Toll-like receptor 9
type: ProteinReference
xref: Reference/UniProt Q9NR96
organism: Homo sapiens

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Protein/14662 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte antigen 96
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Reference/PathWhiz PW070606
type: UnificationXref
id: PW070606
db: PathWhiz

Lymphocyte antigen 96
type: Protein
cellular location: Cell Membrane
entity reference: Lymphocyte antigen 96

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: Reference/UniProt Q15750
organism: Homo sapiens

Protein/2033 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Mitogen-activated protein kinase 14
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 14

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

TLR2,6
type: Complex
cellular location: Cytoplasm
component: Toll-like receptor 6
component: Toll-like receptor 2

Toll-like receptor 7
type: Protein
entity reference: Toll-like receptor 7

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: Reference/UniProt Q9NYJ8
organism: Homo sapiens

Reference/ChEBI CHEBI 59309
type: UnificationXref
id: CHEBI:59309
db: ChEBI

Toll-like receptor 6
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 6

Reference/UniProt Q9BQ95
type: UnificationXref
id: Q9BQ95
db: UniProt

TNF receptor-associated factor 6
type: Protein
cellular location: Cytoplasm
entity reference: TNF receptor-associated factor 6

Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens)_TAB Complex (Homo sapiens)
type: Complex
component stoichiometry: Protein/14355 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/7974 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase kinase kinase 7
component: TAB Complex

Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens)_Toll-interacting protein (Homo sapiens)
type: Complex
component stoichiometry: Protein/14348 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/14663 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-interacting protein
component: Toll/interleukin-1 receptor domain-containing adapter protein

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cytoplasm
entity reference: Monocyte differentiation antigen CD14

Reference/UniProt Q99836
type: UnificationXref
id: Q99836
db: UniProt

Protein/5773 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor alpha
stoichiometric coefficient: 1.0

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4

CpG-DNA
type: DnaReference
organism: Homo sapiens

Double-Stranded RNA
type: DnaReference
organism: Homo sapiens

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt O14920
organism: Homo sapiens

Liproproteins
type: ProteinReference
organism: Homo sapiens

Monocyte differentiation antigen CD14
type: Protein
entity reference: Monocyte differentiation antigen CD14

Reference/UniProt Q04206
type: UnificationXref
id: Q04206
db: UniProt

Reference/UniProt Q9NR97
type: UnificationXref
id: Q9NR97
db: UniProt

Toll-like receptor 1
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 1

LPS core
type: SmallMolecule
cellular location: Cell Membrane
entity reference: LPS core

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cell Membrane
entity reference: Monocyte differentiation antigen CD14

Imiquimod
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014862
xref: Reference/ChEBI CHEBI 36704
xref: Reference/ChemSpider 51809
xref: Reference/PubChem-compound 57469
xref: Reference/CAS 99011-02-6
chemical formula: C14H16N4
molecular weight: 240.1375
structure: ChemicalStructure/PW C009198

Imiquimod
type: SmallMolecule
entity reference: Imiquimod

Toll-like receptor 8
type: ProteinReference
xref: Reference/UniProt Q9NR97
organism: Homo sapiens

Reference/UniProt Q9NR96
type: UnificationXref
id: Q9NR96
db: UniProt

Toll-like receptor 5
type: ProteinReference
xref: Reference/UniProt O60602
organism: Homo sapiens

Reference/UniProt Q16539
type: UnificationXref
id: Q16539
db: UniProt

Flagellin
type: ProteinReference
xref: Reference/UniProt P04949
organism: Homo sapiens

MYD88,IRAK (myddosome)
type: Complex
cellular location: Cytoplasm
component: Myeloid differentiation primary response protein MyD88
component: Interleukin-1 receptor-associated kinase 1

Mitogen-activated protein kinase kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 7

