Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C042596 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-3-methyl-2-oxopentanoate
stoichiometric coefficient: 1.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

2-Methylbutyryl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 6712-02-3
xref: Reference/ChEBI CHEBI 15477
xref: Reference/HMDB HMDB0001041
xref: Reference/KEGG Compound C01033
xref: Reference/ChemSpider 388491
xref: Reference/PubChem-compound 439371
xref: Reference/BioCyc 2-METHYL-BUTYRYL-COA
chemical formula: C26H44N7O17P3S
molecular weight: 851.1727
structure: ChemicalStructure/PW C000820

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reaction7232
type: BiochemicalReaction
participant stoichiometry: Protein/Generic37/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000820/Stoichiometry/1.0
participant stoichiometry: Protein/Generic38/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001378/Stoichiometry/1.0
right: Reduced flavoprotein
right: Tiglyl-CoA
spontaneous: false
left: Oxidized flavoprotein
left: 2-Methylbutyryl-CoA
name: 2-Methylbutyryl-CoA + Oxidized flavoprotein → Reduced flavoprotein + Tiglyl-CoA
conversion direction: LEFT_TO_RIGHT

1.2.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042596/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000820/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
right: NADH
right: Carbon dioxide
right: 2-Methylbutyryl-CoA
spontaneous: false
EC number: 1.2.4.4
left: Coenzyme A
left: (S)-3-methyl-2-oxopentanoate
left: NAD
name: (S)-3-methyl-2-oxopentanoate + Coenzyme A + NAD → 2-Methylbutyryl-CoA + Carbon dioxide + NADH
conversion direction: LEFT_TO_RIGHT

Reaction7234
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000897/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001047/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: 2-Methylacetoacetyl-CoA
spontaneous: false
left: 2-Methyl-3-hydroxybutyryl-CoA
left: NAD
name: 2-Methyl-3-hydroxybutyryl-CoA + NAD → 2-Methylacetoacetyl-CoA + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reaction7233
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001378/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001047/Stoichiometry/1.0
right: 2-Methyl-3-hydroxybutyryl-CoA
spontaneous: false
left: Water
left: Tiglyl-CoA
name: Tiglyl-CoA + Water → 2-Methyl-3-hydroxybutyryl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 52
type: UnificationXref
id: 52
db: ChemSpider

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/BioCyc 2-METHYL-BUTYRYL-COA
type: UnificationXref
id: 2-METHYL-BUTYRYL-COA
db: BioCyc

Reaction7235
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000897/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000988/Stoichiometry/1.0
right: Coenzyme A
right: Acetyl-CoA
right: Propionyl-CoA
spontaneous: false
left: 2-Methylacetoacetyl-CoA
name: 2-Methylacetoacetyl-CoA → Acetyl-CoA + Coenzyme A + Propionyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/CAS 73-32-5
type: UnificationXref
id: 73-32-5
db: CAS

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

(S)-3-methyl-2-oxopentanoate
type: SmallMoleculeReference
chemical formula: C6H10O3
molecular weight: 130.06299
structure: ChemicalStructure/PW C042596

NAD
type: SmallMolecule
entity reference: NAD

Tiglyl-CoA
type: SmallMolecule
entity reference: Tiglyl-CoA

Reference/CAS 52227-66-4
type: UnificationXref
id: 52227-66-4
db: CAS

Reference/UniProt Q9LPM9
type: UnificationXref
id: Q9LPM9
db: UniProt

Reaction7229
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042596/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000112/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: (S)-3-methyl-2-oxopentanoate
right: Carbon dioxide
spontaneous: false
left: L-Isoleucine
left: Hydrogen Ion
name: Hydrogen Ion + L-Isoleucine → (S)-3-methyl-2-oxopentanoate + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reaction7228
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042596/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000112/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: L-Glutamic acid
right: (S)-3-methyl-2-oxopentanoate
spontaneous: false
left: L-Isoleucine
left: Oxoglutaric acid
name: L-Isoleucine + Oxoglutaric acid → (S)-3-methyl-2-oxopentanoate + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Tiglyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15478
xref: Reference/ChemSpider 4444187
xref: Reference/PubChem-compound 5280564
xref: Reference/BioCyc TIGLYL-COA
xref: Reference/HMDB HMDB0002054
xref: Reference/KEGG Compound C03345
chemical formula: C26H42N7O17P3S
molecular weight: 849.15704
structure: ChemicalStructure/PW C001378

