Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Phosphatidate cytidylyltransferase 2
type: ProteinReference
xref: Reference/UniProt O95674
organism: Homo sapiens

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 439162
type: UnificationXref
id: 439162
db: PubChem-compound

Reference/UniProt Q9NUQ2
type: UnificationXref
id: Q9NUQ2
db: UniProt

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Coenzyme A

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Pyrophosphate

Reaction61492
type: BiochemicalReaction
participant stoichiometry: Compound/Generic142 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic158 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Cytidine monophosphate
right: an L-1-phosphatidylglycerol-phosphate
spontaneous: false
left: a CDP-diacylglycerol
left: Glycerol 3-phosphate
name: Glycerol 3-phosphate + a CDP-diacylglycerol → Cytidine monophosphate + an L-1-phosphatidylglycerol-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway68315
pathway component: SubPathwayInteraction68315
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reaction55814
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Cytosol/Stoichiometry/1.0
right: NAD
right: Glycerol 3-phosphate
spontaneous: false
left: Dihydroxyacetone phosphate
left: Hydrogen Ion
left: NADH
name: Dihydroxyacetone phosphate + Hydrogen Ion + NADH → Glycerol 3-phosphate + NAD
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Protein/782 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
stoichiometric coefficient: 2.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

SubPathwayInteraction68315
type: Interaction
name: SubPathway68315Reaction
name: SubPathwayReaction
participant: Dihydroxyacetone phosphate

Cardiolipin synthase
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cardiolipin synthase

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reaction65383
type: BiochemicalReaction
participant stoichiometry: Compound/Generic137 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic210 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic230 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: 1,2-Diacyl-sn-glycerol 3-phosphate
right: Coenzyme A
spontaneous: false
left: Long-chain fatty acyl-CoA
left: 1-Acyl-sn-glycerol 3-phosphate
name: 1-Acyl-sn-glycerol 3-phosphate + Long-chain fatty acyl-CoA → 1,2-Diacyl-sn-glycerol 3-phosphate + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Compound/PW C001104 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Cytidine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Cytidine triphosphate

Compound/PW C000064 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Phosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Compound/Generic156 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-phosphatidyl-glycerol
stoichiometric coefficient: 1.0

Reaction61472
type: BiochemicalReaction
participant stoichiometry: Compound/Generic156 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic158 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: an L-1-phosphatidyl-glycerol
spontaneous: false
left: an L-1-phosphatidylglycerol-phosphate
left: Water
name: Water + an L-1-phosphatidylglycerol-phosphate → Phosphate + an L-1-phosphatidyl-glycerol
conversion direction: LEFT_TO_RIGHT

Reaction61471
type: BiochemicalReaction
participant stoichiometry: Compound/Generic141 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic156 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic142 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Cytidine monophosphate
right: a cardiolipin
spontaneous: false
left: a CDP-diacylglycerol
left: an L-1-phosphatidyl-glycerol
name: a CDP-diacylglycerol + an L-1-phosphatidyl-glycerol → Cytidine monophosphate + a cardiolipin
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ReactionCatalysis51617
type: Catalysis
controller: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
controlled: Reaction61492
control type: ACTIVATION

Compound/Generic230 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-Diacyl-sn-glycerol 3-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

1,2-Diacyl-sn-glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 1,2-Diacyl-sn-glycerol 3-phosphate

Reference/PathWhiz PW075700
type: UnificationXref
id: PW075700
db: PathWhiz

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

1-Acyl-sn-glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: 1-Acyl-sn-glycerol 3-phosphate

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

an L-1-phosphatidylglycerol-phosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: an L-1-phosphatidylglycerol-phosphate

ReactionCatalysis55508
type: Catalysis
controller: 1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon
controlled: Reaction65383
control type: ACTIVATION

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Cytidine monophosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Cytidine monophosphate

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/UniProt Q9HCL2
type: UnificationXref
id: Q9HCL2
db: UniProt

Glycerol 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GLYCEROL-3P
xref: Reference/HMDB HMDB0000126
xref: Reference/ChemSpider 388308
xref: Reference/CAS 17989-41-2
xref: Reference/KEGG Compound C00093
xref: Reference/ChEBI CHEBI 15978
xref: Reference/PubChem-compound 439162
chemical formula: C3H9O6P
molecular weight: 172.01367
structure: ChemicalStructure/PW C000081

Glycerol-3-phosphate acyltransferase 1, mitochondrial
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Glycerol-3-phosphate acyltransferase 1, mitochondrial

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/Generic158 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: an L-1-phosphatidylglycerol-phosphate
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: O7P2
molecular weight: 173.91193
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15978
type: UnificationXref
id: CHEBI:15978
db: ChEBI

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Compound/PW C000081 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388308
type: UnificationXref
id: 388308
db: ChemSpider

Water
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Water

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Cardiolipin synthase
type: ProteinReference
xref: Reference/UniProt Q9UJA2
organism: Homo sapiens

ReactionCatalysis45939
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
controlled: Reaction55814
control type: ACTIVATION

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q32NB8
organism: Homo sapiens

Reference/UniProt Q9UJA2
type: UnificationXref
id: Q9UJA2
db: UniProt

Reference/HMDB HMDB0000126
type: UnificationXref
id: HMDB0000126
db: HMDB

Compound/PW C000057 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: 1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1-Acyl-sn-glycerol 3-phosphate
type: SmallMoleculeReference

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Glycerol 3-phosphate

Compound/PW C000170 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

1,2-Diacyl-sn-glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 1,2-Diacyl-sn-glycerol 3-phosphate

Reference/UniProt Q32NB8
type: UnificationXref
id: Q32NB8
db: UniProt

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate
name: SubPathwayOutput

Glycerol-3-phosphate acyltransferase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9HCL2
organism: Homo sapiens

