Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Inositol 1,4,5-trisphosphate

Reference/ChEBI CHEBI 75466
type: UnificationXref
id: CHEBI:75466
db: ChEBI

Reference/UniProt Q69ZK0
type: UnificationXref
id: Q69ZK0
db: UniProt

PIP(18:1(9Z)/16:0)
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/PubChem-compound 53480165
xref: Reference/ChemSpider 24767851
xref: Reference/HMDB HMDB0009970
chemical formula: C43H82O16P2
molecular weight: 916.5078
structure: ChemicalStructure/PW C006015

Reference/UniProt Q80U44
type: UnificationXref
id: Q80U44
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/KEGG Compound C13861
type: UnificationXref
id: C13861
db: KEGG Compound

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reference/CAS 3123-73-7
type: UnificationXref
id: 3123-73-7
db: CAS

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Compound/PW C006015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP(18:1(9Z)/16:0)
stoichiometric coefficient: 1.0

Reference/UniProt O70161
type: UnificationXref
id: O70161
db: UniProt

Reference/UniProt Q8C5L6
type: UnificationXref
id: Q8C5L6
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Protein/13802 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Extended synaptotagmin-2
stoichiometric coefficient: 1.0

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Putative tyrosine-protein phosphatase auxilin
type: Protein
cellular location: Cell Membrane
entity reference: Putative tyrosine-protein phosphatase auxilin

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
type: Protein
cellular location: Cell Membrane
entity reference: CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Protein/13546 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 3-kinase catalytic subunit type 3
stoichiometric coefficient: 1.0

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

PIP2(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP2(16:0/18:1(9Z))

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

PIP2(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2(16:0/18:1(9Z))

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP2[4,5](16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.68
left: PIP[4'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

3.1.3.86
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.86
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

ReactionCatalysis100509
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
controlled: 2.7.1.68
control type: ACTIVATION

ReactionCatalysis100508
type: Catalysis
controller: SH2 domain-containing protein 1B
controlled: 3.1.3.86
control type: ACTIVATION

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis100507
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
controlled: 2.7.1.149
control type: ACTIVATION

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Polyphosphoinositide phosphatase
type: Complex
component stoichiometry: Protein/13741 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13740 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13739 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Zinc finger FYVE domain-containing protein 16
component: Phosphatidylinositide phosphatase SAC2
component: Protein VAC14 homolog

Dual specificity testis-specific protein kinase 2
type: Protein
cellular location: Cell Membrane
entity reference: Dual specificity testis-specific protein kinase 2

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/SMPDB SMP0120646
type: UnificationXref
id: SMP0120646
db: SMPDB

ChemicalStructure/PW C003022
type: ChemicalStructure
structure format: SMILES

Zinc finger FYVE domain-containing protein 16
type: ProteinReference
xref: Reference/UniProt Q80U44
organism: Mus musculus

2.7.1.67
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.67
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[4'](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100517
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: 2.7.1.153
control type: ACTIVATION

Reference/BioCyc MYO-INOSITOL
type: UnificationXref
id: MYO-INOSITOL
db: BioCyc

2.7.1.154
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.154
left: PIP[4'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100516
type: Catalysis
controller: Putative tyrosine-protein phosphatase auxilin
controlled: Reaction110204
control type: ACTIVATION

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
type: ProteinReference
xref: Reference/UniProt Q69ZK0
organism: Mus musculus

ReactionCatalysis100515
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: 2.7.1.153
control type: ACTIVATION

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.36
left: PIP[4'](16:0/18:1(9Z))
left: Water
name: PIP[4'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100514
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
controlled: 2.7.1.154
control type: ACTIVATION

ReactionCatalysis100513
type: Catalysis
controller: Phosphatidylinositol 3-kinase catalytic subunit type 3
controlled: 2.7.1.67
control type: ACTIVATION

2.7.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP3(16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.153
left: PIP2[4,5](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP2[4,5](16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100512
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003153 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001155 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: DG(16:0/18:1(9Z)/0:0)
right: Inositol 1,4,5-trisphosphate
spontaneous: false
EC number: 3.1.4.11
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → DG(16:0/18:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100511
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

2.7.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.153
left: PIP[4'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100510
type: Catalysis
controller: Inositol polyphosphate 5-phosphatase K
controlled: 3.1.3.36
control type: ACTIVATION

