Reference/ChemSpider 82579
type: UnificationXref
id: 82579
db: ChemSpider

Compound/PW C000009 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortexolone
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

3a-Hydroxy-5b-pregnane-20-one
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3a-Hydroxy-5b-pregnane-20-one

17α,21-Dihydroxypregnenolone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 17α,21-Dihydroxypregnenolone

Reference/HMDB HMDB0006759
type: UnificationXref
id: HMDB0006759
db: HMDB

Reference/BioCyc CHOLESTEROL
type: UnificationXref
id: CHOLESTEROL
db: BioCyc

Compound/PW C000009 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortexolone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006755
type: UnificationXref
id: HMDB0006755
db: HMDB

Reference/HMDB HMDB0006756
type: UnificationXref
id: HMDB0006756
db: HMDB

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/HMDB HMDB0006757
type: UnificationXref
id: HMDB0006757
db: HMDB

Reference/HMDB HMDB0006758
type: UnificationXref
id: HMDB0006758
db: HMDB

ReactionCatalysis100858
type: Catalysis
controller: Unknown
controlled: 1.14.99.10
control type: ACTIVATION

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ReactionCatalysis100857
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: Reaction110539
control type: ACTIVATION

Reference/ChemSpider 83782
type: UnificationXref
id: 83782
db: ChemSpider

Reference/HMDB HMDB0006753
type: UnificationXref
id: HMDB0006753
db: HMDB

ReactionCatalysis100856
type: Catalysis
controller: Corticosteroid 11-beta-dehydrogenase isozyme 1
controlled: 1.1.1.146
control type: ACTIVATION

Reference/HMDB HMDB0006754
type: UnificationXref
id: HMDB0006754
db: HMDB

ReactionCatalysis100855
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: Reaction110537
control type: ACTIVATION

ReactionCatalysis100854
type: Catalysis
controller: Cytochrome P450 2D9
controlled: 1.14.15.4
control type: ACTIVATION

ReactionCatalysis100853
type: Catalysis
controller: Cytochrome P450 2C54
controlled: Reaction110535
control type: ACTIVATION

ReactionCatalysis100852
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: 1.3.1.3
control type: ACTIVATION

ReactionCatalysis100851
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: Reaction110533
control type: ACTIVATION

Reference/PubChem-compound 53477897
type: UnificationXref
id: 53477897
db: PubChem-compound

Reference/PubChem-compound 53477896
type: UnificationXref
id: 53477896
db: PubChem-compound

Compound/PW C002027 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 21-Hydroxypregnenolone
stoichiometric coefficient: 1.0

Reference/PubChem-compound 53477898
type: UnificationXref
id: 53477898
db: PubChem-compound

Compound/PW C001708 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisone
stoichiometric coefficient: 1.0

Reference/ChemSpider 389571
type: UnificationXref
id: 389571
db: ChemSpider

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Reference/PathWhiz PW000050
type: UnificationXref
id: PW000050
db: PathWhiz

Reference/HMDB HMDB0003259
type: UnificationXref
id: HMDB0003259
db: HMDB

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C002031 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 22b-Hydroxycholesterol
stoichiometric coefficient: 1.0

Reference/ChemSpider 216208
type: UnificationXref
id: 216208
db: ChemSpider

Reference/HMDB HMDB0006762
type: UnificationXref
id: HMDB0006762
db: HMDB

11b,17a,21-Trihydroxypreg-nenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 11b,17a,21-Trihydroxypreg-nenolone

Reference/HMDB HMDB0006763
type: UnificationXref
id: HMDB0006763
db: HMDB

Reference/CAS 600-57-7
type: UnificationXref
id: 600-57-7
db: CAS

Reference/HMDB HMDB0006764
type: UnificationXref
id: HMDB0006764
db: HMDB

Reference/HMDB HMDB0006760
type: UnificationXref
id: HMDB0006760
db: HMDB

Compound/PW C000183 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrocorticosterone
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6166
type: UnificationXref
id: 6166
db: PubChem-compound

11b,21-Dihydroxy-5b-pregnane-3,20-dione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 11b,21-Dihydroxy-5b-pregnane-3,20-dione

Reference/ChEBI CHEBI 16113
type: UnificationXref
id: CHEBI:16113
db: ChEBI

Reference/CAS 1164-98-3
type: UnificationXref
id: 1164-98-3
db: CAS

Reference/PubChem-compound 24779614
type: UnificationXref
id: 24779614
db: PubChem-compound

Transport1111
type: Transport
participant stoichiometry: Compound/PW C001216 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Cytoplasm/Stoichiometry/1.0
right: Progesterone
spontaneous: false
left: Progesterone
name: Progesterone (→) Transport: Mus musculus, Cell, Endoplasmic Reticulum to Mus musculus, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C05475
type: UnificationXref
id: C05475
db: KEGG Compound

Compound/PW C002704 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20α-Hydroxycholesterol
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Reference/BioCyc PREGNENOLONE
type: UnificationXref
id: PREGNENOLONE
db: BioCyc

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Progesterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Progesterone

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

ReactionCatalysis100872
type: Catalysis
controller: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
controlled: Reaction110554
control type: ACTIVATION

ReactionCatalysis100871
type: Catalysis
controller: Short-chain dehydrogenase/reductase family 42E member 1
controlled: Reaction110553
control type: ACTIVATION

ReactionCatalysis100870
type: Catalysis
controller: Unknown
controlled: 1.14.99.10
control type: ACTIVATION

1.14.15.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002915 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002704 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 20a,22b-Dihydroxycholesterol
spontaneous: false
EC number: 1.14.15.6
left: 20α-Hydroxycholesterol
left: Reduced adrenal ferredoxin
left: Hydrogen Ion
left: Oxygen
name: 20α-Hydroxycholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 20a,22b-Dihydroxycholesterol + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

1.14.15.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002704 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 20α-Hydroxycholesterol
spontaneous: false
EC number: 1.14.15.6
left: Reduced adrenal ferredoxin
left: Cholesterol
left: Hydrogen Ion
left: Oxygen
name: Cholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 20α-Hydroxycholesterol + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Reaction110564
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000722 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002911 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione
right: NADPH
spontaneous: false
left: Tetrahydrocortisone
left: NADP
name: NADP + Tetrahydrocortisone ↔ 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

ReactionCatalysis100879
type: Catalysis
controller: Cytochrome P450 2C39
controlled: 1.14.15.6
control type: ACTIVATION

1.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000045 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001823 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Cortisol
right: NADPH
spontaneous: false
EC number: 1.3.1.3
left: Dihydrocortisol
left: NADP
name: Dihydrocortisol + NADP ↔ Cortisol + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

ReactionCatalysis100878
type: Catalysis
controller: Cytochrome P450 2C39
controlled: 1.14.15.6
control type: ACTIVATION

Reaction110562
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002916 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002704 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
right: Water
right: 17a,20a-Dihydroxycholesterol
right: NADP
spontaneous: false
left: 20α-Hydroxycholesterol
left: NADPH
left: Hydrogen Ion
left: Oxygen
name: 20α-Hydroxycholesterol + Hydrogen Ion + NADPH + Oxygen → 17a,20a-Dihydroxycholesterol + NADP + Water
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100877
type: Catalysis
controller: Cytochrome P450 2C39
controlled: 1.14.15.6
control type: ACTIVATION

1.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001708 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002911 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Cortisone
right: NADPH
spontaneous: false
EC number: 1.3.1.3
left: 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione
left: NADP
name: 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione + NADP ↔ Cortisone + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

ReactionCatalysis100876
type: Catalysis
controller: Cytochrome P450 2C39
controlled: 1.14.15.6
control type: ACTIVATION

1.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001964 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Cytoplasm/Stoichiometry/1.0
right: 5a-Pregnane-3,20-dione
right: NADP
spontaneous: false
EC number: 1.3.1.3
left: Hydrogen Ion
left: NADPH
left: Progesterone
name: Hydrogen Ion + NADPH + Progesterone ↔ 5a-Pregnane-3,20-dione + NADP
conversion direction: REVERSIBLE

ReactionCatalysis100875
type: Catalysis
controller: Cytochrome P450 2C39
controlled: 1.14.15.6
control type: ACTIVATION

Reaction110569
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001964 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002912 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: 5a-Pregnane-3,20-dione
right: NADPH
spontaneous: false
left: 3a-Hydroxy-5b-pregnane-20-one
left: NADP
name: 3a-Hydroxy-5b-pregnane-20-one + NADP ↔ 5a-Pregnane-3,20-dione + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

ReactionCatalysis100874
type: Catalysis
controller: Cytochrome P450 2C39
controlled: 1.14.15.6
control type: ACTIVATION

