Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Protein/16702 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribose-phosphate pyrophosphokinase 1
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00672
type: UnificationXref
id: C00672
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000691 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xylulose 5-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16132
type: UnificationXref
id: CHEBI:16132
db: ChEBI

Reference/KEGG Compound C00673
type: UnificationXref
id: C00673
db: KEGG Compound

Reference/HMDB HMDB0001068
type: UnificationXref
id: HMDB0001068
db: HMDB

SubPathwayInteraction108641
type: Interaction
name: SubPathway108641Reaction
name: SubPathwayReaction
participant: Phosphoribosyl pyrophosphate

SubPathwayInteraction108642
type: Interaction
name: SubPathwayReaction
name: SubPathway108642Reaction
participant: Phosphoribosyl pyrophosphate

SubPathwayInteraction108643
type: Interaction
name: SubPathwayReaction
name: SubPathway108643Reaction
participant: D-Erythrose 4-phosphate

SubPathwayInteraction108644
type: Interaction
name: SubPathwayReaction
name: SubPathway108644Reaction
participant: D-Erythrose 4-phosphate

Compound/PW C000191 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose
stoichiometric coefficient: 1.0

Protein/17153 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Transketolase
stoichiometric coefficient: 2.0

SubPathwayInteraction108640
type: Interaction
name: SubPathway108640Reaction
name: SubPathwayReaction
participant: Phosphoribosyl pyrophosphate

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001058
xref: Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
xref: Reference/CAS 488-69-7
xref: Reference/ChEBI CHEBI 16905
xref: Reference/ChemSpider 393165
xref: Reference/KEGG Compound C00354
xref: Reference/PubChem-compound 445557
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000833

D-Ribulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribulose 5-phosphate

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PathWhiz PW000053
type: UnificationXref
id: PW000053
db: PathWhiz

Reference/PathWhiz PW000052
type: UnificationXref
id: PW000052
db: PathWhiz

Reference/UniProt P05370
type: UnificationXref
id: P05370
db: UniProt

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/UniProt D3ZVU4
type: UnificationXref
id: D3ZVU4
db: UniProt

Compound/PW C000479 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribulose 5-phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003498
type: UnificationXref
id: HMDB0003498
db: HMDB

Reference/PathWhiz PW000043
type: UnificationXref
id: PW000043
db: PathWhiz

Reference/ChemSpider 5743
type: UnificationXref
id: 5743
db: ChemSpider

Transketolase
type: Complex
component stoichiometry: Protein/17153 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Transketolase

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 439184
type: UnificationXref
id: 439184
db: PubChem-compound

D-Ribose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribose 5-phosphate

Reference/PathWhiz PW000042
type: UnificationXref
id: PW000042
db: PathWhiz

Reference/ChemSpider 388330
type: UnificationXref
id: 388330
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/PathWhiz PW000160
type: UnificationXref
id: PW000160
db: PathWhiz

Ribulose-phosphate 3-epimerase
type: Protein
cellular location: Cytosol
entity reference: Ribulose-phosphate 3-epimerase

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

ChemicalStructure/PW C001083
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Deoxyribose 5-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 102916-66-5
xref: Reference/PubChem-compound 45934311
xref: Reference/ChEBI CHEBI 16132
xref: Reference/HMDB HMDB0001031
xref: Reference/ChemSpider 25057464
xref: Reference/KEGG Compound C00673
xref: Reference/BioCyc DEOXY-RIBOSE-5P
chemical formula: C5H11O7P
molecular weight: 214.02425
structure: ChemicalStructure/PW C000813

β-D-Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 388538
xref: Reference/KEGG Compound C01172
xref: Reference/ChEBI CHEBI 17719
xref: Reference/HMDB HMDB0003498
xref: Reference/PubChem-compound 439427
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001906

SubPathwayInteraction108645
type: Interaction
name: SubPathwayReaction
name: SubPathway108645Reaction
participant: D-Glyceraldehyde 3-phosphate

SubPathwayInteraction108646
type: Interaction
name: SubPathway108646Reaction
name: SubPathwayReaction
participant: Fructose 6-phosphate

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

D-Sedoheptulose 7-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Sedoheptulose 7-phosphate

Reference/CAS 2646-35-7
type: UnificationXref
id: 2646-35-7
db: CAS

Compound/PW C001083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00345
type: UnificationXref
id: C00345
db: KEGG Compound

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

Reference/PubChem-compound 439167
type: UnificationXref
id: 439167
db: PubChem-compound

Reference/CAS 488-69-7
type: UnificationXref
id: 488-69-7
db: CAS

Reference/PubChem-compound 439287
type: UnificationXref
id: 439287
db: PubChem-compound

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Reference/KEGG Compound C00117
type: UnificationXref
id: C00117
db: KEGG Compound

