Pterin Biosynthesis (Folate Precursor)
type: Pathway
pathway order: PathwayEnzymeReaction/211495
pathway order: PathwayTransport/211496
pathway order: PathwaySubPathway/4416
pathway order: PathwayEnzymeReaction/211487
pathway order: PathwaySubPathway/4417
pathway order: PathwaySubPathway/4418
pathway order: PathwayEnzymeReaction/211509
pathway order: PathwayEnzymeReaction/211494
pathway order: PathwayEnzymeReaction/211488
pathway order: PathwayEnzymeReaction/211510
pathway order: PathwayEnzymeReaction/211511
pathway order: PathwayEnzymeReaction/211512
pathway component: ReactionCatalysis37573
pathway component: ReactionCatalysis37556
pathway component: ReactionCatalysis37558
pathway component: ReactionCatalysis37569
pathway component: ReactionCatalysis37557
pathway component: Folate Biosynthesis
pathway component: pABA Synthesis Sub-Pathway
pathway component: 3.5.4.16
pathway component: Purine Metabolism
pathway component: 3.6.1.67
pathway component: 4.1.2.25
pathway component: 3.6.1.-
pathway component: 5.1.99.-
pathway component: ReactionCatalysis37570
pathway component: Reaction47425
pathway component: 2.7.6.3
pathway component: ReactionCatalysis37572
pathway component: 2.5.1.15
pathway component: ReactionCatalysis37571
pathway component: Transport887
pathway component: TransportCatalysis787
xref: Reference/PathWhiz PW012873
xref: Reference/SMPDB SMP0012013
organism: Arabidopsis thaliana

Reference/TAXONOMY 3702
type: UnificationXref
id: 3702
db: TAXONOMY

dihydroneopterin phosphate phosphatase
type: Protein
cellular location: Cytosol
entity reference: dihydroneopterin phosphate phosphatase

ReactionCatalysis37569
type: Catalysis
controller: dihydroneopterin aldolase
controlled: 4.1.2.25
control type: ACTIVATION

ChemicalStructure/PW C001537
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1

Reference/PubChem-compound 7057990
type: UnificationXref
id: 7057990
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

HMDHP pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: HMDHP pyrophosphate

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/HMDB HMDB0002275
type: UnificationXref
id: HMDB0002275
db: HMDB

Reference/KEGG Compound C04807
type: UnificationXref
id: C04807
db: KEGG Compound

Reference/KEGG Compound C00568
type: UnificationXref
id: C00568
db: KEGG Compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/KEGG Compound C21008
type: UnificationXref
id: C21008
db: KEGG Compound

GTP cyclohydrolase
type: Complex
component stoichiometry: Protein/11474 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: GTP cyclohydrolase I

ReactionCatalysis37556
type: Catalysis
controller: GTP cyclohydrolase
controlled: 3.5.4.16
control type: ACTIVATION

ReactionCatalysis37558
type: Catalysis
controller: dihydroneopterin phosphate phosphatase
controlled: 3.6.1.-
control type: ACTIVATION

ReactionCatalysis37557
type: Catalysis
controller: Nudix hydrolase 1
controlled: 3.6.1.67
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
type: UnificationXref
id: DIHYDROXYPHENYLGLYCOLALDEHYDE
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/CAS 20574-65-6
type: UnificationXref
id: 20574-65-6
db: CAS

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

HMDHP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: HMDHP
name: SubPathwayInput

Reference/ChemSpider 21865614
type: UnificationXref
id: 21865614
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C01300
type: UnificationXref
id: C01300
db: KEGG Compound

Reference/ChemSpider 953
type: UnificationXref
id: 953
db: ChemSpider

Compound/PW C001850 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycolaldehyde
stoichiometric coefficient: 1.0

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/PathWhiz PW012873
type: UnificationXref
id: PW012873
db: PathWhiz

dihydroneopterin aldolase
type: Complex
component stoichiometry: Protein/11477 Cytosol/Stoichiometry/8.0
cellular location: Cytosol
component: dihydroneopterin aldolase 1

Reference/GENE ONTOLOGY GO 0009507
type: UnificationXref
id: GO:0009507
db: GENE ONTOLOGY

Compound/PW C002953 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroneopterin phosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate
name: SubPathwayOutput