Reaction110204
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PIP2[4,5](16:0/18:1(9Z))
spontaneous: false
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2[4,5](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: Reference/UniProt O35904
organism: Mus musculus

Reference/PathWhiz PW000156
type: UnificationXref
id: PW000156
db: PathWhiz

Phosphoinositide 3-kinase regulatory subunit 4
type: ProteinReference
xref: Reference/UniProt Q8VD65
organism: Mus musculus

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Phosphatidylinositide phosphatase SAC2
type: ProteinReference
xref: Reference/UniProt Q8CDA1
organism: Mus musculus

Protein VAC14 homolog
type: ProteinReference
xref: Reference/UniProt Q80WQ2
organism: Mus musculus

Reference/ChemSpider 24767914
type: UnificationXref
id: 24767914
db: ChemSpider

myo-Inositol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000211
xref: Reference/ChEBI CHEBI 17268
xref: Reference/ChemSpider 10239179
xref: Reference/CAS 87-89-8
xref: Reference/BioCyc MYO-INOSITOL
xref: Reference/KEGG Compound C00137
xref: Reference/PubChem-compound 892
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000137

Reference/ChemSpider 4445454
type: UnificationXref
id: 4445454
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

1-phosphatidylinositol 3-phosphate 5-kinase
type: Complex
component stoichiometry: Protein/13741 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13740 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13739 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Zinc finger FYVE domain-containing protein 16
component: Phosphatidylinositide phosphatase SAC2
component: Protein VAC14 homolog

PI(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24767668
xref: Reference/HMDB HMDB0009783
chemical formula: C43H81O13P
molecular weight: 836.5415
structure: ChemicalStructure/PW C005831

Reference/CAS 87-89-8
type: UnificationXref
id: 87-89-8
db: CAS

ReactionCatalysis100506
type: Catalysis
controller: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
controlled: 3.1.3.66
control type: ACTIVATION

2.7.1.149
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP2[4,5](16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.149
left: PIP[5'](16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP[5'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53480165
type: UnificationXref
id: 53480165
db: PubChem-compound

ReactionCatalysis100505
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.36
left: PIP[5'](16:0/18:1(9Z))
left: Water
name: PIP[5'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100504
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
controlled: 2.7.1.68
control type: ACTIVATION

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
right: PIP[4'](16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

ReactionCatalysis100503
type: Catalysis
controller: 1-phosphatidylinositol 3-phosphate 5-kinase
controlled: 2.7.1.150
control type: ACTIVATION

ChemicalStructure/PW C003153
type: ChemicalStructure
structure format: SMILES

3.1.3.86
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PIP[5'](16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.86
left: PIP2[4,5](16:0/18:1(9Z))
left: Water
name: PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[5'](16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis100502
type: Catalysis
controller: Phosphatidylinositol 3-kinase catalytic subunit type 3
controlled: 2.7.1.137
control type: ACTIVATION

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

ReactionCatalysis100501
type: Catalysis
controller: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
controlled: 2.7.1.153
control type: ACTIVATION

ReactionCatalysis100500
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP[5'](16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.-
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP[5'](16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.68
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17268
type: UnificationXref
id: CHEBI:17268
db: ChEBI