Reference/ChemSpider 388313
type: UnificationXref
id: 388313
db: ChemSpider

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

2.7.6.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: Phosphoribosyl pyrophosphate
spontaneous: false
EC number: 2.7.6.1
left: Adenosine triphosphate
left: D-Ribose 5-phosphate
name: Adenosine triphosphate + D-Ribose 5-phosphate ↔ Adenosine monophosphate + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C000843 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Sedoheptulose 7-phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-2961
type: UnificationXref
id: CPD-2961
db: BioCyc

Reference/PubChem-compound 45934311
type: UnificationXref
id: 45934311
db: PubChem-compound

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Reference/KEGG Compound C00231
type: UnificationXref
id: C00231
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00354
type: UnificationXref
id: C00354
db: KEGG Compound

Deoxyribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyribose 1-phosphate

Transketolase
type: ProteinReference
xref: Reference/UniProt P50137
organism: Rattus norvegicus

Compound/PW C001146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/UniProt P50137
type: UnificationXref
id: P50137
db: UniProt

Transaldolase
type: ProteinReference
xref: Reference/UniProt Q6PCV1
organism: Rattus norvegicus

Fructose 1,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 1,6-bisphosphate

Glucose-6-phosphate 1-dehydrogenase
type: Complex
component stoichiometry: Protein/17129 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glucose-6-phosphate 1-dehydrogenase

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

ChemicalStructure/PW C001906
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00121
type: UnificationXref
id: C00121
db: KEGG Compound

Reference/PubChem-compound 122357
type: UnificationXref
id: 122357
db: PubChem-compound

Reference/CAS 921-62-0
type: UnificationXref
id: 921-62-0
db: CAS

Reference/BioCyc DEOXY-RIBOSE-1P
type: UnificationXref
id: DEOXY-RIBOSE-1P
db: BioCyc

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/PubChem-compound 439190
type: UnificationXref
id: 439190
db: PubChem-compound

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 6-phosphate
name: SubPathwayOutput

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

ChemicalStructure/PW C000813
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Deoxyribose-phosphate aldolase
type: ProteinReference
xref: Reference/UniProt F1M1H0
organism: Rattus norvegicus

Reference/ChemSpider 388538
type: UnificationXref
id: 388538
db: ChemSpider

D-Sedoheptulose 7-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001068
xref: Reference/ChemSpider 17216052
xref: Reference/BioCyc D-SEDOHEPTULOSE-7-P
xref: Reference/PubChem-compound 22833559
xref: Reference/ChEBI CHEBI 15721
xref: Reference/KEGG Compound C00281
xref: Reference/CAS 2646-35-7
chemical formula: C7H15O10P
molecular weight: 290.04028
structure: ChemicalStructure/PW C000843

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

Reference/ChEBI CHEBI 17363
type: UnificationXref
id: CHEBI:17363
db: ChEBI

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Glucose-6-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate isomerase

Transketolase
type: Protein
cellular location: Cytosol
entity reference: Transketolase

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/ChemSpider 388420
type: UnificationXref
id: 388420
db: ChemSpider

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChEBI CHEBI 48928
type: UnificationXref
id: CHEBI:48928
db: ChEBI

Compound/PW C001191 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose 5-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001019
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)[C@@H](O)C=O

Compound/PW C000784 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00279
type: UnificationXref
id: C00279
db: KEGG Compound

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

ChemicalStructure/PW C001146
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00281
type: UnificationXref
id: C00281
db: KEGG Compound

Protein/15628 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: ATP-dependent 6-phosphofructokinase, liver type
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C001019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Erythrose 4-phosphate
stoichiometric coefficient: 1.0

D-Erythrose 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Erythrose 4-phosphate
name: SubPathwayInput

Reference/UniProt P30835
type: UnificationXref
id: P30835
db: UniProt

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Reference/UniProt Q64594
type: UnificationXref
id: Q64594
db: UniProt

Reference/HMDB HMDB0001351
type: UnificationXref
id: HMDB0001351
db: HMDB

Glucose-6-phosphate 1-dehydrogenase
type: ProteinReference
xref: Reference/UniProt P05370
organism: Rattus norvegicus

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/UniProt Q63038
type: UnificationXref
id: Q63038
db: UniProt

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 4170
type: UnificationXref
id: CHEBI:4170
db: ChEBI

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001489
type: UnificationXref
id: HMDB0001489
db: HMDB

Reference/PubChem-compound 22833559
type: UnificationXref
id: 22833559
db: PubChem-compound

6-phosphogluconolactonase
type: ProteinReference
xref: Reference/UniProt P85971
organism: Rattus norvegicus