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

ReactionCatalysis37573
type: Catalysis
controller: HPPK-DHPS
controlled: 2.5.1.15
control type: ACTIVATION

Compound/PW C001090 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydropteroic acid
stoichiometric coefficient: 1.0

Reference/UniProt Q9SF23
type: UnificationXref
id: Q9SF23
db: UniProt

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

ReactionCatalysis37570
type: Catalysis
controller: dihydroneopterin aldolase
controlled: 5.1.99.-
control type: ACTIVATION

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/BioCyc DIHYDRONEOPTERIN-P3
type: UnificationXref
id: DIHYDRONEOPTERIN-P3
db: BioCyc

ReactionCatalysis37572
type: Catalysis
controller: HPPK-DHPS
controlled: 2.7.6.3
control type: ACTIVATION

7,8-dihydromonapterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C21008
xref: Reference/ChEBI CHEBI 71175
xref: Reference/PubChem-compound 45479435
xref: Reference/BioCyc CPD-11770
chemical formula: C9H13N5O4
molecular weight: 255.09676
structure: ChemicalStructure/PW C057874

HMDHP
type: SmallMoleculeReference
xref: Reference/ChemSpider 213
xref: Reference/PubChem-compound 218
xref: Reference/ChEBI CHEBI 17083
xref: Reference/BioCyc AMINO-OH-HYDROXYMETHYL-DIHYDROPTERIDINE
xref: Reference/KEGG Compound C01300
chemical formula: C7H9N5O2
molecular weight: 195.07562
structure: ChemicalStructure/PW C057873

ReactionCatalysis37571
type: Catalysis
controller: dihydroneopterin aldolase
controlled: Reaction47425
control type: ACTIVATION

Reference/HMDB HMDB0001412
type: UnificationXref
id: HMDB0001412
db: HMDB

Reference/ChEBI CHEBI 4581
type: UnificationXref
id: CHEBI:4581
db: ChEBI

Compound/PW C001850 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycolaldehyde
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25244074
type: UnificationXref
id: 25244074
db: PubChem-compound

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C057873 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: HMDHP
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001090
type: ChemicalStructure
structure format: SMILES

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Protein/11474 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: GTP cyclohydrolase I
stoichiometric coefficient: 2.0

Reference/KEGG Compound C05925
type: UnificationXref
id: C05925
db: KEGG Compound

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

HPPK-DHPS
type: Protein
cellular location: Cytosol
entity reference: HPPK-DHPS

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 213
type: UnificationXref
id: 213
db: ChemSpider

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00921
type: UnificationXref
id: C00921
db: KEGG Compound

Compound/PW C057873 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: HMDHP
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/CAS 141-46-8
type: UnificationXref
id: 141-46-8
db: CAS

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Glycolaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycolaldehyde

Dihydroneopterin triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroneopterin triphosphate

HMDHP
type: SmallMolecule
cellular location: Cytosol
entity reference: HMDHP

Glycolaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17071
xref: Reference/PubChem-compound 756
xref: Reference/BioCyc DIHYDROXYPHENYLGLYCOLALDEHYDE
xref: Reference/ChemSpider 736
xref: Reference/HMDB HMDB0003344
xref: Reference/CAS 141-46-8
xref: Reference/KEGG Compound C00266
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C001850

Reference/ChemSpider 108735
type: UnificationXref
id: 108735
db: ChemSpider

Reference/CAS 150-13-0
type: UnificationXref
id: 150-13-0
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Protein/11477 Cytosol/Stoichiometry/8.0
type: Stoichiometry
physical entity: dihydroneopterin aldolase 1
stoichiometric coefficient: 8.0

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/ChEBI CHEBI 17001
type: UnificationXref
id: CHEBI:17001
db: ChEBI

p-Aminobenzoic acid
type: SmallMolecule
cellular location: Chloroplast
entity reference: p-Aminobenzoic acid
name: SubPathwayOutput

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

dihydroneopterin aldolase 1
type: Protein
cellular location: Cytoplasm
entity reference: dihydroneopterin aldolase 1

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/PubChem-compound 218
type: UnificationXref
id: 218
db: PubChem-compound

HMDHP transporter
type: Protein
entity reference: HMDHP transporter

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Compound/PW C001537 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydroneopterin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00266
type: UnificationXref
id: C00266
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/UniProt Q9CA40
type: UnificationXref
id: Q9CA40
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Nudix hydrolase 1
type: Protein
cellular location: Cytosol
entity reference: Nudix hydrolase 1

