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Pathway Description
Valine Degradation
Arabidopsis thaliana
Metabolic Pathway
The degradation of valine starts either in the mitochondria or the cytosol. L-valine reacts with 2-oxoglutarate through a branch-chain amino acid aminotransferase resulting in the release of L-glutamate and 3-methyl-2-oxobutanoate. The latter compound reacts with 2-oxoisovalerate carboxy-lyase resulting in the release of carbon dioxide and isobutanal. Isobutanal can then be turned into isobutanol through a alcohol dehydrogenase
References
Valine Degradation References
Binder S: Branched-Chain Amino Acid Metabolism in Arabidopsis thaliana. Arabidopsis Book. 2010;8:e0137. doi: 10.1199/tab.0137. Epub 2010 Aug 23.
Pubmed: 22303262
Diebold R, Schuster J, Daschner K, Binder S: The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins. Plant Physiol. 2002 Jun;129(2):540-50. doi: 10.1104/pp.001602.
Pubmed: 12068099
Gerbling H, Gerhardt B: Peroxisomal degradation of branched-chain 2-oxo acids. Plant Physiol. 1989 Dec;91(4):1387-92.
Pubmed: 16667190
Schuster J, Binder S: The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana. Plant Mol Biol. 2005 Jan;57(2):241-54. doi: 10.1007/s11103-004-7533-1.
Pubmed: 15821880
Taylor NL, Heazlewood JL, Day DA, Millar AH: Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Plant Physiol. 2004 Feb;134(2):838-48. doi: 10.1104/pp.103.035675. Epub 2004 Feb 5.
Pubmed: 14764908
Knill T, Schuster J, Reichelt M, Gershenzon J, Binder S: Arabidopsis branched-chain aminotransferase 3 functions in both amino acid and glucosinolate biosynthesis. Plant Physiol. 2008 Mar;146(3):1028-39. doi: 10.1104/pp.107.111609. Epub 2007 Dec 27.
Pubmed: 18162591
Millar AH, Sweetlove LJ, Giege P, Leaver CJ: Analysis of the Arabidopsis mitochondrial proteome. Plant Physiol. 2001 Dec;127(4):1711-27.
Pubmed: 11743115
Richmond TA, Bleecker AB: A defect in beta-oxidation causes abnormal inflorescence development in Arabidopsis. Plant Cell. 1999 Oct;11(10):1911-24.
Pubmed: 10521521
Rubio S, Larson TR, Gonzalez-Guzman M, Alejandro S, Graham IA, Serrano R, Rodriguez PL: An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. Plant Physiol. 2006 Mar;140(3):830-43. doi: 10.1104/pp.105.072066. Epub 2006 Jan 13.
Pubmed: 16415216
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