Reference/ChemSpider 10239179
type: UnificationXref
id: 10239179
db: ChemSpider

Compound/PW C006078 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Joubert Syndrome
type: Pathway
pathway order: PathwayEnzymeReaction/2111790
pathway order: PathwayEnzymeReaction/2111770
pathway order: PathwayEnzymeReaction/2111792
pathway order: PathwayEnzymeReaction/2111791
pathway order: PathwayEnzymeReaction/2111772
pathway order: PathwayEnzymeReaction/2111794
pathway order: PathwayEnzymeReaction/2111771
pathway order: PathwayEnzymeReaction/2111793
pathway order: PathwayEnzymeReaction/2111774
pathway order: PathwayEnzymeReaction/2111796
pathway order: PathwayEnzymeReaction/2111773
pathway order: PathwayEnzymeReaction/2111795
pathway order: PathwayEnzymeReaction/2111776
pathway order: PathwayEnzymeReaction/2111775
pathway order: PathwayEnzymeReaction/2111778
pathway order: PathwayEnzymeReaction/2111777
pathway order: PathwayEnzymeReaction/2111779
pathway order: PathwayEnzymeReaction/2111781
pathway order: PathwayEnzymeReaction/2111780
pathway order: PathwayEnzymeReaction/2111783
pathway order: PathwayEnzymeReaction/2111782
pathway order: PathwayEnzymeReaction/2111785
pathway order: PathwaySubPathway/108064
pathway order: PathwayEnzymeReaction/2111784
pathway order: PathwaySubPathway/108065
pathway order: PathwayEnzymeReaction/2111787
pathway order: PathwayEnzymeReaction/2111786
pathway order: PathwayEnzymeReaction/2111789
pathway order: PathwayEnzymeReaction/2111788
pathway order: PathwayEnzymeReaction/2111769
pathway order: PathwayEnzymeReaction/2111768
pathway component: 2.7.1.137
pathway component: 2.7.8.11
pathway component: 3.1.3.36
pathway component: 2.7.1.153
pathway component: ReactionCatalysis100499
pathway component: ReactionCatalysis100519
pathway component: ReactionCatalysis100518
pathway component: ReactionCatalysis100520
pathway component: 3.1.3.66
pathway component: 2.7.1.150
pathway component: 2.7.1.68
pathway component: 2.7.1.149
pathway component: 3.1.3.86
pathway component: ReactionCatalysis100527
pathway component: ReactionCatalysis100526
pathway component: ReactionCatalysis100525
pathway component: ReactionCatalysis100524
pathway component: ReactionCatalysis100523
pathway component: ReactionCatalysis100522
pathway component: ReactionCatalysis100521
pathway component: ReactionCatalysis100509
pathway component: ReactionCatalysis100508
pathway component: ReactionCatalysis100507
pathway component: 2.7.1.67
pathway component: ReactionCatalysis100517
pathway component: 2.7.1.154
pathway component: ReactionCatalysis100516
pathway component: ReactionCatalysis100515
pathway component: ReactionCatalysis100514
pathway component: ReactionCatalysis100513
pathway component: ReactionCatalysis100512
pathway component: 3.1.4.11
pathway component: ReactionCatalysis100511
pathway component: ReactionCatalysis100510
pathway component: Reaction110204
pathway component: Inositol Phosphate Metabolism
pathway component: ReactionCatalysis100506

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: Complex
component stoichiometry: Protein/7725 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13546 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Unknown
component: Phosphatidylinositol 3-kinase catalytic subunit type 3

myo-Inositol
type: SmallMolecule
cellular location: Cytosol
entity reference: myo-Inositol
name: SubPathwayOutput

Reference/HMDB HMDB0000211
type: UnificationXref
id: HMDB0000211
db: HMDB

PIP[4'](16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP[4'](16:0/18:1(9Z))

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

ReactionCatalysis100499
type: Catalysis
controller: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
controlled: 2.7.8.11
control type: ACTIVATION

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/PubChem-compound 53480228
type: UnificationXref
id: 53480228
db: PubChem-compound

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Phosphoinositide 3-kinase regulatory subunit 4
type: Protein
cellular location: Cell Membrane
entity reference: Phosphoinositide 3-kinase regulatory subunit 4

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt Q8VDP6
type: UnificationXref
id: Q8VDP6
db: UniProt

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000137
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

ChemicalStructure/PW C005831
type: ChemicalStructure
structure format: SMILES

Dual specificity testis-specific protein kinase 2
type: ProteinReference
xref: Reference/UniProt Q8VCT9
organism: Mus musculus

Putative tyrosine-protein phosphatase auxilin
type: ProteinReference
xref: Reference/UniProt Q80TZ3
organism: Mus musculus

Inositol polyphosphate 5-phosphatase K
type: ProteinReference
xref: Reference/UniProt Q8C5L6
organism: Mus musculus

Extended synaptotagmin-2
type: ProteinReference
xref: Reference/UniProt Q3TZZ7
organism: Mus musculus

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
type: ProteinReference
xref: Reference/UniProt O70161
organism: Mus musculus