Reference/BioCyc TIGLYL-COA
type: UnificationXref
id: TIGLYL-COA
db: BioCyc

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/PubChem-compound 53
type: UnificationXref
id: 53
db: PubChem-compound

Reference/UniProt Q9M7Z1
type: UnificationXref
id: Q9M7Z1
db: UniProt

Reference/BioCyc 2-METHYL-ACETO-ACETYL-COA
type: UnificationXref
id: 2-METHYL-ACETO-ACETYL-COA
db: BioCyc

Dihydrolipoyl dehydrogenase 2, mitochondrial
type: Protein
entity reference: Dihydrolipoyl dehydrogenase 2, mitochondrial

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
type: Protein
entity reference: 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial

2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
type: Protein
entity reference: 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
type: Protein
entity reference: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

Branched-chain-amino-acid aminotransferase 6
type: Protein
entity reference: Branched-chain-amino-acid aminotransferase 6

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/HMDB HMDB0002054
type: UnificationXref
id: HMDB0002054
db: HMDB

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C000897/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methylacetoacetyl-CoA
stoichiometric coefficient: 1.0

Protein/Generic37/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced flavoprotein
stoichiometric coefficient: 1.0

2-Methylbutyryl-CoA
type: SmallMolecule
entity reference: 2-Methylbutyryl-CoA

Reference/KEGG Compound C00100
type: UnificationXref
id: C00100
db: KEGG Compound

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Branched-chain-amino-acid aminotransferase 1, mitochondrial
type: Protein
entity reference: Branched-chain-amino-acid aminotransferase 1, mitochondrial

ReactionCatalysis7219
type: Catalysis
controller: branched-chain keto-acid dehydrogenase complex
controlled: 1.2.4.4
control type: ACTIVATION

Compound/PW C000820/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methylbutyryl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439164
type: UnificationXref
id: 439164
db: PubChem-compound

Compound/PW C001378/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tiglyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis7217
type: Catalysis
controller: Branched-chain-amino-acid aminotransferase 6
controlled: Reaction7229
control type: ACTIVATION

ReactionCatalysis7216
type: Catalysis
controller: Branched-chain-amino-acid aminotransferase 1, mitochondrial
controlled: Reaction7228
control type: ACTIVATION

(S)-3-methyl-2-oxopentanoate
type: SmallMolecule
cellular location: Cytosol
entity reference: (S)-3-methyl-2-oxopentanoate

Propionyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 317-66-8
xref: Reference/PubChem-compound 439164
xref: Reference/KEGG Compound C00100
xref: Reference/ChEBI CHEBI 15539
xref: Reference/BioCyc PROPIONYL-COA
xref: Reference/ChemSpider 388310
xref: Reference/HMDB HMDB0001275
chemical formula: C24H40N7O17P3S
molecular weight: 823.1414
structure: ChemicalStructure/PW C000988

Reference/UniProt Q93Y32
type: UnificationXref
id: Q93Y32
db: UniProt

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

2-Methylacetoacetyl-CoA
type: SmallMolecule
entity reference: 2-Methylacetoacetyl-CoA

Branched-chain-amino-acid aminotransferase 6
type: ProteinReference
xref: Reference/UniProt Q9LPM9

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 388310
type: UnificationXref
id: 388310
db: ChemSpider

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/CAS 6712-02-3
type: UnificationXref
id: 6712-02-3
db: CAS

Reference/PubChem-compound 5280564
type: UnificationXref
id: 5280564
db: PubChem-compound