Reference/CAS 585-18-2
type: UnificationXref
id: 585-18-2
db: CAS

Reference/HMDB HMDB0000150
type: UnificationXref
id: HMDB0000150
db: HMDB

Reference/ChemSpider 25057464
type: UnificationXref
id: 25057464
db: ChemSpider

Compound/PW C001015 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Phosphogluconic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Fructose-1,6-bisphosphatase 1
type: Protein
cellular location: Cytosol
entity reference: Fructose-1,6-bisphosphatase 1

Gluconolactone
type: SmallMolecule
cellular location: Cytosol
entity reference: Gluconolactone

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Reference/CAS 613-83-2
type: UnificationXref
id: 613-83-2
db: CAS

Reference/PubChem-compound 445557
type: UnificationXref
id: 445557
db: PubChem-compound

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

6-phosphofructokinase, liver type
type: Complex
component stoichiometry: Protein/15628 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: ATP-dependent 6-phosphofructokinase, liver type

Ribose 5-phosphate isomerase A
type: ProteinReference
xref: Reference/UniProt D4A7L6
organism: Rattus norvegicus

ChemicalStructure/PW C001015
type: ChemicalStructure
structure format: SMILES

Ribokinase
type: ProteinReference
xref: Reference/UniProt D3ZVU4
organism: Rattus norvegicus

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Acetaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15343
xref: Reference/KEGG Compound C00084
xref: Reference/CAS 75-07-0
xref: Reference/BioCyc ACETALD
xref: Reference/ChemSpider 172
xref: Reference/PubChem-compound 177
xref: Reference/HMDB HMDB0000990
chemical formula: C2H4O
molecular weight: 44.026215
structure: ChemicalStructure/PW C000784

Ribulose-phosphate 3-epimerase
type: ProteinReference
organism: Rattus norvegicus

Reference/HMDB HMDB0000283
type: UnificationXref
id: HMDB0000283
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc RIBULOSE-5P
type: UnificationXref
id: RIBULOSE-5P
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C00199
type: UnificationXref
id: C00199
db: KEGG Compound

Reference/KEGG Compound C00198
type: UnificationXref
id: C00198
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ReactionCatalysis137934
type: Catalysis
controller: Ribose-phosphate pyrophosphokinase 3
controlled: 2.7.6.1
control type: ACTIVATION

Transaldolase
type: Protein
cellular location: Cytosol
entity reference: Transaldolase

ChemicalStructure/PW C000097
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Reference/KEGG Compound C00084
type: UnificationXref
id: C00084
db: KEGG Compound

Reference/KEGG Compound C01172
type: UnificationXref
id: C01172
db: KEGG Compound

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

D-Ribulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 4151-19-3
xref: Reference/BioCyc RIBULOSE-5P
xref: Reference/KEGG Compound C00199
xref: Reference/PubChem-compound 439184
xref: Reference/HMDB HMDB0000618
xref: Reference/ChEBI CHEBI 17363
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000479

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Ribose-phosphate pyrophosphokinase 3
type: Complex
component stoichiometry: Protein/16702 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Ribose-phosphate pyrophosphokinase 1

Reference/PubChem-compound 7027
type: UnificationXref
id: 7027
db: PubChem-compound

Reference/KEGG Compound C00092
type: UnificationXref
id: C00092
db: KEGG Compound

Reference/BioCyc RIBOSE-5P
type: UnificationXref
id: RIBOSE-5P
db: BioCyc

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayInput

ChemicalStructure/PW C001191
type: ChemicalStructure
structure format: SMILES
structure data: OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O

Reference/HMDB HMDB0001031
type: UnificationXref
id: HMDB0001031
db: HMDB

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 56-73-5
type: UnificationXref
id: 56-73-5
db: CAS

Reference/BioCyc XYLULOSE-5-PHOSPHATE
type: UnificationXref
id: XYLULOSE-5-PHOSPHATE
db: BioCyc

Reference/UniProt P85971
type: UnificationXref
id: P85971
db: UniProt

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ChemicalStructure/PW C001042
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 393165
type: UnificationXref
id: 393165
db: ChemSpider

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt Q6P6V0
organism: Rattus norvegicus

Xylulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000868
xref: Reference/KEGG Compound C00231
xref: Reference/BioCyc XYLULOSE-5-PHOSPHATE
xref: Reference/PubChem-compound 439190
xref: Reference/CAS 60802-29-1
xref: Reference/ChEBI CHEBI 16332
xref: Reference/ChemSpider 388330
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000691

ChemicalStructure/PW C000191
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(O)[C@H](O)[C@@H]1O

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001058
type: UnificationXref
id: HMDB0001058
db: HMDB

Protein/15640 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-bisphosphate aldolase A
stoichiometric coefficient: 4.0

