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Tryptophan 2,3-dioxygenase Kynureninase ArylForMamiDase ArylForMamiDase Kynureninase Unknown Kynurenine 3-monooxygenase Kynureninase Peroxisomal catalase 1 Unknown 3- hydroxyanthranilate 3,4-dioxygenase 2-amino-3- carboxymuconate- 6- semialdehyde decarboxylase Probable phenylalanine- 4-hydroxylase 1 Tyrosine decarboxylase Kynurenine 3-monooxygenase ALdehyde deHydrogenase Unknown ArylForMamiDase Unknown Tyrosine decarboxylase Kynurenine 3-monooxygenase Unknown Unknown CYtochrome P450 family Unknown Nicotinamide N- methyltransferase Unknown Tyrosine decarboxylase Kynurenine 3-monooxygenase ALdehyde deHydrogenase Nicotinamide N- methyltransferase Probable aldehyde oxidase gad-3 Unknown Tryptophanyl(W) Amino-acyl tRNA Synthetase Tryptophan-- tRNA ligase, mitochondrial Quinolinic acid L-Tryptophan L-Tryptophan O2 N'- Formylkynurenine H2O Formylanthranilic acid L-Alanine H2O L-Kynurenine Formic acid H2O 2-Aminobenzoic acid Formic acid H2O L-Alanine 4-(2- Aminophenyl)- 2,4- dioxobutanoic acid Kynurenic acid Oxoglutaric acid L-Glutamic acid NADPH O2 L-3- Hydroxykynurenine NADP H2O H2O 3- Hydroxyanthranilic acid L-Alanine O2 Cinnavalininate H2O Oxoglutaric acid 4-(2-Amino-3- hydroxyphenyl)- 2,4- dioxobutanoic acid L-Glutamic acid Xanthurenic acid O2 2-Amino-3- carboxymuconic acid semialdehyde 2-Aminomuconic acid semialdehyde CO2 Tetrahydrobiopterin O2 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Serotonin CO2 NADPH O2 5- Hydroxyindoleacetaldehyde NADP H2O NAD H2O 5- Hydroxyindoleacetic acid NADH S-Adenosylmethionine 5-Methoxyindoleacetate S-Adenosylhomocysteine 5-Hydroxy-N- formylkynurenine H2O 5-Hydroxykynurenine Formic acid O2 5-Hydroxykynurenamine CO2 NADPH O2 4,6- Dihydroxyquinoline NADP H2O Acetyl-CoA N-Acetylserotonin CoA S-Adenosylmethionine Melatonin S-Adenosylhomocysteine O2 6-Hydroxymelatonin H2O O2 Acetyl-N-formyl-5- methoxykynurenamine S-Adenosylmethionine N-Methylserotonin S-Adenosylhomocysteine O2 Formyl-5-hydroxykynurenamine Tryptamine CO2 NADPH O2 Indoleacetaldehyde NADP H2O NAD H2O Indoleacetic acid NADH S- Adenosylmethionine N- Methyltryptamine S- Adenosylhomocysteine H2O O2 H2O2 O2 ATP AMP PPi ATP AMP PPi Heme Pyrophosphate Pyrophosphate Pyridoxal 5'-phosphate FAD Pyrophosphate Heme NADP Pyridoxal 5'-phosphate Fe2+ Fe2+ Pyridoxal 5'-phosphate FAD Heme Pyridoxal 5'-phosphate FAD Heme Heme Heme Pyridoxal 5'-phosphate FAD FAD Molybdopterin 2Fe-2S Heme Reduced flavoprotein Oxidized flavoprotein tRNA(Trp) L- Tryptophyl- tRNA(Trp) tRNA(Trp) L- Tryptophyl- tRNA(Trp) Nicotinate and Nicotinamide Metabolism Extracellular space Intracellular space Mitochondria Endoplasmic Reticulum Peroxisome
tdo-2 flu-2 afmd-1 afmd-1 flu-2 Unknown kmo-1 flu-2 ctl-2 Unknown haao-1 acsd-1 pah-1 tdc-1 kmo-1 alh-1 Unknown afmd-1 Unknown tdc-1 kmo-1 Unknown Unknown cyp-33c9 Unknown anmt-1 Unknown tdc-1 kmo-1 alh-1 anmt-1 gad-3 Unknown wars-1 wars-2 Quinolinic acid L-Tryptophan L-Tryptophan Oxygen N'- Formylkynurenine Water Formylanthranilic acid L-Alanine Water L-Kynurenine Formic acid Water 2-Aminobenzoic acid Formic acid Water L-Alanine 4-(2- Aminophenyl)- 2,4- dioxobutanoic acid Kynurenic acid Oxoglutaric acid L-Glutamic acid NADPH Oxygen