Tropane, piperidine, and pyridine alkaloids are alkaloid compounds found in some plants containing a tropane, piperidine, or pyridine ring respectively . In Arabidopsis thaliana, the tropane, piperidine and pyridine alkaloid biosynthesis pathway consists of several separate reactions that are known. L-phenylalanine, which may be sourced from the phenylalanine, tyrosine, and tryptophan biosynthesis pathway or the phenylalanine metabolism pathway, may reversibly react with oxoglutaric acid to produce phenylpyruvate (aka. 2-oxo-3-phenylpropanoic acid) and L-glutamic acid. This reaction may be catalyzed by tyrosine aminotransferase, aspartate aminotransferase, or histidinol phosphate aminotransferase. Primary amine oxidase may catalyze the reactions of N-methylputrescine or cadaverine with oxygen and hydrogen to produce hydrogen peroxide, ammonia, and either 1-methylpyrrolinium or 5-aminopentanal respectively. Tropinone may react with hydrogen and NADPH to produce tropine and NADP, with catalyzation by tropinone reductase.

Tropane, Piperidine, and Pyridine Alkaloid Biosynthesis References