Reference/UniProt P38652
type: UnificationXref
id: P38652
db: UniProt

Fructose-bisphosphate aldolase A
type: Protein
cellular location: Cytosol
entity reference: Fructose-bisphosphate aldolase A

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

4.1.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 4.1.2.13
left: Fructose 1,6-bisphosphate
name: Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

3.1.3.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Fructose 6-phosphate
spontaneous: false
EC number: 3.1.3.11
left: Fructose 1,6-bisphosphate
left: Water
name: Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15721
type: UnificationXref
id: CHEBI:15721
db: ChEBI

Glucose-6-phosphate isomerase
type: Complex
component stoichiometry: Protein/16127 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glucose-6-phosphate isomerase

Reference/BioCyc RIBOSE-1P
type: UnificationXref
id: RIBOSE-1P
db: BioCyc

ChemicalStructure/PW C000691
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Protein/17149 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribulose-phosphate 3-epimerase
stoichiometric coefficient: 2.0

Compound/PW C000833 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

2.7.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Fructose 1,6-bisphosphate
spontaneous: false
EC number: 2.7.1.11
left: Adenosine triphosphate
left: Fructose 6-phosphate
name: Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate
conversion direction: LEFT_TO_RIGHT

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Deoxyribose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyribose 5-phosphate

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Fructose-1,6-bisphosphatase 1
type: Complex
component stoichiometry: Protein/15633 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Fructose-1,6-bisphosphatase 1

Histidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108640
pathway component: SubPathwayInteraction108640
xref: Reference/PathWhiz PW000043
xref: Reference/SMPDB SMP0000044
name: SubPathway

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108645
pathway order: SubPathwayInteractionSteps/SubPathway108646
pathway component: SubPathwayInteraction108645
pathway component: SubPathwayInteraction108646
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

6-Phosphogluconic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48928
xref: Reference/BioCyc CPD-2961
xref: Reference/HMDB HMDB0001316
xref: Reference/CAS 921-62-0
xref: Reference/PubChem-compound 91493
xref: Reference/ChemSpider 82615
xref: Reference/KEGG Compound C00345
chemical formula: C6H13O10P
molecular weight: 276.02463
structure: ChemicalStructure/PW C001015

ReactionCatalysis137581
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

6-Phosphogluconic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Phosphogluconic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyrimidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108642
pathway component: SubPathwayInteraction108642
xref: Reference/SMPDB SMP0000046
xref: Reference/PathWhiz PW000160
name: SubPathway

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/CAS 90-80-2
type: UnificationXref
id: 90-80-2
db: CAS

Protein/17157 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Transaldolase
stoichiometric coefficient: 2.0

ATP-dependent 6-phosphofructokinase, liver type
type: Protein
cellular location: Cytosol
entity reference: ATP-dependent 6-phosphofructokinase, liver type

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/HMDB HMDB0001401
type: UnificationXref
id: HMDB0001401
db: HMDB

Purine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108641
pathway component: SubPathwayInteraction108641
xref: Reference/SMPDB SMP0000050
xref: Reference/PathWhiz PW000052
name: SubPathway

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChEBI CHEBI 16905
type: UnificationXref
id: CHEBI:16905
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: O4P
molecular weight: 94.95342
structure: ChemicalStructure/PW C001104

6-phosphogluconolactonase
type: Protein
cellular location: Cytosol
entity reference: 6-phosphogluconolactonase

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

D-Ribose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Ribose

Reference/UniProt Q6PCV1
type: UnificationXref
id: Q6PCV1
db: UniProt

Ribulose-phosphate 3-epimerase
type: Complex
component stoichiometry: Protein/17149 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Ribulose-phosphate 3-epimerase

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Ribokinase
type: Protein
cellular location: Cytosol
entity reference: Ribokinase

ReactionCatalysis137419
type: Catalysis
controller: Fructose-bisphosphate aldolase A
controlled: 4.1.2.13
control type: ACTIVATION

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

ReactionCatalysis137416
type: Catalysis
controller: 6-phosphofructokinase, liver type
controlled: 2.7.1.11
control type: ACTIVATION

ReactionCatalysis137417
type: Catalysis
controller: Fructose-1,6-bisphosphatase 1
controlled: 3.1.3.11
control type: ACTIVATION

Deoxyribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439287
xref: Reference/KEGG Compound C00672
xref: Reference/CAS 17210-42-3
xref: Reference/BioCyc DEOXY-RIBOSE-1P
xref: Reference/HMDB HMDB0001351
xref: Reference/ChemSpider 388420
xref: Reference/ChEBI CHEBI 28542
chemical formula: C5H11O7P
molecular weight: 214.02425
structure: ChemicalStructure/PW C001042

