit

Formate dehydrogenase-O iron-sulfur subunit
type: ProteinReference
xref: Reference/UniProt P0AAJ5
organism: Escherichia coli

NADH-quinone oxidoreductase subunit N
type: ProteinReference
xref: Reference/UniProt P0AFF0
organism: Escherichia coli

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

NADH-quinone oxidoreductase subunit M
type: ProteinReference
xref: Reference/UniProt P0AFE8
organism: Escherichia coli

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

NADH-quinone oxidoreductase subunit B
type: Protein
cellular location: Inner Membrane
entity reference: NADH-quinone oxidoreductase subunit B

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C000092 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/TAXONOMY 562
type: UnificationXref
id: 562
db: TAXONOMY

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

ReactionCoupledTransportCatalysis207
type: Catalysis
controller: trimethylamine N-oxide reductase TorCA
controlled: ReactionCoupledTransport173
control type: ACTIVATION

ReactionCoupledTransportCatalysis206
type: Catalysis
controller: NADH:quinone oxidoreductase I
controlled: 1.6.99.5
control type: ACTIVATION

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Electron
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Electron

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Cytochrome c-type protein torC
type: ProteinReference
xref: Reference/UniProt P33226
organism: Escherichia coli

N-Oxide Electron Transfer
type: Pathway
pathway order: PathwayEnzymeReaction/19707
pathway order: PathwayEnzymeReaction/19708
pathway order: PathwayEnzymeReaction/19709
pathway order: PathwayEnzymeReaction/19710
pathway component: ReactionCoupledTransportCatalysis207
pathway component: ReactionCoupledTransportCatalysis206
pathway component: 1.12.99.6
pathway component: 1.2.1.2
pathway component: 1.6.99.5
pathway component: ReactionCoupledTransportCatalysis209
pathway component: ReactionCoupledTransport173
pathway component: ReactionCoupledTransportCatalysis208
xref: Reference/SMPDB SMP0001903
xref: Reference/PathWhiz PW001889
organism: Escherichia coli

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Trimethylamine N-oxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 1113
xref: Reference/ChEBI CHEBI 15724
xref: Reference/CAS 1184-78-7
xref: Reference/PubChem-compound 1145
xref: Reference/BioCyc TRIMENTHLAMINE-N-O
xref: Reference/HMDB HMDB0000925
xref: Reference/KEGG Compound C01104
chemical formula: C3H9NO
molecular weight: 75.06841
structure: ChemicalStructure/PW C000738

Trimethylamine-N-oxide reductase 1
type: ProteinReference
xref: Reference/UniProt P33225
organism: Escherichia coli

Compound/PW C000725 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Trimethylamine
stoichiometric coefficient: 1.0

Compound/PW C040034 Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

Cytochrome c-type protein torC
type: Protein
cellular location: Inner Membrane
entity reference: Cytochrome c-type protein torC

Reference/BioCyc TRIMENTHLAMINE-N-O
type: UnificationXref
id: TRIMENTHLAMINE-N-O
db: BioCyc

Compound/PW C000721 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 61684
type: UnificationXref
id: CHEBI:61684
db: ChEBI