Reaction110566
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001823 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000757 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Dihydrocortisol
right: NADPH
spontaneous: false
left: Tetrahydrocortisol
left: NADP
name: NADP + Tetrahydrocortisol ↔ Dihydrocortisol + Hydrogen Ion + NADPH
conversion direction: REVERSIBLE

ReactionCatalysis100873
type: Catalysis
controller: Unknown
controlled: 1.14.99.10
control type: ACTIVATION

Compound/PW C000047 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

1.14.15.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002913 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002914 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 11b,17a,21-Trihydroxypreg-nenolone
spontaneous: false
EC number: 1.14.15.4
left: Reduced adrenal ferredoxin
left: 17α,21-Dihydroxypregnenolone
left: Oxygen
name: 17α,21-Dihydroxypregnenolone + Oxygen + Reduced adrenal ferredoxin → 11b,17a,21-Trihydroxypreg-nenolone + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53477678
type: UnificationXref
id: 53477678
db: PubChem-compound

Reference/CAS 68-54-2
type: UnificationXref
id: 68-54-2
db: CAS

ReactionCatalysis100859
type: Catalysis
controller: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
controlled: Reaction110541
control type: ACTIVATION

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Protein/Generic33 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Reduced adrenal ferredoxin
stoichiometric coefficient: 2.0

Reference/PubChem-compound 167685
type: UnificationXref
id: 167685
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/ChEBI CHEBI 16485
type: UnificationXref
id: CHEBI:16485
db: ChEBI

Reference/UniProt P11714
type: UnificationXref
id: P11714
db: UniProt

ReactionCatalysis100861
type: Catalysis
controller: Cytochrome P450 2D9
controlled: 1.14.15.4
control type: ACTIVATION

ReactionCatalysis100860
type: Catalysis
controller: Unknown
controlled: 1.14.99.10
control type: ACTIVATION

1.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000045 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001708 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Cortisone
right: NADPH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.-
left: Cortisol
left: NADP
name: Cortisol + NADP → Cortisone + Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

Reaction110572
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000045 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002913 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NAD
right: 11b,17a,21-Trihydroxypreg-nenolone
spontaneous: false
left: NADH
left: Cortisol
left: Hydrogen Ion
name: Cortisol + Hydrogen Ion + NADH ↔ 11b,17a,21-Trihydroxypreg-nenolone + NAD
conversion direction: REVERSIBLE

1.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002028 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001190 Endoplasmic Reticulum/Stoichiometry/1.0
right: 11-Dehydrocorticosterone
right: NADPH
spontaneous: false
EC number: 1.1.1.-
left: Corticosterone
left: NADP
name: Corticosterone + NADP → 11-Dehydrocorticosterone + NADPH
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100869
type: Catalysis
controller: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
controlled: Reaction110551
control type: ACTIVATION

ReactionCatalysis100868
type: Catalysis
controller: Cytochrome P450 2D9
controlled: 1.14.15.4
control type: ACTIVATION

ReactionCatalysis100867
type: Catalysis
controller: Cytochrome P450 2D9
controlled: 1.14.15.4
control type: ACTIVATION

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

ReactionCatalysis100866
type: Catalysis
controller: Unknown
controlled: 1.14.99.10
control type: ACTIVATION

Compound/PW C002910 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11b,21-Dihydroxy-5b-pregnane-3,20-dione
stoichiometric coefficient: 1.0

ReactionCatalysis100865
type: Catalysis
controller: Cytochrome P450 2C54
controlled: Reaction110547
control type: ACTIVATION

ReactionCatalysis100864
type: Catalysis
controller: Short-chain dehydrogenase/reductase family 42E member 1
controlled: Reaction110546
control type: ACTIVATION

ReactionCatalysis100863
type: Catalysis
controller: Unknown
controlled: 1.14.99.10
control type: ACTIVATION

ReactionCatalysis100862
type: Catalysis
controller: Short-chain dehydrogenase/reductase family 42E member 1
controlled: Reaction110544
control type: ACTIVATION

Reference/ChEBI CHEBI 17026
type: UnificationXref
id: CHEBI:17026
db: ChEBI

1.14.99.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000173 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002027 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Acceptor
right: 21-Hydroxypregnenolone
spontaneous: false
EC number: 1.14.99.10
left: Oxygen
left: Pregnenolone
left: Reduced acceptor
name: Oxygen + Pregnenolone + Reduced acceptor → 21-Hydroxypregnenolone + Acceptor + Water
conversion direction: LEFT_TO_RIGHT

1.14.15.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002029 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 21-Deoxycortisol
spontaneous: false
EC number: 1.14.15.4
left: Reduced adrenal ferredoxin
left: 17-Hydroxyprogesterone
left: Oxygen
name: 17-Hydroxyprogesterone + Oxygen + Reduced adrenal ferredoxin → 21-Deoxycortisol + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C001964 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5a-Pregnane-3,20-dione
stoichiometric coefficient: 1.0

Compound/PW C000026 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Compound/PW C000010 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxycorticosterone
stoichiometric coefficient: 1.0

Reference/BioCyc 20A-HYDROXY-CHOLESTEROL
type: UnificationXref
id: 20A-HYDROXY-CHOLESTEROL
db: BioCyc

Corticosteroid 11-beta-dehydrogenase isozyme 1
type: Complex
component stoichiometry: Protein/13873 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
cellular location: Endoplasmic Reticulum Membrane
component: Short-chain dehydrogenase/reductase family 16C member 6

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Tetrahydrocortisol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrocortisol

Compound/PW C001708 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisone
stoichiometric coefficient: 1.0

1.14.99.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000045 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002029 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Acceptor
right: Cortisol
spontaneous: false
EC number: 1.14.99.10
left: 21-Deoxycortisol
left: Oxygen
left: Reduced acceptor
name: 21-Deoxycortisol + Oxygen + Reduced acceptor → Acceptor + Cortisol + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

1.14.15.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000010 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001190 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: Corticosterone
spontaneous: false
EC number: 1.14.15.4
left: Reduced adrenal ferredoxin
left: Deoxycorticosterone
left: Oxygen
name: Deoxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Corticosterone + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

1.14.99.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001190 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002030 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Corticosterone
right: Acceptor
spontaneous: false
EC number: 1.14.99.10
left: Oxygen
left: Reduced acceptor
left: 11b-Hydroxyprogesterone
name: 11b-Hydroxyprogesterone + Oxygen + Reduced acceptor → Acceptor + Corticosterone + Water
conversion direction: LEFT_TO_RIGHT

Reaction110541
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002030 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002029 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Oxygen
right: Reduced acceptor
right: 11b-Hydroxyprogesterone
spontaneous: false
left: Water
left: 21-Deoxycortisol
left: Acceptor
name: 21-Deoxycortisol + Acceptor + Water → 11b-Hydroxyprogesterone + Oxygen + Reduced acceptor
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 28043
type: UnificationXref
id: CHEBI:28043
db: ChEBI

Reaction110546
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000173 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NADH
right: Progesterone
right: Hydrogen Ion
spontaneous: false
left: Pregnenolone
left: NAD
name: NAD + Pregnenolone → Hydrogen Ion + NADH + Progesterone
conversion direction: LEFT_TO_RIGHT

Reaction110547
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002030 Mitochondrion/Stoichiometry/1.0
right: 11b-Hydroxyprogesterone
right: Water
right: Oxidized adrenal ferredoxin
spontaneous: false
left: Reduced adrenal ferredoxin
left: Progesterone
left: Oxygen
name: Oxygen + Progesterone + Reduced adrenal ferredoxin → 11b-Hydroxyprogesterone + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Reaction110544
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002027 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000010 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NADH
right: Deoxycorticosterone
right: Hydrogen Ion
spontaneous: false
left: NAD
left: 21-Hydroxypregnenolone
name: 21-Hydroxypregnenolone + NAD → Deoxycorticosterone + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

1.14.99.10
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000010 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Acceptor
right: Deoxycorticosterone
spontaneous: false
EC number: 1.14.99.10
left: Oxygen
left: Progesterone
left: Reduced acceptor
name: Oxygen + Progesterone + Reduced acceptor → Acceptor + Deoxycorticosterone + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 21506239
type: UnificationXref
id: 21506239
db: ChemSpider

Compound/PW C001190 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Corticosterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