Reference/UniProt Q9H0E2
type: UnificationXref
id: Q9H0E2
db: UniProt

Reference/BioCyc CPD0-2271
type: UnificationXref
id: CPD0-2271
db: BioCyc

Toll-Like Receptor Pathway 2
type: Pathway
pathway order: PathwayInteraction/863
pathway order: PathwayInteraction/864
pathway order: PathwayInteraction/865
pathway order: PathwayInteraction/866
pathway order: PathwayInteraction/867
pathway order: PathwayInteraction/868
pathway order: PathwayInteraction/869
pathway order: PathwayInteraction/848
pathway order: PathwayInteraction/849
pathway order: PathwayEnzymeReaction/1302283
pathway order: PathwayInteraction/860
pathway order: PathwayInteraction/861
pathway order: PathwayInteraction/862
pathway order: PathwayInteraction/852
pathway order: PathwayInteraction/874
pathway order: PathwayInteraction/896
pathway order: PathwayInteraction/853
pathway order: PathwayInteraction/854
pathway order: PathwayInteraction/898
pathway order: PathwayInteraction/855
pathway order: PathwayInteraction/856
pathway order: PathwayInteraction/857
pathway order: PathwayInteraction/858
pathway order: PathwayInteraction/859
pathway order: PathwayInteraction/870
pathway order: PathwayInteraction/892
pathway order: PathwayInteraction/871
pathway order: PathwayInteraction/893
pathway order: PathwayInteraction/850
pathway order: PathwayInteraction/872
pathway order: PathwayInteraction/894
pathway order: PathwayInteraction/851
pathway order: PathwayInteraction/873
pathway component: Interaction870
pathway component: Interaction892
pathway component: Interaction850
pathway component: Interaction872
pathway component: Interaction894
pathway component: Interaction871
pathway component: Interaction893
pathway component: Interaction852
pathway component: Interaction874
pathway component: Interaction896
pathway component: Interaction851
pathway component: Interaction873
pathway component: Interaction854
pathway component: Interaction898
pathway component: Interaction853
pathway component: Interaction856
pathway component: Interaction855
pathway component: Interaction858
pathway component: Interaction857
pathway component: Interaction859
pathway component: Reaction118800
pathway component: Interaction861
pathway component: Interaction860
pathway component: Interaction863
pathway component: Interaction862
pathway component: Interaction865
pathway component: Interaction864
pathway component: Interaction867
pathway component: Interaction866
pathway component: Interaction869
pathway component: Interaction868
pathway component: Interaction849
pathway component: Interaction848
xref: Reference/PathWhiz PW070606
xref: Reference/SMPDB SMP0069593
organism: Homo sapiens

Reference/UniProt Q9Y4K3
type: UnificationXref
id: Q9Y4K3
db: UniProt

Reference/KEGG Compound c0338
type: UnificationXref
id: c0338
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Toll-like receptor 2
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 2

Reference/HMDB HMDB0014862
type: UnificationXref
id: HMDB0014862
db: HMDB

Toll-like receptor 7
type: ProteinReference
xref: Reference/UniProt Q9NYK1
organism: Homo sapiens

Toll-like receptor 3
type: ProteinReference
xref: Reference/UniProt O15455
organism: Homo sapiens

NFKBIA, NFKB1, RELA complex
type: Complex
cellular location: Cytoplasm
component: Nuclear factor NF-kappa-B p105 subunit
component: NF-kappa-B inhibitor alpha
component: Transcription factor p65

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: Reference/UniProt P45985
organism: Homo sapiens

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

Transcription factor p65
type: ProteinReference
xref: Reference/UniProt Q04206
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 8

Toll-like receptor 4 (Homo sapiens)_Lymphocyte antigen 96 (Homo sapiens)
type: Complex
component stoichiometry: Protein/2033 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/14662 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Toll-like receptor 4
component: Lymphocyte antigen 96

Reference/ChemSpider 51809
type: UnificationXref
id: 51809
db: ChemSpider

Reference/UniProt O60602
type: UnificationXref
id: O60602
db: UniProt

NF-kappa-B essential modulator
type: ProteinReference
xref: Reference/UniProt Q9Y6K9
organism: Homo sapiens

Reference/UniProt O60603
type: UnificationXref
id: O60603
db: UniProt

Reference/UniProt P25963
type: UnificationXref
id: P25963
db: UniProt

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt P19838
organism: Homo sapiens

Reference/PubChem-compound 53481794
type: UnificationXref
id: 53481794
db: PubChem-compound

Toll/interleukin-1 receptor domain-containing adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll/interleukin-1 receptor domain-containing adapter protein

ChemicalStructure/PW C009198
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CN1C=NC2=C1C1=CC=CC=C1N=C2N

