Protein/7936/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-6
stoichiometric coefficient: 1.0

Interaction692
type: MolecularInteraction
interaction type: direct_interaction
name: E3 ubiquitin-protein ligase CHIP (E3) activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
participant: Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
participant: E3 ubiquitin-protein ligase CHIP

Interaction691
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
participant: Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
participant: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens)

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt P0CG47
type: UnificationXref
id: P0CG47
db: UniProt

Interaction693
type: MolecularInteraction
interaction type: direct_interaction
name: Protein Substrates activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
participant: Protein Substrates
participant: Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)

Proteasome subunit beta type-3
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-3

Protein Substrates
type: Protein
entity reference: Protein Substrates

Reference/UniProt P0CG48
type: UnificationXref
id: P0CG48
db: UniProt

Protein/7951 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 13
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-2
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-2

Ubiquitin-like modifier-activating enzyme 1
type: Protein
entity reference: Ubiquitin-like modifier-activating enzyme 1

direct_interaction
type: InteractionVocabulary

Ubiquitin-conjugating enzyme E2 E1
type: Protein
entity reference: Ubiquitin-conjugating enzyme E2 E1

Protein/7936 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-6
stoichiometric coefficient: 1.0

Reference/UniProt O15205
type: UnificationXref
id: O15205
db: UniProt

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Protein/7935/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-5
stoichiometric coefficient: 1.0

26S proteasome
type: Complex
component stoichiometry: Protein/7933 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7942 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7935 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7940 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7937 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7939 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7951 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7947 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7949 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7943 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7945 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7941 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7932 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7934 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7936 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7952 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7938 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7950 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7948 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7944 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7931 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/7946 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Proteasome subunit alpha type-3
component: Proteasome subunit alpha type-5
component: Proteasome subunit beta type-3
component: 26S proteasome non-ATPase regulatory subunit 4
component: 26S protease regulatory subunit 6B
component: Proteasome subunit alpha type-2
component: 26S protease regulatory subunit 10B
component: Proteasome subunit alpha type-6
component: Proteasome subunit alpha type-1
component: 26S protease regulatory subunit 8
component: Proteasome subunit alpha type-7
component: Proteasome subunit beta type-7
component: 26S proteasome non-ATPase regulatory subunit 13
component: Proteasome subunit beta type-2
component: Proteasome subunit beta type-6
component: Proteasome subunit beta type-5
component: Proteasome subunit beta type-1
component: 26S protease regulatory subunit 4
component: 26S protease regulatory subunit 7
component: 26S protease regulatory subunit 6A
component: Proteasome subunit alpha type-4
component: Proteasome subunit beta type-4

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Proteasome subunit alpha type-1
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-1

Protein/7934/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-4
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Protein/Generic404 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Proteasome subunit alpha type-4
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-4

Protein/Generic404/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates
stoichiometric coefficient: 1.0

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ProteinComplex/7836 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin Complex
stoichiometric coefficient: 1.0

E3 ubiquitin-protein ligase CHIP
type: Protein
entity reference: E3 ubiquitin-protein ligase CHIP

Polyubiquitin-B
type: Protein
entity reference: Polyubiquitin-B

Reference/UniProt P49721
type: UnificationXref
id: P49721
db: UniProt

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Ubiquitin D
type: Protein
entity reference: Ubiquitin D

Reference/UniProt P49720
type: UnificationXref
id: P49720
db: UniProt

Protein/7939/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-2
stoichiometric coefficient: 1.0

Reference/PathWhiz PW064821
type: UnificationXref
id: PW064821
db: PathWhiz

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Ubiquitin–Proteasome Pathway
type: Pathway
pathway order: PathwayInteraction/687
pathway order: PathwayEnzymeReaction/1193104
pathway order: PathwayEnzymeReaction/1193148
pathway order: PathwayEnzymeReaction/1193159
pathway order: PathwayEnzymeReaction/1193103
pathway order: PathwayInteraction/689
pathway order: PathwayEnzymeReaction/1193157
pathway order: PathwayEnzymeReaction/1193095
pathway order: PathwayEnzymeReaction/1193087
pathway order: PathwayEnzymeReaction/1193098
pathway order: PathwayEnzymeReaction/1193160
pathway order: PathwayInteraction/691
pathway order: PathwayInteraction/692
pathway order: PathwayInteraction/693
pathway order: PathwayInteraction/686
pathway component: Reaction110968
pathway component: Reaction110969
pathway component: Interaction692
pathway component: Reaction110966
pathway component: Interaction691
pathway component: Interaction693
pathway component: Interaction687
pathway component: Interaction686
pathway component: Interaction689
pathway component: Reaction110960
pathway component: Reaction110961
pathway component: Reaction110970
pathway component: Reaction110964
pathway component: Reaction110965
pathway component: Reaction110962
xref: Reference/PathWhiz PW064821
xref: Reference/SMPDB SMP0063816
organism: Homo sapiens