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

2-Methyl-3-hydroxybutyryl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001356
xref: Reference/ChEBI CHEBI 15449
xref: Reference/KEGG Compound C04405
xref: Reference/ChemSpider 389295
xref: Reference/PubChem-compound 440326
xref: Reference/CAS 52227-66-4
xref: Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
chemical formula: C26H44N7O18P3S
molecular weight: 867.16766
structure: ChemicalStructure/PW C001047

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChemSpider 4444187
type: UnificationXref
id: 4444187
db: ChemSpider

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc PROPIONYL-COA
type: UnificationXref
id: PROPIONYL-COA
db: BioCyc

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

(S)-3-methyl-2-oxopentanoate
type: SmallMolecule
entity reference: (S)-3-methyl-2-oxopentanoate

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

(S)-3-methyl-2-oxopentanoate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (S)-3-methyl-2-oxopentanoate

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

2-Methyl-3-hydroxybutyryl-CoA
type: SmallMolecule
entity reference: 2-Methyl-3-hydroxybutyryl-CoA

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reduced flavoprotein
type: Protein
entity reference: Reduced flavoprotein

ChemicalStructure/PW C000112
type: ChemicalStructure
structure format: SMILES
structure data: CC[C@H](C)[C@H](N)C(O)=O

Oxidized flavoprotein
type: Protein
entity reference: Oxidized flavoprotein

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Isoleucine Degradation
type: Pathway
pathway order: PathwayEnzymeReaction/26626
pathway order: PathwayEnzymeReaction/26627
pathway order: PathwayEnzymeReaction/26628
pathway order: PathwayTransport/26629
pathway order: PathwayEnzymeReaction/26630
pathway order: PathwayEnzymeReaction/26623
pathway order: PathwayEnzymeReaction/26624
pathway order: PathwayEnzymeReaction/26625
pathway component: Reaction7229
pathway component: Reaction7228
pathway component: ReactionCatalysis7219
pathway component: Reaction7232
pathway component: 1.2.4.4
pathway component: Reaction7234
pathway component: Reaction7233
pathway component: Reaction7235
pathway component: ReactionCatalysis7217
pathway component: ReactionCatalysis7216
pathway component: Transport577
xref: Reference/SMPDB SMP0002431
xref: Reference/PathWhiz PW002538
organism: Arabidopsis thaliana

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/ChemSpider 6067
type: UnificationXref
id: 6067
db: ChemSpider

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Propionyl-CoA
type: SmallMolecule
entity reference: Propionyl-CoA

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Compound/PW C000988/Stoichiometry/1.0
type: Stoichiometry
physical entity: Propionyl-CoA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/CAS 317-66-8
type: UnificationXref
id: 317-66-8
db: CAS

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15449
type: UnificationXref
id: CHEBI:15449
db: ChEBI

Reference/PubChem-compound 6306
type: UnificationXref
id: 6306
db: PubChem-compound

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/BioCyc 2-METHYL-3-HYDROXY-BUTYRYL-COA
type: UnificationXref
id: 2-METHYL-3-HYDROXY-BUTYRYL-COA
db: BioCyc

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

Compound/PW C000112/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Isoleucine
stoichiometric coefficient: 1.0

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/KEGG Compound C04405
type: UnificationXref
id: C04405
db: KEGG Compound

Reference/ChemSpider 389295
type: UnificationXref
id: 389295
db: ChemSpider

Reference/BioCyc ILE
type: UnificationXref
id: ILE
db: BioCyc

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/HMDB HMDB0001356
type: UnificationXref
id: HMDB0001356
db: HMDB

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/ChEBI CHEBI 17191
type: UnificationXref
id: CHEBI:17191
db: ChEBI

Compound/PW C001047/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Methyl-3-hydroxybutyryl-CoA
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0002431
type: UnificationXref
id: SMP0002431
db: SMPDB

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000820
type: ChemicalStructure
structure format: SMILES

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/PubChem-compound 440326
type: UnificationXref
id: 440326
db: PubChem-compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 6712-01-2
type: UnificationXref
id: 6712-01-2
db: CAS

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/ChEBI CHEBI 15539
type: UnificationXref
id: CHEBI:15539
db: ChEBI

