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Pathway Description
Operon: Cell Division Control
Escherichia coli
Protein Pathway
The dicB-ydfDE-insD7-intQ operon in E. coli contains five genes, the first of which is part of the inhibition of cell division in E. coli. The other genes may produce proteins of unknown function, and are prophage genes that are present in the E. coli population. This operon can be inactivated by the HTH-type transcriptional regulator DicA, allowing cell division to occur.
The first gene in the operon, dicB, encodes the division inhibition protein DicB which prevents cell division from occurring.
The second gene, ydfD, encodes an uncharacterized protein YdfD, which may be involved in viral infection of the cell.
The third gene, ydfE, encodes a putative uncharacterized protein YdfE, which may be shortened by an insertion element between this gene and intQ.
The fourth gene, insD7, which encodes the transpose InsD for insertion element IS2 on F plasmid, a protein involved in transposing the insertion sequence IS2.
The final gene, intQ, encodes the putative defective protein IntQ, an integrase used to insert and remove the prophage from the E. coli genome. In this case, the protein may be non-functional due to the presence of the insertion element between the ydfE and intQ genes.
References
Operon: Cell Division Control References
Bouche F, Bouche JP: Genetic evidence that DicF, a second division inhibitor encoded by the Escherichia coli dicB operon, is probably RNA. Mol Microbiol. 1989 Jul;3(7):991-4.
Pubmed: 2477663
Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y: Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form. Eur J Biochem. 1990 Aug 17;191(3):563-9. doi: 10.1111/j.1432-1033.1990.tb19158.x.
Pubmed: 2129526
Hansen KR, Resta R, Webb CF, Thompson LF: Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene. Gene. 1995 Dec 29;167(1-2):307-12. doi: 10.1016/0378-1119(95)00574-9.
Pubmed: 8566797
Knapp K, Zebisch M, Pippel J, El-Tayeb A, Muller CE, Strater N: Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling. Structure. 2012 Dec 5;20(12):2161-73. doi: 10.1016/j.str.2012.10.001. Epub 2012 Nov 8.
Pubmed: 23142347
Yun, S.H., Ji, S.C., Jeon, H.J., Wang, X., Kim, S.W., Bak, G., Lee, Y. and Lim, H.M., 2012. The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli.
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