Protein/7932/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-2
stoichiometric coefficient: 1.0

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Protein/7940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-3
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-5
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-5

Protein/7939 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-2
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-6
type: Protein
entity reference: Proteasome subunit alpha type-6

Protein/7937/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-7
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-5
type: Protein
entity reference: Proteasome subunit alpha type-5

Proteasome subunit alpha type-4
type: Protein
entity reference: Proteasome subunit alpha type-4

Proteasome subunit alpha type-3
type: Protein
entity reference: Proteasome subunit alpha type-3

Proteasome subunit beta type-2
type: Protein
entity reference: Proteasome subunit beta type-2

Proteasome subunit beta type-1
type: Protein
entity reference: Proteasome subunit beta type-1

Protein/7945 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 4
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-7
type: Protein
entity reference: Proteasome subunit alpha type-7

Protein/7934 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-4
stoichiometric coefficient: 1.0

Reference/UniProt P25789
type: UnificationXref
id: P25789
db: UniProt

Proteasome subunit alpha type-2
type: Protein
entity reference: Proteasome subunit alpha type-2

Reference/UniProt P25788
type: UnificationXref
id: P25788
db: UniProt

Proteasome subunit beta type-5
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-5

Reference/UniProt Q9UNM6
type: UnificationXref
id: Q9UNM6
db: UniProt

Proteasome subunit alpha type-1
type: Protein
entity reference: Proteasome subunit alpha type-1

Reference/UniProt P25787
type: UnificationXref
id: P25787
db: UniProt

Reference/UniProt P25786
type: UnificationXref
id: P25786
db: UniProt

Protein/7940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-3
stoichiometric coefficient: 1.0

Protein/585/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin-like modifier-activating enzyme 1
stoichiometric coefficient: 1.0

Protein/7933 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-3
stoichiometric coefficient: 1.0

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

26S protease regulatory subunit 6A
type: Protein
entity reference: 26S protease regulatory subunit 6A

26S protease regulatory subunit 7
type: Protein
entity reference: 26S protease regulatory subunit 7

Peptide
type: Protein
entity reference: Peptide

26S protease regulatory subunit 4
type: Protein
entity reference: 26S protease regulatory subunit 4

Proteasome subunit alpha type-6
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-6

26S proteasome
type: Complex
component stoichiometry: Protein/7936/Stoichiometry/1.0
component stoichiometry: Protein/7952/Stoichiometry/1.0
component stoichiometry: Protein/7946/Stoichiometry/1.0
component stoichiometry: Protein/7949/Stoichiometry/1.0
component stoichiometry: Protein/7933/Stoichiometry/1.0
component stoichiometry: Protein/7943/Stoichiometry/1.0
component stoichiometry: Protein/7937/Stoichiometry/1.0
component stoichiometry: Protein/7951/Stoichiometry/1.0
component stoichiometry: Protein/7939/Stoichiometry/1.0
component stoichiometry: Protein/7934/Stoichiometry/1.0
component stoichiometry: Protein/7941/Stoichiometry/1.0
component stoichiometry: Protein/7931/Stoichiometry/1.0
component stoichiometry: Protein/7944/Stoichiometry/1.0
component stoichiometry: Protein/7950/Stoichiometry/1.0
component stoichiometry: Protein/7947/Stoichiometry/1.0
component stoichiometry: Protein/7945/Stoichiometry/1.0
component stoichiometry: Protein/7940/Stoichiometry/1.0
component stoichiometry: Protein/7932/Stoichiometry/1.0
component stoichiometry: Protein/7942/Stoichiometry/1.0
component stoichiometry: Protein/7948/Stoichiometry/1.0
component stoichiometry: Protein/7935/Stoichiometry/1.0
component stoichiometry: Protein/7938/Stoichiometry/1.0
component: Proteasome subunit alpha type-6
component: 26S protease regulatory subunit 6A
component: Proteasome subunit alpha type-5
component: 26S protease regulatory subunit 7
component: Proteasome subunit alpha type-4
component: 26S protease regulatory subunit 4
component: Proteasome subunit alpha type-3
component: Proteasome subunit beta type-7
component: Proteasome subunit beta type-2
component: Proteasome subunit beta type-1
component: 26S protease regulatory subunit 8
component: Proteasome subunit alpha type-7
component: 26S protease regulatory subunit 6B
component: 26S protease regulatory subunit 10B
component: Proteasome subunit alpha type-2
component: Proteasome subunit beta type-6
component: Proteasome subunit alpha type-1
component: Proteasome subunit beta type-5
component: Proteasome subunit beta type-4
component: 26S proteasome non-ATPase regulatory subunit 4
component: Proteasome subunit beta type-3
component: 26S proteasome non-ATPase regulatory subunit 13