1.14.15.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002031 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 22b-Hydroxycholesterol
spontaneous: false
EC number: 1.14.15.6
left: Reduced adrenal ferredoxin
left: Cholesterol
left: Hydrogen Ion
left: Oxygen
name: Cholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 22b-Hydroxycholesterol + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Tetrahydrocortisol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05472
xref: Reference/PubChem-compound 44725717
xref: Reference/HMDB HMDB0000949
xref: Reference/CAS 53-02-1
xref: Reference/ChemSpider 21506239
chemical formula: C21H34O5
molecular weight: 366.24063
structure: ChemicalStructure/PW C000757

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/CAS 566-65-4
type: UnificationXref
id: 566-65-4
db: CAS

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADP

5a-Pregnane-3,20-dione
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03681
xref: Reference/ChEBI CHEBI 28952
xref: Reference/HMDB HMDB0003759
xref: Reference/CAS 566-65-4
xref: Reference/ChemSpider 83782
xref: Reference/PubChem-compound 92810
xref: Reference/BioCyc CPD-293
chemical formula: C21H32O2
molecular weight: 316.24023
structure: ChemicalStructure/PW C001964

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Protein/Generic33 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced adrenal ferredoxin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Reference/HMDB HMDB0004029
type: UnificationXref
id: HMDB0004029
db: HMDB

5a-Pregnane-3,20-dione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5a-Pregnane-3,20-dione

1.14.15.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000009 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000045 Mitochondrion/Stoichiometry/1.0
right: Cortisol
right: Water
right: Oxidized adrenal ferredoxin
spontaneous: false
EC number: 1.14.15.4
left: Cortexolone
left: Reduced adrenal ferredoxin
left: Oxygen
name: Cortexolone + Oxygen + Reduced adrenal ferredoxin → Cortisol + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Reaction110553
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002914 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000009 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NAD
right: 17α,21-Dihydroxypregnenolone
spontaneous: false
left: NADH
left: Cortexolone
left: Hydrogen Ion
name: Cortexolone + Hydrogen Ion + NADH ← 17α,21-Dihydroxypregnenolone + NAD
conversion direction: RIGHT_TO_LEFT

11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al

Reaction110554
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000173 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Acceptor
right: 17a-Hydroxypregnenolone
spontaneous: false
left: Oxygen
left: Pregnenolone
left: Reduced acceptor
name: Oxygen + Pregnenolone + Reduced acceptor → 17a-Hydroxypregnenolone + Acceptor + Water
conversion direction: LEFT_TO_RIGHT

Reaction110551
type: BiochemicalReaction
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001216 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 17-Hydroxyprogesterone
right: Acceptor
spontaneous: false
left: Oxygen
left: Progesterone
left: Reduced acceptor
name: Oxygen + Progesterone + Reduced acceptor → 17-Hydroxyprogesterone + Acceptor + Water
conversion direction: LEFT_TO_RIGHT

22b-Hydroxycholesterol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 22b-Hydroxycholesterol

1.14.99.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000009 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Acceptor
right: Cortexolone
spontaneous: false
EC number: 1.14.99.10
left: Oxygen
left: 17-Hydroxyprogesterone
left: Reduced acceptor
name: 17-Hydroxyprogesterone + Oxygen + Reduced acceptor → Acceptor + Cortexolone + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0004026
type: UnificationXref
id: HMDB0004026
db: HMDB

1.14.15.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001016 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002916 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 4-Methylpentanal
right: 17a-Hydroxypregnenolone
spontaneous: false
EC number: 1.14.15.6
left: Reduced adrenal ferredoxin
left: Hydrogen Ion
left: 17a,20a-Dihydroxycholesterol
left: Oxygen
name: 17a,20a-Dihydroxycholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 17a-Hydroxypregnenolone + 4-Methylpentanal + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

17a-Hydroxypregnenolone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 17a-Hydroxypregnenolone

Reference/CAS 57-88-5
type: UnificationXref
id: 57-88-5
db: CAS

1.14.15.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002915 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002031 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 20a,22b-Dihydroxycholesterol
spontaneous: false
EC number: 1.14.15.6
left: Reduced adrenal ferredoxin
left: Hydrogen Ion
left: 22b-Hydroxycholesterol
left: Oxygen
name: 22b-Hydroxycholesterol + Hydrogen Ion + Oxygen + Reduced adrenal ferredoxin → 20a,22b-Dihydroxycholesterol + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C002914 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17α,21-Dihydroxypregnenolone
stoichiometric coefficient: 1.0

1.14.99.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002914 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 17α,21-Dihydroxypregnenolone
right: NADP
spontaneous: false
EC number: 1.14.99.10
left: Oxygen
left: NADPH
left: 17a-Hydroxypregnenolone
left: Hydrogen Ion
name: 17a-Hydroxypregnenolone + Hydrogen Ion + NADPH + Oxygen ↔ 17α,21-Dihydroxypregnenolone + NADP + Water
conversion direction: REVERSIBLE

Corticosterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Corticosterone

1.14.15.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C002915 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001016 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000173 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/2.0
right: Pregnenolone
right: Water
right: Oxidized adrenal ferredoxin
right: 4-Methylpentanal
spontaneous: false
EC number: 1.14.15.6
left: Reduced adrenal ferredoxin
left: Hydrogen Ion
left: 20a,22b-Dihydroxycholesterol
left: Oxygen
name: 20a,22b-Dihydroxycholesterol + 2 Hydrogen Ion + Oxygen + 2 Reduced adrenal ferredoxin → 4-Methylpentanal + 2 Oxidized adrenal ferredoxin + Pregnenolone + 2 Water
conversion direction: LEFT_TO_RIGHT

3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440695
xref: Reference/KEGG Compound C05474
xref: Reference/ChemSpider 389571
xref: Reference/HMDB HMDB0006753
chemical formula: C21H32O5
molecular weight: 364.22498
structure: ChemicalStructure/PW C002906

11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05473
xref: Reference/PubChem-compound 53477896
xref: Reference/HMDB HMDB0006754
chemical formula: C21H32O5
molecular weight: 364.22498
structure: ChemicalStructure/PW C002907

3a,21-Dihydroxy-5b-pregnane-11,20-dione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006755
xref: Reference/CAS 566-03-0
xref: Reference/PubChem-compound 44263347
xref: Reference/ChemSpider 24850110
xref: Reference/KEGG Compound C05478
chemical formula: C21H32O4
molecular weight: 348.23007
structure: ChemicalStructure/PW C002908

Reference/CAS 15234-55-6
type: UnificationXref
id: 15234-55-6
db: CAS

21-Hydroxy-5b-pregnane-3,11,20-trione
type: SmallMoleculeReference
xref: Reference/CAS 10417-86-4
xref: Reference/PubChem-compound 44263345
xref: Reference/HMDB HMDB0006756
xref: Reference/KEGG Compound C05477
xref: Reference/ChemSpider 24850108
chemical formula: C21H30O4
molecular weight: 346.21442
structure: ChemicalStructure/PW C002909

Tetrahydrocortisone
type: SmallMoleculeReference
xref: Reference/CAS 53-05-4
xref: Reference/PubChem-compound 12444617
xref: Reference/ChemSpider 16735652
xref: Reference/HMDB HMDB0000903
chemical formula: C21H32O5
molecular weight: 364.22498
structure: ChemicalStructure/PW C000722

Compound/PW C001216 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H28N7O14P2
molecular weight: 664.11694
structure: ChemicalStructure/PW C000721

Deoxycorticosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Deoxycorticosterone

Reference/HMDB HMDB0000903
type: UnificationXref
id: HMDB0000903
db: HMDB

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

ReactionCatalysis99989
type: Catalysis
controller: Short-chain dehydrogenase/reductase family 42E member 1
controlled: Reaction109716
control type: ACTIVATION

11-Dehydrocorticosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 11-Dehydrocorticosterone

Oxygen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxygen

Compound/PW C001216 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C000026 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004031
type: UnificationXref
id: HMDB0004031
db: HMDB

Reference/HMDB HMDB0004030
type: UnificationXref
id: HMDB0004030
db: HMDB

Reference/HMDB HMDB0004035
type: UnificationXref
id: HMDB0004035
db: HMDB

Compound/PW C002906 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al
stoichiometric coefficient: 1.0

Reaction110539
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002909 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002908 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: 21-Hydroxy-5b-pregnane-3,11,20-trione
right: Hydrogen Ion
right: NADPH
spontaneous: false
left: 3a,21-Dihydroxy-5b-pregnane-11,20-dione
left: NADP
name: 3a,21-Dihydroxy-5b-pregnane-11,20-dione + NADP → 21-Hydroxy-5b-pregnane-3,11,20-trione + Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

17a,20a-Dihydroxycholesterol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53477898
xref: Reference/ChEBI CHEBI 783
xref: Reference/HMDB HMDB0006764
xref: Reference/KEGG Compound C05499
chemical formula: C27H46O3
molecular weight: 418.3447
structure: ChemicalStructure/PW C002916

