Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/UniProt Q6P1F7
type: UnificationXref
id: Q6P1F7
db: UniProt

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

b(0,+)-type amino acid transporter 1
type: Protein
entity reference: b(0,+)-type amino acid transporter 1

Urea transporter 2
type: Protein
entity reference: Urea transporter 2

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 57-13-6
type: UnificationXref
id: 57-13-6
db: CAS

Sodium/potassium ATPase
type: Complex
cellular location: Cell Membrane
component: Unknown
name: SubPathwayOutput

Reference/ChEBI CHEBI 33709
type: UnificationXref
id: CHEBI:33709
db: ChEBI

Neutral and basic amino acid transport protein rBAT
type: Protein
entity reference: Neutral and basic amino acid transport protein rBAT

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

L-Cysteine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Cysteine

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Chloride channel protein ClC-Ka
type: ProteinReference
xref: Reference/UniProt Q8JZU7

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

SubPathwayInteraction109282
type: Interaction
name: SubPathway109282Reaction
name: SubPathwayReaction
participant: Active Mineralocorticoid receptor (Mus musculus)_Aldosterone
participant: Sodium/potassium ATPase
participant: Epithelial Sodium Channel

Imino acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Imino acids

Y+L amino acid transporter 2
type: Protein
entity reference: Y+L amino acid transporter 2

Reference/SMPDB SMP0120655
type: UnificationXref
id: SMP0120655
db: SMPDB

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC([O-])=O

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Y+L amino acid transporter 1
type: Protein
entity reference: Y+L amino acid transporter 1

Compound/Generic51 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Large neutral amino acids transporter small subunit 1
type: Protein
entity reference: Large neutral amino acids transporter small subunit 1

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Compound/PW C000026 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Reference/ChemSpider 1143
type: UnificationXref
id: 1143
db: ChemSpider

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sodium- and chloride-dependent transporter XTRP3A
type: Protein
entity reference: Sodium- and chloride-dependent transporter XTRP3A

Reference/BioCyc UREA
type: UnificationXref
id: UREA
db: BioCyc

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

Compound/Generic39 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Epithelial Sodium Channel
type: Complex
component: Unknown

Active Mineralocorticoid receptor
type: Complex
component stoichiometry: Protein/7736 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Unknown

4F2 cell-surface antigen heavy chain
type: Protein
entity reference: 4F2 cell-surface antigen heavy chain

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Urea
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Urea

Large neutral amino acids transporter small subunit 2
type: Protein
entity reference: Large neutral amino acids transporter small subunit 2

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Reference/ChEBI CHEBI 26271
type: UnificationXref
id: CHEBI:26271
db: ChEBI

ChemicalStructure/PW C000200
type: ChemicalStructure
structure format: SMILES
structure data: NC(N)=O

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Reference/ChEBI CHEBI 15705
type: UnificationXref
id: CHEBI:15705
db: ChEBI

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Reference/UniProt Q91WV7
type: UnificationXref
id: Q91WV7
db: UniProt

Imino acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Imino acids

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

L-Amino acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15705

Y+L amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt Q8CFY3

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Large Neutral Amino Acids

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Large neutral amino acids transporter small subunit 1
type: ProteinReference
xref: Reference/UniProt Q9JMI4

Y+L amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q9QWS1

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 25697
type: UnificationXref
id: CHEBI:25697
db: ChEBI

Reference/ChEBI CHEBI 25696
type: UnificationXref
id: CHEBI:25696
db: ChEBI

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

Cystinuria
type: Pathway
pathway order: PathwayTransport/2118859
pathway order: PathwayTransport/2118854
pathway order: PathwayTransport/2118865
pathway order: PathwayTransport/2118853
pathway order: PathwayTransport/2118864
pathway order: PathwayTransport/2118852
pathway order: PathwayTransport/2118863
pathway order: PathwayTransport/2118874
pathway order: PathwayTransport/2118862
pathway order: PathwayTransport/2118873
pathway order: PathwayTransport/2118858
pathway order: PathwayTransport/2118857
pathway order: PathwayTransport/2118856
pathway order: PathwayTransport/2118867
pathway order: PathwayTransport/2118855
pathway order: PathwayTransport/2118866
pathway order: PathwayTransport/2118861
pathway order: PathwayTransport/2118872
pathway order: PathwayTransport/2118860
pathway order: PathwayTransport/2118871
pathway order: PathwayTransport/2118870
pathway order: PathwaySubPathway/109282
pathway component: TransportCatalysis1269
pathway component: TransportCatalysis1268
pathway component: TransportCatalysis1264
pathway component: TransportCatalysis1266
pathway component: Transport10068
pathway component: Transport10069
pathway component: Transport10064
pathway component: Transport10065
pathway component: Transport10066
pathway component: Transport10067
pathway component: Transport10060
pathway component: Transport10061
pathway component: Transport10062
pathway component: Transport10063
pathway component: Transcription/Translation
pathway component: TransportCatalysis1263
pathway component: TransportCatalysis1279
pathway component: TransportCatalysis1276
pathway component: TransportCatalysis1275
pathway component: TransportCatalysis1278
pathway component: TransportCatalysis1277
pathway component: Transport10057
pathway component: Transport10058
pathway component: Transport10059
pathway component: Transport10053
pathway component: Transport10054
pathway component: Transport10055
pathway component: Transport10056
pathway component: Transport10051
pathway component: Transport10052
pathway component: TransportCatalysis1272
pathway component: TransportCatalysis1271
pathway component: TransportCatalysis1270
xref: Reference/SMPDB SMP0120655
xref: Reference/PathWhiz PW121911
organism: Mus musculus