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/BioCyc CPD-11770
type: UnificationXref
id: CPD-11770
db: BioCyc

Reference/KEGG Compound C04874
type: UnificationXref
id: C04874
db: KEGG Compound

Compound/PW C057874 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydromonapterin
stoichiometric coefficient: 1.0

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

7,8-Dihydroneopterin
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 7,8-Dihydroneopterin

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/BioCyc 7,8-dihydropteroate
type: UnificationXref
id: 7,8-dihydropteroate
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/CAS 1218-98-0
type: UnificationXref
id: 1218-98-0
db: CAS

7,8-Dihydropteroic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 7,8-Dihydropteroic acid

Reference/PubChem-compound 756
type: UnificationXref
id: 756
db: PubChem-compound

ChemicalStructure/PW C057873
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC2=C(N=C(CO)CN2)C(=O)N1

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

ChemicalStructure/PW C057874
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C057875
type: ChemicalStructure
structure format: SMILES
structure data: OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O

Reference/ChEBI CHEBI 17071
type: UnificationXref
id: CHEBI:17071
db: ChEBI

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Transport887
type: Transport
participant stoichiometry: Compound/PW C057873 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057873 Cytosol/Stoichiometry/1.0
right: HMDHP
spontaneous: false
left: HMDHP
name: HMDHP (→) Transport: Arabidopsis thaliana, Cell, Cytosol to Arabidopsis thaliana, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

7,8-Dihydropteroic acid
type: SmallMoleculeReference
xref: Reference/CAS 2134-76-1
xref: Reference/KEGG Compound C00921
xref: Reference/HMDB HMDB0001412
xref: Reference/ChEBI CHEBI 4581
xref: Reference/PubChem-compound 170
xref: Reference/ChemSpider 165
xref: Reference/BioCyc 7,8-dihydropteroate
chemical formula: C14H14N6O3
molecular weight: 314.11273
structure: ChemicalStructure/PW C001090

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q1ENB6
type: UnificationXref
id: Q1ENB6
db: UniProt

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

dihydroneopterin aldolase 1
type: Protein
cellular location: Cytosol
entity reference: dihydroneopterin aldolase 1

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/BioCyc 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
type: UnificationXref
id: 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
db: BioCyc

Reference/SMPDB SMP0012013
type: UnificationXref
id: SMP0012013
db: SMPDB

Arabidopsis thaliana
type: BioSource
xref: Reference/TAXONOMY 3702

Reference/ChEBI CHEBI 18372
type: UnificationXref
id: CHEBI:18372
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/KEGG Compound C04895
type: UnificationXref
id: C04895
db: KEGG Compound

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/ChEBI CHEBI 71175
type: UnificationXref
id: CHEBI:71175
db: ChEBI

Compound/PW C001077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: p-Aminobenzoic acid
stoichiometric coefficient: 1.0

Reference/BioCyc AMINO-OH-HYDROXYMETHYL-DIHYDROPTERIDINE
type: UnificationXref
id: AMINO-OH-HYDROXYMETHYL-DIHYDROPTERIDINE
db: BioCyc

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/ChEBI CHEBI 48954
type: UnificationXref
id: CHEBI:48954
db: ChEBI

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Dihydroneopterin triphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000980
xref: Reference/CAS 20574-65-6
xref: Reference/PubChem-compound 121885
xref: Reference/ChemSpider 108735
xref: Reference/BioCyc 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY
xref: Reference/ChEBI CHEBI 18372
xref: Reference/KEGG Compound C04895
chemical formula: C9H16N5O13P3
molecular weight: 494.99576
structure: ChemicalStructure/PW C000779

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 659
type: UnificationXref
id: 659
db: PubChem-compound

HMDHP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: HMDHP

Dihydroneopterin phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24771767
xref: Reference/KEGG Compound C05925
xref: Reference/HMDB HMDB0006824
xref: Reference/ChemSpider 21865614
xref: Reference/ChEBI CHEBI 48954
chemical formula: C9H14N5O7P
molecular weight: 335.06308
structure: ChemicalStructure/PW C002953

Protein/11477 Cytoplasm/Stoichiometry/8.0
type: Stoichiometry
physical entity: dihydroneopterin aldolase 1
stoichiometric coefficient: 8.0