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Dihydrolipoyl dehydrogenase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9M5K2

Reference/UniProt Q84JL2
type: UnificationXref
id: Q84JL2
db: UniProt

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9M7Z1

2-Methylacetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001157
xref: Reference/ChEBI CHEBI 15476
xref: Reference/CAS 6712-01-2
xref: Reference/BioCyc 2-METHYL-ACETO-ACETYL-COA
xref: Reference/PubChem-compound 53
xref: Reference/ChemSpider 52
xref: Reference/KEGG Compound C03344
chemical formula: C26H42N7O18P3S
molecular weight: 865.152
structure: ChemicalStructure/PW C000897

2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9LDY2

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q84JL2

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Branched-chain-amino-acid aminotransferase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q93Y32

Reference/KEGG Compound C01033
type: UnificationXref
id: C01033
db: KEGG Compound

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/UniProt Q9M5K2
type: UnificationXref
id: Q9M5K2
db: UniProt

branched-chain keto-acid dehydrogenase complex
type: Complex
component: Dihydrolipoyl dehydrogenase 2, mitochondrial
component: 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
component: 2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
component: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

ChemicalStructure/PW C001378
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Protein/Generic38/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized flavoprotein
stoichiometric coefficient: 1.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/UniProt Q9LDY2
type: UnificationXref
id: Q9LDY2
db: UniProt

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reduced flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086

Reference/KEGG Compound C03344
type: UnificationXref
id: C03344
db: KEGG Compound

Oxidized flavoprotein
type: ProteinReference
xref: Reference/ChEBI CHEBI 5086

Reference/KEGG Compound C03345
type: UnificationXref
id: C03345
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

L-Isoleucine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00407
xref: Reference/ChEBI CHEBI 17191
xref: Reference/PubChem-compound 6306
xref: Reference/HMDB HMDB0000172
xref: Reference/BioCyc ILE
xref: Reference/ChemSpider 6067
xref: Reference/CAS 73-32-5
chemical formula: C6H13NO2
molecular weight: 131.09464
structure: ChemicalStructure/PW C000112

Reference/HMDB HMDB0000172
type: UnificationXref
id: HMDB0000172
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/KEGG Compound C00407
type: UnificationXref
id: C00407
db: KEGG Compound

ChemicalStructure/PW C000897
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001157
type: UnificationXref
id: HMDB0001157
db: HMDB

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/HMDB HMDB0001275
type: UnificationXref
id: HMDB0001275
db: HMDB

Compound/PW C042596/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-3-methyl-2-oxopentanoate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/ChemSpider 388491
type: UnificationXref
id: 388491
db: ChemSpider

ChemicalStructure/PW C000988
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

L-Isoleucine
type: SmallMolecule
entity reference: L-Isoleucine

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C001047
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001041
type: UnificationXref
id: HMDB0001041
db: HMDB

ChemicalStructure/PW C042596
type: ChemicalStructure
structure format: SMILES
structure data: CC[C@H](C)C(=O)C(O)=O

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/PathWhiz PW002538
type: UnificationXref
id: PW002538
db: PathWhiz

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Transport577
type: Transport
participant stoichiometry: Compound/PW C042596 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042596 Cytosol/Stoichiometry/1.0
right: (S)-3-methyl-2-oxopentanoate
spontaneous: false
left: (S)-3-methyl-2-oxopentanoate
name: (S)-3-methyl-2-oxopentanoate (→) Transport: Arabidopsis thaliana, Cell, Mitochondrial Matrix to Arabidopsis thaliana, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15476
type: UnificationXref
id: CHEBI:15476
db: ChEBI

Reference/ChEBI CHEBI 15478
type: UnificationXref
id: CHEBI:15478
db: ChEBI

Reference/ChEBI CHEBI 15477
type: UnificationXref
id: CHEBI:15477
db: ChEBI

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/PubChem-compound 439371
type: UnificationXref
id: 439371
db: PubChem-compound

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C042596 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-3-methyl-2-oxopentanoate
stoichiometric coefficient: 1.0