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

b(0,+)-type amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q9QXA6

Reference/UniProt Q9JMI4
type: UnificationXref
id: Q9JMI4
db: UniProt

Urea
type: SmallMolecule
cellular location: Cytosol
entity reference: Urea

Urea transporter 2
type: ProteinReference
xref: Reference/UniProt Q9ES05

Compound/Generic50 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Neutral and basic amino acid transport protein rBAT
type: ProteinReference
xref: Reference/UniProt Q91WV7

Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Organic Anion
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Anion

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/UniProt Q9ES05
type: UnificationXref
id: Q9ES05
db: UniProt

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Active Mineralocorticoid receptor (Mus musculus)_Aldosterone
type: Complex
component stoichiometry: ProteinComplex/10886 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C000026 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aldosterone
component: Active Mineralocorticoid receptor
name: SubPathwayInput

Transcription/Translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109282
pathway component: SubPathwayInteraction109282
xref: Reference/SMPDB SMP0000019
xref: Reference/PathWhiz PW000455
name: SubPathway

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Large Neutral Amino Acids

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Unknown
type: Protein
entity reference: Unknown

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/Generic32 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Organic Anion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Anion

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/UniProt Q3USE2
type: UnificationXref
id: Q3USE2
db: UniProt

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Compound/Generic39 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/UniProt Q8VIE7
type: UnificationXref
id: Q8VIE7
db: UniProt

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
type: Complex
component: Large neutral amino acids transporter small subunit 1
component: 4F2 cell-surface antigen heavy chain

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
type: Complex
component: Large neutral amino acids transporter small subunit 2
component: 4F2 cell-surface antigen heavy chain

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/SMPDB SMP0000019
type: UnificationXref
id: SMP0000019
db: SMPDB

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000455
type: UnificationXref
id: PW000455
db: PathWhiz

Compound/Generic5 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

SLC3A2/4F2hc Y+L amino acid transporter 2
type: Complex
component: Y+L amino acid transporter 2
component: 4F2 cell-surface antigen heavy chain

Compound/PW C000200 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Imino acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26271

Sodium-coupled neutral amino acid transporter 4
type: Protein
entity reference: Sodium-coupled neutral amino acid transporter 4

SLC3A2/4F2hc Y+L amino acid transporter 1
type: Complex
component: 4F2 cell-surface antigen heavy chain
component: Y+L amino acid transporter 1

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Epithelial Sodium Channel
type: Complex
cellular location: Cell Membrane
component: Unknown
name: SubPathwayOutput

Reference/UniProt Q9QXW9
type: UnificationXref
id: Q9QXW9
db: UniProt

Urea
type: SmallMoleculeReference
xref: Reference/BioCyc UREA
xref: Reference/CAS 57-13-6
xref: Reference/KEGG Compound C00086
xref: Reference/HMDB HMDB0000294
xref: Reference/ChemSpider 1143
xref: Reference/PubChem-compound 1176
xref: Reference/ChEBI CHEBI 16199
chemical formula: CH4N2O
molecular weight: 60.032364
structure: ChemicalStructure/PW C000200

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

4F2 cell-surface antigen heavy chain
type: ProteinReference
xref: Reference/UniProt Q54AH5

Aldosterone
type: SmallMolecule
cellular location: Nucleus
entity reference: Aldosterone

Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Reference/UniProt Q8CFY3
type: UnificationXref
id: Q8CFY3
db: UniProt

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: b(0,+)-type amino acid transporter 1
component: Neutral and basic amino acid transport protein rBAT

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Compound/Generic5 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt Q6P1F7

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Large neutral amino acids transporter small subunit 2
type: ProteinReference
xref: Reference/UniProt Q9QXW9

Reference/ChEBI CHEBI 16199
type: UnificationXref
id: CHEBI:16199
db: ChEBI

L-Amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Amino acid

Large Neutral Amino Acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 33709

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Organic Cation
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25697

Unknown
type: ProteinReference
organism: Mus musculus

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Organic Anion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25696

Sodium- and chloride-dependent transporter XTRP3A
type: ProteinReference
xref: Reference/UniProt Q3USE2

Compound/Generic32 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Protein/7736 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/UniProt Q9QWS1
type: UnificationXref
id: Q9QWS1
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Unknown
type: ProteinReference