Proteasome subunit beta type-7
type: Protein
entity reference: Proteasome subunit beta type-7

Protein/7943 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-6
stoichiometric coefficient: 1.0

26S protease regulatory subunit 8
type: Protein
entity reference: 26S protease regulatory subunit 8

26S proteasome non-ATPase regulatory subunit 13
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome non-ATPase regulatory subunit 13

26S protease regulatory subunit 6B
type: Protein
entity reference: 26S protease regulatory subunit 6B

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Ubiquitin-like modifier-activating enzyme 1
type: ProteinReference
xref: Reference/UniProt P22314
organism: Homo sapiens

BoundComplex/69/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens)
stoichiometric coefficient: 1.0

Ubiquitin-conjugating enzyme E2 E1
type: ProteinReference
xref: Reference/UniProt P51965
organism: Homo sapiens

Proteasome subunit beta type-6
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-6

Ubiquitin D
type: Protein
cellular location: Cytoplasm
entity reference: Ubiquitin D

Proteasome subunit beta type-6
type: Protein
entity reference: Proteasome subunit beta type-6

Proteasome subunit beta type-5
type: Protein
entity reference: Proteasome subunit beta type-5

Proteasome subunit beta type-4
type: Protein
entity reference: Proteasome subunit beta type-4

Proteasome subunit beta type-3
type: Protein
entity reference: Proteasome subunit beta type-3

Reference/UniProt P55036
type: UnificationXref
id: P55036
db: UniProt

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

26S protease regulatory subunit 10B
type: Protein
cellular location: Cytoplasm
entity reference: 26S protease regulatory subunit 10B

Protein Substrates
type: ProteinReference
organism: Homo sapiens

Proteasome subunit alpha type-7
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-7

Proteasome subunit beta type-7
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-7

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

26S protease regulatory subunit 10B
type: Protein
entity reference: 26S protease regulatory subunit 10B

Protein/7944/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-7
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 4
type: Protein
entity reference: 26S proteasome non-ATPase regulatory subunit 4

BoundComplex/71/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates_Ubiquitin Complex (Homo sapiens)
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 13
type: Protein
entity reference: 26S proteasome non-ATPase regulatory subunit 13

Protein/7944 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-7
stoichiometric coefficient: 1.0

Protein/7942 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-5
stoichiometric coefficient: 1.0

Reference/UniProt P62333
type: UnificationXref
id: P62333
db: UniProt

26S protease regulatory subunit 8
type: Protein
cellular location: Cytoplasm
entity reference: 26S protease regulatory subunit 8

Protein/7941/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-4
stoichiometric coefficient: 1.0

Protein/7932 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-2
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Protein/7938/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-1
stoichiometric coefficient: 1.0

Polyubiquitin-C
type: Protein
entity reference: Polyubiquitin-C

Protein Substrates_Ubiquitin Complex (Homo sapiens)
type: Complex
component stoichiometry: ProteinComplex/7836 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/Generic404 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Protein Substrates
component: Ubiquitin Complex

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Protein/7931/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-1
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt P20618
type: UnificationXref
id: P20618
db: UniProt

Protein/7931 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-1
stoichiometric coefficient: 1.0

Proteasome subunit beta type-2
type: ProteinReference
xref: Reference/UniProt P49721
organism: Homo sapiens

