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Pathway Description
Operon: Phosphonate Utilization
Escherichia coli
Protein Pathway
The phosphonate utilization operon is a polycistronic operon consist of the genes: phnC, phnD, phnE, phnF, phnG, phnH, phnI, phnJ, phnK, phnL, phnM, phnN,phnO and phnQ. This operon's transcription is activated by a PhoB-Phosphorylated DNA-binding transcriptional dual regulator binding on an unspecified binding site.
References
Operon: Phosphonate Utilization References
Huerta AM, Collado-Vides J: Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. J Mol Biol. 2003 Oct 17;333(2):261-78.
Pubmed: 14529615
Jiang W, Metcalf WW, Lee KS, Wanner BL: Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2. J Bacteriol. 1995 Nov;177(22):6411-21.
Pubmed: 7592415
Makino K, Kim SK, Shinagawa H, Amemura M, Nakata A: Molecular analysis of the cryptic and functional phn operons for phosphonate use in Escherichia coli K-12. J Bacteriol. 1991 Apr;173(8):2665-72.
Pubmed: 1840580
Marzan LW, Hasan CM, Shimizu K: Effect of acidic condition on the metabolic regulation of Escherichia coli and its phoB mutant. Arch Microbiol. 2013 Mar;195(3):161-71. doi: 10.1007/s00203-012-0861-7. Epub 2012 Dec 30.
Pubmed: 23274360
Metcalf WW, Wanner BL: Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. J Bacteriol. 1991 Jan;173(2):587-600.
Pubmed: 1846145
Metcalf WW, Wanner BL: Mutational analysis of an Escherichia coli fourteen-gene operon for phosphonate degradation, using TnphoA' elements. J Bacteriol. 1993 Jun;175(11):3430-42.
Pubmed: 8388873
Wanner BL, Boline JA: Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. J Bacteriol. 1990 Mar;172(3):1186-96.
Pubmed: 2155195
Wanner BL, Metcalf WW: Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation. FEMS Microbiol Lett. 1992 Dec 15;100(1-3):133-9.
Pubmed: 1335942
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