PathWhiz

Pathway Description

Operon: Folylpolyglutamate Synthase

Escherichia coli

Signaling Pathway

The folC-dedD operon in E. coli contains two genes that are involved in various processes in the cell. There are currently no known activators or inhibitors of the operon. The first gene, folC, encodes a bifunctional dihydrofolate synthase and folylpolyglutamate synthase protein. This catalyzes the conversion of 7,8-dihydrofolate fro glutamate and d7,8-dihydropteroate, as well as the formation of folylpolyglutamates. These are further used in cofactor biosynthesis by the cell. The second gene, dedD, encodes a cell division protein. It is non-essential for the cell, and may be used during cell constriction during division, making the process more efficient.

References

Operon: Folylpolyglutamate Synthase References

Bermingham A, Derrick JP: The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays. 2002 Jul;24(7):637-48. doi: 10.1002/bies.10114.

Pubmed: 12111724

Bognar AL, Osborne C, Shane B, Singer SC, Ferone R: Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product. J Biol Chem. 1985 May 10;260(9):5625-30.

Pubmed: 2985605

Bognar AL, Osborne C, Shane B: Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene. J Biol Chem. 1987 Sep 5;262(25):12337-43.

Pubmed: 3040739

Highlighted elements will appear in red.

Highlight Compounds

	Magnesium
	Potassium

Highlight Proteins

	Bifunctional protein folC
	Cell division protein DedD

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