7,8-dihydromonapterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 7,8-dihydromonapterin

Reference/ChemSpider 24784870
type: UnificationXref
id: 24784870
db: ChemSpider

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

p-Aminobenzoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30753
xref: Reference/KEGG Compound C00568
xref: Reference/BioCyc P-AMINO-BENZOATE
xref: Reference/CAS 150-13-0
xref: Reference/PubChem-compound 7057990
xref: Reference/HMDB HMDB0001392
xref: Reference/ChemSpider 953
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C001077

Reference/BioCyc P-AMINO-BENZOATE
type: UnificationXref
id: P-AMINO-BENZOATE
db: BioCyc

Reference/PubChem-compound 121885
type: UnificationXref
id: 121885
db: PubChem-compound

Reference/HMDB HMDB0006824
type: UnificationXref
id: HMDB0006824
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

4.1.2.25
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001850 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057873 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001537 Cytoplasm/Stoichiometry/1.0
right: Glycolaldehyde
right: HMDHP
spontaneous: false
EC number: 4.1.2.25
left: 7,8-Dihydroneopterin
name: 7,8-Dihydroneopterin → Glycolaldehyde + HMDHP
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 736
type: UnificationXref
id: 736
db: ChemSpider

5.1.99.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057874 Cytosol/Stoichiometry/1.0
right: 7,8-dihydromonapterin
spontaneous: false
EC number: 5.1.99.-
left: 7,8-Dihydroneopterin
name: 7,8-Dihydroneopterin → 7,8-dihydromonapterin
conversion direction: LEFT_TO_RIGHT

Reaction47425
type: BiochemicalReaction
participant stoichiometry: Compound/PW C057873 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057874 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001850 Cytosol/Stoichiometry/1.0
right: HMDHP
right: Glycolaldehyde
spontaneous: false
left: 7,8-dihydromonapterin
name: 7,8-dihydromonapterin → Glycolaldehyde + HMDHP
conversion direction: LEFT_TO_RIGHT

2.7.6.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057873 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057875 Cytosol/Stoichiometry/1.0
right: HMDHP pyrophosphate
right: Adenosine monophosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.6.3
left: Adenosine triphosphate
left: HMDHP
name: Adenosine triphosphate + HMDHP → Adenosine monophosphate + HMDHP pyrophosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

2.5.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001090 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C057875 Cytosol/Stoichiometry/1.0
right: 7,8-Dihydropteroic acid
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.15
left: p-Aminobenzoic acid
left: HMDHP pyrophosphate
name: HMDHP pyrophosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

HMDHP pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04807
xref: Reference/BioCyc DIHYDROPTERIN-CH2OH-PP
xref: Reference/ChEBI CHEBI 57602
xref: Reference/PubChem-compound 25244074
xref: Reference/ChemSpider 24784870
chemical formula: C7H8N5O8P2
molecular weight: 351.9848
structure: ChemicalStructure/PW C057875

Reference/ChEBI CHEBI 30753
type: UnificationXref
id: CHEBI:30753
db: ChEBI

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/PubChem-compound 170
type: UnificationXref
id: 170
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C057875 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: HMDHP pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

p-Aminobenzoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: p-Aminobenzoic acid

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Chloroplast
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0009507

Compound/PW C000779 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroneopterin triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Folate Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway4418
pathway component: SubPathwayInteraction4418
name: SubPathway

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

pABA Synthesis Sub-Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway4417
pathway component: SubPathwayInteraction4417
name: SubPathway

Purine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway4416
pathway component: SubPathwayInteraction4416
name: SubPathway

7,8-Dihydroneopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 7,8-Dihydroneopterin

ChemicalStructure/PW C002953
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

ChemicalStructure/PW C000779
type: ChemicalStructure
structure format: SMILES

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/HMDB HMDB0000980
type: UnificationXref
id: HMDB0000980
db: HMDB

ChemicalStructure/PW C001077
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=C(C=C1)C(O)=O

Reference/ChEBI CHEBI 57602
type: UnificationXref
id: CHEBI:57602
db: ChEBI

Reference/PubChem-compound 24771767
type: UnificationXref
id: 24771767
db: PubChem-compound

Dihydroneopterin phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroneopterin phosphate