Reference/PubChem-compound 11222
type: UnificationXref
id: 11222
db: PubChem-compound

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reaction110537
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000183 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002910 Cytoplasm/Stoichiometry/1.0
right: 11b,21-Dihydroxy-5b-pregnane-3,20-dione
right: NADPH
spontaneous: false
left: Tetrahydrocorticosterone
left: NADP
name: NADP + Tetrahydrocorticosterone ↔ 11b,21-Dihydroxy-5b-pregnane-3,20-dione + NADPH
conversion direction: REVERSIBLE

Cortisone
type: SmallMoleculeReference
xref: Reference/ChemSpider 193441
xref: Reference/ChEBI CHEBI 16962
xref: Reference/PubChem-compound 222786
xref: Reference/HMDB HMDB0002802
xref: Reference/CAS 53-06-5
xref: Reference/BioCyc CPD-286
xref: Reference/KEGG Compound C00762
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C001708

1.1.1.146
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002908 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000183 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 3a,21-Dihydroxy-5b-pregnane-11,20-dione
right: NADPH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.146
left: Tetrahydrocorticosterone
left: NADP
name: NADP + Tetrahydrocorticosterone → 3a,21-Dihydroxy-5b-pregnane-11,20-dione + Hydrogen Ion + NADPH
conversion direction: LEFT_TO_RIGHT

Reference/CAS 72-23-1
type: UnificationXref
id: 72-23-1
db: CAS

Reference/ChemSpider 5773
type: UnificationXref
id: 5773
db: ChemSpider

Reference/ChEBI CHEBI 17252
type: UnificationXref
id: CHEBI:17252
db: ChEBI

11b,21-Dihydroxy-5b-pregnane-3,20-dione
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44263339
xref: Reference/HMDB HMDB0006757
xref: Reference/KEGG Compound C05475
xref: Reference/ChemSpider 24850104
xref: Reference/CAS 566-01-8
chemical formula: C21H32O4
molecular weight: 348.23007
structure: ChemicalStructure/PW C002910

Reference/PubChem-compound 6238
type: UnificationXref
id: 6238
db: PubChem-compound

Reference/ChemSpider 5775
type: UnificationXref
id: 5775
db: ChemSpider

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

17a,21-Dihydroxy-5b-pregnane-3,11,20-trione
type: SmallMoleculeReference
xref: Reference/ChemSpider 58997
xref: Reference/PubChem-compound 65554
xref: Reference/CAS 68-54-2
xref: Reference/HMDB HMDB0006758
xref: Reference/ChEBI CHEBI 18093
xref: Reference/KEGG Compound C05469
chemical formula: C21H30O5
molecular weight: 362.20932
structure: ChemicalStructure/PW C002911

Dihydrocortisol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003259
xref: Reference/ChemSpider 144508
xref: Reference/CAS 1482-50-4
xref: Reference/KEGG Compound C05471
xref: Reference/PubChem-compound 164838
chemical formula: C21H32O5
molecular weight: 364.22498
structure: ChemicalStructure/PW C001823

3a-Hydroxy-5b-pregnane-20-one
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006759
xref: Reference/KEGG Compound C05480
xref: Reference/PubChem-compound 24779614
xref: Reference/ChemSpider 23141070
chemical formula: C21H34O2
molecular weight: 318.2559
structure: ChemicalStructure/PW C002912

11b,17a,21-Trihydroxypreg-nenolone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440708
xref: Reference/ChemSpider 389583
xref: Reference/HMDB HMDB0006760
xref: Reference/KEGG Compound C05489
chemical formula: C21H32O5
molecular weight: 364.22498
structure: ChemicalStructure/PW C002913

17α,21-Dihydroxypregnenolone
type: SmallMoleculeReference
xref: Reference/ChemSpider 167253
xref: Reference/PubChem-compound 192735
xref: Reference/ChEBI CHEBI 27832
xref: Reference/HMDB HMDB0006762
xref: Reference/CAS 1167-48-2
xref: Reference/KEGG Compound C05487
chemical formula: C21H32O4
molecular weight: 348.23007
structure: ChemicalStructure/PW C002914

17a-Hydroxypregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 17a-Hydroxypregnenolone

20a,22b-Dihydroxycholesterol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53477897
xref: Reference/ChEBI CHEBI 1294
xref: Reference/CAS 15234-55-6
xref: Reference/HMDB HMDB0006763
xref: Reference/KEGG Compound C05501
chemical formula: C27H46O3
molecular weight: 418.3447
structure: ChemicalStructure/PW C002915

Reference/PathWhiz PW121886
type: UnificationXref
id: PW121886
db: PathWhiz

Reaction110535
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000223 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000026 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: Aldosterone
spontaneous: false
left: Reduced adrenal ferredoxin
left: 18-Hydroxycorticosterone
left: Oxygen
name: 18-Hydroxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Aldosterone + Oxidized adrenal ferredoxin + 2 Water
conversion direction: LEFT_TO_RIGHT

1.14.15.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000223 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic34 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001190 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic33 Mitochondrion/Stoichiometry/1.0
right: Water
right: Oxidized adrenal ferredoxin
right: 18-Hydroxycorticosterone
spontaneous: false
EC number: 1.14.15.4
left: Reduced adrenal ferredoxin
left: Oxygen
left: Corticosterone
name: Corticosterone + Oxygen + Reduced adrenal ferredoxin → 18-Hydroxycorticosterone + Oxidized adrenal ferredoxin + Water
conversion direction: LEFT_TO_RIGHT

Reaction110533
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002906 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002907 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al
right: NADP
spontaneous: false
left: 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al
left: NADPH
name: 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al + NADPH → 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al + NADP
conversion direction: LEFT_TO_RIGHT

1.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002907 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000026 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Aldosterone
right: NADPH
spontaneous: false
EC number: 1.3.1.3
left: 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al
left: NADP
name: 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al + NADP → Aldosterone + NADPH
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 44263339
type: UnificationXref
id: 44263339
db: PubChem-compound

Compound/PW C000045 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisol
stoichiometric coefficient: 1.0

20α-Hydroxycholesterol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 20α-Hydroxycholesterol

Reference/KEGG Compound C01124
type: UnificationXref
id: C01124
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000015
type: UnificationXref
id: HMDB0000015
db: HMDB

ChemicalStructure/PW C000173
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000016
type: UnificationXref
id: HMDB0000016
db: HMDB

Compound/PW C002907 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al
stoichiometric coefficient: 1.0

Reference/PubChem-compound 13783449
type: UnificationXref
id: 13783449
db: PubChem-compound

Reference/HMDB HMDB0000253
type: UnificationXref
id: HMDB0000253
db: HMDB

Reference/HMDB HMDB0000374
type: UnificationXref
id: HMDB0000374
db: HMDB

Compound/PW C002908 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3a,21-Dihydroxy-5b-pregnane-11,20-dione
stoichiometric coefficient: 1.0

17-Hydroxyprogesterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 17-Hydroxyprogesterone

Compound/PW C000173 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05499
type: UnificationXref
id: C05499
db: KEGG Compound

Compound/PW C000223 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 18-Hydroxycorticosterone
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000268
type: UnificationXref
id: HMDB0000268
db: HMDB

Reference/KEGG Compound C03681
type: UnificationXref
id: C03681
db: KEGG Compound

Progesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Progesterone

Compound/PW C002028 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11-Dehydrocorticosterone
stoichiometric coefficient: 1.0

Compound/PW C002029 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 21-Deoxycortisol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000183
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9D665
type: UnificationXref
id: Q9D665
db: UniProt

Progesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Progesterone

Pregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Pregnenolone

Reference/KEGG Compound C05502
type: UnificationXref
id: C05502
db: KEGG Compound

Reference/KEGG Compound C03205
type: UnificationXref
id: C03205
db: KEGG Compound

17a,20a-Dihydroxycholesterol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 17a,20a-Dihydroxycholesterol

Reference/PubChem-compound 44725717
type: UnificationXref
id: 44725717
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

20α-Hydroxycholesterol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006283
xref: Reference/ChEBI CHEBI 1296
xref: Reference/BioCyc 20A-HYDROXY-CHOLESTEROL
xref: Reference/CAS 516-72-3
xref: Reference/PubChem-compound 440711
xref: Reference/ChemSpider 389586
xref: Reference/KEGG Compound C05500
chemical formula: C27H46O2
molecular weight: 402.3498
structure: ChemicalStructure/PW C002704

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05501
type: UnificationXref
id: C05501
db: KEGG Compound