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: ProteinReference
xref: Reference/UniProt P21695
organism: Homo sapiens

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/UniProt P21695
type: UnificationXref
id: P21695
db: UniProt

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Compound/PW C000081 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])(=O)OP([O-])([O-])=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Phosphatidate cytidylyltransferase 2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Phosphatidate cytidylyltransferase 2

Compound/Generic230 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-Diacyl-sn-glycerol 3-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

2.7.7.41
type: BiochemicalReaction
participant stoichiometry: Compound/Generic142 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic230 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Pyrophosphate
right: a CDP-diacylglycerol
spontaneous: false
EC number: 2.7.7.41
left: Cytidine triphosphate
left: 1,2-Diacyl-sn-glycerol 3-phosphate
name: 1,2-Diacyl-sn-glycerol 3-phosphate + Cytidine triphosphate → Pyrophosphate + a CDP-diacylglycerol
conversion direction: LEFT_TO_RIGHT

Long-chain fatty acyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Long-chain fatty acyl-CoA

ReactionCatalysis51597
type: Catalysis
controller: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
controlled: Reaction61472
control type: ACTIVATION

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

ReactionCatalysis51596
type: Catalysis
controller: Cardiolipin synthase
controlled: Reaction61471
control type: ACTIVATION

Reference/UniProt Q8WUK0
type: UnificationXref
id: Q8WUK0
db: UniProt

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Compound/Generic142 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: a CDP-diacylglycerol
stoichiometric coefficient: 1.0

an L-1-phosphatidylglycerol-phosphate
type: SmallMoleculeReference

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Cardiolipin Biosynthesis (Barth Syndrome)
type: Pathway
pathway order: PathwayEnzymeReaction/1401152
pathway order: PathwayEnzymeReaction/1401153
pathway order: PathwaySubPathway/68315
pathway order: PathwayEnzymeReaction/1401160
pathway order: PathwayEnzymeReaction/1401156
pathway order: PathwayEnzymeReaction/1401157
pathway order: PathwayTransport/1401163
pathway order: PathwayEnzymeReaction/1401158
pathway order: PathwayEnzymeReaction/1401159
pathway component: 2.3.1.15
pathway component: ReactionCatalysis45523
pathway component: 2.7.7.41
pathway component: ReactionCatalysis45939
pathway component: ReactionCatalysis51597
pathway component: Reaction61492
pathway component: Reaction65383
pathway component: ReactionCatalysis51662
pathway component: ReactionCatalysis51596
pathway component: Reaction61472
pathway component: Reaction61471
pathway component: Glycolysis
pathway component: Reaction55814
pathway component: ReactionCatalysis51617
pathway component: Transport1194
pathway component: ReactionCatalysis55508
xref: Reference/PathWhiz PW075700
xref: Reference/SMPDB SMP0074684
organism: Homo sapiens

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Compound/Generic141 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: a cardiolipin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

an L-1-phosphatidyl-glycerol
type: SmallMoleculeReference

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Compound/Generic210 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Long-chain fatty acyl-CoA
stoichiometric coefficient: 1.0

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycerol 3-phosphate

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Transport1194
type: Transport
participant stoichiometry: Compound/Generic230 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic230 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: 1,2-Diacyl-sn-glycerol 3-phosphate
spontaneous: true
left: 1,2-Diacyl-sn-glycerol 3-phosphate
name: 1,2-Diacyl-sn-glycerol 3-phosphate (?) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Inner Membrane
conversion direction: REVERSIBLE

a cardiolipin
type: SmallMoleculeReference

a CDP-diacylglycerol
type: SmallMoleculeReference

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt O95674
type: UnificationXref
id: O95674
db: UniProt

a CDP-diacylglycerol
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: a CDP-diacylglycerol

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ReactionCatalysis51662
type: Catalysis
controller: Phosphatidate cytidylyltransferase 2
controlled: 2.7.7.41
control type: ACTIVATION

a cardiolipin
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: a cardiolipin

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Glycerol 3-phosphate

Long-chain fatty acyl-CoA
type: SmallMoleculeReference

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Compound/Generic137 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Acyl-sn-glycerol 3-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/CAS 17989-41-2
type: UnificationXref
id: 17989-41-2
db: CAS

Reference/BioCyc GLYCEROL-3P
type: UnificationXref
id: GLYCEROL-3P
db: BioCyc

Reference/KEGG Compound C00093
type: UnificationXref
id: C00093
db: KEGG Compound

an L-1-phosphatidyl-glycerol
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: an L-1-phosphatidyl-glycerol

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
type: ProteinReference
xref: Reference/UniProt Q8WUK0
organism: Homo sapiens

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

ReactionCatalysis45523
type: Catalysis
controller: Glycerol-3-phosphate acyltransferase 1, mitochondrial
controlled: 2.3.1.15
control type: ACTIVATION

Compound/PW C000081 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

1-Acyl-sn-glycerol-3-phosphate acyltransferase epsilon
type: ProteinReference
xref: Reference/UniProt Q9NUQ2
organism: Homo sapiens

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

1,2-Diacyl-sn-glycerol 3-phosphate
type: SmallMoleculeReference

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

2.3.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/Generic210 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic137 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: 1-Acyl-sn-glycerol 3-phosphate
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.15
left: Long-chain fatty acyl-CoA
left: Glycerol 3-phosphate
name: Glycerol 3-phosphate + Long-chain fatty acyl-CoA → 1-Acyl-sn-glycerol 3-phosphate + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reference/SMPDB SMP0074684
type: UnificationXref
id: SMP0074684
db: SMPDB

Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Complex
component stoichiometry: Protein/782 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

ChemicalStructure/PW C000081
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)COP(O)(O)=O