Reference/HMDB HMDB0010150
type: UnificationXref
id: HMDB0010150
db: HMDB

Reference/ChemSpider 24767668
type: UnificationXref
id: 24767668
db: ChemSpider

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/HMDB HMDB0010037
type: UnificationXref
id: HMDB0010037
db: HMDB

Reference/KEGG Compound C00137
type: UnificationXref
id: C00137
db: KEGG Compound

SubPathwayInteraction108064
type: Interaction
name: SubPathwayReaction
name: SubPathway108064Reaction
participant: Inositol 1,4,5-trisphosphate

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

DG(16:0/18:1(9Z)/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: DG(16:0/18:1(9Z)/0:0)

Protein/13740 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositide phosphatase SAC2
stoichiometric coefficient: 1.0

SubPathwayInteraction108065
type: Interaction
name: SubPathwayReaction
name: SubPathway108065Reaction
participant: myo-Inositol

ChemicalStructure/PW C040459
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040458
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 24765811
type: UnificationXref
id: 24765811
db: ChemSpider

ChemicalStructure/PW C040457
type: ChemicalStructure
structure format: SMILES

PIP[5'](16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP[5'](16:0/18:1(9Z))

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00269
type: UnificationXref
id: C00269
db: KEGG Compound

Compound/PW C000137 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: myo-Inositol
stoichiometric coefficient: 1.0

Reference/UniProt Q91WF7
type: UnificationXref
id: Q91WF7
db: UniProt

Reference/UniProt O35324
type: UnificationXref
id: O35324
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

PIP2[4,5](16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP2[4,5](16:0/18:1(9Z))

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Reference/HMDB HMDB0009970
type: UnificationXref
id: HMDB0009970
db: HMDB

Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Protein/13742 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
stoichiometric coefficient: 1.0

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
type: ProteinReference
xref: Reference/UniProt Q8VDP6
organism: Mus musculus

Polyphosphoinositide phosphatase
type: ProteinReference
xref: Reference/UniProt Q91WF7
organism: Mus musculus

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

Inositol polyphosphate 5-phosphatase K
type: Protein
cellular location: Cell Membrane
entity reference: Inositol polyphosphate 5-phosphatase K

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Cytidine monophosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Cytidine monophosphate

2.7.1.137
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
right: PIP(18:1(9Z)/16:0)
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.137
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

CDP-DG(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17962
xref: Reference/BioCyc CDPDIACYLGLYCEROL
xref: Reference/ChemSpider 24765811
xref: Reference/HMDB HMDB0006971
xref: Reference/PubChem-compound 53477915
xref: Reference/KEGG Compound C00269
chemical formula: C46H83N3O15P2
molecular weight: 979.52997
structure: ChemicalStructure/PW C003022

Reference/UniProt Q80WQ2
type: UnificationXref
id: Q80WQ2
db: UniProt

2.7.8.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003022 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000137 Cell Membrane/Stoichiometry/1.0
right: Cytidine monophosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.8.11
left: myo-Inositol
left: CDP-DG(16:0/18:1(9Z))
name: CDP-DG(16:0/18:1(9Z)) + myo-Inositol → Cytidine monophosphate + PI(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: PI(16:0/18:1(9Z))
spontaneous: false
EC number: 3.1.3.36
left: PIP(18:1(9Z)/16:0)
left: Water
name: PIP(18:1(9Z)/16:0) + Water → PI(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

2.7.1.153
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
right: PIP(18:1(9Z)/16:0)
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.153
left: Adenosine triphosphate
left: PI(16:0/18:1(9Z))
name: Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0)
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
type: ProteinReference
xref: Reference/UniProt Q6U7H8
organism: Mus musculus

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C005831 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PI(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

PIP[5'](16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061187
chemical formula: C43H82O16P2
molecular weight: 916.5078
structure: ChemicalStructure/PW C040457

PIP2[4,5](16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061188
chemical formula: C42H82O19P3
molecular weight: 983.4663
structure: ChemicalStructure/PW C040458

PIP[4'](16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061186
chemical formula: C43H82O16P2
molecular weight: 916.5078
structure: ChemicalStructure/PW C040459

Reference/ChemSpider 24767851
type: UnificationXref
id: 24767851
db: ChemSpider

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/ChemSpider 24768027
type: UnificationXref
id: 24768027
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: PIP(18:1(9Z)/16:0)
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP2(16:0/18:1(9Z))
left: Water
name: PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q8CDA1
type: UnificationXref
id: Q8CDA1
db: UniProt