Reference/KEGG Compound C05500
type: UnificationXref
id: C05500
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

ChemicalStructure/PW C000273
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 24850110
type: UnificationXref
id: 24850110
db: ChemSpider

Reference/CAS 1167-48-2
type: UnificationXref
id: 1167-48-2
db: CAS

Reference/UniProt Q05A13
type: UnificationXref
id: Q05A13
db: UniProt

Reference/PubChem-compound 247020
type: UnificationXref
id: 247020
db: PubChem-compound

Reference/BioCyc 4-METHYLPENTANAL
type: UnificationXref
id: 4-METHYLPENTANAL
db: BioCyc

Reference/PubChem-compound 44263345
type: UnificationXref
id: 44263345
db: PubChem-compound

Compound/PW C002030 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11b-Hydroxyprogesterone
stoichiometric coefficient: 1.0

Reference/PubChem-compound 44263347
type: UnificationXref
id: 44263347
db: PubChem-compound

Reference/CAS 68-96-2
type: UnificationXref
id: 68-96-2
db: CAS

Compound/PW C001016 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Methylpentanal
stoichiometric coefficient: 1.0

Compound/PW C002916 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a,20a-Dihydroxycholesterol
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00187
type: UnificationXref
id: C00187
db: KEGG Compound

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/KEGG Compound C02373
type: UnificationXref
id: C02373
db: KEGG Compound

ChemicalStructure/PW C001016
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CCC=O

Compound/PW C002909 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 21-Hydroxy-5b-pregnane-3,11,20-trione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000047
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000045
type: ChemicalStructure
structure format: SMILES

18-Hydroxycorticosterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 18-Hydroxycorticosterone

Reference/PubChem-compound 44263342
type: UnificationXref
id: 44263342
db: PubChem-compound

Reference/ChemSpider 24850104
type: UnificationXref
id: 24850104
db: ChemSpider

Reference/ChemSpider 24850108
type: UnificationXref
id: 24850108
db: ChemSpider

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/ChemSpider 24850107
type: UnificationXref
id: 24850107
db: ChemSpider

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reaction109716
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: NADH
right: 17-Hydroxyprogesterone
right: Hydrogen Ion
spontaneous: false
left: NAD
left: 17a-Hydroxypregnenolone
name: 17a-Hydroxypregnenolone + NAD → 17-Hydroxyprogesterone + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Cortexolone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Cortexolone

Reference/PubChem-compound 65554
type: UnificationXref
id: 65554
db: PubChem-compound

Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reduced adrenal ferredoxin
type: ProteinReference
xref: Reference/ChEBI CHEBI 16906
organism: Mus musculus

Oxidized adrenal ferredoxin
type: ProteinReference
xref: Reference/ChEBI CHEBI 16341
organism: Mus musculus

Reference/PubChem-compound 92810
type: UnificationXref
id: 92810
db: PubChem-compound

Compound/PW C000183 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrocorticosterone
stoichiometric coefficient: 1.0

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002029
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-293
type: UnificationXref
id: CPD-293
db: BioCyc

Reference/KEGG Compound C02140
type: UnificationXref
id: C02140
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ReactionCatalysis100893
type: Catalysis
controller: Short-chain dehydrogenase/reductase family 42E member 1
controlled: Reaction110572
control type: ACTIVATION

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/CAS 152-58-9
type: UnificationXref
id: 152-58-9
db: CAS

Reference/PubChem-compound 192735
type: UnificationXref
id: 192735
db: PubChem-compound

ReactionCatalysis100891
type: Catalysis
controller: Unknown
controlled: 1.1.1.-
control type: ACTIVATION

Reference/CAS 1119-16-0
type: UnificationXref
id: 1119-16-0
db: CAS

ChemicalStructure/PW C002030
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002031
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

3a,21-Dihydroxy-5b-pregnane-11,20-dione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3a,21-Dihydroxy-5b-pregnane-11,20-dione

Reduced adrenal ferredoxin
type: Protein
cellular location: Mitochondrion
entity reference: Reduced adrenal ferredoxin

Reference/UniProt Q9JII6
type: UnificationXref
id: Q9JII6
db: UniProt

Reference/KEGG Compound C01176
type: UnificationXref
id: C01176
db: KEGG Compound

20a,22b-Dihydroxycholesterol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 20a,22b-Dihydroxycholesterol

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

ReactionCatalysis100883
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: 1.3.1.3
control type: ACTIVATION

Cytochrome P450 2C39
type: Protein
cellular location: Mitochondrion
entity reference: Cytochrome P450 2C39

Reference/HMDB HMDB0000067
type: UnificationXref
id: HMDB0000067
db: HMDB

ReactionCatalysis100882
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: Reaction110564
control type: ACTIVATION

ReactionCatalysis100881
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: 1.3.1.3
control type: ACTIVATION

ReactionCatalysis100880
type: Catalysis
controller: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
controlled: Reaction110562
control type: ACTIVATION

ChemicalStructure/PW C001190
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis100889
type: Catalysis
controller: Unknown
controlled: 1.1.1.-
control type: ACTIVATION

Reference/CAS 68-42-8
type: UnificationXref
id: 68-42-8
db: CAS

ReactionCatalysis100887
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: Reaction110569
control type: ACTIVATION

Reference/HMDB HMDB0000063
type: UnificationXref
id: HMDB0000063
db: HMDB

ReactionCatalysis100886
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: 1.3.1.3
control type: ACTIVATION

ReactionCatalysis100885
type: Catalysis
controller: Cytochrome P450 2D9
controlled: 1.14.15.4
control type: ACTIVATION

ReactionCatalysis100884
type: Catalysis
controller: Alcohol dehydrogenase [NADP(+)]
controlled: Reaction110566
control type: ACTIVATION

Oxidized adrenal ferredoxin
type: Protein
cellular location: Mitochondrion
entity reference: Oxidized adrenal ferredoxin

Reference/UniProt Q64441
type: UnificationXref
id: Q64441
db: UniProt

Unknown
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Unknown

Dihydrocortisol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dihydrocortisol

17α,21-Dihydroxypregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 17α,21-Dihydroxypregnenolone

Reference/BioCyc CPD-272
type: UnificationXref
id: CPD-272
db: BioCyc

21-Deoxycortisol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 21-Deoxycortisol

Compound/PW C002029 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 21-Deoxycortisol
stoichiometric coefficient: 1.0

Compound/PW C000757 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrocortisol
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/ChemSpider 144508
type: UnificationXref
id: 144508
db: ChemSpider

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Cytochrome P450 2C54
type: Protein
cellular location: Mitochondrion
entity reference: Cytochrome P450 2C54

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/CAS 50-23-7
type: UnificationXref
id: 50-23-7
db: CAS

Reference/ChemSpider 5932
type: UnificationXref
id: 5932
db: ChemSpider

Reference/BioCyc CPD-286
type: UnificationXref
id: CPD-286
db: BioCyc

11b,17a,21-Trihydroxypreg-nenolone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 11b,17a,21-Trihydroxypreg-nenolone

17a,21-Dihydroxy-5b-pregnane-3,11,20-trione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione

Reference/PubChem-compound 9863245
type: UnificationXref
id: 9863245
db: PubChem-compound

11b-Hydroxyprogesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 11b-Hydroxyprogesterone

21-Hydroxy-5b-pregnane-3,11,20-trione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 21-Hydroxy-5b-pregnane-3,11,20-trione

ChemicalStructure/PW C002027
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002028
type: ChemicalStructure
structure format: SMILES

Protein/13873 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Short-chain dehydrogenase/reductase family 16C member 6
stoichiometric coefficient: 2.0

18-Hydroxycorticosterone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11222
xref: Reference/ChemSpider 10748
xref: Reference/HMDB HMDB0000319
xref: Reference/CAS 561-65-9
xref: Reference/KEGG Compound C01124
xref: Reference/ChEBI CHEBI 16485
chemical formula: C21H30O5
molecular weight: 362.20932
structure: ChemicalStructure/PW C000223

Reference/CAS 566-01-8
type: UnificationXref
id: 566-01-8
db: CAS

Cytochrome P450 2D9
type: Protein
cellular location: Mitochondrion
entity reference: Cytochrome P450 2D9

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 440708
type: UnificationXref
id: 440708
db: PubChem-compound

Reference/PubChem-compound 440707
type: UnificationXref
id: 440707
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

Reference/PubChem-compound 129
type: UnificationXref
id: 129
db: PubChem-compound

Corticosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Corticosterone

Reference/ChEBI CHEBI 27832
type: UnificationXref
id: CHEBI:27832
db: ChEBI

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Compound/PW C002028 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11-Dehydrocorticosterone
stoichiometric coefficient: 1.0