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Toll-like receptor 7
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 7

Toll/interleukin-1 receptor domain-containing adapter protein
type: ProteinReference
xref: Reference/UniProt P58753
organism: Homo sapiens

Toll-like receptor 2
type: ProteinReference
xref: Reference/UniProt O60603
organism: Homo sapiens

Toll-like receptor 1
type: ProteinReference
xref: Reference/UniProt Q15399
organism: Homo sapiens

Reference/UniProt P58753
type: UnificationXref
id: P58753
db: UniProt

Liproproteins
type: Protein
cellular location: Cytoplasm
entity reference: Liproproteins

NFKB1,RELA complex
type: Complex
cellular location: Cytoplasm
component: Nuclear factor NF-kappa-B p105 subunit
component: Transcription factor p65

Protein/14662 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte antigen 96
stoichiometric coefficient: 1.0

Reaction118800
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/7715 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/7716 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/5773 Cytoplasm/Stoichiometry/1.0
right: NFKB1,RELA complex
right: NF-kappa-B inhibitor alpha
spontaneous: false
left: NFKBIA, NFKB1, RELA complex
name: NFKBIA, NFKB1, RELA complex → NFKB1,RELA complex + NFKBIA with phosphate
conversion direction: LEFT_TO_RIGHT

Protein/14348 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll/interleukin-1 receptor domain-containing adapter protein
stoichiometric coefficient: 1.0

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt Q99836
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: Reference/UniProt O43318
organism: Homo sapiens

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9BQ95
organism: Homo sapiens

TNF receptor-associated factor 6
type: ProteinReference
xref: Reference/UniProt Q9Y4K3
organism: Homo sapiens

Interleukin-1 receptor-associated kinase 1
type: ProteinReference
xref: Reference/UniProt P51617
organism: Homo sapiens

Toll-like receptor 6
type: ProteinReference
xref: Reference/UniProt Q9Y2C9
organism: Homo sapiens

Protein/2033 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Toll-like receptor 5
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 5

Interaction849
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR2,6
participant: TLR2,6
participant: Liproproteins

Interaction848
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates Monocyte differentiation antigen CD14
participant: Monocyte differentiation antigen CD14
participant: Liproproteins

Reference/UniProt P04949
type: UnificationXref
id: P04949
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ProteinComplex/7715 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKBIA, NFKB1, RELA complex
stoichiometric coefficient: 1.0

Interaction850
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR2,6
participant: TLR2,6
participant: Monocyte differentiation antigen CD14

ProteinComplex/7716 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKB1,RELA complex
stoichiometric coefficient: 1.0

Interaction852
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR1,2
participant: Monocyte differentiation antigen CD14
participant: TLR1,2

Interaction851
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR1,2
participant: Liproproteins
participant: TLR1,2

Interaction854
type: MolecularInteraction
interaction type: direct_interaction
name: TLR2,6 activates MYD88,IRAK (myddosome)
participant: TLR2,6
participant: MYD88,IRAK (myddosome)

Interaction853
type: MolecularInteraction
interaction type: direct_interaction
name: TLR1,2 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: TLR1,2

Interaction856
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Toll-like receptor 4 (Homo sapiens) + Lymphocyte antigen 96 (Homo sapiens)
participant: Toll-like receptor 4 (Homo sapiens)_Lymphocyte antigen 96 (Homo sapiens)
participant: LPS core

Interaction855
type: MolecularInteraction
interaction type: direct_interaction
name: MYD88,IRAK (myddosome) activates TNF receptor-associated factor 6
participant: MYD88,IRAK (myddosome)
participant: TNF receptor-associated factor 6

Transcription factor p65
type: Protein
cellular location: Cytoplasm
entity reference: Transcription factor p65

Interaction858
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates Toll-like receptor 4 (Homo sapiens) + Lymphocyte antigen 96 (Homo sapiens)
participant: Toll-like receptor 4 (Homo sapiens)_Lymphocyte antigen 96 (Homo sapiens)
participant: Monocyte differentiation antigen CD14

Interaction857
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Monocyte differentiation antigen CD14
participant: LPS core
participant: Monocyte differentiation antigen CD14

