PathWhiz

Pathway Description

Phospholipase C Signaling Pathway

Homo sapiens

Signaling Pathway

Calcium signaling is a process whereby the extremely low cytoplasmic Ca2+ concentration increases in a deliberate and specific manner to trigger downstream cellular events. Phospholipase C can produce (or modulate), directly, three distinct signals: inositol 1,4,5-trisphosphate (IP3), diacylglycerol, and phosphatidylinositol 4,5-bisphosphate (PIP2).

References

Phospholipase C Signaling Pathway References

Putney JW, Tomita T: Phospholipase C signaling and calcium influx. Adv Biol Regul. 2012 Jan;52(1):152-64. doi: 10.1016/j.advenzreg.2011.09.005.

Pubmed: 21933679

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Calcium
		Water

Visualize Protein Data

		1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
		1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
		Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
		Phosphoinositide 3-kinase regulatory subunit 6
		Proto-oncogene vav
		Proto-oncogene vav
		RAC-alpha serine/threonine-protein kinase
		RAC-alpha serine/threonine-protein kinase

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