17-Hydroxyprogesterone
type: SmallMoleculeReference
xref: Reference/CAS 68-96-2
xref: Reference/ChEBI CHEBI 17252
xref: Reference/KEGG Compound C01176
xref: Reference/PubChem-compound 6238
xref: Reference/ChemSpider 6002
xref: Reference/HMDB HMDB0000374
chemical formula: C21H30O3
molecular weight: 330.21948
structure: ChemicalStructure/PW C000273

Compound/PW C002912 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3a-Hydroxy-5b-pregnane-20-one
stoichiometric coefficient: 1.0

21-Hydroxypregnenolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 21-Hydroxypregnenolone

Reference/CAS 50-22-6
type: UnificationXref
id: 50-22-6
db: CAS

Cortisol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Cortisol

Reference/ChemSpider 6002
type: UnificationXref
id: 6002
db: ChemSpider

Reference/ChemSpider 126
type: UnificationXref
id: 126
db: ChemSpider

ChemicalStructure/PW C000223
type: ChemicalStructure
structure format: SMILES

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Reference/UniProt Q6XVG2
type: UnificationXref
id: Q6XVG2
db: UniProt

Cholesterol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000067
xref: Reference/ChEBI CHEBI 16113
xref: Reference/BioCyc CHOLESTEROL
xref: Reference/KEGG Compound C00187
xref: Reference/ChemSpider 5775
xref: Reference/PubChem-compound 5997
xref: Reference/CAS 57-88-5
chemical formula: C27H46O
molecular weight: 386.35486
structure: ChemicalStructure/PW C000047

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Cortisol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00735
xref: Reference/CAS 50-23-7
xref: Reference/PubChem-compound 5754
xref: Reference/HMDB HMDB0000063
xref: Reference/ChemSpider 5551
xref: Reference/ChEBI CHEBI 17650
chemical formula: C21H30O5
molecular weight: 362.20932
structure: ChemicalStructure/PW C000045

Compound/PW C001420 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/CAS 17954-98-2
type: UnificationXref
id: 17954-98-2
db: CAS

Cortexolone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28324
xref: Reference/HMDB HMDB0000015
xref: Reference/CAS 152-58-9
xref: Reference/PubChem-compound 440707
xref: Reference/BioCyc 11-DEOXY-CORTISOL
xref: Reference/ChemSpider 389582
xref: Reference/KEGG Compound C05488
chemical formula: C21H30O4
molecular weight: 346.21442
structure: ChemicalStructure/PW C000009

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C002908 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3a,21-Dihydroxy-5b-pregnane-11,20-dione
stoichiometric coefficient: 1.0

Compound/PW C001216 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05469
type: UnificationXref
id: C05469
db: KEGG Compound

Reference/PubChem-compound 5754
type: UnificationXref
id: 5754
db: PubChem-compound

Progesterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001830
xref: Reference/ChEBI CHEBI 17026
xref: Reference/CAS 57-83-0
xref: Reference/ChemSpider 5773
xref: Reference/PubChem-compound 5994
xref: Reference/BioCyc CPD-272
xref: Reference/KEGG Compound C00410
chemical formula: C21H30O2
molecular weight: 314.22458
structure: ChemicalStructure/PW C001216

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/PubChem-compound 5997
type: UnificationXref
id: 5997
db: PubChem-compound

Reference/PubChem-compound 5994
type: UnificationXref
id: 5994
db: PubChem-compound

Reference/PubChem-compound 5753
type: UnificationXref
id: 5753
db: PubChem-compound

Compound/PW C002030 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11b-Hydroxyprogesterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05473
type: UnificationXref
id: C05473
db: KEGG Compound

Reference/KEGG Compound C05472
type: UnificationXref
id: C05472
db: KEGG Compound

Reference/KEGG Compound C05474
type: UnificationXref
id: C05474
db: KEGG Compound

Protein/Generic34 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxidized adrenal ferredoxin
stoichiometric coefficient: 2.0

Reference/KEGG Compound C05471
type: UnificationXref
id: C05471
db: KEGG Compound

Reference/ChEBI CHEBI 18093
type: UnificationXref
id: CHEBI:18093
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Deoxycorticosterone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6166
xref: Reference/CAS 64-85-7
xref: Reference/BioCyc 11-DEOXYCORTICOSTERONE
xref: Reference/ChEBI CHEBI 16973
xref: Reference/HMDB HMDB0000016
xref: Reference/ChemSpider 5932
xref: Reference/KEGG Compound C03205
chemical formula: C21H30O3
molecular weight: 330.21948
structure: ChemicalStructure/PW C000010

Reference/ChEBI CHEBI 16906
type: UnificationXref
id: CHEBI:16906
db: ChEBI

Tetrahydrocortisone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrocortisone

SubPathwayInteraction57668
type: Interaction
name: SubPathwayReaction
name: SubPathway57668Reaction
participant: Cholesterol

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Tetrahydrocorticosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrocorticosterone

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Compound/PW C000010 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxycorticosterone
stoichiometric coefficient: 1.0

Reference/CAS 566-03-0
type: UnificationXref
id: 566-03-0
db: CAS

Reference/SMPDB SMP0120630
type: UnificationXref
id: SMP0120630
db: SMPDB

Reference/HMDB HMDB0000319
type: UnificationXref
id: HMDB0000319
db: HMDB

Reference/KEGG Compound C05477
type: UnificationXref
id: C05477
db: KEGG Compound

Reference/KEGG Compound C05476
type: UnificationXref
id: C05476
db: KEGG Compound

Reference/PubChem-compound 440711
type: UnificationXref
id: 440711
db: PubChem-compound

Reference/CAS 53-02-1
type: UnificationXref
id: 53-02-1
db: CAS

Reference/KEGG Compound C05478
type: UnificationXref
id: C05478
db: KEGG Compound

Reference/KEGG Compound C05485
type: UnificationXref
id: C05485
db: KEGG Compound

Reference/KEGG Compound C05480
type: UnificationXref
id: C05480
db: KEGG Compound

Aldosterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Aldosterone

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

17a-Hydroxypregnenolone
type: SmallMoleculeReference
xref: Reference/ChemSpider 82579
xref: Reference/PubChem-compound 91451
xref: Reference/CAS 387-79-1
xref: Reference/HMDB HMDB0000363
xref: Reference/KEGG Compound C05138
xref: Reference/ChEBI CHEBI 28750
chemical formula: C21H32O3
molecular weight: 332.23514
structure: ChemicalStructure/PW C000263

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16973
type: UnificationXref
id: CHEBI:16973
db: ChEBI

Acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Acceptor

ChemicalStructure/PW C001216
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/KEGG Compound C05488
type: UnificationXref
id: C05488
db: KEGG Compound

Reference/KEGG Compound C05487
type: UnificationXref
id: C05487
db: KEGG Compound

ChemicalStructure/PW C000009
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C05489
type: UnificationXref
id: C05489
db: KEGG Compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C000010
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Protein/Generic34 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized adrenal ferredoxin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05497
type: UnificationXref
id: C05497
db: KEGG Compound

Cortisone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cortisone

Compound/PW C002913 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11b,17a,21-Trihydroxypreg-nenolone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05490
type: UnificationXref
id: C05490
db: KEGG Compound

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0001547
type: UnificationXref
id: HMDB0001547
db: HMDB

NADH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADH

21-Deoxycortisol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 21-Deoxycortisol

Reference/CAS 64-85-7
type: UnificationXref
id: 64-85-7
db: CAS

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Compound/Generic41 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05498
type: UnificationXref
id: C05498
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADPH

Reference/KEGG Compound C05138
type: UnificationXref
id: C05138
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000263
type: ChemicalStructure
structure format: SMILES

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C000173 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 1294
type: UnificationXref
id: CHEBI:1294
db: ChEBI

Reference/ChEBI CHEBI 28952
type: UnificationXref
id: CHEBI:28952
db: ChEBI

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1296
type: UnificationXref
id: CHEBI:1296
db: ChEBI

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

21-Hydroxypregnenolone
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05485
xref: Reference/CAS 1164-98-3
xref: Reference/ChemSpider 216208
xref: Reference/ChEBI CHEBI 28043
xref: Reference/HMDB HMDB0004026
xref: Reference/PubChem-compound 247020
chemical formula: C21H32O3
molecular weight: 332.23514
structure: ChemicalStructure/PW C002027

Reference/PubChem-compound 91451
type: UnificationXref
id: 91451
db: PubChem-compound

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

17-Hydroxyprogesterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 17-Hydroxyprogesterone