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

D-Ribose
type: SmallMoleculeReference
xref: Reference/ChemSpider 5575
xref: Reference/KEGG Compound C00121
xref: Reference/PubChem-compound 5779
xref: Reference/CAS 613-83-2
xref: Reference/BioCyc CPD-560
xref: Reference/HMDB HMDB0000283
xref: Reference/ChEBI CHEBI 47013
chemical formula: C5H10O5
molecular weight: 150.05283
structure: ChemicalStructure/PW C000191

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: [O-]P([O-])([O-])=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0001548
type: UnificationXref
id: HMDB0001548
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/PathWhiz PW122064
type: UnificationXref
id: PW122064
db: PathWhiz

Reference/SMPDB SMP0000046
type: UnificationXref
id: SMP0000046
db: SMPDB

Reference/SMPDB SMP0000044
type: UnificationXref
id: SMP0000044
db: SMPDB

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0000050
type: UnificationXref
id: SMP0000050
db: SMPDB

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001316
type: UnificationXref
id: HMDB0001316
db: HMDB

Reference/CAS 102916-66-5
type: UnificationXref
id: 102916-66-5
db: CAS

Phenylalanine and Tyrosine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108643
pathway component: SubPathwayInteraction108643
xref: Reference/SMPDB SMP0000008
xref: Reference/PathWhiz PW000042
name: SubPathway

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Compound/PW C001042 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

D-Erythrose 4-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48153
xref: Reference/HMDB HMDB0001321
xref: Reference/CAS 585-18-2
xref: Reference/BioCyc ERYTHROSE-4P
xref: Reference/PubChem-compound 122357
xref: Reference/ChemSpider 109096
xref: Reference/KEGG Compound C00279
chemical formula: C4H9O7P
molecular weight: 200.00859
structure: ChemicalStructure/PW C001019

Reference/HMDB HMDB0001321
type: UnificationXref
id: HMDB0001321
db: HMDB

Reference/PubChem-compound 5958
type: UnificationXref
id: 5958
db: PubChem-compound

Ribose 5-phosphate isomerase A
type: Protein
cellular location: Cytosol
entity reference: Ribose 5-phosphate isomerase A

Ribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 14075-00-4
xref: Reference/ChEBI CHEBI 16300
xref: Reference/HMDB HMDB0001489
xref: Reference/PubChem-compound 439236
xref: Reference/ChemSpider 388373
xref: Reference/BioCyc RIBOSE-1P
xref: Reference/KEGG Compound C00620
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001146

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Vitamin B6 Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway108644
pathway component: SubPathwayInteraction108644
xref: Reference/SMPDB SMP0000017
xref: Reference/PathWhiz PW000053
name: SubPathway

Reference/CAS 60802-29-1
type: UnificationXref
id: 60802-29-1
db: CAS

Reference/BioCyc ERYTHROSE-4P
type: UnificationXref
id: ERYTHROSE-4P
db: BioCyc

ChemicalStructure/PW C000479
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

Reference/BioCyc CPD-560
type: UnificationXref
id: CPD-560
db: BioCyc

Deoxyribose-phosphate aldolase
type: Protein
cellular location: Cytosol
entity reference: Deoxyribose-phosphate aldolase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/UniProt F1M1H0
type: UnificationXref
id: F1M1H0
db: UniProt

Reference/CAS 4151-19-3
type: UnificationXref
id: 4151-19-3
db: CAS

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate
name: SubPathwayOutput

Phosphoglucomutase-1
type: ProteinReference
xref: Reference/UniProt P38652
organism: Rattus norvegicus

Reference/SMPDB SMP0000008
type: UnificationXref
id: SMP0000008
db: SMPDB

ChemicalStructure/PW C000843
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Reference/ChemSpider 82615
type: UnificationXref
id: 82615
db: ChemSpider

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/ChEBI CHEBI 52742
type: UnificationXref
id: CHEBI:52742
db: ChEBI

Reference/ChemSpider 17216052
type: UnificationXref
id: 17216052
db: ChemSpider

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: Fructose 6-phosphate
name: Fructose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00092
xref: Reference/BioCyc GLC-6-P
xref: Reference/HMDB HMDB0001401
xref: Reference/PubChem-compound 5958
xref: Reference/ChemSpider 5743
xref: Reference/CAS 56-73-5
xref: Reference/ChEBI CHEBI 4170
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001083

Ribose-phosphate pyrophosphokinase 1
type: ProteinReference
xref: Reference/UniProt Q5M8A4
organism: Rattus norvegicus

Protein/16127 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16300
type: UnificationXref
id: CHEBI:16300
db: ChEBI

Reference/UniProt Q5M8A4
type: UnificationXref
id: Q5M8A4
db: UniProt

Reference/BioCyc D-SEDOHEPTULOSE-7-P
type: UnificationXref
id: D-SEDOHEPTULOSE-7-P
db: BioCyc

