PathWhiz

Pathway Description

CXCR4 Signaling Pathway

Homo sapiens

Protein Pathway

CXCR4 is a chemokine G-protein-coupled receptor. Chemokine receptors couple to the pertussis toxin-sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response. Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is involved in the metastasis of some cancers. Pertussis toxin ADP-ribosylates guanine nucleotide binding protein alpha inhibiting (Gai) proteins inhibiting GPCR/Gi coupling. Activated Gai inhibits adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the endoplasmic reticulum and the activation of protein kinase C.

References

CXCR4 Signaling Pathway References

https://cgap.nci.nih.gov/Pathways/BioCarta/h_cxcr4Pathway

Busillo JM, Benovic JL: Regulation of CXCR4 signaling. Biochim Biophys Acta. 2007 Apr;1768(4):952-63. doi: 10.1016/j.bbamem.2006.11.002. Epub 2006 Nov 10.

Pubmed: 17169327

Kremer KN, Clift IC, Miamen AG, Bamidele AO, Qian NX, Humphreys TD, Hedin KE: Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-beta3 and phospholipase C-gamma1 for distinct cellular responses. J Immunol. 2011 Aug 1;187(3):1440-7. doi: 10.4049/jimmunol.1100820. Epub 2011 Jun 24.

Pubmed: 21705626

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Visualize Compound Data

		Calcium
		Phosphate

Visualize Protein Data

		1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
		Adapter molecule crk
		Breast cancer anti-estrogen resistance protein 1
		C-X-C chemokine receptor type 4
		Dual specificity mitogen-activated protein kinase kinase 1
		Focal adhesion kinase 1
		GTPase HRas
		Guanine nucleotide-binding protein G(i) subunit alpha-1
		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
		Guanine nucleotide-binding protein G(q) subunit alpha
		Guanine nucleotide-binding protein G(T) subunit gamma-T1
		Mitogen-activated protein kinase 1
		Mitogen-activated protein kinase 3
		NF-kappa-B inhibitor alpha
		Nuclear factor NF-kappa-B p105 subunit
		Paxillin
		Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
		Protein-tyrosine kinase 2-beta
		RAF proto-oncogene serine/threonine-protein kinase
		Stromal cell-derived factor 1

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