3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al

Reference/ChemSpider 10748
type: UnificationXref
id: 10748
db: ChemSpider

4-Methylpentanal
type: SmallMoleculeReference
xref: Reference/ChemSpider 126
xref: Reference/BioCyc 4-METHYLPENTANAL
xref: Reference/KEGG Compound C02373
xref: Reference/ChEBI CHEBI 17998
xref: Reference/PubChem-compound 129
xref: Reference/CAS 1119-16-0
xref: Reference/HMDB HMDB0001318
chemical formula: C6H12O
molecular weight: 100.08881
structure: ChemicalStructure/PW C001016

Reference/ChemSpider 16735652
type: UnificationXref
id: 16735652
db: ChemSpider

Reference/BioCyc 11-DEOXY-CORTISOL
type: UnificationXref
id: 11-DEOXY-CORTISOL
db: BioCyc

Reference/HMDB HMDB0001318
type: UnificationXref
id: HMDB0001318
db: HMDB

Reference/PubChem-compound 222803
type: UnificationXref
id: 222803
db: PubChem-compound

Compound/PW C000273 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17-Hydroxyprogesterone
stoichiometric coefficient: 1.0

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Cortisone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Cortisone

Aldosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Aldosterone

Reference/ChEBI CHEBI 16827
type: UnificationXref
id: CHEBI:16827
db: ChEBI

Pregnenolone
type: SmallMoleculeReference
xref: Reference/CAS 145-13-1
xref: Reference/KEGG Compound C01953
xref: Reference/PubChem-compound 53477678
xref: Reference/ChEBI CHEBI 16581
xref: Reference/BioCyc PREGNENOLONE
xref: Reference/HMDB HMDB0000253
chemical formula: C21H32O2
molecular weight: 316.24023
structure: ChemicalStructure/PW C000173

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

17-alpha-Hydroxylase Deficiency (CYP17)
type: Pathway
pathway order: PathwayEnzymeReaction/1190682
pathway order: PathwayEnzymeReaction/1190681
pathway order: PathwayEnzymeReaction/1190680
pathway order: PathwayEnzymeReaction/1190664
pathway order: PathwayEnzymeReaction/1190686
pathway order: PathwayEnzymeReaction/1190685
pathway order: PathwayEnzymeReaction/1190684
pathway order: PathwayEnzymeReaction/1190683
pathway order: PathwayTransport/1190707
pathway order: PathwayEnzymeReaction/1190679
pathway order: PathwayEnzymeReaction/1190678
pathway order: PathwayEnzymeReaction/1190677
pathway order: PathwayEnzymeReaction/1190699
pathway order: PathwayEnzymeReaction/1190676
pathway order: PathwayEnzymeReaction/1190698
pathway order: PathwayEnzymeReaction/1190671
pathway order: PathwayEnzymeReaction/1190693
pathway order: PathwayEnzymeReaction/1190670
pathway order: PathwayEnzymeReaction/1190692
pathway order: PathwayEnzymeReaction/1190691
pathway order: PathwayEnzymeReaction/1190690
pathway order: PathwayEnzymeReaction/1190675
pathway order: PathwayEnzymeReaction/1190697
pathway order: PathwayEnzymeReaction/1190674
pathway order: PathwayEnzymeReaction/1190696
pathway order: PathwayEnzymeReaction/1190673
pathway order: PathwayEnzymeReaction/1190695
pathway order: PathwayEnzymeReaction/1190672
pathway order: PathwayEnzymeReaction/1190694
pathway order: PathwayEnzymeReaction/1190706
pathway order: PathwaySubPathway/57668
pathway order: PathwayEnzymeReaction/1190668
pathway order: PathwayEnzymeReaction/1190701
pathway order: PathwayEnzymeReaction/1190667
pathway order: PathwayEnzymeReaction/1190689
pathway order: PathwayEnzymeReaction/1190700
pathway order: PathwayEnzymeReaction/1190666
pathway order: PathwayEnzymeReaction/1190688
pathway order: PathwayEnzymeReaction/1190665
pathway order: PathwayEnzymeReaction/1190687
pathway order: PathwayEnzymeReaction/1190705
pathway order: PathwayEnzymeReaction/1190704
pathway order: PathwayEnzymeReaction/1190703
pathway order: PathwayEnzymeReaction/1190669
pathway order: PathwayEnzymeReaction/1190702
pathway component: Reaction109716
pathway component: 1.14.99.10
pathway component: 1.14.15.4
pathway component: ReactionCatalysis100893
pathway component: ReactionCatalysis100891
pathway component: ReactionCatalysis100858
pathway component: ReactionCatalysis100857
pathway component: ReactionCatalysis100856
pathway component: ReactionCatalysis100855
pathway component: Reaction110541
pathway component: ReactionCatalysis100854
pathway component: Reaction110546
pathway component: ReactionCatalysis100853
pathway component: Reaction1214
pathway component: Reaction110547
pathway component: ReactionCatalysis100852
pathway component: Reaction110544
pathway component: ReactionCatalysis100851
pathway component: 1.14.15.6
pathway component: ReactionCatalysis100883
pathway component: ReactionCatalysis100882
pathway component: ReactionCatalysis100881
pathway component: ReactionCatalysis100880
pathway component: Reaction110553
pathway component: Reaction110554
pathway component: Reaction110551
pathway component: ReactionCatalysis100889

Reference/ChEBI CHEBI 16962
type: UnificationXref
id: CHEBI:16962
db: ChEBI

Progesterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Progesterone

Reference/ChemSpider 24840621
type: UnificationXref
id: 24840621
db: ChemSpider

Reference/ChemSpider 23141070
type: UnificationXref
id: 23141070
db: ChemSpider

Compound/PW C040034 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Steroid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway57668
pathway component: SubPathwayInteraction57668
xref: Reference/SMPDB SMP0000023
xref: Reference/PathWhiz PW000050
name: SubPathway

Reference/ChEBI CHEBI 385115
type: UnificationXref
id: CHEBI:385115
db: ChEBI

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/HMDB HMDB0003759
type: UnificationXref
id: HMDB0003759
db: HMDB

Cortisol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cortisol

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000273 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17-Hydroxyprogesterone
stoichiometric coefficient: 1.0

Compound/PW C001823 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrocortisol
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000363
type: UnificationXref
id: HMDB0000363
db: HMDB

Tetrahydrocorticosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000268
xref: Reference/ChemSpider 8038941
xref: Reference/CAS 68-42-8
xref: Reference/KEGG Compound C05476
xref: Reference/PubChem-compound 9863245
chemical formula: C21H34O4
molecular weight: 350.2457
structure: ChemicalStructure/PW C000183

ChemicalStructure/PW C002906
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002907
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002908
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002909
type: ChemicalStructure
structure format: SMILES

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/CAS 516-72-3
type: UnificationXref
id: 516-72-3
db: CAS

ChemicalStructure/PW C000722
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

11b-Hydroxyprogesterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 11b-Hydroxyprogesterone

Reference/PubChem-compound 222786
type: UnificationXref
id: 222786
db: PubChem-compound

Compound/Generic40 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

Reference/CAS 561-65-9
type: UnificationXref
id: 561-65-9
db: CAS

11-Dehydrocorticosterone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 11-Dehydrocorticosterone

Reference/BioCyc 11-DEOXYCORTICOSTERONE
type: UnificationXref
id: 11-DEOXYCORTICOSTERONE
db: BioCyc

Reference/ChemSpider 167253
type: UnificationXref
id: 167253
db: ChemSpider

ChemicalStructure/PW C001708
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 58997
type: UnificationXref
id: 58997
db: ChemSpider

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Reference/ChEBI CHEBI 17998
type: UnificationXref
id: CHEBI:17998
db: ChEBI

ChemicalStructure/PW C001823
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002913
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002914
type: ChemicalStructure
structure format: SMILES

Reduced acceptor
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced acceptor

ChemicalStructure/PW C002915
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

ChemicalStructure/PW C002916
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002910
type: ChemicalStructure
structure format: SMILES

Compound/PW C002911 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a,21-Dihydroxy-5b-pregnane-3,11,20-trione
stoichiometric coefficient: 1.0

Reference/ChemSpider 5551
type: UnificationXref
id: 5551
db: ChemSpider

ChemicalStructure/PW C002911
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5550
type: UnificationXref
id: 5550
db: ChemSpider

ChemicalStructure/PW C002912
type: ChemicalStructure
structure format: SMILES

Compound/PW C000045 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisol
stoichiometric coefficient: 1.0

4-Methylpentanal
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 4-Methylpentanal

NAD
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NAD

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/ChEBI CHEBI 28750
type: UnificationXref
id: CHEBI:28750
db: ChEBI