Reference/SMPDB SMP0000017
type: UnificationXref
id: SMP0000017
db: SMPDB

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 6760
type: UnificationXref
id: 6760
db: ChemSpider

Reference/BioCyc DEOXY-RIBOSE-5P
type: UnificationXref
id: DEOXY-RIBOSE-5P
db: BioCyc

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/PubChem-compound 91493
type: UnificationXref
id: 91493
db: PubChem-compound

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

ATP-dependent 6-phosphofructokinase, liver type
type: ProteinReference
xref: Reference/UniProt P30835
organism: Rattus norvegicus

Reference/PubChem-compound 439427
type: UnificationXref
id: 439427
db: PubChem-compound

Reference/CAS 14075-00-4
type: UnificationXref
id: 14075-00-4
db: CAS

Compound/PW C001906 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose 6-phosphate
stoichiometric coefficient: 1.0

Fructose-1,6-bisphosphatase 1
type: ProteinReference
xref: Reference/UniProt Q64594
organism: Rattus norvegicus

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

β-D-Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Glucose 6-phosphate

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0120803
type: UnificationXref
id: SMP0120803
db: SMPDB

Reference/ChEBI CHEBI 48153
type: UnificationXref
id: CHEBI:48153
db: ChEBI

Ribose-phosphate pyrophosphokinase 1
type: Protein
cellular location: Cytosol
entity reference: Ribose-phosphate pyrophosphokinase 1

Reference/ChEBI CHEBI 17719
type: UnificationXref
id: CHEBI:17719
db: ChEBI

Gluconolactone
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16217
xref: Reference/CAS 90-80-2
xref: Reference/BioCyc GLC-D-LACTONE
xref: Reference/KEGG Compound C00198
xref: Reference/HMDB HMDB0000150
xref: Reference/ChemSpider 6760
xref: Reference/PubChem-compound 7027
chemical formula: C6H10O6
molecular weight: 178.04774
structure: ChemicalStructure/PW C000097

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
type: UnificationXref
id: FRUCTOSE-16-DIPHOSPHATE
db: BioCyc

Fructose-bisphosphate aldolase A
type: ProteinReference
xref: Reference/UniProt Q63038
organism: Rattus norvegicus

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/ChemSpider 5575
type: UnificationXref
id: 5575
db: ChemSpider

ChemicalStructure/PW C000833
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00620
type: UnificationXref
id: C00620
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/UniProt D4A7L6
type: UnificationXref
id: D4A7L6
db: UniProt

Reference/BioCyc GLC-6-P
type: UnificationXref
id: GLC-6-P
db: BioCyc

Glucose-6-phosphate 1-dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate 1-dehydrogenase

Compound/PW C000813 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyribose 5-phosphate
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

D-Ribose 5-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00117
xref: Reference/ChEBI CHEBI 52742
xref: Reference/ChemSpider 388313
xref: Reference/HMDB HMDB0001548
xref: Reference/BioCyc RIBOSE-5P
xref: Reference/PubChem-compound 439167
xref: Reference/CAS 4300-28-1
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001191

Compound/PW C000079 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis138107
type: Catalysis
controller: 6-phosphogluconolactonase
controlled: 3.1.1.31
control type: ACTIVATION

ReactionCatalysis138106
type: Catalysis
controller: Glucose-6-phosphate 1-dehydrogenase
controlled: 1.1.1.49
control type: ACTIVATION

Compound/PW C000097 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gluconolactone
stoichiometric coefficient: 1.0

Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 6-phosphate

Reference/ChEBI CHEBI 16217
type: UnificationXref
id: CHEBI:16217
db: ChEBI

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

Reference/PubChem-compound 5779
type: UnificationXref
id: 5779
db: PubChem-compound

ReactionCatalysis138109
type: Catalysis
controller: Ribose 5-phosphate isomerase A
controlled: 5.3.1.6
control type: ACTIVATION

Reference/ChEBI CHEBI 16332
type: UnificationXref
id: CHEBI:16332
db: ChEBI

Reference/PubChem-compound 439236
type: UnificationXref
id: 439236
db: PubChem-compound

Reference/CAS 75-07-0
type: UnificationXref
id: 75-07-0
db: CAS

Reference/ChemSpider 172
type: UnificationXref
id: 172
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ReactionCatalysis138116
type: Catalysis
controller: Deoxyribose-phosphate aldolase
controlled: 4.1.2.4
control type: ACTIVATION

ReactionCatalysis138115
type: Catalysis
controller: Transketolase
controlled: 2.2.1.1
control type: ACTIVATION

ReactionCatalysis138118
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: 5.3.1.9
control type: ACTIVATION

ReactionCatalysis138117
type: Catalysis
controller: Ribokinase
controlled: 2.7.1.15
control type: ACTIVATION