Protein/7949/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 8
stoichiometric coefficient: 1.0

Proteasome subunit beta type-1
type: ProteinReference
xref: Reference/UniProt P20618
organism: Homo sapiens

Proteasome subunit alpha type-7
type: ProteinReference
xref: Reference/UniProt O14818
organism: Homo sapiens

Proteasome subunit alpha type-6
type: ProteinReference
xref: Reference/UniProt P60900
organism: Homo sapiens

Proteasome subunit alpha type-5
type: ProteinReference
xref: Reference/UniProt P28066
organism: Homo sapiens

Proteasome subunit alpha type-4
type: ProteinReference
xref: Reference/UniProt P25789
organism: Homo sapiens

Proteasome subunit alpha type-3
type: ProteinReference
xref: Reference/UniProt P25788
organism: Homo sapiens

Proteasome subunit alpha type-2
type: ProteinReference
xref: Reference/UniProt P25787
organism: Homo sapiens

Proteasome subunit alpha type-1
type: ProteinReference
xref: Reference/UniProt P25786
organism: Homo sapiens

Protein/7951/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 13
stoichiometric coefficient: 1.0

Reference/UniProt Q9UNE7
type: UnificationXref
id: Q9UNE7
db: UniProt

Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens)
type: Complex
component stoichiometry: ProteinComplex/7836/Stoichiometry/1.0
component stoichiometry: Protein/585/Stoichiometry/1.0
component: Ubiquitin-like modifier-activating enzyme 1
component: Ubiquitin Complex

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/UniProt P17980
type: UnificationXref
id: P17980
db: UniProt

Protein/7948/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 6B
stoichiometric coefficient: 1.0

Protein/7946 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 7
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Protein/7952/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 4
stoichiometric coefficient: 1.0

Protein/7935 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-5
stoichiometric coefficient: 1.0

26S protease regulatory subunit 8
type: ProteinReference
xref: Reference/UniProt P62195
organism: Homo sapiens

26S protease regulatory subunit 6B
type: ProteinReference
xref: Reference/UniProt P43686
organism: Homo sapiens

26S protease regulatory subunit 6A
type: ProteinReference
xref: Reference/UniProt P17980
organism: Homo sapiens

26S protease regulatory subunit 7
type: ProteinReference
xref: Reference/UniProt P35998
organism: Homo sapiens

26S protease regulatory subunit 4
type: ProteinReference
xref: Reference/UniProt P62191
organism: Homo sapiens

Proteasome subunit beta type-7
type: ProteinReference
xref: Reference/UniProt Q99436
organism: Homo sapiens

Reference/UniProt P28070
type: UnificationXref
id: P28070
db: UniProt

Proteasome subunit beta type-6
type: ProteinReference
xref: Reference/UniProt P28072
organism: Homo sapiens

Proteasome subunit beta type-5
type: ProteinReference
xref: Reference/UniProt P28074
organism: Homo sapiens

Proteasome subunit beta type-4
type: ProteinReference
xref: Reference/UniProt P28070
organism: Homo sapiens

Reference/UniProt P28072
type: UnificationXref
id: P28072
db: UniProt

Proteasome subunit beta type-3
type: ProteinReference
xref: Reference/UniProt P49720
organism: Homo sapiens

Reference/UniProt P28074
type: UnificationXref
id: P28074
db: UniProt

Protein/7941 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-4
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Protein/7950 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 10B
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0063816
type: UnificationXref
id: SMP0063816
db: SMPDB

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

26S protease regulatory subunit 6A
type: Protein
cellular location: Cytoplasm
entity reference: 26S protease regulatory subunit 6A

26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
type: Complex
component stoichiometry: ProteinComplex/1681 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7836 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/Generic404 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: 26S proteasome
component: Ubiquitin Complex
component: Protein Substrates

Reaction110968
type: BiochemicalReaction
participant stoichiometry: BoundComplex/72/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7836/Stoichiometry/1.0
right: Ubiquitin Complex
spontaneous: false
left: 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
name: 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates → Ubiquitin Complex
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P35998
type: UnificationXref
id: P35998
db: UniProt

Reaction110969
type: BiochemicalReaction
participant stoichiometry: BoundComplex/72/Stoichiometry/1.0
participant stoichiometry: Protein/Generic19/Stoichiometry/1.0
right: Peptide
spontaneous: false
left: 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
name: 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates → Peptide
conversion direction: LEFT_TO_RIGHT