3.1.3.66
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: PIP(18:1(9Z)/16:0)
spontaneous: false
EC number: 3.1.3.66
left: PIP2(16:0/18:1(9Z))
left: Water
name: PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

DG(16:0/18:1(9Z)/0:0)
type: SmallMoleculeReference
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/ChemSpider 4445454
xref: Reference/KEGG Compound C13861
xref: Reference/PubChem-compound 5282283
xref: Reference/ChEBI CHEBI 75466
xref: Reference/CAS 3123-73-7
xref: Reference/HMDB HMDB0007102
chemical formula: C37H70O5
molecular weight: 594.52234
structure: ChemicalStructure/PW C003153

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

2.7.1.150
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.150
left: PIP(18:1(9Z)/16:0)
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.68
left: PIP(18:1(9Z)/16:0)
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

2.7.1.68
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: PIP3(16:0/18:1(9Z))
spontaneous: false
EC number: 2.7.1.68
left: PIP2(16:0/18:1(9Z))
left: Adenosine triphosphate
name: Adenosine triphosphate + PIP2(16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Protein/13741 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein VAC14 homolog
stoichiometric coefficient: 1.0

2.7.1.149
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.149
left: Adenosine triphosphate
left: PIP(18:1(9Z)/16:0)
name: Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z))
conversion direction: LEFT_TO_RIGHT

3.1.3.86
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.86
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O35904
type: UnificationXref
id: O35904
db: UniProt

3.1.3.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006191 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006078 Cell Membrane/Stoichiometry/1.0
right: PIP2(16:0/18:1(9Z))
right: Phosphate
spontaneous: false
EC number: 3.1.3.36
left: PIP3(16:0/18:1(9Z))
left: Water
name: PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q80TZ3
type: UnificationXref
id: Q80TZ3
db: UniProt

Protein/13739 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Zinc finger FYVE domain-containing protein 16
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

PIP(18:1(9Z)/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP(18:1(9Z)/16:0)

Reference/UniProt Q6PF93
type: UnificationXref
id: Q6PF93
db: UniProt

Reference/HMDB HMDB0061187
type: UnificationXref
id: HMDB0061187
db: HMDB

Reference/ChEBI CHEBI 17962
type: UnificationXref
id: CHEBI:17962
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/HMDB HMDB0061188
type: UnificationXref
id: HMDB0061188
db: HMDB

PIP3(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010150
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24768027
chemical formula: C43H84O22P4
molecular weight: 1076.4404
structure: ChemicalStructure/PW C006191

Reference/HMDB HMDB0061186
type: UnificationXref
id: HMDB0061186
db: HMDB

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Protein/7725 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/PubChem-compound 5282283
type: UnificationXref
id: 5282283
db: PubChem-compound

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Compound/PW C000064 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C006015
type: ChemicalStructure
structure format: SMILES

myo-Inositol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: myo-Inositol

Reference/BioCyc CDPDIACYLGLYCEROL
type: UnificationXref
id: CDPDIACYLGLYCEROL
db: BioCyc

PIP2(16:0/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53480228
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/ChemSpider 24767914
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010037
chemical formula: C43H83O19P3
molecular weight: 996.4741
structure: ChemicalStructure/PW C006078

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/HMDB HMDB0007102
type: UnificationXref
id: HMDB0007102
db: HMDB

Extended synaptotagmin-2
type: Protein
cellular location: Cell Membrane
entity reference: Extended synaptotagmin-2

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Unknown
type: ProteinReference
organism: Mus musculus

Protein/13743 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 4
stoichiometric coefficient: 1.0

Reference/PubChem-compound 892
type: UnificationXref
id: 892
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Protein VAC14 homolog
type: Protein
cellular location: Cell Membrane
entity reference: Protein VAC14 homolog

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

Inositol Phosphate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108065
pathway order: SubPathwayInteractionSteps/SubPathway108064
pathway component: SubPathwayInteraction108064
pathway component: SubPathwayInteraction108065
xref: Reference/PathWhiz PW000156
xref: Reference/SMPDB SMP0000462
name: SubPathway

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

PIP3(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PIP3(16:0/18:1(9Z))