Reference/ChemSpider 165
type: UnificationXref
id: 165
db: ChemSpider

Reference/PubChem-compound 45479435
type: UnificationXref
id: 45479435
db: PubChem-compound

GTP cyclohydrolase I
type: Protein
cellular location: Cytosol
entity reference: GTP cyclohydrolase I

Reference/HMDB HMDB0001392
type: UnificationXref
id: HMDB0001392
db: HMDB

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Nudix hydrolase 1
type: ProteinReference
xref: Reference/UniProt Q9CA40
organism: Arabidopsis thaliana

GTP cyclohydrolase I
type: ProteinReference
xref: Reference/UniProt Q9SFV7
organism: Arabidopsis thaliana

dihydroneopterin aldolase 1
type: ProteinReference
xref: Reference/UniProt Q9SF23
organism: Arabidopsis thaliana

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

dihydroneopterin phosphate phosphatase
type: ProteinReference
xref: Reference/UniProt Z0Z000
organism: Arabidopsis thaliana

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/UniProt Q9SFV7
type: UnificationXref
id: Q9SFV7
db: UniProt

SubPathwayInteraction4418
type: Interaction
name: SubPathwayReaction
name: SubPathway4418Reaction
participant: HMDHP

SubPathwayInteraction4417
type: Interaction
name: SubPathway4417Reaction
name: SubPathwayReaction
participant: p-Aminobenzoic acid

SubPathwayInteraction4416
type: Interaction
name: SubPathway4416Reaction
name: SubPathwayReaction
participant: Guanosine triphosphate

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 639
type: UnificationXref
id: 639
db: ChemSpider

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

7,8-Dihydroneopterin
type: SmallMoleculeReference
xref: Reference/CAS 1218-98-0
xref: Reference/PubChem-compound 659
xref: Reference/ChemSpider 639
xref: Reference/KEGG Compound C04874
xref: Reference/BioCyc DIHYDRONEOPTERIN-P3
xref: Reference/HMDB HMDB0002275
xref: Reference/ChEBI CHEBI 17001
chemical formula: C9H13N5O4
molecular weight: 255.09676
structure: ChemicalStructure/PW C001537

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 2134-76-1
type: UnificationXref
id: 2134-76-1
db: CAS

Compound/PW C057873 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: HMDHP
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChEBI CHEBI 17083
type: UnificationXref
id: CHEBI:17083
db: ChEBI

Reference/UniProt Z0Z000
type: UnificationXref
id: Z0Z000
db: UniProt

HMDHP transporter
type: ProteinReference
xref: Reference/UniProt Z0Z000

HPPK-DHPS
type: ProteinReference
xref: Reference/UniProt Q1ENB6
organism: Arabidopsis thaliana

Reference/HMDB HMDB0003344
type: UnificationXref
id: HMDB0003344
db: HMDB

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

dihydroneopterin aldolase
type: Complex
component stoichiometry: Protein/11477 Cytoplasm/Stoichiometry/8.0
cellular location: Cytoplasm
component: dihydroneopterin aldolase 1

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000779 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
right: Formic acid
right: Dihydroneopterin triphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 3.5.4.16
left: Guanosine triphosphate
left: Water
name: Guanosine triphosphate + Water → Dihydroneopterin triphosphate + Formic acid + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

3.6.1.67
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000779 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002953 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Dihydroneopterin phosphate
right: Hydrogen Ion
right: Pyrophosphate
spontaneous: false
EC number: 3.6.1.67
left: Dihydroneopterin triphosphate
left: Water
name: Dihydroneopterin triphosphate + Water → Dihydroneopterin phosphate + Hydrogen Ion + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

3.6.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001537 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002953 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: 7,8-Dihydroneopterin
spontaneous: false
EC number: 3.6.1.-
left: Dihydroneopterin phosphate
left: Water
name: Dihydroneopterin phosphate + Water → 7,8-Dihydroneopterin + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc DIHYDROPTERIN-CH2OH-PP
type: UnificationXref
id: DIHYDROPTERIN-CH2OH-PP
db: BioCyc

Compound/PW C001537 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-Dihydroneopterin
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001850
type: ChemicalStructure
structure format: SMILES
structure data: OCC=O

Glycolaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycolaldehyde

TransportCatalysis787
type: Catalysis
controller: HMDHP transporter
controlled: Transport887
control type: ACTIVATION