Interaction859
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 4 (Homo sapiens) + Lymphocyte antigen 96 (Homo sapiens) activates Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens) + Toll-interacting protein (Homo sapiens)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens)_Toll-interacting protein (Homo sapiens)
participant: Toll-like receptor 4 (Homo sapiens)_Lymphocyte antigen 96 (Homo sapiens)

Inhibitor of nuclear factor kappa-B kinase
type: Complex
cellular location: Cytoplasm
component: Inhibitor of nuclear factor kappa-B kinase subunit beta
component: Inhibitor of nuclear factor kappa-B kinase subunit alpha
component: NF-kappa-B essential modulator

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor alpha

Interaction861
type: MolecularInteraction
interaction type: direct_interaction
name: CpG-DNA activates Toll-like receptor 9
participant: Toll-like receptor 9
participant: CpG-DNA

Interaction860
type: MolecularInteraction
interaction type: direct_interaction
name: Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens) + Toll-interacting protein (Homo sapiens) activates MYD88,IRAK (myddosome)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens)_Toll-interacting protein (Homo sapiens)
participant: MYD88,IRAK (myddosome)

Reference/SMPDB SMP0069593
type: UnificationXref
id: SMP0069593
db: SMPDB

Interaction863
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 3
participant: Toll-like receptor 3
participant: Double-Stranded RNA

Interaction862
type: MolecularInteraction
interaction type: direct_interaction
name: Imiquimod activates Toll-like receptor 7
participant: Toll-like receptor 7
participant: Imiquimod

Reference/UniProt Q9Y2C9
type: UnificationXref
id: Q9Y2C9
db: UniProt

Interaction865
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 8
participant: Toll-like receptor 8
participant: Double-Stranded RNA

Interaction864
type: MolecularInteraction
interaction type: direct_interaction
name: Flagellin activates Toll-like receptor 5
participant: Flagellin
participant: Toll-like receptor 5

Interaction867
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 3 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 3

Interaction866
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 9 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 9

Reference/UniProt Q8N5C8
type: UnificationXref
id: Q8N5C8
db: UniProt

Interaction869
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 7 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 7

Reference/UniProt Q9Y6K9
type: UnificationXref
id: Q9Y6K9
db: UniProt

Interaction868
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 8 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 8

Double-Stranded RNA
type: Dna
entity reference: Double-Stranded RNA

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

CpG-DNA
type: Dna
entity reference: CpG-DNA

ProteinComplex/7974 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TAB Complex
stoichiometric coefficient: 1.0

Reference/UniProt Q15399
type: UnificationXref
id: Q15399
db: UniProt

Toll-like receptor 3
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 3

Reference/UniProt O00206
type: UnificationXref
id: O00206
db: UniProt

Toll-interacting protein
type: ProteinReference
xref: Reference/UniProt Q9H0E2
organism: Homo sapiens

Toll-like receptor 8
type: Protein
entity reference: Toll-like receptor 8

Interaction870
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 5 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 5

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

Lymphocyte antigen 96
type: ProteinReference
xref: Reference/UniProt Q9Y6Y9
organism: Homo sapiens

Monocyte differentiation antigen CD14
type: ProteinReference
xref: Reference/UniProt P08571
organism: Homo sapiens

Flagellin
type: Protein
entity reference: Flagellin

Interaction872
type: MolecularInteraction
interaction type: direct_interaction
name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Toll-like receptor 5
type: Protein
entity reference: Toll-like receptor 5

Interaction871
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: TNF receptor-associated factor 6
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Interaction874
type: MolecularInteraction
interaction type: direct_interaction
name: Inhibitor of nuclear factor kappa-B kinase activates NFKBIA, NFKB1, RELA complex
participant: Inhibitor of nuclear factor kappa-B kinase
participant: NFKBIA, NFKB1, RELA complex

Interaction873
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Inhibitor of nuclear factor kappa-B kinase
participant: Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase kinase kinase 1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
type: ProteinReference
xref: Reference/UniProt Q8N5C8
organism: Homo sapiens

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt P25963
organism: Homo sapiens

Toll-like receptor 8
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 8

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Reference/CAS 99011-02-6
type: UnificationXref
id: 99011-02-6
db: CAS

