Loader
Loading Pathway...
G-protein coupled bile acid receptor 1 Glucagon-like peptide 1 receptor Ileal sodium/bile acid cotransporter Glucagon-like peptide 1 Bile Acid Bile Acid Bile Acid Blood-Brain Barrier (BBB) Neuron Cell Gallbladder Bile acids are synthesized in the liver and stored in the gallbladder. Following food intake, bile acids are released into the duodenum and travel down the intestine. TGR5 activation also triggers an increase in mitochondrial OXPHOS, which is associated with a rise in the ATP/ADP ratio and a subsequent closure of the ATP-dependent potassium channel (KATP) and calcium mobilization (Cav). As a consequence, incretin glucagon-like peptide-1 (GLP-1) is released. It is questionable whether GLP-1 reaches the brain to interact with GLP-1 receptor sufficiently Nucleus of the Solitary Tract (NTS)
GPBAR1 GLP1R SLC10A2 Glucagon-like peptide 1 Bile Acid Bile Acid Bile Acid
GPBAR1 GLP1R SLC10A2 GLP1 BA BA BA Blood-Brain Barrier (BBB) Neuron Cell Gallbladder Bile acids are synthesized in the liver and stored in the gallbladder. Following food intake, bile acids are released into the duodenum and travel down the intestine. TGR5 activation also triggers an increase in mitochondrial OXPHOS, which is associated with a rise in the ATP/ADP ratio and a subsequent closure of the ATP-dependent potassium channel (KATP) and calcium mobilization (Cav). As a consequence, incretin glucagon-like peptide-1 (GLP-1) is released. It is questionable whether GLP-1 reaches the brain to interact with GLP-1 receptor sufficiently Nucleus of the Solitary Tract (NTS)
GPBAR1 GLP1R SLC10A2 GLP1 BA BA BA