Compound/PW C001155 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inositol 1,4,5-trisphosphate
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

ChemicalStructure/PW C006191
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

PIP(18:1(9Z)/16:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP(18:1(9Z)/16:0)

Phosphatidylinositide phosphatase SAC2
type: Protein
cellular location: Cell Membrane
entity reference: Phosphatidylinositide phosphatase SAC2

Reference/UniProt Q3TZZ7
type: UnificationXref
id: Q3TZZ7
db: UniProt

Compound/PW C040459 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP[4'](16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: Complex
component stoichiometry: Protein/13742 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13743 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/7725 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
component: Unknown
component: Phosphoinositide 3-kinase regulatory subunit 4

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: Complex
component stoichiometry: Protein/13803 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/7725 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/13802 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Unknown
component: Extended synaptotagmin-2
component: Dual specificity testis-specific protein kinase 2

SH2 domain-containing protein 1B
type: Protein
cellular location: Cell Membrane
entity reference: SH2 domain-containing protein 1B

Reference/UniProt Q8VCT9
type: UnificationXref
id: Q8VCT9
db: UniProt

ChemicalStructure/PW C006078
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0009783
type: UnificationXref
id: HMDB0009783
db: HMDB

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Compound/PW C040458 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2[4,5](16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

ReactionCatalysis100519
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
controlled: 2.7.1.68
control type: ACTIVATION

ReactionCatalysis100518
type: Catalysis
controller: Unknown
controlled: 3.1.4.11
control type: ACTIVATION

Polyphosphoinositide phosphatase
type: Protein
cellular location: Cell Membrane
entity reference: Polyphosphoinositide phosphatase

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

PI(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: PI(16:0/18:1(9Z))

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

ReactionCatalysis100520
type: Catalysis
controller: SH2 domain-containing protein 1B
controlled: 3.1.3.86
control type: ACTIVATION

ReactionCatalysis100527
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
controlled: 2.7.1.68
control type: ACTIVATION

ReactionCatalysis100526
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.-
control type: ACTIVATION

ReactionCatalysis100525
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

CDP-DG(16:0/18:1(9Z))
type: SmallMolecule
cellular location: Cell Membrane
entity reference: CDP-DG(16:0/18:1(9Z))

ReactionCatalysis100524
type: Catalysis
controller: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
controlled: 2.7.1.149
control type: ACTIVATION

ReactionCatalysis100523
type: Catalysis
controller: SH2 domain-containing protein 1B
controlled: 3.1.3.86
control type: ACTIVATION

ReactionCatalysis100522
type: Catalysis
controller: Polyphosphoinositide phosphatase
controlled: 3.1.3.36
control type: ACTIVATION

ReactionCatalysis100521
type: Catalysis
controller: Inositol polyphosphate 5-phosphatase K
controlled: 3.1.3.36
control type: ACTIVATION

Compound/PW C003022 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP-DG(16:0/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/PathWhiz PW121902
type: UnificationXref
id: PW121902
db: PathWhiz

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0006971
type: UnificationXref
id: HMDB0006971
db: HMDB

Reference/SMPDB SMP0000462
type: UnificationXref
id: SMP0000462
db: SMPDB

Compound/PW C006015 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP(18:1(9Z)/16:0)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt Q6U7H8
type: UnificationXref
id: Q6U7H8
db: UniProt

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Protein/13803 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity testis-specific protein kinase 2
stoichiometric coefficient: 1.0

Compound/PW C003153 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/18:1(9Z)/0:0)
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Inositol 1,4,5-trisphosphate
name: SubPathwayInput

Zinc finger FYVE domain-containing protein 16
type: Protein
cellular location: Cell Membrane
entity reference: Zinc finger FYVE domain-containing protein 16

Reference/PubChem-compound 53477915
type: UnificationXref
id: 53477915
db: PubChem-compound

Reference/UniProt Q8VD65
type: UnificationXref
id: Q8VD65
db: UniProt

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: Reference/UniProt Q6PF93
organism: Mus musculus

Compound/PW C040457 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP[5'](16:0/18:1(9Z))
stoichiometric coefficient: 1.0

SH2 domain-containing protein 1B
type: ProteinReference
xref: Reference/UniProt O35324
organism: Mus musculus