ReactionCatalysis138112
type: Catalysis
controller: Ribulose-phosphate 3-epimerase
controlled: 5.1.3.1
control type: ACTIVATION

Xylulose 5-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Xylulose 5-phosphate

ReactionCatalysis138111
type: Catalysis
controller: Phosphoglucomutase-1
controlled: 5.4.2.2
control type: ACTIVATION

Fructose-bisphosphate aldolase A
type: Complex
component stoichiometry: Protein/15640 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Fructose-bisphosphate aldolase A

ReactionCatalysis138114
type: Catalysis
controller: Transaldolase
controlled: 2.2.1.2
control type: ACTIVATION

1.1.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000097 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Gluconolactone
right: NADPH
spontaneous: false
EC number: 1.1.1.49
left: β-D-Glucose 6-phosphate
left: NADP
name: NADP + β-D-Glucose 6-phosphate → Gluconolactone + NADPH
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis138113
type: Catalysis
controller: Transketolase
controlled: 2.2.1.1
control type: ACTIVATION

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/BioCyc ACETALD
type: UnificationXref
id: ACETALD
db: BioCyc

3.1.1.31
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000097 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 6-Phosphogluconic acid
spontaneous: false
EC number: 3.1.1.31
left: Gluconolactone
left: Water
name: Gluconolactone + Water → 6-Phosphogluconic acid
conversion direction: LEFT_TO_RIGHT

Acetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetaldehyde

Reaction147842
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001015 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: D-Ribulose 5-phosphate
right: Carbon dioxide
right: NADPH
spontaneous: false
left: 6-Phosphogluconic acid
left: NADP
name: 6-Phosphogluconic acid + NADP → Carbon dioxide + D-Ribulose 5-phosphate + NADPH
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

5.3.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 5.3.1.6
left: D-Ribulose 5-phosphate
name: D-Ribulose 5-phosphate ↔ D-Ribose 5-phosphate
conversion direction: REVERSIBLE

2.7.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000191 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 2.7.1.15
left: Adenosine triphosphate
left: D-Ribose
name: Adenosine triphosphate + D-Ribose → Adenosine diphosphate + D-Ribose 5-phosphate
conversion direction: LEFT_TO_RIGHT

5.4.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytosol/Stoichiometry/1.0
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 5.4.2.2
left: Ribose 1-phosphate
name: Ribose 1-phosphate ↔ D-Ribose 5-phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000618
type: UnificationXref
id: HMDB0000618
db: HMDB

5.1.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000479 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000691 Cytosol/Stoichiometry/1.0
right: Xylulose 5-phosphate
spontaneous: false
EC number: 5.1.3.1
left: D-Ribulose 5-phosphate
name: D-Ribulose 5-phosphate → Xylulose 5-phosphate
conversion direction: LEFT_TO_RIGHT

2.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000843 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000691 Cytosol/Stoichiometry/1.0
right: Xylulose 5-phosphate
right: D-Ribose 5-phosphate
spontaneous: false
EC number: 2.2.1.1
left: D-Sedoheptulose 7-phosphate
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate ↔ D-Ribose 5-phosphate + Xylulose 5-phosphate
conversion direction: REVERSIBLE

2.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000843 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: D-Sedoheptulose 7-phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 2.2.1.2
left: D-Erythrose 4-phosphate
left: Fructose 6-phosphate
name: D-Erythrose 4-phosphate + Fructose 6-phosphate ↔ D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate
conversion direction: REVERSIBLE

2.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000691 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: D-Glyceraldehyde 3-phosphate
right: Fructose 6-phosphate
spontaneous: false
EC number: 2.2.1.1
left: Xylulose 5-phosphate
left: D-Erythrose 4-phosphate
name: D-Erythrose 4-phosphate + Xylulose 5-phosphate ↔ D-Glyceraldehyde 3-phosphate + Fructose 6-phosphate
conversion direction: REVERSIBLE

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Phosphoglucomutase-1
type: Protein
cellular location: Cytosol
entity reference: Phosphoglucomutase-1

ChemicalStructure/PW C000784
type: ChemicalStructure
structure format: SMILES
structure data: CC=O

