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Pathway Description
Methylglyoxal Degradation I
Escherichia coli
Metabolic Pathway
The degradation of methylglyoxal starts with methylglyoxal being degraded by interacting with glutathione and a glyoxalase resulting in the release of a (R)-S-lactoylglutatione. This compound in turn reacts with a water molecule through a glyoxalase II resulting in the releas of glutathione, a hydrogen ion and an R-lactate. The R-lactate in turn reacts with an ubiquinone through a D-lactate dehydrogenase resulting in the release of an ubiquinol and a pyruvate which can then be incorporated the pyruvate metabolism
References
Methylglyoxal Degradation I References
Dym O, Pratt EA, Ho C, Eisenberg D: The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9413-8.
Pubmed: 10944213
Gonzalez CF, Proudfoot M, Brown G, Korniyenko Y, Mori H, Savchenko AV, Yakunin AF: Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG. J Biol Chem. 2006 May 19;281(20):14514-22. doi: 10.1074/jbc.M600996200. Epub 2006 Mar 27.
Pubmed: 16567800
Kalapos MP: Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications. Toxicol Lett. 1999 Nov 22;110(3):145-75.
Pubmed: 10597025
Ozyamak E, Black SS, Walker CA, Maclean MJ, Bartlett W, Miller S, Booth IR: The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli. Mol Microbiol. 2010 Dec;78(6):1577-90. doi: 10.1111/j.1365-2958.2010.07426.x. Epub 2010 Oct 29.
Pubmed: 21143325
Reiger M, Lassak J, Jung K: Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli. FEMS Microbiol Lett. 2015 Jan;362(2):1-7. doi: 10.1093/femsle/fnu014. Epub 2014 Dec 4.
Pubmed: 25670698
Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from PW002113
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