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Interleukin-1 receptor- associated kinase 4 Interleukin-1 receptor- associated kinase 1 TNF receptor- associated factor 6 TGF-beta- activated kinase 1 and MAP3K7-binding protein 1 TGF-beta- activated kinase 1 and MAP3K7-binding protein 2 Mitogen- activated protein kinase kinase kinase 7 Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha Transcription factor p65 Cytochrome c oxidase subunit 2 NADH-ubiquinone oxidoreductase chain 1 Complex I intermediate- associated protein 30, mitochondrial Insulin Insulin receptor Insulin Insulin receptor Toll-like receptor 1 Toll-like receptor 2 Toll/interleukin- 1 receptor domain- containing adapter protein Myeloid differentiation primary response protein MyD88 Toll-like receptor 2 Toll-like receptor 6 Toll/interleukin- 1 receptor domain- containing adapter protein Myeloid differentiation primary response protein MyD88 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Symmetric dimethylarginine NF-κB MEK MAPK HDL JNK Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors Nucleus Toll-like receptor Pathway MAPK/ERK Pathway ↑ Inflammation, Immune Regulation, Survival, Proliferation Modified High Density Lipoprotein Insulin Resistance Insulin Resistance