Reference/UniProt Q9Y6Y9
type: UnificationXref
id: Q9Y6Y9
db: UniProt

Reference/PubChem-compound 57469
type: UnificationXref
id: 57469
db: PubChem-compound

Reference/UniProt P19838
type: UnificationXref
id: P19838
db: UniProt

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q13233
organism: Homo sapiens

Reference/HMDB HMDB0013471
type: UnificationXref
id: HMDB0013471
db: HMDB

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt O00206
organism: Homo sapiens

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

Toll-like receptor 9
type: Protein
entity reference: Toll-like receptor 9

Double-Stranded RNA
type: Dna
cellular location: Cytoplasm
entity reference: Double-Stranded RNA

LPS core
type: SmallMolecule
entity reference: LPS core

LPS core
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 59309
xref: Reference/KEGG Compound c0338
xref: Reference/PubChem-compound 53481794
xref: Reference/HMDB HMDB0013471
xref: Reference/BioCyc CPD0-2271
chemical formula: C175H317N5O101P6
molecular weight: 4290.8247
structure: ChemicalStructure/PW C008388

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: Reference/UniProt O15111
organism: Homo sapiens

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/UniProt Q13233
type: UnificationXref
id: Q13233
db: UniProt

Interaction892
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens) + TAB Complex (Homo sapiens)
participant: TNF receptor-associated factor 6
participant: Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens)_TAB Complex (Homo sapiens)

Interaction894
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 14 activates Inhibitor of nuclear factor kappa-B kinase
participant: Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase 14

Interaction893
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens) + TAB Complex (Homo sapiens) activates Mitogen-activated protein kinase kinase kinase 14
participant: Mitogen-activated protein kinase 14
participant: Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens)_TAB Complex (Homo sapiens)

Interaction896
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens) + TAB Complex (Homo sapiens) activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 4
participant: Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens)_TAB Complex (Homo sapiens)

TAB Complex
type: Complex
cellular location: Cytoplasm
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Interaction898
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 without Magnesium
participant: Dual specificity mitogen-activated protein kinase kinase 4
participant: Mitogen-activated protein kinase 8

Reference/UniProt P45985
type: UnificationXref
id: P45985
db: UniProt

Reference/UniProt P45983
type: UnificationXref
id: P45983
db: UniProt

Reference/UniProt O43318
type: UnificationXref
id: O43318
db: UniProt

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Mitogen-activated protein kinase 14
type: ProteinReference
xref: Reference/UniProt Q16539
organism: Homo sapiens

Reference/UniProt O15111
type: UnificationXref
id: O15111
db: UniProt

Toll-interacting protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll-interacting protein

ChemicalStructure/PW C008388
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9NYJ8
type: UnificationXref
id: Q9NYJ8
db: UniProt

Reference/UniProt Q15750
type: UnificationXref
id: Q15750
db: UniProt

Reference/UniProt P08571
type: UnificationXref
id: P08571
db: UniProt

Toll-like receptor 9
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 9

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

NF-kappa-B essential modulator
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B essential modulator

Protein/14663 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-interacting protein
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 4
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 4

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P45983
organism: Homo sapiens

Reference/UniProt O15455
type: UnificationXref
id: O15455
db: UniProt

Interleukin-1 receptor-associated kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-1 receptor-associated kinase 1

Reference/UniProt Q9NYK1
type: UnificationXref
id: Q9NYK1
db: UniProt

Lymphocyte antigen 96
type: Protein
cellular location: Cytoplasm
entity reference: Lymphocyte antigen 96

TLR1,2
type: Complex
cellular location: Cytoplasm
component: Toll-like receptor 1
component: Toll-like receptor 2

Reference/UniProt P51617
type: UnificationXref
id: P51617
db: UniProt

Toll-like receptor 4 (Homo sapiens)_Lymphocyte antigen 96 (Homo sapiens)
type: Complex
component stoichiometry: Protein/2033 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/14662 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-like receptor 4
component: Lymphocyte antigen 96

Reference/ChEBI CHEBI 36704
type: UnificationXref
id: CHEBI:36704
db: ChEBI

Protein/14355 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase kinase kinase 7
stoichiometric coefficient: 1.0

Reference/UniProt O14920
type: UnificationXref
id: O14920
db: UniProt