Reference/UniProt Q54AH5
type: UnificationXref
id: Q54AH5
db: UniProt

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1176
type: UnificationXref
id: 1176
db: PubChem-compound

Unknown
type: Protein
cellular location: Cell Membrane
entity reference: Unknown

Organic Cation
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Cation

Chloride channel protein ClC-Ka
type: Protein
entity reference: Chloride channel protein ClC-Ka

Compound/PW C000374 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Sodium-coupled neutral amino acid transporter 4
type: ProteinReference
xref: Reference/UniProt Q8VIE7

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Hydrogen carbonate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen carbonate

Reference/UniProt Q8JZU7
type: UnificationXref
id: Q8JZU7
db: UniProt

Reference/HMDB HMDB0000294
type: UnificationXref
id: HMDB0000294
db: HMDB

Reference/UniProt Q9QXA6
type: UnificationXref
id: Q9QXA6
db: UniProt

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/KEGG Compound C00086
type: UnificationXref
id: C00086
db: KEGG Compound

Compound/Generic51 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

TransportCatalysis1269
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
controlled: Transport10061
control type: ACTIVATION

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

TransportCatalysis1268
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport10060
control type: ACTIVATION

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

TransportCatalysis1264
type: Catalysis
controller: Chloride channel protein ClC-Ka
controlled: Transport10053
control type: ACTIVATION

TransportCatalysis1266
type: Catalysis
controller: Epithelial Sodium Channel
controlled: Transport10059
control type: ACTIVATION

L-Amino acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Amino acid

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Transport10068
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10069
type: Transport
participant stoichiometry: Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
spontaneous: false
left: L-Cysteine
name: L-Cysteine (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10064
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10065
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10066
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10067
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10060
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: L-Amino acid
right: Sodium
spontaneous: false
left: Sodium
left: L-Amino acid
name: L-Amino acid (→), Sodium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Transport10061
type: Transport
participant stoichiometry: Compound/Generic50 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic50 Extracellular Space/Stoichiometry/1.0
right: Large Neutral Amino Acids
spontaneous: false
left: Large Neutral Amino Acids
name: Large Neutral Amino Acids (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10062
type: Transport
participant stoichiometry: Compound/Generic51 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic51 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Imino acids
right: Chloride ion
right: Sodium
spontaneous: false
left: Imino acids
left: Sodium
left: Chloride ion
name: Imino acids (→), Sodium (→), Chloride ion (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10063
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

ProteinComplex/10886 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor
stoichiometric coefficient: 1.0

TransportCatalysis1263
type: Catalysis
controller: Unknown
controlled: Transport10051
control type: ACTIVATION

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

TransportCatalysis1279
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport10069
control type: ACTIVATION

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

TransportCatalysis1276
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 2
controlled: Transport10064
control type: ACTIVATION

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

TransportCatalysis1275
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 1
controlled: Transport10064
control type: ACTIVATION

TransportCatalysis1278
type: Catalysis
controller: Urea transporter 2
controlled: Transport10066
control type: ACTIVATION

TransportCatalysis1277
type: Catalysis
controller: Urea transporter 2
controlled: Transport10065
control type: ACTIVATION

Organic Cation
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Cation

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Transport10057
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
spontaneous: false
left: Chloride ion
left: Potassium
name: Chloride ion (→), Potassium (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10058
type: Transport
participant stoichiometry: Compound/Generic39 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic39 Extracellular Space/Stoichiometry/1.0
right: Organic Cation
spontaneous: false
left: Organic Cation
name: Organic Cation (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10059
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW121911
type: UnificationXref
id: PW121911
db: PathWhiz

Transport10053
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
name: Chloride ion (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport10054
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (↔) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/Generic50 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Transport10055
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
left: Potassium
name: Sodium (→), Potassium (→), Chloride ion (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10056
type: Transport
participant stoichiometry: Compound/Generic32 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic32 Cytosol/Stoichiometry/1.0
right: Organic Anion
spontaneous: false
left: Organic Anion
name: Organic Anion (→) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Unknown
type: Protein
cellular location: Nucleus
entity reference: Unknown

Transport10051
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
name: Chloride ion (→), Sodium (→) Transport: Mus musculus, Extracellular Space to Mus musculus, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport10052
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Mus musculus, Cell, Cytosol to Mus musculus, Extracellular Space
conversion direction: LEFT_TO_RIGHT

TransportCatalysis1272
type: Catalysis
controller: Sodium-coupled neutral amino acid transporter 4
controlled: Transport10063
control type: ACTIVATION

TransportCatalysis1271
type: Catalysis
controller: Sodium- and chloride-dependent transporter XTRP3A
controlled: Transport10062
control type: ACTIVATION

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CHO3
molecular weight: 60.99257
structure: ChemicalStructure/PW C000463

TransportCatalysis1270
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
controlled: Transport10061
control type: ACTIVATION

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0