Ribose-5-phosphate Isomerase Deficiency
type: Pathway
pathway order: PathwayEnzymeReaction/2114902
pathway order: PathwayEnzymeReaction/2114901
pathway order: PathwayEnzymeReaction/2114900
pathway order: PathwayEnzymeReaction/2114906
pathway order: PathwayEnzymeReaction/2114905
pathway order: PathwayEnzymeReaction/2114904
pathway order: PathwayEnzymeReaction/2114903
pathway order: PathwaySubPathway/108640
pathway order: PathwaySubPathway/108641
pathway order: PathwayEnzymeReaction/2114898
pathway order: PathwayEnzymeReaction/2114897
pathway order: PathwayEnzymeReaction/2114913
pathway order: PathwaySubPathway/108646
pathway order: PathwayEnzymeReaction/2114912
pathway order: PathwayEnzymeReaction/2114911
pathway order: PathwayEnzymeReaction/2114899
pathway order: PathwayEnzymeReaction/2114910
pathway order: PathwaySubPathway/108642
pathway order: PathwaySubPathway/108643
pathway order: PathwaySubPathway/108644
pathway order: PathwayEnzymeReaction/2114914
pathway order: PathwaySubPathway/108645
pathway order: PathwayEnzymeReaction/2114909
pathway order: PathwayEnzymeReaction/2114908
pathway order: PathwayEnzymeReaction/2114907
pathway component: ReactionCatalysis138107
pathway component: 4.1.2.13
pathway component: ReactionCatalysis138106
pathway component: 2.7.6.1
pathway component: 3.1.3.11
pathway component: 4.1.2.4
pathway component: 2.7.1.15
pathway component: ReactionCatalysis137419
pathway component: 5.3.1.9
pathway component: ReactionCatalysis138109
pathway component: ReactionCatalysis137416
pathway component: ReactionCatalysis137934
pathway component: ReactionCatalysis137417
pathway component: Purine Metabolism
pathway component: 2.7.1.11
pathway component: Vitamin B6 Metabolism
pathway component: ReactionCatalysis138116
pathway component: ReactionCatalysis138115
pathway component: ReactionCatalysis138118
pathway component: ReactionCatalysis138117
pathway component: ReactionCatalysis138112
pathway component: ReactionCatalysis138111
pathway component: ReactionCatalysis138114
pathway component: 1.1.1.49
pathway component: ReactionCatalysis138113
pathway component: 3.1.1.31
pathway component: Reaction147842
pathway component: 5.3.1.6
pathway component: 5.4.2.2
pathway component: 5.1.3.1
pathway component: 2.2.1.1
pathway component: 2.2.1.2
pathway component: Histidine Metabolism
pathway component: Glycolysis
pathway component: Phenylalanine and Tyrosine Metabolism
pathway component: ReactionCatalysis138110
pathway component: ReactionCatalysis137581
pathway component: Pyrimidine Metabolism
xref: Reference/SMPDB SMP0120803
xref: Reference/PathWhiz PW122064
organism: Rattus norvegicus

ReactionCatalysis138110
type: Catalysis
controller: Ribokinase
controlled: 2.7.1.15
control type: ACTIVATION

Protein/17129 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glucose-6-phosphate 1-dehydrogenase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 47013
type: UnificationXref
id: CHEBI:47013
db: ChEBI

Reference/ChEBI CHEBI 15343
type: UnificationXref
id: CHEBI:15343
db: ChEBI

4.1.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000813 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784 Cytosol/Stoichiometry/1.0
right: Deoxyribose 5-phosphate
spontaneous: false
EC number: 4.1.2.4
left: D-Glyceraldehyde 3-phosphate
left: Acetaldehyde
name: Acetaldehyde + D-Glyceraldehyde 3-phosphate ↔ Deoxyribose 5-phosphate
conversion direction: REVERSIBLE

2.7.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000813 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001042 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Deoxyribose 5-phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.15
left: Deoxyribose 1-phosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Deoxyribose 1-phosphate ↔ Adenosine diphosphate + Deoxyribose 5-phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000868
type: UnificationXref
id: HMDB0000868
db: HMDB

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001906 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: β-D-Glucose 6-phosphate
name: β-D-Glucose 6-phosphate ↔ Glucose 6-phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 388373
type: UnificationXref
id: 388373
db: ChemSpider

Reference/CAS 17210-42-3
type: UnificationXref
id: 17210-42-3
db: CAS

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/HMDB HMDB0000990
type: UnificationXref
id: HMDB0000990
db: HMDB

Ribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Ribose 1-phosphate

Reference/ChEBI CHEBI 28542
type: UnificationXref
id: CHEBI:28542
db: ChEBI

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/BioCyc GLC-D-LACTONE
type: UnificationXref
id: GLC-D-LACTONE
db: BioCyc

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 109096
type: UnificationXref
id: 109096
db: ChemSpider

Reference/PubChem-compound 177
type: UnificationXref
id: 177
db: PubChem-compound

Reference/UniProt Q6P6V0
type: UnificationXref
id: Q6P6V0
db: UniProt

Transaldolase
type: Complex
component stoichiometry: Protein/17157 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Transaldolase

Reference/CAS 4300-28-1
type: UnificationXref
id: 4300-28-1
db: CAS

Protein/15633 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-1,6-bisphosphatase 1
stoichiometric coefficient: 4.0