Reference/KEGG Compound C00735
type: UnificationXref
id: C00735
db: KEGG Compound

Compound/PW C002915 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20a,22b-Dihydroxycholesterol
stoichiometric coefficient: 1.0

Reference/UniProt P56656
type: UnificationXref
id: P56656
db: UniProt

11-Dehydrocorticosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004029
xref: Reference/KEGG Compound C05490
xref: Reference/CAS 72-23-1
xref: Reference/PubChem-compound 13783449
xref: Reference/ChemSpider 24850107
chemical formula: C21H28O4
molecular weight: 344.19876
structure: ChemicalStructure/PW C002028

21-Deoxycortisol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05497
xref: Reference/CAS 641-77-0
xref: Reference/HMDB HMDB0004030
xref: Reference/PubChem-compound 222803
xref: Reference/ChemSpider 193458
chemical formula: C21H30O4
molecular weight: 346.21442
structure: ChemicalStructure/PW C002029

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/HMDB HMDB0000949
type: UnificationXref
id: HMDB0000949
db: HMDB

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

22b-Hydroxycholesterol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 385115
xref: Reference/ChemSpider 146693
xref: Reference/KEGG Compound C05502
xref: Reference/CAS 17954-98-2
xref: Reference/PubChem-compound 167685
xref: Reference/HMDB HMDB0004035
chemical formula: C27H46O2
molecular weight: 402.3498
structure: ChemicalStructure/PW C002031

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Compound/PW C000263 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a-Hydroxypregnenolone
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/SMPDB SMP0000023
type: UnificationXref
id: SMP0000023
db: SMPDB

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Deoxycorticosterone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Deoxycorticosterone

11b-Hydroxyprogesterone
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44263342
xref: Reference/ChemSpider 24840621
xref: Reference/HMDB HMDB0004031
xref: Reference/CAS 600-57-7
xref: Reference/KEGG Compound C05498
xref: Reference/BioCyc CPD-272
chemical formula: C20H28O4
molecular weight: 332.19876
structure: ChemicalStructure/PW C002030

Reference/KEGG Compound C01953
type: UnificationXref
id: C01953
db: KEGG Compound

Cortisol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Cortisol

Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 53-06-5
type: UnificationXref
id: 53-06-5
db: CAS

Unknown
type: ProteinReference
organism: Mus musculus

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Compound/PW C001190 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Corticosterone
stoichiometric coefficient: 1.0

Tetrahydrocorticosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Tetrahydrocorticosterone

Cholesterol
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Cholesterol
name: SubPathwayInput

Alcohol dehydrogenase [NADP(+)]
type: Protein
cellular location: Cytoplasm
entity reference: Alcohol dehydrogenase [NADP(+)]

Corticosterone
type: SmallMoleculeReference
xref: Reference/CAS 50-22-6
xref: Reference/KEGG Compound C02140
xref: Reference/HMDB HMDB0001547
xref: Reference/ChEBI CHEBI 16827
xref: Reference/PubChem-compound 5753
xref: Reference/ChemSpider 5550
chemical formula: C21H30O4
molecular weight: 346.21442
structure: ChemicalStructure/PW C001190

Compound/PW C001190 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Corticosterone
stoichiometric coefficient: 1.0

Cytochrome P450 2C39
type: ProteinReference
xref: Reference/UniProt P56656
organism: Mus musculus

Cytochrome P450 2D9
type: ProteinReference
xref: Reference/UniProt P11714
organism: Mus musculus

Short-chain dehydrogenase/reductase family 16C member 6
type: ProteinReference
xref: Reference/UniProt Q05A13
organism: Mus musculus

Compound/PW C000721 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Cytochrome P450 2C54
type: ProteinReference
xref: Reference/UniProt Q6XVG2
organism: Mus musculus

Reference/CAS 57-83-0
type: UnificationXref
id: 57-83-0
db: CAS

Short-chain dehydrogenase/reductase family 42E member 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Short-chain dehydrogenase/reductase family 42E member 1

ChemicalStructure/PW C002704
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/ChEBI CHEBI 28324
type: UnificationXref
id: CHEBI:28324
db: ChEBI

Compound/PW C001216 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

Reference/CAS 10417-86-4
type: UnificationXref
id: 10417-86-4
db: CAS

Compound/PW C001190 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Corticosterone
stoichiometric coefficient: 1.0

Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reaction1214
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002910 Cytoplasm/Stoichiometry/1.0
right: 11b,21-Dihydroxy-5b-pregnane-3,20-dione
spontaneous: true
left: Corticosterone
name: Corticosterone → 11b,21-Dihydroxy-5b-pregnane-3,20-dione
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 193458
type: UnificationXref
id: 193458
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChemSpider 193441
type: UnificationXref
id: 193441
db: ChemSpider

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/HMDB HMDB0006283
type: UnificationXref
id: HMDB0006283
db: HMDB

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChemSpider 146693
type: UnificationXref
id: 146693
db: ChemSpider

Reference/CAS 53-05-4
type: UnificationXref
id: 53-05-4
db: CAS

Reference/PubChem-compound 12444617
type: UnificationXref
id: 12444617
db: PubChem-compound

3a,21-Dihydroxy-5b-pregnane-11,20-dione
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 3a,21-Dihydroxy-5b-pregnane-11,20-dione

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/ChEBI CHEBI 16581
type: UnificationXref
id: CHEBI:16581
db: ChEBI

Reference/ChEBI CHEBI 16341
type: UnificationXref
id: CHEBI:16341
db: ChEBI

Compound/PW C000045 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cortisol
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00762
type: UnificationXref
id: C00762
db: KEGG Compound

Compound/PW C000263 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17a-Hydroxypregnenolone
stoichiometric coefficient: 1.0

Reference/PubChem-compound 440695
type: UnificationXref
id: 440695
db: PubChem-compound

Reference/HMDB HMDB0001830
type: UnificationXref
id: HMDB0001830
db: HMDB

Reference/CAS 145-13-1
type: UnificationXref
id: 145-13-1
db: CAS

Corticosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Corticosterone

Reference/HMDB HMDB0002802
type: UnificationXref
id: HMDB0002802
db: HMDB

Reference/ChEBI CHEBI 783
type: UnificationXref
id: CHEBI:783
db: ChEBI

Reference/CAS 387-79-1
type: UnificationXref
id: 387-79-1
db: CAS

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

Compound/PW C002914 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 17α,21-Dihydroxypregnenolone
stoichiometric coefficient: 1.0

Cortexolone
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cortexolone

Reference/PubChem-compound 164838
type: UnificationXref
id: 164838
db: PubChem-compound

Reference/ChemSpider 389583
type: UnificationXref
id: 389583
db: ChemSpider

Reference/ChemSpider 389582
type: UnificationXref
id: 389582
db: ChemSpider

Reference/ChemSpider 389586
type: UnificationXref
id: 389586
db: ChemSpider

Reference/KEGG Compound C00410
type: UnificationXref
id: C00410
db: KEGG Compound

Compound/PW C002913 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11b,17a,21-Trihydroxypreg-nenolone
stoichiometric coefficient: 1.0

Corticosterone
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Corticosterone

Reference/CAS 641-77-0
type: UnificationXref
id: 641-77-0
db: CAS

Reaction1234
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002909 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002028 Cytoplasm/Stoichiometry/1.0
right: 21-Hydroxy-5b-pregnane-3,11,20-trione
spontaneous: true
left: 11-Dehydrocorticosterone
name: 11-Dehydrocorticosterone → 21-Hydroxy-5b-pregnane-3,11,20-trione
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Alcohol dehydrogenase [NADP(+)]
type: ProteinReference
xref: Reference/UniProt Q9JII6
organism: Mus musculus

Short-chain dehydrogenase/reductase family 42E member 1
type: ProteinReference
xref: Reference/UniProt Q9D665
organism: Mus musculus

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q64441
organism: Mus musculus

Reference/CAS 1482-50-4
type: UnificationXref
id: 1482-50-4
db: CAS

ChemicalStructure/PW C001964
type: ChemicalStructure
structure format: SMILES

Short-chain dehydrogenase/reductase family 16C member 6
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Short-chain dehydrogenase/reductase family 16C member 6

Reference/ChEBI CHEBI 17650
type: UnificationXref
id: CHEBI:17650
db: ChEBI

ChemicalStructure/PW C000757
type: ChemicalStructure
structure format: SMILES

Pregnenolone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pregnenolone

Compound/PW C000722 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrocortisone
stoichiometric coefficient: 1.0

Reference/ChemSpider 8038941
type: UnificationXref
id: 8038941
db: ChemSpider