Reaction110966
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/1681 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/72 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/71 Cytoplasm/Stoichiometry/1.0
right: 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
spontaneous: false
left: 26S proteasome
left: Protein Substrates_Ubiquitin Complex (Homo sapiens)
name: 26S proteasome + Protein Substrates + Ubiquitin Complex (Homo sapiens) → 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates
conversion direction: LEFT_TO_RIGHT

Peptide
type: ProteinReference
xref: Reference/ChEBI CHEBI 16670
organism: Homo sapiens

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ProteinComplex/7836/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin Complex
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 4
type: ProteinReference
xref: Reference/UniProt P55036
organism: Homo sapiens

26S proteasome non-ATPase regulatory subunit 13
type: ProteinReference
xref: Reference/UniProt Q9UNM6
organism: Homo sapiens

26S protease regulatory subunit 10B
type: ProteinReference
xref: Reference/UniProt P62333
organism: Homo sapiens

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

BoundComplex/72/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
stoichiometric coefficient: 1.0

Reference/UniProt Q99436
type: UnificationXref
id: Q99436
db: UniProt

Protein/7952 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome non-ATPase regulatory subunit 4
stoichiometric coefficient: 1.0

Proteasome subunit beta type-1
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-1

Reaction110960
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Protein/585/Stoichiometry/1.0
right: Adenosine monophosphate
spontaneous: false
left: Ubiquitin-like modifier-activating enzyme 1
name: Ubiquitin-like modifier-activating enzyme 1 with ATP → Adenosine monophosphate
conversion direction: LEFT_TO_RIGHT

Protein/7945/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 4
stoichiometric coefficient: 1.0

Reaction110961
type: BiochemicalReaction
participant stoichiometry: BoundComplex/69/Stoichiometry/1.0
participant stoichiometry: Protein/585/Stoichiometry/1.0
right: Ubiquitin-like modifier-activating enzyme 1
spontaneous: false
left: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens)
name: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) → Ubiquitin-like modifier-activating enzyme 1 (E1)
conversion direction: LEFT_TO_RIGHT

Reaction110964
type: BiochemicalReaction
participant stoichiometry: BoundComplex/70/Stoichiometry/1.0
participant stoichiometry: BoundComplex/71/Stoichiometry/1.0
right: Protein Substrates_Ubiquitin Complex (Homo sapiens)
spontaneous: false
left: Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
name: Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) → Protein Substrates + Ubiquitin Complex (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reaction110965
type: BiochemicalReaction
participant stoichiometry: BoundComplex/71/Stoichiometry/1.0
right: Protein Substrates_Ubiquitin Complex (Homo sapiens)
spontaneous: false
left: Protein Substrates_Ubiquitin Complex (Homo sapiens)
name: Protein Substrates + Ubiquitin Complex (Homo sapiens) → Protein Substrates + Ubiquitin Complex (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reaction110962
type: BiochemicalReaction
participant stoichiometry: BoundComplex/70/Stoichiometry/1.0
participant stoichiometry: Protein/587/Stoichiometry/1.0
right: Ubiquitin-conjugating enzyme E2 E1
spontaneous: false
left: Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
name: Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) → Ubiquitin-conjugating enzyme E2 E1
conversion direction: LEFT_TO_RIGHT

Ubiquitin D
type: ProteinReference
xref: Reference/UniProt O15205
organism: Homo sapiens

Polyubiquitin-B
type: ProteinReference
xref: Reference/UniProt P0CG47
organism: Homo sapiens

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

26S proteasome non-ATPase regulatory subunit 4
type: Protein
cellular location: Cytoplasm
entity reference: 26S proteasome non-ATPase regulatory subunit 4

26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
type: Complex
component stoichiometry: Protein/Generic404/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7836/Stoichiometry/1.0
component stoichiometry: ProteinComplex/1681/Stoichiometry/1.0
component: Protein Substrates
component: 26S proteasome
component: Ubiquitin Complex

Protein Substrates_Ubiquitin Complex (Homo sapiens)
type: Complex
component stoichiometry: Protein/Generic404/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7836/Stoichiometry/1.0
component: Protein Substrates
component: Ubiquitin Complex

Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
type: Complex
component stoichiometry: Protein/587/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7836/Stoichiometry/1.0
component: Ubiquitin-conjugating enzyme E2 E1
component: Ubiquitin Complex

26S protease regulatory subunit 6B
type: Protein
cellular location: Cytoplasm
entity reference: 26S protease regulatory subunit 6B

Protein/Generic19/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/UniProt P22314
type: UnificationXref
id: P22314
db: UniProt

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Protein/7950/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 10B
stoichiometric coefficient: 1.0

Polyubiquitin-C
type: Protein
cellular location: Cytoplasm
entity reference: Polyubiquitin-C

Protein/7947/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 6A
stoichiometric coefficient: 1.0

26S protease regulatory subunit 4
type: Protein
cellular location: Cytoplasm
entity reference: 26S protease regulatory subunit 4

Protein Substrates
type: Protein
cellular location: Cytoplasm
entity reference: Protein Substrates

Reaction110970
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

E3 ubiquitin-protein ligase CHIP
type: ProteinReference
xref: Reference/UniProt Q9UNE7
organism: Homo sapiens

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

BoundComplex/70/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens)
stoichiometric coefficient: 1.0

Protein/7943/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-6
stoichiometric coefficient: 1.0

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

BoundComplex/71 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein Substrates_Ubiquitin Complex (Homo sapiens)
stoichiometric coefficient: 1.0

Reference/UniProt P43686
type: UnificationXref
id: P43686
db: UniProt

Reference/UniProt P62195
type: UnificationXref
id: P62195
db: UniProt

Reference/UniProt P62191
type: UnificationXref
id: P62191
db: UniProt

Ubiquitin Complex
type: Complex
cellular location: Cytoplasm
component: Polyubiquitin-B
component: Ubiquitin D
component: Polyubiquitin-C

Protein/7942/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-5
stoichiometric coefficient: 1.0

Reference/UniProt P60900
type: UnificationXref
id: P60900
db: UniProt

Protein/587/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquitin-conjugating enzyme E2 E1
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Protein/7949 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 8
stoichiometric coefficient: 1.0

ProteinComplex/1681/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome
stoichiometric coefficient: 1.0

Polyubiquitin-B
type: Protein
cellular location: Cytoplasm
entity reference: Polyubiquitin-B

Protein/7938 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit beta type-1
stoichiometric coefficient: 1.0

BoundComplex/72 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates
stoichiometric coefficient: 1.0

Reference/UniProt P28066
type: UnificationXref
id: P28066
db: UniProt

ProteinComplex/1681 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S proteasome
stoichiometric coefficient: 1.0

Protein/7946/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 7
stoichiometric coefficient: 1.0

Protein/7937 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-7
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Protein/7933/Stoichiometry/1.0
type: Stoichiometry
physical entity: Proteasome subunit alpha type-3
stoichiometric coefficient: 1.0

Protein/7947 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 6A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16670
type: UnificationXref
id: CHEBI:16670
db: ChEBI

Reference/UniProt P51965
type: UnificationXref
id: P51965
db: UniProt

Polyubiquitin-C
type: ProteinReference
xref: Reference/UniProt P0CG48
organism: Homo sapiens

26S protease regulatory subunit 7
type: Protein
cellular location: Cytoplasm
entity reference: 26S protease regulatory subunit 7

Ubiquitin Complex
type: Complex
component: Polyubiquitin-C
component: Polyubiquitin-B
component: Ubiquitin D

Reference/UniProt O14818
type: UnificationXref
id: O14818
db: UniProt

Proteasome subunit beta type-4
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-4

Proteasome subunit alpha type-3
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit alpha type-3

Interaction687
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin Complex activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens)
participant: Ubiquitin Complex
participant: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens)

Interaction686
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin-like modifier-activating enzyme 1 with ATP activates Ubiquitin Complex
participant: Ubiquitin-like modifier-activating enzyme 1
participant: Ubiquitin Complex

Interaction689
type: MolecularInteraction
interaction type: direct_interaction
name: Ubiquitin-conjugating enzyme E2 E1 activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens)
participant: Ubiquitin-conjugating enzyme E2 E1
participant: Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens)

Proteasome subunit beta type-2
type: Protein
cellular location: Cytoplasm
entity reference: Proteasome subunit beta type-2

Protein/7948 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 26S protease regulatory subunit 6B
stoichiometric coefficient: 1.0