L-3- Hydroxykynurenine NADP Water Water 3- Hydroxyanthranilic acid L-Alanine Oxygen Cinnavalininate Water Oxoglutaric acid 4-(2-Amino-3- hydroxyphenyl)- 2,4- dioxobutanoic acid L-Glutamic acid Xanthurenic acid Oxygen 2-Amino-3- carboxymuconic acid semialdehyde 2-Aminomuconic acid semialdehyde Carbon dioxide Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Serotonin Carbon dioxide NADPH Oxygen 5- Hydroxyindoleacetaldehyde NADP Water NAD Water 5- Hydroxyindoleacetic acid NADH S- Adenosylmethionine 5- Methoxyindoleacetate S- Adenosylhomocysteine 5-Hydroxy-N- formylkynurenine Water 5- Hydroxykynurenine Formic acid Oxygen 5- Hydroxykynurenamine Carbon dioxide NADPH Oxygen 4,6- Dihydroxyquinoline NADP Water Acetyl-CoA N- Acetylserotonin Coenzyme A S- Adenosylmethionine Melatonin S- Adenosylhomocysteine Oxygen 6- Hydroxymelatonin Water Oxygen Acetyl-N- formyl-5- methoxykynurenamine S- Adenosylmethionine N- Methylserotonin S- Adenosylhomocysteine Oxygen Formyl-5- hydroxykynurenamine Tryptamine Carbon dioxide NADPH Oxygen Indoleacetaldehyde NADP Water NAD Water Indoleacetic acid NADH S- Adenosylmethionine N- Methyltryptamine S- Adenosylhomocysteine Water Oxygen Hydrogen peroxide Oxygen Adenosine triphosphate Adenosine monophosphate Pyrophosphate Adenosine triphosphate Adenosine monophosphate Pyrophosphate Reduced flavoprotein Oxidized flavoprotein tRNA(Trp) L- Tryptophyl- tRNA(Trp) tRNA(Trp) L- Tryptophyl- tRNA(Trp) Nicotinate and Nicotinamide Metabolism
tdo-2 flu-2 afmd-1 afmd-1 flu-2 kmo-1 flu-2 ctl-2 haao-1 acsd-1 pah-1 tdc-1 kmo-1 alh-1 afmd-1 tdc-1 kmo-1 cyp- 33c9 anmt-1 tdc-1 kmo-1 alh-1 anmt-1 gad-3 wars-1 wars-2 Quinoli Trp Trp O2 Formylk H2O Formyla Ala H2O L-Kynr Formate H2O 2AA Formate H2O Ala 42A24D Kynuren AKG Glu NADPH O2 L-3-HK NADP H2O H2O 3-OHAa Ala O2 CinVal H2O AKG 42A3H24 Glu Xanthur O2 2Am3CSa 2-AaSa CO2 BH4 O2 5-HTP 4aHtHbp 5-HT CO2 NADPH O2 5-Hial NADP H2O NAD H2O 5HIDA NADH SAMe Methoxy SAH 5HNFKN H2O 5HKnn Formate O2 5-Hkynm CO2 NADPH O2 46Q NADP H2O Ac-CoA NAsertn CoA SAMe Meltn SAH O2 6HMeltn H2O O2 AceNf5m SAMe NMetser SAH O2 F5H Tryptam CO2 NADPH O2 Tryptal NADP H2O NAD H2O Indolaa NADH SAMe N-Metrp SAH H2O O2 H2O2 O2 ATP AMP PPi ATP AMP PPi Heme Ppi Ppi Pyr-5'P FAD Ppi Heme NADP Pyr-5'P Fe2+ Fe2+ Pyr-5'P FAD Heme Pyr-5'P FAD Heme Heme Heme Pyr-5'P FAD FAD mlyBdpn 2Fe2S Heme RF OF TRNATRP LTTT TRNATRP LTTT PW000151 Extracellular space Intracellular space Mitochondria Endoplasmic Reticulum Peroxisome
tdo-2 flu-2 afmd-1 afmd-1 flu-2 kmo-1 flu-2 ctl-2 haao-1 acsd-1 pah-1 tdc-1 kmo-1 alh-1 afmd-1 tdc-1 kmo-1 cyp- 33c9 anmt-1 tdc-1 kmo-1 alh-1 anmt-1 gad-3 wars-1 wars-2 Quinoli Trp Trp O2 Formylk H2O Formyla Ala H2O L-Kynr Formate H2O 2AA Formate H2O Ala 42A24D Kynuren AKG Glu NADPH O2 L-3-HK NADP H2O H2O 3-OHAa Ala O2 CinVal H2O AKG 42A3H24 Glu Xanthur O2 2Am3CSa 2-AaSa CO2 BH4 O2 5-HTP 4aHtHbp 5-HT CO2 NADPH O2 5-Hial NADP H2O NAD H2O 5HIDA NADH SAMe Methoxy SAH 5HNFKN H2O 5HKnn Formate O2 5-Hkynm CO2 NADPH O2 46Q NADP H2O Ac-CoA NAsertn CoA SAMe Meltn SAH O2 6HMeltn H2O O2 AceNf5m SAMe NMetser SAH O2 F5H Tryptam CO2 NADPH O2 Tryptal NADP H2O NAD H2O Indolaa NADH SAMe N-Metrp SAH H2O O2 H2O2 O2 ATP AMP Ppi ATP AMP Ppi RF OF TRNATRP LTTT TRNATRP LTTT PW000151